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Sulphonylureas

Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves

Type
Drug
ID
PH440
Version ID
880
Data Sources
Valid event data range
01/01/2000 - 31/12/2007
Sex
Female, Male
Agreement Date
2011-06-28
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.

Publications

  • Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011.

Clinical Code List

Rows: 55
Code Description Entity type Category Coding System (GPRD_product_code)
1335009 glibenclamide tabs 5mg [aps] sulphonylureas drug GPRD_product_code
1335010 glibenclamide tabs 2.5mg [aps] sulphonylureas drug GPRD_product_code
1356009 glibenclamide tabs 5mg [berk] sulphonylureas drug GPRD_product_code
1356010 glibenclamide tabs 2.5mg [berk] sulphonylureas drug GPRD_product_code
14098001 glibenclamide oral susp 5mg/5ml sulphonylureas drug GPRD_product_code
1451009 glibenclamide tabs 5mg [numark] sulphonylureas drug GPRD_product_code
14734001 glibenclamide oral liq sulphonylureas drug GPRD_product_code
1581009 glibenclamide tabs 2.5mg [lagap] sulphonylureas drug GPRD_product_code
1581010 glibenclamide tabs 5mg [lagap] sulphonylureas drug GPRD_product_code
1811009 chlorpropamide tabs 100mg [aps] sulphonylureas drug GPRD_product_code
1811010 chlorpropamide tabs 250mg [aps] sulphonylureas drug GPRD_product_code
212001 daonil tabs 5mg sulphonylureas drug GPRD_product_code
2224009 chlorpropamide tabs 100mg [alphar/cox] sulphonylureas drug GPRD_product_code
2224010 chlorpropamide tabs 250mg [alphar/cox] sulphonylureas drug GPRD_product_code
2248009 glibenclamide tabs 2.5mg [alphar/cox] sulphonylureas drug GPRD_product_code
2248010 glibenclamide tabs 5mg [alphar/cox] sulphonylureas drug GPRD_product_code
235001 diabinese tabs 100mg sulphonylureas drug GPRD_product_code
235002 diabinese tabs 250mg sulphonylureas drug GPRD_product_code
2416001 libanil tabs 2.5mg sulphonylureas drug GPRD_product_code
2416002 libanil tabs 5mg sulphonylureas drug GPRD_product_code
2447009 glibenclamide tabs 2.5mg [ivax] sulphonylureas drug GPRD_product_code
2447010 glibenclamide tabs 5mg [ivax] sulphonylureas drug GPRD_product_code
2462001 diabetamide tabs 2.5mg sulphonylureas drug GPRD_product_code
2462002 diabetamide tabs 5mg sulphonylureas drug GPRD_product_code
2866007 chloropropamide 500 mg tab sulphonylureas drug GPRD_product_code
2872001 glibenclamide tabs 2.5mg sulphonylureas drug GPRD_product_code
2872002 glibenclamide tabs 5mg sulphonylureas drug GPRD_product_code
2902001 malix tabs 2.5mg sulphonylureas drug GPRD_product_code
2902002 malix tabs 5mg sulphonylureas drug GPRD_product_code
2942001 calabren tabs 5mg sulphonylureas drug GPRD_product_code
2942002 calabren tabs 2.5mg sulphonylureas drug GPRD_product_code
3244001 chlorpropamide tabs 100mg sulphonylureas drug GPRD_product_code
3244002 chlorpropamide tabs 250mg sulphonylureas drug GPRD_product_code
331001 euglucon tabs 2.5mg sulphonylureas drug GPRD_product_code
331002 euglucon tabs 5mg sulphonylureas drug GPRD_product_code
3312001 glymese tabs 250mg sulphonylureas drug GPRD_product_code
3384009 chlorpropamide tabs 100mg [sussex] sulphonylureas drug GPRD_product_code
3384010 chlorpropamide tabs 250mg [sussex] sulphonylureas drug GPRD_product_code
3440009 glibenclamide tabs 2.5mg [kent] sulphonylureas drug GPRD_product_code
3778009 glibenclamide tabs 2.5mg [gen (uk)] sulphonylureas drug GPRD_product_code
3779009 glibenclamide tabs 5mg [gen (uk)] sulphonylureas drug GPRD_product_code
417009 glibenclamide tabs 5mg [cp pharm] sulphonylureas drug GPRD_product_code
417010 glibenclamide tabs 2.5mg [cp pharm] sulphonylureas drug GPRD_product_code
418009 glibenclamide tabs 2.5mg [celltech] sulphonylureas drug GPRD_product_code
418010 glibenclamide tabs 5mg [celltech] sulphonylureas drug GPRD_product_code
419009 glibenclamide tabs 5mg [hillcross] sulphonylureas drug GPRD_product_code
419010 glibenclamide tabs 2.5mg [hillcross] sulphonylureas drug GPRD_product_code
4398009 glibenclamide tabs 5mg [kent] sulphonylureas drug GPRD_product_code
7481001 grenamide tabs 2.5mg sulphonylureas drug GPRD_product_code
7481002 grenamide tabs 5mg sulphonylureas drug GPRD_product_code
752009 chlorpropamide tabs 100mg [cp pharm] sulphonylureas drug GPRD_product_code
752010 chlorpropamide tabs 250mg [cp pharm] sulphonylureas drug GPRD_product_code
753009 chlorpropamide tabs 100mg [celltech] sulphonylureas drug GPRD_product_code
753010 chlorpropamide tabs 250mg [celltech] sulphonylureas drug GPRD_product_code
854001 semi-daonil tabs 2.5mg sulphonylureas drug GPRD_product_code

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH440/version/880/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH440/version/880/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH440', '880', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH440/version/880/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH440/version/880/export/codes/?format=json
CSV site_root/phenotypes/PH440/version/880/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH440', '880', api_client=client)

Version History

Version
ID
Name Owner Publish date
880 Sulphonylureas ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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