Print

Substance Misuse

Hayley C Gorton, Roger T Webb, Mathew J Carr, Marcos Delpozo-Banos, Ann John, Darren M Ashcroft

Type
Disease or Syndrome
ID
PH472
Version ID
944
Data Sources
Valid event data range
01/01/1998 - 31/03/2014
Sex
Female, Male
Agreement Date
2018-04-09
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Importance:

People with epilepsy are at increased risk of mortality, but, to date, the cause-specific risks of all unnatural causes have not been reported.

Objective:

To estimate cause-specific unnatural mortality risks in people with epilepsy and to identify the medication types involved in poisoning deaths.

Design, Setting, and Participants:

This population-based cohort study used 2 electronic primary care data sets linked to hospitalization and mortality records, the Clinical Practice Research Datalink (CPRD) in England (from January 1, 1998, to March 31, 2014) and the Secure Anonymised Information Linkage (SAIL) Databank in Wales (from January 1, 2001, to December 31, 2014). Each person with epilepsy was matched on age (within 2 years), sex, and general practice with up to 20 individuals without epilepsy. Unnatural mortality was determined using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes V01 through Y98 in the Office for National Statistics mortality records. Hazard ratios (HRs) were estimated in each data set using a stratified Cox proportional hazards model, and meta-analyses were conducted using DerSimonian and Laird random-effects models. The analysis was performed from January 5, 2016, to November 16, 2017.

Exposures:

People with epilepsy were identified using primary care epilepsy diagnoses and associated antiepileptic drug prescriptions.

Main Outcomes and Measures:

Hazard ratios (HRs) for unnatural mortality and the frequency of each involved medication type estimated as a percentage of all medication poisoning deaths.

Results:

In total, 44678 individuals in the CPRD and 14 051 individuals in the SAIL Databank were identified in the prevalent epilepsy cohorts, and 891 429 (CPRD) and 279 365 (SAIL) individuals were identified in the comparison cohorts. In both data sets, 51% of the epilepsy and comparison cohorts were male, and the median age at entry was 40 years (interquartile range, 25-60 years) in the CPRD cohorts and 43 years (interquartile range, 24-64 years) in the SAIL cohorts. People with epilepsy were significantly more likely to die of any unnatural cause (HR, 2.77; 95% CI, 2.43-3.16), unintentional injury or poisoning (HR, 2.97; 95% CI, 2.54-3.48) or suicide (HR, 2.15; 95% CI, 1.51-3.07) than people in the comparison cohort. Particularly large risk increases were observed in the epilepsy cohorts for unintentional medication poisoning (HR, 4.99; 95% CI, 3.22-7.74) and intentional self-poisoning with medication (HR, 3.55; 95% CI, 1.01-12.53). Opioids (56.5% [95% CI, 43.3%-69.0%]) and psychotropic medication (32.3% [95% CI, 20.9%-45.3%)] were more commonly involved than antiepileptic drugs (9.7% [95% CI, 3.6%-19.9%]) in poisoning deaths in people with epilepsy.

Conclusions and Relevance:

Compared with people without epilepsy, people with epilepsy are at increased risk of unnatural death and thus should be adequately advised about unintentional injury prevention and monitored for suicidal ideation, thoughts, and behaviors. The suitability and toxicity of concomitant medication should be considered when prescribing for comorbid conditions.

Publications

  • Hayley C Gorton, Roger T Webb, Mathew J Carr, Marcos Delpozo-Banos, Ann John, Darren M Ashcroft, Risk of Unnatural Mortality in People With Epilepsy. JAMA Neurology, 75(8), 929-038, 2018.

