Phenotype Library | phenotype: Prostate Cancer

Prostate Cancer

Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenbury

PH460

Version ID

920

Type

Disease or Syndrome

Data Sources

QResearch

Valid event data range

01/01/1998 - 31/12/2013

Sex

♀ Female ♂ Male

Agreement Date

2014-11-14

Coding system

Read codes v2

Collections

ClinicalCodes Repository Phenotype Library

Definition

A cohort study based on primary care data from the QResearch database will include patients with one of the three common tumours: breast, bowel and prostate. The primary outcome will be overall survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare the survival of patients with cancer taking VGSC-inhibiting drugs (including anticonvulsants and class I antiarrhythmic agents) with patients with cancer not exposed to these drugs, adjusting for age and sex. Exposure to VGSC-inhibiting drugs will be defined as having at least one prescription for these drugs prior to cancer diagnosis. High and low exposure groups will be identified based on the length of use. A number of sensitivity and secondary analyses will be conducted.

Publications

Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenburry, Exposure to sodium channel-inhibiting drugs and cancer survival protocol for a cohort study using the QResearch primary care database. BMJ Open, 4:e006604 2014.

Clinical Code List

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JSON

XML

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C1819/4776 Prostate Cancer - Primary Care - Read codes v2

Rows: 18

Code	Description	Entity type	Category	Coding System (Read)
14270	H/O: prostate cancer	res17: Prostate cancer	diagnostic	Read
1J08	Suspected prostate cancer	res17: Prostate cancer	diagnostic	Read
4M0	Gleason grading of prostate cancer	res17: Prostate cancer	diagnostic	Read
4M00	Gleason prostate grade 2-4 (low)	res17: Prostate cancer	diagnostic	Read
4M01	Gleason prostate grade 5-7 (medium)	res17: Prostate cancer	diagnostic	Read
4M02	Gleason prostate grade 8-10 (high)	res17: Prostate cancer	diagnostic	Read
B46	Malignant neoplasm of prostate	res17: Prostate cancer	diagnostic	Read
B58y5	Secondary malignant neoplasm of prostate	res17: Prostate cancer	diagnostic	Read
B7C20	Adenoma of prostate	res17: Prostate cancer	diagnostic	Read
B834	Carcinoma in situ of prostate	res17: Prostate cancer	diagnostic	Read
B8340	High grade prostatic intraepithelial neoplasia	res17: Prostate cancer	diagnostic	Read
B8341	Prostatic intraepithelial neoplasia	res17: Prostate cancer	diagnostic	Read
B915	Neoplasm of uncertain behaviour of prostate	res17: Prostate cancer	diagnostic	Read
EMISNQPR140	Prostatic intraepithelial neoplasia	res17: Prostate cancer	diagnostic	Read
HNG0200	[RFC] Cancer of the prostate	res17: Prostate cancer	diagnostic	Read
K223	Dysplasia of prostate	res17: Prostate cancer	diagnostic	Read
PCSDT1PR16	Prostate carcinoma	res17: Prostate cancer	diagnostic	Read
ZV104-5	[V]Personal history of malignant neoplasm of prostate	res17: Prostate cancer	diagnostic	Read

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH460/version/920/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH460/version/920/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH460', '920', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH460/version/920/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH460/version/920/export/codes/?format=json
CSV	site_root/phenotypes/PH460/version/920/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH460', '920', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
920	Prostate Cancer	ieuan.scanlon	2021-10-06	currently shown