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Smoking Status

Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury

Type
Lifestyle Risk Factor
ID
PH462
Version ID
924
Data Sources
Valid event data range
start - 31/12/2014
Sex
Female, Male
Agreement Date
2016-09-06
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Introduction:

Voltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.

Methods and analysis:

A cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.

Publications

  • Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016.

Clinical Code List

Rows: 59
Code Description Entity type Category Coding System (Read)
137..11 Smoker - amount smoked res47: Smoking status test Read
1371.11 Non-smoker res47: Smoking status test Read
1372.11 Occasional smoker res47: Smoking status test Read
137A.00 Ex-heavy smoker (20-39/day) res47: Smoking status test Read
137B.00 Ex-very heavy smoker (40+/day) res47: Smoking status test Read
137C.00 Keeps trying to stop smoking res47: Smoking status test Read
137D.00 Admitted tobacco cons untrue ? res47: Smoking status test Read
137E.00 Tobacco consumption unknown res47: Smoking status test Read
137F.00 Ex-smoker - amount unknown res47: Smoking status test Read
137G.00 Trying to give up smoking res47: Smoking status test Read
137H.00 Pipe smoker res47: Smoking status test Read
137I.00 Passive smoker res47: Smoking status test Read
137I000 Exposed to tobacco smoke at home res47: Smoking status test Read
137J.00 Cigar smoker res47: Smoking status test Read
137K.00 Stopped smoking res47: Smoking status test Read
137K000 Recently stopped smoking res47: Smoking status test Read
137L.00 Current non-smoker res47: Smoking status test Read
137M.00 Rolls own cigarettes res47: Smoking status test Read
137N.00 Ex pipe smoker res47: Smoking status test Read
137O.00 Ex cigar smoker res47: Smoking status test Read
137P.00 Cigarette smoker res47: Smoking status test Read
137P.11 Smoker res47: Smoking status test Read
137Q.00 Smoking started res47: Smoking status test Read
137Q.11 Smoking restarted res47: Smoking status test Read
137R.00 Current smoker res47: Smoking status test Read
137S.00 Ex smoker res47: Smoking status test Read
137T.00 Date ceased smoking res47: Smoking status test Read
137U.00 Not a passive smoker res47: Smoking status test Read
137V.00 Smoking reduced res47: Smoking status test Read
137W.00 Chews tobacco res47: Smoking status test Read
137X.00 Cigarette consumption res47: Smoking status test Read
137Y.00 Cigar consumption res47: Smoking status test Read
137Z.00 Tobacco consumption NOS res47: Smoking status test Read
137a.00 Pipe tobacco consumption res47: Smoking status test Read
137b.00 Ready to stop smoking res47: Smoking status test Read
137c.00 Thinking about stopping smoking res47: Smoking status test Read
137d.00 Not interested in stopping smoking res47: Smoking status test Read
137e.00 Smoking restarted res47: Smoking status test Read
137f.00 Reason for restarting smoking res47: Smoking status test Read
137g.00 Cigarette pack-years res47: Smoking status test Read
137h.00 Minutes from waking to first tobacco consumption res47: Smoking status test Read
137i.00 Ex-tobacco chewer res47: Smoking status test Read
137j.00 Ex-cigarette smoker res47: Smoking status test Read
137k.00 Refusal to give smoking status res47: Smoking status test Read
137l.00 Ex roll-up cigarette smoker res47: Smoking status test Read
137m.00 Failed attempt to stop smoking res47: Smoking status test Read
137n.00 Total time smoked res47: Smoking status test Read
137o.00 Waterpipe tobacco consumption res47: Smoking status test Read
13WF.11 Smoker in the family res47: Smoking status test Read
13p..00 Smoking cessation milestones res47: Smoking status test Read
13p0.00 Negotiated date for cessation of smoking res47: Smoking status test Read
13p1.00 Smoking status at 4 weeks res47: Smoking status test Read
13p2.00 Smoking status between 4 and 52 weeks res47: Smoking status test Read
13p3.00 Smoking status at 52 weeks res47: Smoking status test Read
13p4.00 Smoking free weeks res47: Smoking status test Read
13p5.00 Smoking cessation programme start date res47: Smoking status test Read
13p7.00 Smoking status at 12 weeks res47: Smoking status test Read
9ko..00 Current smoker annual review - enhanced services admin res47: Smoking status test Read
9ko..11 Current smoker annual review res47: Smoking status test Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH462/version/924/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH462/version/924/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH462', '924', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH462/version/924/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH462/version/924/export/codes/?format=json
CSV site_root/phenotypes/PH462/version/924/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH462', '924', api_client=client)

Version History

Version
ID
Name Owner Publish date
924 Smoking Status ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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