Clinical Code List

Rows: 393
Code Description Entity type Category Coding System (Read)
13c..00 Drug user res55: substance_misuse diagnostic Read
13c0.00 Injecting drug user res55: substance_misuse diagnostic Read
13c1.00 Intravenous drug user res55: substance_misuse diagnostic Read
13c3.00 Intramuscular drug user res55: substance_misuse diagnostic Read
13c4.00 Intranasal drug user res55: substance_misuse diagnostic Read
13c5.00 Substance misuse increased res55: substance_misuse diagnostic Read
13c6.00 Substance misuse decreased res55: substance_misuse diagnostic Read
13c7.00 Current drug user res55: substance_misuse diagnostic Read
13c8.00 Reduced drugs misuse res55: substance_misuse diagnostic Read
13c9.00 Subcutaneous drug user res55: substance_misuse diagnostic Read
13cA.00 Smokes drugs res55: substance_misuse diagnostic Read
13cB.00 Misuses drugs orally res55: substance_misuse diagnostic Read
13cC.00 Continuous use of drugs res55: substance_misuse diagnostic Read
13cD.00 Episodic use of drugs res55: substance_misuse diagnostic Read
13cE.00 Prolonged high dose use of cannabis res55: substance_misuse diagnostic Read
13cF.00 Preoccupied with substance misuse res55: substance_misuse diagnostic Read
13cH.00 Persistent substance misuse res55: substance_misuse diagnostic Read
13cJ.00 Previously injecting drug user res55: substance_misuse diagnostic Read
13cM.00 Substance misuse res55: substance_misuse diagnostic Read
146C.00 Failed heroin detoxification res55: substance_misuse diagnostic Read
146F.00 H/O: drug abuse res55: substance_misuse diagnostic Read
1T...00 History of substance misuse res55: substance_misuse diagnostic Read
1T0..00 H/O heroin misuse res55: substance_misuse diagnostic Read
1T00.00 H/O daily heroin misuse res55: substance_misuse diagnostic Read
1T01.00 H/O weekly heroin misuse res55: substance_misuse diagnostic Read
1T02.00 Previous history of heroin misuse res55: substance_misuse diagnostic Read
1T03.00 H/O infrequent heroin misuse res55: substance_misuse diagnostic Read
1T1..00 H/O methadone misuse res55: substance_misuse diagnostic Read
1T10.00 H/O daily methadone misuse res55: substance_misuse diagnostic Read
1T11.00 H/O weekly methadone misuse res55: substance_misuse diagnostic Read
1T12.00 H/O infrequent methadone misuse res55: substance_misuse diagnostic Read
1T13.00 Previous history of methadone misuse res55: substance_misuse diagnostic Read
1T2..00 H/O ecstasy misuse res55: substance_misuse diagnostic Read
1T20.00 H/O daily ecstasy misuse res55: substance_misuse diagnostic Read
1T21.00 H/O weekly ecstasy misuse res55: substance_misuse diagnostic Read
1T22.00 H/O infrequent ecstasy misuse res55: substance_misuse diagnostic Read
1T23.00 Previous history of ecstasy misuse res55: substance_misuse diagnostic Read
1T3..00 H/O benzodiazepine misuse res55: substance_misuse diagnostic Read
1T30.00 H/O daily benzodiazepine misuse res55: substance_misuse diagnostic Read
1T31.00 H/O weekly benzodiazepine misuse res55: substance_misuse diagnostic Read
1T32.00 H/O infrequent benzodiazepine misuse res55: substance_misuse diagnostic Read
1T33.00 Previous history of benzodiazepine misuse res55: substance_misuse diagnostic Read
1T4..00 H/O amphetamine misuse res55: substance_misuse diagnostic Read
1T40.00 H/O daily amphetamine misuse res55: substance_misuse diagnostic Read
1T41.00 H/O weekly amphetamine misuse res55: substance_misuse diagnostic Read
1T42.00 H/O infrequent amphetamine misuse res55: substance_misuse diagnostic Read
1T43.00 Previous history of amphetamine misuse res55: substance_misuse diagnostic Read
1T5..00 H/O cocaine misuse res55: substance_misuse diagnostic Read
1T50.00 H/O daily cocaine misuse res55: substance_misuse diagnostic Read
1T51.00 H/O weekly cocaine misuse res55: substance_misuse diagnostic Read
1T52.00 H/O infrequent cocaine misuse res55: substance_misuse diagnostic Read
1T53.00 Previous history of cocaine misuse res55: substance_misuse diagnostic Read
1T6..00 H/O crack cocaine misuse res55: substance_misuse diagnostic Read
1T60.00 H/O daily crack cocaine misuse res55: substance_misuse diagnostic Read
1T61.00 H/O weekly crack cocaine misuse res55: substance_misuse diagnostic Read
1T62.00 H/O infrequent crack cocaine misuse res55: substance_misuse diagnostic Read
