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Cancer

Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury

Type
Disease or Syndrome
ID
PH451
Version ID
902
Data Sources
Valid event data range
start - 31/12/2014
Sex
Female, Male
Agreement Date
2016-09-06
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Introduction:

Voltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.

Methods and analysis:

A cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.

Publications

  • Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016.

Clinical Code List

Rows: 97
Code Description Entity type Category Coding System (Read)
1427000 H/O: prostate cancer res47: Cancer diagnostic Read
1J08.00 Suspected prostate cancer res47: Cancer diagnostic Read
4M0..00 Gleason grading of prostate cancer res47: Cancer diagnostic Read
4M00.00 Gleason prostate grade 2-4 (low) res47: Cancer diagnostic Read
4M01.00 Gleason prostate grade 5-7 (medium) res47: Cancer diagnostic Read
4M02.00 Gleason prostate grade 8-10 (high) res47: Cancer diagnostic Read
B13..00 Malignant neoplasm of colon res47: Cancer diagnostic Read
B130.00 Malignant neoplasm of hepatic flexure of colon res47: Cancer diagnostic Read
B131.00 Malignant neoplasm of transverse colon res47: Cancer diagnostic Read
B132.00 Malignant neoplasm of descending colon res47: Cancer diagnostic Read
B133.00 Malignant neoplasm of sigmoid colon res47: Cancer diagnostic Read
B134.00 Malignant neoplasm of caecum res47: Cancer diagnostic Read
B134.11 Carcinoma of caecum res47: Cancer diagnostic Read
B135.00 Malignant neoplasm of appendix res47: Cancer diagnostic Read
B136.00 Malignant neoplasm of ascending colon res47: Cancer diagnostic Read
B137.00 Malignant neoplasm of splenic flexure of colon res47: Cancer diagnostic Read
B138.00 Malignant neoplasm, overlapping lesion of colon res47: Cancer diagnostic Read
B139.00 Hereditary nonpolyposis colon cancer res47: Cancer diagnostic Read
B13y.00 Malignant neoplasm of other specified sites of colon res47: Cancer diagnostic Read
B13z.00 Malignant neoplasm of colon NOS res47: Cancer diagnostic Read
B13z.11 Colonic cancer res47: Cancer diagnostic Read
B14..00 Malignant neoplasm of rectum, rectosigmoid junction and anus res47: Cancer diagnostic Read
B140.00 Malignant neoplasm of rectosigmoid junction res47: Cancer diagnostic Read
B141.00 Malignant neoplasm of rectum res47: Cancer diagnostic Read
B141.11 Carcinoma of rectum res47: Cancer diagnostic Read
B141.12 Rectal carcinoma res47: Cancer diagnostic Read
B142.00 Malignant neoplasm of anal canal res47: Cancer diagnostic Read
B142.11 Anal carcinoma res47: Cancer diagnostic Read
B142000 Malignant neoplasm of cloacogenic zone res47: Cancer diagnostic Read
B143.00 Malignant neoplasm of anus unspecified res47: Cancer diagnostic Read
B14y.00 Malig neop other site rectum, rectosigmoid junction and anus res47: Cancer diagnostic Read
B14z.00 Malignant neoplasm rectum,rectosigmoid junction and anus NOS res47: Cancer diagnostic Read
B1z0.11 Cancer of bowel res47: Cancer diagnostic Read
B34..00 Malignant neoplasm of female breast res47: Cancer diagnostic Read
B34..11 Ca female breast res47: Cancer diagnostic Read
B340.00 Malignant neoplasm of nipple and areola of female breast res47: Cancer diagnostic Read
B340000 Malignant neoplasm of nipple of female breast res47: Cancer diagnostic Read
B340100 Malignant neoplasm of areola of female breast res47: Cancer diagnostic Read
B340z00 Malignant neoplasm of nipple or areola of female breast NOS res47: Cancer diagnostic Read
B341.00 Malignant neoplasm of central part of female breast res47: Cancer diagnostic Read
B342.00 Malignant neoplasm of upper-inner quadrant of female breast res47: Cancer diagnostic Read
B343.00 Malignant neoplasm of lower-inner quadrant of female breast res47: Cancer diagnostic Read
B344.00 Malignant neoplasm of upper-outer quadrant of female breast res47: Cancer diagnostic Read
B345.00 Malignant neoplasm of lower-outer quadrant of female breast res47: Cancer diagnostic Read
B346.00 Malignant neoplasm of axillary tail of female breast res47: Cancer diagnostic Read
B347.00 Malignant neoplasm, overlapping lesion of breast res47: Cancer diagnostic Read
B34y.00 Malignant neoplasm of other site of female breast res47: Cancer diagnostic Read
B34y000 Malignant neoplasm of ectopic site of female breast res47: Cancer diagnostic Read
B34yz00 Malignant neoplasm of other site of female breast NOS res47: Cancer diagnostic Read
