Print

Physical Activity

Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury

Type
Lifestyle Risk Factor
ID
PH459
Version ID
918
Data Sources
Valid event data range
start - 31/12/2014
Sex
Female, Male
Agreement Date
2016-09-06
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Introduction:

Voltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.

Methods and analysis:

A cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.

Publications

  • Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016.

Clinical Code List

Rows: 34
Code Description Entity type Category Coding System (Read)
1381.00 Exercise physically impossible res47: Physical activity test Read
1382.00 Avoids even trivial exercise res47: Physical activity test Read
1383.00 Enjoys light exercise res47: Physical activity test Read
1384.00 Enjoys moderate exercise res47: Physical activity test Read
1385.00 Enjoys heavy exercise res47: Physical activity test Read
1386.00 Competitive athlete res47: Physical activity test Read
1388.00 Aerobic exercise 0 times/week res47: Physical activity test Read
1389.00 Aerobic exercise 1 time/week res47: Physical activity test Read
138A.00 Aerobic exercise 2 times/week res47: Physical activity test Read
138B.00 Aerobic exercise 3+ times/week res47: Physical activity test Read
138C.00 Anaerobic exercise 0 times/wk res47: Physical activity test Read
138D.00 Anaerobic exercise 1 time/week res47: Physical activity test Read
138E.00 Anaerobic exercise 2 times/wk res47: Physical activity test Read
138F.00 Anaerobic exercise 3+ times/wk res47: Physical activity test Read
138G.00 Attends exercise classes res47: Physical activity test Read
138H.00 Enjoys intermediate exercise res47: Physical activity test Read
138I.00 FITT activity level 0; no mod/vig activity of 20 mins duratn res47: Physical activity test Read
138J.00 FITT activity level 1; 1-4 occas of mod/vig activit in 4 wks res47: Physical activity test Read
138K.00 FITT activity level 2; 5-11 occas of mod/vig activt in 4 wks res47: Physical activity test Read
138L.00 FITT activity level 3; 12+ occas of mod activity in 4 weeks res47: Physical activity test Read
138M.00 FITT activity level 4; 12+ occas of mod/vig activit in 4 wks res47: Physical activity test Read
138N.00 FITT activity level 5; 12+ occas of vig activity in 4 weeks res47: Physical activity test Read
138O.00 Takes inadequate exercise res47: Physical activity test Read
138P.00 Aerobic exercise three times a week res47: Physical activity test Read
138Q.00 Aerobic exercise four times a week res47: Physical activity test Read
138R.00 Aerobic exercise five times a week res47: Physical activity test Read
138S.00 Declined referral to physical exercise programme res47: Physical activity test Read
138T.00 30 mins/day of at least mod intensty physc activity >=5 week res47: Physical activity test Read
138V.00 30 minutes a day of at least moderate intensity walk >=5week res47: Physical activity test Read
138W.00 Less than 30 mins/day of at least mod int physc act >=5 week res47: Physical activity test Read
138X.00 GPPAQ physical activity index: inactive res47: Physical activity test Read
138Y.00 GPPAQ physical activity index: moderately inactive res47: Physical activity test Read
138a.00 GPPAQ physical activity index: moderately active res47: Physical activity test Read
138b.00 GPPAQ physical activity index: active res47: Physical activity test Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH459/version/918/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH459/version/918/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH459', '918', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH459/version/918/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH459/version/918/export/codes/?format=json
CSV site_root/phenotypes/PH459/version/918/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH459', '918', api_client=client)

Version History

Version
ID
Name Owner Publish date
918 Physical Activity ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

Print - Print page.