1T63.00 Previous history of crack cocaine misuse res55: substance_misuse diagnostic Read
1T7..00 H/O hallucinogen misuse res55: substance_misuse diagnostic Read
1T73.00 Previous history of hallucinogen misuse res55: substance_misuse diagnostic Read
1T8..00 H/O cannabis misuse res55: substance_misuse diagnostic Read
1T80.00 H/O daily cannabis misuse res55: substance_misuse diagnostic Read
1T81.00 H/O weekly cannabis misuse res55: substance_misuse diagnostic Read
1T82.00 H/O infrequent cannabis misuse res55: substance_misuse diagnostic Read
1T83.00 Previous history of cannabis misuse res55: substance_misuse diagnostic Read
1T9..00 H/O solvent misuse res55: substance_misuse diagnostic Read
1T90.00 H/O daily solvent misuse res55: substance_misuse diagnostic Read
1T91.00 H/O weekly solvent misuse res55: substance_misuse diagnostic Read
1T92.00 H/O infrequent solvent misuse res55: substance_misuse diagnostic Read
1T93.00 Previous history of solvent misuse res55: substance_misuse diagnostic Read
1TA..00 H/O barbiturate misuse res55: substance_misuse diagnostic Read
1TA3.00 Previous history of barbiturate misuse res55: substance_misuse diagnostic Read
1TB..00 H/O major tranquilliser misuse res55: substance_misuse diagnostic Read
1TB0.00 H/O daily major tranquilliser misuse res55: substance_misuse diagnostic Read
1TC..00 H/O anti-depressant misuse res55: substance_misuse diagnostic Read
1TC0.00 H/O daily anti-depressant misuse res55: substance_misuse diagnostic Read
1TC3.00 Previous history of anti-depressant misuse res55: substance_misuse diagnostic Read
1TD..00 H/O opiate misuse res55: substance_misuse diagnostic Read
1TD0.00 H/O daily opiate misuse res55: substance_misuse diagnostic Read
1TD1.00 H/O weekly opiate misuse res55: substance_misuse diagnostic Read
1TD2.00 H/O infrequent opiate misuse res55: substance_misuse diagnostic Read
1TD3.00 Previous history of opiate misuse res55: substance_misuse diagnostic Read
1TE..00 Uses heroin on top of substitution therapy res55: substance_misuse diagnostic Read
1TF..00 Does not use heroin on top of substitution therapy res55: substance_misuse diagnostic Read
1V...00 Drug misuse behaviour res55: substance_misuse diagnostic Read
1V0..00 Misuses drugs res55: substance_misuse diagnostic Read
1V00.00 Occasional drug user res55: substance_misuse diagnostic Read
1V01.00 Long-term drug misuser res55: substance_misuse diagnostic Read
1V02.00 Poly-drug misuser res55: substance_misuse diagnostic Read
1V07.00 Notified addict res55: substance_misuse diagnostic Read
1V08.00 Smokes drugs in cigarette form res55: substance_misuse diagnostic Read
1V09.00 Smokes drugs through a pipe res55: substance_misuse diagnostic Read
1V0A.00 Chases the dragon res55: substance_misuse diagnostic Read
1V0B.00 Sniffs drugs res55: substance_misuse diagnostic Read
1V0C.00 Drug addict res55: substance_misuse diagnostic Read
1V0E.00 Health problem secondary to drug misuse res55: substance_misuse diagnostic Read
1V22.00 Age at starting drug misuse res55: substance_misuse diagnostic Read
1V26.00 Misused drugs in past res55: substance_misuse diagnostic Read
1V35.00 Shares drug equipment res55: substance_misuse diagnostic Read
1V38.00 Sharing of drug injecting equipment res55: substance_misuse diagnostic Read
1V6..00 Drug-related offending behaviour res55: substance_misuse diagnostic Read
1V63.00 Possession of drugs res55: substance_misuse diagnostic Read
1V64.00 Illicit drug use res55: substance_misuse diagnostic Read
1V65.00 Heroin misuse res55: substance_misuse diagnostic Read
1V66.00 Ecstasy misuse res55: substance_misuse diagnostic Read
677T.00 Substance misuse structured counselling res55: substance_misuse diagnostic Read
7P22000 Delivery of rehabilitation for drug addiction res55: substance_misuse diagnostic Read
8AA..00 Drug abuse monitoring res55: substance_misuse diagnostic Read
8B23.00 Drug addiction therapy res55: substance_misuse diagnostic Read
8B23.11 Drug addictn therap-methadone res55: substance_misuse diagnostic Read
8B2N.00 Drug addiction detoxification therapy - methadone res55: substance_misuse diagnostic Read
8B2P.00 Drug addiction maintenance therapy - methadone res55: substance_misuse diagnostic Read
