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Colorectal Cancer

Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenbury

Type
Disease or Syndrome
ID
PH453
Version ID
906
Data Sources
QResearch
Valid event data range
01/01/1998 - 31/12/2013
Sex
Female, Male
Agreement Date
2014-11-14
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

A cohort study based on primary care data from the QResearch database will include patients with one of the three common tumours: breast, bowel and prostate. The primary outcome will be overall survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare the survival of patients with cancer taking VGSC-inhibiting drugs (including anticonvulsants and class I antiarrhythmic agents) with patients with cancer not exposed to these drugs, adjusting for age and sex. Exposure to VGSC-inhibiting drugs will be defined as having at least one prescription for these drugs prior to cancer diagnosis. High and low exposure groups will be identified based on the length of use. A number of sensitivity and secondary analyses will be conducted.

Publications

  • Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenburry, Exposure to sodium channel-inhibiting drugs and cancer survival protocol for a cohort study using the QResearch primary care database. BMJ Open, 4:e006604 2014.

Clinical Code List

Rows: 60
Code Description Entity type Category Coding System (Read)
B13 Malignant neoplasm of colon res17: Colorectal cancer diagnostic Read
B130 Malignant neoplasm of hepatic flexure of colon res17: Colorectal cancer diagnostic Read
B130-99 Ca hepatic flexure - colon res17: Colorectal cancer diagnostic Read
B131 Malignant neoplasm of transverse colon res17: Colorectal cancer diagnostic Read
B131-99 Ca transverse colon res17: Colorectal cancer diagnostic Read
B132 Malignant neoplasm of descending colon res17: Colorectal cancer diagnostic Read
B132-99 Ca descending colon res17: Colorectal cancer diagnostic Read
B133 Malignant neoplasm of sigmoid colon res17: Colorectal cancer diagnostic Read
B133-99 Ca sigmoid colon res17: Colorectal cancer diagnostic Read
B134 Malignant neoplasm of caecum res17: Colorectal cancer diagnostic Read
B134-1 Carcinoma of caecum res17: Colorectal cancer diagnostic Read
B135 Malignant neoplasm of appendix res17: Colorectal cancer diagnostic Read
B136 Malignant neoplasm of ascending colon res17: Colorectal cancer diagnostic Read
B136-99 Ca ascending colon res17: Colorectal cancer diagnostic Read
B137 Malignant neoplasm of splenic flexure of colon res17: Colorectal cancer diagnostic Read
B137-99 Ca splenic flexure - colon res17: Colorectal cancer diagnostic Read
B138 Malignant neoplasm, overlapping lesion of colon res17: Colorectal cancer diagnostic Read
B139 Hereditary nonpolyposis colon cancer res17: Colorectal cancer diagnostic Read
B13y Malignant neoplasm of other specified sites of colon res17: Colorectal cancer diagnostic Read
B13z Malignant neoplasm of colon NOS res17: Colorectal cancer diagnostic Read
B13z-1 Colonic cancer res17: Colorectal cancer diagnostic Read
B14 Malignant neoplasm of rectum, rectosigmoid junction and anus res17: Colorectal cancer diagnostic Read
B14-99 Ca rectum + Ca anus res17: Colorectal cancer diagnostic Read
B140 Malignant neoplasm of rectosigmoid junction res17: Colorectal cancer diagnostic Read
B140-99 Ca rectosigmoid junction res17: Colorectal cancer diagnostic Read
B141 Malignant neoplasm of rectum res17: Colorectal cancer diagnostic Read
B141-1 Carcinoma of rectum res17: Colorectal cancer diagnostic Read
B141-2 Rectal carcinoma res17: Colorectal cancer diagnostic Read
B141-99 Adenocarcinoma of rectum res17: Colorectal cancer diagnostic Read
B1420 Malignant neoplasm of cloacogenic zone res17: Colorectal cancer diagnostic Read
B143 Malignant neoplasm of anus unspecified res17: Colorectal cancer diagnostic Read
B14y Malig neop other site rectum, rectosigmoid junction and anus res17: Colorectal cancer diagnostic Read
B14z Malignant neoplasm rectum,rectosigmoid junction and anus NOS res17: Colorectal cancer diagnostic Read
B14z-99 Ca rectum + Ca anus NOS res17: Colorectal cancer diagnostic Read
B1z0-1 Cancer of bowel res17: Colorectal cancer diagnostic Read
B575 Secondary malignant neoplasm of large intestine and rectum res17: Colorectal cancer diagnostic Read
B5750 Secondary malignant neoplasm of colon res17: Colorectal cancer diagnostic Read
B5751 Secondary malignant neoplasm of rectum res17: Colorectal cancer diagnostic Read
B575z Secondary malig neop of large intestine or rectum NOS res17: Colorectal cancer diagnostic Read
B803 Carcinoma in situ of colon res17: Colorectal cancer diagnostic Read
B8030 Carcinoma in situ of hepatic flexure of colon res17: Colorectal cancer diagnostic Read
B8031 Carcinoma in situ of transverse colon res17: Colorectal cancer diagnostic Read
B8032 Carcinoma in situ of descending colon res17: Colorectal cancer diagnostic Read
B8033 Carcinoma in situ of sigmoid colon res17: Colorectal cancer diagnostic Read
B8036 Carcinoma in situ of ascending colon res17: Colorectal cancer diagnostic Read
B8037 Carcinoma in situ of splenic flexure of colon res17: Colorectal cancer diagnostic Read
B8038 High grade dysplasia of colon res17: Colorectal cancer diagnostic Read
B803z Carcinoma in situ of colon NOS res17: Colorectal cancer diagnostic Read
B804 Carcinoma in situ of rectum and rectosigmoid junction res17: Colorectal cancer diagnostic Read
B8040 Carcinoma in situ of rectosigmoid junction res17: Colorectal cancer diagnostic Read
B8041 Carcinoma in situ of rectum res17: Colorectal cancer diagnostic Read
B804z Carcinoma in situ of rectum or rectosigmoid junction NOS res17: Colorectal cancer diagnostic Read
B902 Neop of uncertain behaviour stomach, intestines and rectum res17: Colorectal cancer diagnostic Read
B9024 Neoplasm of uncertain behaviour of colon res17: Colorectal cancer diagnostic Read
B9025 Neoplasm of uncertain behaviour of rectum res17: Colorectal cancer diagnostic Read
B902z Neop of uncertain behaviour stomach, intestine or rectum NOS res17: Colorectal cancer diagnostic Read
BB5N [M]Adenomatous and adenocarcinomatous polyps of colon res17: Colorectal cancer diagnostic Read
EGTON2B152 Cause of Death- Ca Rectum res17: Colorectal cancer diagnostic Read
EMISNQHE41 Hereditary nonpolyposis colon cancer res17: Colorectal cancer diagnostic Read
HNG0201 [RFC] Cancer of the rectum res17: Colorectal cancer diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH453/version/906/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH453/version/906/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH453', '906', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH453/version/906/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH453/version/906/export/codes/?format=json
CSV site_root/phenotypes/PH453/version/906/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH453', '906', api_client=client)

Version History

Version
ID
Name Owner Publish date
906 Colorectal Cancer ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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