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Alcohol Intake

Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury

Type
Lifestyle Risk Factor
ID
PH446
Version ID
892
Data Sources
Valid event data range
start - 31/12/2014
Sex
Female, Male
Agreement Date
2016-09-06
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Introduction:

Voltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.

Methods and analysis:

A cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.

Publications

  • Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016.

Clinical Code List

Rows: 36
Code Description Entity type Category Coding System (Read)
136..00 Alcohol consumption res47: Alcohol intake test Read
1361.11 Non drinker alcohol res47: Alcohol intake test Read
1361.12 Non-drinker alcohol res47: Alcohol intake test Read
1362.11 Drinks rarely res47: Alcohol intake test Read
1362.12 Drinks occasionally res47: Alcohol intake test Read
136A.00 Ex-trivial drinker (<1u/day) res47: Alcohol intake test Read
136B.00 Ex-light drinker - (1-2u/day) res47: Alcohol intake test Read
136C.00 Ex-moderate drinker - (3-6u/d) res47: Alcohol intake test Read
136D.00 Ex-heavy drinker - (7-9u/day) res47: Alcohol intake test Read
136E.00 Ex-very heavy drinker-(>9u/d) res47: Alcohol intake test Read
136F.00 Spirit drinker res47: Alcohol intake test Read
136G.00 Beer drinker res47: Alcohol intake test Read
136H.00 Drinks beer and spirits res47: Alcohol intake test Read
136I.00 Drinks wine res47: Alcohol intake test Read
136J.00 Social drinker res47: Alcohol intake test Read
136K.00 Alcohol intake above recommended sensible limits res47: Alcohol intake test Read
136L.00 Alcohol intake within recommended sensible limits res47: Alcohol intake test Read
136M.00 Current non drinker res47: Alcohol intake test Read
136N.00 Light drinker res47: Alcohol intake test Read
136O.00 Moderate drinker res47: Alcohol intake test Read
136P.00 Heavy drinker res47: Alcohol intake test Read
136Q.00 Very heavy drinker res47: Alcohol intake test Read
136R.00 Binge drinker res47: Alcohol intake test Read
136S.00 Hazardous alcohol use res47: Alcohol intake test Read
136T.00 Harmful alcohol use res47: Alcohol intake test Read
136V.00 Alcohol units per week res47: Alcohol intake test Read
136W.00 Alcohol misuse res47: Alcohol intake test Read
136X.00 Alcohol units consumed on heaviest drinking day res47: Alcohol intake test Read
136Y.00 Drinks in morning to get rid of hangover res47: Alcohol intake test Read
136Z.00 Alcohol consumption NOS res47: Alcohol intake test Read
136a.00 Increasing risk drinking res47: Alcohol intake test Read
136b.00 Feels should cut down drinking res47: Alcohol intake test Read
136c.00 Higher risk drinking res47: Alcohol intake test Read
136d.00 Lower risk drinking res47: Alcohol intake test Read
136e.00 Declines to state current alcohol consumption res47: Alcohol intake test Read
E23..12 Alcohol problem drinking res47: Alcohol intake test Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH446/version/892/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH446/version/892/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH446', '892', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH446/version/892/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH446/version/892/export/codes/?format=json
CSV site_root/phenotypes/PH446/version/892/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH446', '892', api_client=client)

Version History

Version
ID
Name Owner Publish date
892 Alcohol Intake ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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