8B2Q.00 Drug addiction maintenance therapy - buprenorphine res55: substance_misuse diagnostic Read
8B2R.00 Drug addiction detoxification therapy - buprenorphine res55: substance_misuse diagnostic Read
8B2S.00 Opioid agonist substitution therapy res55: substance_misuse diagnostic Read
8B2T.00 Opioid antagonist therapy res55: substance_misuse diagnostic Read
8BAW.00 Drug dependence self detoxification res55: substance_misuse diagnostic Read
8BAX.00 Drug dependence home detoxification res55: substance_misuse diagnostic Read
8BAd.00 Opiate dependence detoxification res55: substance_misuse diagnostic Read
8BAo.00 Benzodiazepine dependence detoxification res55: substance_misuse diagnostic Read
8H7x.00 Referral to drug abuse counsellor res55: substance_misuse diagnostic Read
8Hh1.00 Self referral to substance misuse service res55: substance_misuse diagnostic Read
8HkF.00 Referral to substance misuse service res55: substance_misuse diagnostic Read
8Hq..00 Admission to substance misuse detoxification centre res55: substance_misuse diagnostic Read
9G2..00 Drug addiction notification res55: substance_misuse diagnostic Read
9G2..11 Drug addict notific admin res55: substance_misuse diagnostic Read
9G21.00 Drug addict notific to CMO res55: substance_misuse diagnostic Read
9G22.00 Drug addict re-notific due res55: substance_misuse diagnostic Read
9G23.00 Drug addict re-notif to CMO res55: substance_misuse diagnostic Read
9G24.00 Drug addict-notify local SMR22 res55: substance_misuse diagnostic Read
9G2Z.00 Drug addiction notif NOS res55: substance_misuse diagnostic Read
9HC..00 Substance misuse monitoring res55: substance_misuse diagnostic Read
9HC1.00 Follow up substance misuse assessment res55: substance_misuse diagnostic Read
9HC2.00 Substance misuse clinical management plan agreed res55: substance_misuse diagnostic Read
9HC3.00 Substance misuse clinical management plan reviewed res55: substance_misuse diagnostic Read
9HC4.00 Substance misuse treatment withdrawn res55: substance_misuse diagnostic Read
9HC5.00 Substance misuse treatment programme completed res55: substance_misuse diagnostic Read
9HC6.00 Substance misuse treatment declined res55: substance_misuse diagnostic Read
9K4..00 SMR25a drug misuse initial assessment form res55: substance_misuse diagnostic Read
9N1yJ00 Seen in drug misuse clinic res55: substance_misuse diagnostic Read
9N4i.00 DNA - Did not attend substance misuse clinic res55: substance_misuse diagnostic Read
9NdN.00 Declined consent for notification of drug misuse res55: substance_misuse diagnostic Read
9No5.00 Seen in substance misuse clinic res55: substance_misuse diagnostic Read
9k5..00 Drug misuse - enhanced services administration res55: substance_misuse diagnostic Read
9k50.00 Drug misuse - enhanced service completed res55: substance_misuse diagnostic Read
9k51.00 Shared care drug misuse treatment - enhanced services admin res55: substance_misuse diagnostic Read
9k51.11 Shared care drug misuse treatment res55: substance_misuse diagnostic Read
9k52.00 Drug misuse treatment primary care - enhanced services admin res55: substance_misuse diagnostic Read
9k53.00 Pharmacy attended for drug misuse - enhanced services admin res55: substance_misuse diagnostic Read
9kS..00 Drug misuse assessment declined - enhanced services administ res55: substance_misuse diagnostic Read
9s...00 Drug misuse clinic administration res55: substance_misuse diagnostic Read
E24..00 Drug dependence res55: substance_misuse diagnostic Read
E24..11 Drug addiction res55: substance_misuse diagnostic Read
E240.00 Opioid type drug dependence res55: substance_misuse diagnostic Read
E240.11 Heroin dependence res55: substance_misuse diagnostic Read
E240.12 Methadone dependence res55: substance_misuse diagnostic Read
E240.13 Morphine dependence res55: substance_misuse diagnostic Read
E240.14 Opium dependence res55: substance_misuse diagnostic Read
E240000 Unspecified opioid dependence res55: substance_misuse diagnostic Read
E240100 Continuous opioid dependence res55: substance_misuse diagnostic Read
E240200 Episodic opioid dependence res55: substance_misuse diagnostic Read
E240300 Opioid dependence in remission res55: substance_misuse diagnostic Read
E240z00 Opioid drug dependence NOS res55: substance_misuse diagnostic Read
