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Body Mass Index

Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury

Type
Biomarker
ID
PH449
Version ID
898
Data Sources
Valid event data range
start - 31/12/2014
Sex
Female, Male
Agreement Date
2016-09-06
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Introduction:

Voltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.

Methods and analysis:

A cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.

Publications

  • Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016.

Clinical Code List

Rows: 13
Code Description Entity type Category Coding System (Read)
22K..00 Body Mass Index res47: Body mass index test Read
22K1.00 Body Mass Index normal K/M2 res47: Body mass index test Read
22K2.00 Body Mass Index high K/M2 res47: Body mass index test Read
22K3.00 Body Mass Index low K/M2 res47: Body mass index test Read
22K4.00 Body mass index index 25-29 - overweight res47: Body mass index test Read
22K5.00 Body mass index 30+ - obesity res47: Body mass index test Read
22K6.00 Body mass index less than 20 res47: Body mass index test Read
22K7.00 Body mass index 40+ - severely obese res47: Body mass index test Read
22K8.00 Body mass index 20-24 - normal res47: Body mass index test Read
22K9.00 Body mass index centile res47: Body mass index test Read
22K9000 Baseline body mass index centile res47: Body mass index test Read
22KA.00 Target body mass index res47: Body mass index test Read
22KB.00 Baseline body mass index res47: Body mass index test Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH449/version/898/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH449/version/898/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH449', '898', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH449/version/898/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH449/version/898/export/codes/?format=json
CSV site_root/phenotypes/PH449/version/898/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH449', '898', api_client=client)

Version History

Version
ID
Name Owner Publish date
898 Body Mass Index ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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