Introduction:
Voltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.
Methods and analysis:
A cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.
Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016.
| Code | Description | Entity type | Category | Coding System (Read) |
|---|---|---|---|---|
| 1381.00 | Exercise physically impossible | res47: Physical activity | test | Read |
| 1382.00 | Avoids even trivial exercise | res47: Physical activity | test | Read |
| 1383.00 | Enjoys light exercise | res47: Physical activity | test | Read |
| 1384.00 | Enjoys moderate exercise | res47: Physical activity | test | Read |
| 1385.00 | Enjoys heavy exercise | res47: Physical activity | test | Read |
| 1386.00 | Competitive athlete | res47: Physical activity | test | Read |
| 1388.00 | Aerobic exercise 0 times/week | res47: Physical activity | test | Read |
| 1389.00 | Aerobic exercise 1 time/week | res47: Physical activity | test | Read |
| 138A.00 | Aerobic exercise 2 times/week | res47: Physical activity | test | Read |
| 138B.00 | Aerobic exercise 3+ times/week | res47: Physical activity | test | Read |
| 138C.00 | Anaerobic exercise 0 times/wk | res47: Physical activity | test | Read |
| 138D.00 | Anaerobic exercise 1 time/week | res47: Physical activity | test | Read |
| 138E.00 | Anaerobic exercise 2 times/wk | res47: Physical activity | test | Read |
| 138F.00 | Anaerobic exercise 3+ times/wk | res47: Physical activity | test | Read |
| 138G.00 | Attends exercise classes | res47: Physical activity | test | Read |
| 138H.00 | Enjoys intermediate exercise | res47: Physical activity | test | Read |
| 138I.00 | FITT activity level 0; no mod/vig activity of 20 mins duratn | res47: Physical activity | test | Read |
| 138J.00 | FITT activity level 1; 1-4 occas of mod/vig activit in 4 wks | res47: Physical activity | test | Read |
| 138K.00 | FITT activity level 2; 5-11 occas of mod/vig activt in 4 wks | res47: Physical activity | test | Read |
| 138L.00 | FITT activity level 3; 12+ occas of mod activity in 4 weeks | res47: Physical activity | test | Read |
| 138M.00 | FITT activity level 4; 12+ occas of mod/vig activit in 4 wks | res47: Physical activity | test | Read |
| 138N.00 | FITT activity level 5; 12+ occas of vig activity in 4 weeks | res47: Physical activity | test | Read |
| 138O.00 | Takes inadequate exercise | res47: Physical activity | test | Read |
| 138P.00 | Aerobic exercise three times a week | res47: Physical activity | test | Read |
| 138Q.00 | Aerobic exercise four times a week | res47: Physical activity | test | Read |
| 138R.00 | Aerobic exercise five times a week | res47: Physical activity | test | Read |
| 138S.00 | Declined referral to physical exercise programme | res47: Physical activity | test | Read |
| 138T.00 | 30 mins/day of at least mod intensty physc activity >=5 week | res47: Physical activity | test | Read |
| 138V.00 | 30 minutes a day of at least moderate intensity walk >=5week | res47: Physical activity | test | Read |
| 138W.00 | Less than 30 mins/day of at least mod int physc act >=5 week | res47: Physical activity | test | Read |
| 138X.00 | GPPAQ physical activity index: inactive | res47: Physical activity | test | Read |
| 138Y.00 | GPPAQ physical activity index: moderately inactive | res47: Physical activity | test | Read |
| 138a.00 | GPPAQ physical activity index: moderately active | res47: Physical activity | test | Read |
| 138b.00 | GPPAQ physical activity index: active | res47: Physical activity | test | Read |
To Export Phenotype Details:
| Format | API |
|---|---|
| XML | site_root/api/v1/public/phenotypes/PH459/version/918/detail/?format=xml |
| JSON | site_root/api/v1/public/phenotypes/PH459/version/918/detail/?format=json |
| R Package |
|
To Export Phenotype Code List:
| Format | API |
|---|---|
| XML | site_root/api/v1/public/phenotypes/PH459/version/918/export/codes/?format=xml |
| JSON | site_root/api/v1/public/phenotypes/PH459/version/918/export/codes/?format=json |
| CSV | site_root/phenotypes/PH459/version/918/export/codes/ |
| R Package |
|
| Version ID |
Name | Owner | Publish date | |
|---|---|---|---|---|
| 918 | Physical Activity | ieuan.scanlon | 2021-10-06 | currently shown |
Export - export all codes into a csv file/JSON/XML for the current phenotype version.
Print - Print page.