E241.15 Librium dependence res55: substance_misuse diagnostic Read
E242.00 Cocaine type drug dependence res55: substance_misuse diagnostic Read
E242000 Cocaine dependence, unspecified res55: substance_misuse diagnostic Read
E242100 Cocaine dependence, continuous res55: substance_misuse diagnostic Read
E242200 Cocaine dependence, episodic res55: substance_misuse diagnostic Read
E242300 Cocaine dependence in remission res55: substance_misuse diagnostic Read
E242z00 Cocaine drug dependence NOS res55: substance_misuse diagnostic Read
E243.00 Cannabis type drug dependence res55: substance_misuse diagnostic Read
E243.11 Hashish dependence res55: substance_misuse diagnostic Read
E243.12 Hemp dependence res55: substance_misuse diagnostic Read
E243.13 Marihuana dependence res55: substance_misuse diagnostic Read
E243000 Cannabis dependence, unspecified res55: substance_misuse diagnostic Read
E243100 Cannabis dependence, continuous res55: substance_misuse diagnostic Read
E243200 Cannabis dependence, episodic res55: substance_misuse diagnostic Read
E243300 Cannabis dependence in remission res55: substance_misuse diagnostic Read
E243z00 Cannabis drug dependence NOS res55: substance_misuse diagnostic Read
E244.00 Amphetamine or other psychostimulant dependence res55: substance_misuse diagnostic Read
E244.11 Psychostimulant dependence res55: substance_misuse diagnostic Read
E244.12 Stimulant dependence res55: substance_misuse diagnostic Read
E244000 Amphetamine or psychostimulant dependence, unspecified res55: substance_misuse diagnostic Read
E244011 Amfetamine or psychostimulant dependence, unspecified res55: substance_misuse diagnostic Read
E244100 Amphetamine or psychostimulant dependence, continuous res55: substance_misuse diagnostic Read
E244200 Amphetamine or psychostimulant dependence, episodic res55: substance_misuse diagnostic Read
E244300 Amphetamine or psychostimulant dependence in remission res55: substance_misuse diagnostic Read
E244z00 Amphetamine or psychostimulant dependence NOS res55: substance_misuse diagnostic Read
E244z11 Amfetamine or psychostimulant dependence NOS res55: substance_misuse diagnostic Read
E245.00 Hallucinogen dependence res55: substance_misuse diagnostic Read
E245.11 LSD dependence res55: substance_misuse diagnostic Read
E245.12 Lysergic acid diethylamide dependence res55: substance_misuse diagnostic Read
E245000 Hallucinogen dependence, unspecified res55: substance_misuse diagnostic Read
E245100 Hallucinogen dependence, continuous res55: substance_misuse diagnostic Read
E245200 Hallucinogen dependence, episodic res55: substance_misuse diagnostic Read
E245300 Hallucinogen dependence in remission res55: substance_misuse diagnostic Read
E245z00 Hallucinogen dependence NOS res55: substance_misuse diagnostic Read
E246.00 Glue sniffing dependence res55: substance_misuse diagnostic Read
E246000 Glue sniffing dependence, unspecified res55: substance_misuse diagnostic Read
E246100 Glue sniffing dependence, continuous res55: substance_misuse diagnostic Read
E246200 Glue sniffing dependence, episodic res55: substance_misuse diagnostic Read
E246300 Glue sniffing dependence in remission res55: substance_misuse diagnostic Read
E246z00 Glue sniffing dependence NOS res55: substance_misuse diagnostic Read
E247100 Other specified drug dependence, continuous res55: substance_misuse diagnostic Read
E247200 Other specified drug dependence, episodic res55: substance_misuse diagnostic Read
E247300 Other specified drug dependence in remission res55: substance_misuse diagnostic Read
E248.00 Combined opioid with other drug dependence res55: substance_misuse diagnostic Read
E248000 Combined opioid with other drug dependence, unspecified res55: substance_misuse diagnostic Read
E248100 Combined opioid with other drug dependence, continuous res55: substance_misuse diagnostic Read
E248200 Combined opioid with other drug dependence, episodic res55: substance_misuse diagnostic Read
E248300 Combined opioid with other drug dependence in remission res55: substance_misuse diagnostic Read
E248z00 Combined opioid with other drug dependence NOS res55: substance_misuse diagnostic Read
E249.00 Combined drug dependence, excluding opioids res55: substance_misuse diagnostic Read