B34z.00 Malignant neoplasm of female breast NOS res47: Cancer diagnostic Read
B35..00 Malignant neoplasm of male breast res47: Cancer diagnostic Read
B350.00 Malignant neoplasm of nipple and areola of male breast res47: Cancer diagnostic Read
B350000 Malignant neoplasm of nipple of male breast res47: Cancer diagnostic Read
B350100 Malignant neoplasm of areola of male breast res47: Cancer diagnostic Read
B35z.00 Malignant neoplasm of other site of male breast res47: Cancer diagnostic Read
B35z000 Malignant neoplasm of ectopic site of male breast res47: Cancer diagnostic Read
B35zz00 Malignant neoplasm of male breast NOS res47: Cancer diagnostic Read
B36..00 Local recurrence of malignant tumour of breast res47: Cancer diagnostic Read
B46..00 Malignant neoplasm of prostate res47: Cancer diagnostic Read
B575.00 Secondary malignant neoplasm of large intestine and rectum res47: Cancer diagnostic Read
B575000 Secondary malignant neoplasm of colon res47: Cancer diagnostic Read
B575100 Secondary malignant neoplasm of rectum res47: Cancer diagnostic Read
B575z00 Secondary malig neop of large intestine or rectum NOS res47: Cancer diagnostic Read
B58y000 Secondary malignant neoplasm of breast res47: Cancer diagnostic Read
B58y500 Secondary malignant neoplasm of prostate res47: Cancer diagnostic Read
B7C2000 Adenoma of prostate res47: Cancer diagnostic Read
B803.00 Carcinoma in situ of colon res47: Cancer diagnostic Read
B803000 Carcinoma in situ of hepatic flexure of colon res47: Cancer diagnostic Read
B803100 Carcinoma in situ of transverse colon res47: Cancer diagnostic Read
B803200 Carcinoma in situ of descending colon res47: Cancer diagnostic Read
B803300 Carcinoma in situ of sigmoid colon res47: Cancer diagnostic Read
B803400 Carcinoma in situ of caecum res47: Cancer diagnostic Read
B803500 Carcinoma in situ of appendix res47: Cancer diagnostic Read
B803600 Carcinoma in situ of ascending colon res47: Cancer diagnostic Read
B803700 Carcinoma in situ of splenic flexure of colon res47: Cancer diagnostic Read
B803800 High grade dysplasia of colon res47: Cancer diagnostic Read
B803z00 Carcinoma in situ of colon NOS res47: Cancer diagnostic Read
B804.00 Carcinoma in situ of rectum and rectosigmoid junction res47: Cancer diagnostic Read
B804000 Carcinoma in situ of rectosigmoid junction res47: Cancer diagnostic Read
B804100 Carcinoma in situ of rectum res47: Cancer diagnostic Read
B804z00 Carcinoma in situ of rectum or rectosigmoid junction NOS res47: Cancer diagnostic Read
B830.00 Carcinoma in situ of breast res47: Cancer diagnostic Read
B830000 Lobular carcinoma in situ of breast res47: Cancer diagnostic Read
B830100 Intraductal carcinoma in situ of breast res47: Cancer diagnostic Read
B834.00 Carcinoma in situ of prostate res47: Cancer diagnostic Read
B834000 High grade prostatic intraepithelial neoplasia res47: Cancer diagnostic Read
B834100 Prostatic intraepithelial neoplasia res47: Cancer diagnostic Read
B902000 Neoplasm of uncertain behaviour of stomach res47: Cancer diagnostic Read
B902400 Neoplasm of uncertain behaviour of colon res47: Cancer diagnostic Read
B902500 Neoplasm of uncertain behaviour of rectum res47: Cancer diagnostic Read
B902z00 Neop of uncertain behaviour stomach, intestine or rectum NOS res47: Cancer diagnostic Read
B915.00 Neoplasm of uncertain behaviour of prostate res47: Cancer diagnostic Read
B933.00 Neoplasm of uncertain behaviour of breast res47: Cancer diagnostic Read
BA03.00 Neoplasm of unspecified nature of breast res47: Cancer diagnostic Read
BB94.11 [M]Secretory breast carcinoma res47: Cancer diagnostic Read
Byu6.00 [X]Malignant neoplasm of breast res47: Cancer diagnostic Read
ZV10415 [V]Personal history of malignant neoplasm of prostate res47: Cancer diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH451/version/902/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH451/version/902/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH451', '902', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH451/version/902/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH451/version/902/export/codes/?format=json
CSV site_root/phenotypes/PH451/version/902/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH451', '902', api_client=client)

Version History

Version
ID
Name Owner Publish date
902 Cancer ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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