E249000 Combined drug dependence, excluding opioid, unspecified res55: substance_misuse diagnostic Read
E249100 Combined drug dependence, excluding opioid, continuous res55: substance_misuse diagnostic Read
E249200 Combined drug dependence, excluding opioid, episodic res55: substance_misuse diagnostic Read
E249300 Combined drug dependence, excluding opioid, in remission res55: substance_misuse diagnostic Read
E249z00 Combined drug dependence, excluding opioid, NOS res55: substance_misuse diagnostic Read
E24A.00 Ecstasy type drug dependence res55: substance_misuse diagnostic Read
E24z.00 Drug dependence NOS res55: substance_misuse diagnostic Read
E25..00 Nondependent abuse of drugs res55: substance_misuse diagnostic Read
E252.00 Nondependent cannabis abuse res55: substance_misuse diagnostic Read
E252000 Nondependent cannabis abuse, unspecified res55: substance_misuse diagnostic Read
E252100 Nondependent cannabis abuse, continuous res55: substance_misuse diagnostic Read
E252200 Nondependent cannabis abuse, episodic res55: substance_misuse diagnostic Read
E252300 Nondependent cannabis abuse in remission res55: substance_misuse diagnostic Read
E252z00 Nondependent cannabis abuse NOS res55: substance_misuse diagnostic Read
E253.00 Nondependent hallucinogen abuse res55: substance_misuse diagnostic Read
E253000 Nondependent hallucinogen abuse, unspecified res55: substance_misuse diagnostic Read
E253100 Nondependent hallucinogen abuse, continuous res55: substance_misuse diagnostic Read
E253200 Nondependent hallucinogen abuse, episodic res55: substance_misuse diagnostic Read
E253300 Nondependent hallucinogen abuse in remission res55: substance_misuse diagnostic Read
E253z00 Nondependent hallucinogen abuse NOS res55: substance_misuse diagnostic Read
E254.00 Nondependent hypnotic or anxiolytic abuse res55: substance_misuse diagnostic Read
E254.11 Barbiturate abuse res55: substance_misuse diagnostic Read
E254.12 Hypnotic or anxiolytic abuse res55: substance_misuse diagnostic Read
E254.13 Sedative abuse res55: substance_misuse diagnostic Read
E254.14 Tranquilliser abuse res55: substance_misuse diagnostic Read
E254000 Nondependent hypnotic or anxiolytic abuse, unspecified res55: substance_misuse diagnostic Read
E254100 Nondependent hypnotic or anxiolytic abuse, continuous res55: substance_misuse diagnostic Read
E254200 Nondependent hypnotic or anxiolytic abuse, episodic res55: substance_misuse diagnostic Read
E254300 Nondependent hypnotic or anxiolytic abuse in remission res55: substance_misuse diagnostic Read
E254z00 Nondependent hypnotic or anxiolytic abuse NOS res55: substance_misuse diagnostic Read
E255.00 Nondependent opioid abuse res55: substance_misuse diagnostic Read
E255000 Nondependent opioid abuse, unspecified res55: substance_misuse diagnostic Read
E255100 Nondependent opioid abuse, continuous res55: substance_misuse diagnostic Read
E255200 Nondependent opioid abuse, episodic res55: substance_misuse diagnostic Read
E255300 Nondependent opioid abuse in remission res55: substance_misuse diagnostic Read
E255z00 Nondependent opioid abuse NOS res55: substance_misuse diagnostic Read
E256.00 Nondependent cocaine abuse res55: substance_misuse diagnostic Read
E256000 Nondependent cocaine abuse, unspecified res55: substance_misuse diagnostic Read
E256100 Nondependent cocaine abuse, continuous res55: substance_misuse diagnostic Read
E256200 Nondependent cocaine abuse, episodic res55: substance_misuse diagnostic Read
E256300 Nondependent cocaine abuse in remission res55: substance_misuse diagnostic Read
E256z00 Nondependent cocaine abuse NOS res55: substance_misuse diagnostic Read
E257.00 Nondependent amphetamine or other psychostimulant abuse res55: substance_misuse diagnostic Read
E257.11 Psychostimulant abuse res55: substance_misuse diagnostic Read
E257.12 Stimulant abuse res55: substance_misuse diagnostic Read
E257000 Nondependent amphetamine/psychostimulant abuse, unspecified res55: substance_misuse diagnostic Read
E257100 Nondependent amphetamine/psychostimulant abuse, continuous res55: substance_misuse diagnostic Read
E257200 Nondependent amphetamine or psychostimulant abuse, episodic res55: substance_misuse diagnostic Read
E257300 Nondependent amphetamine/psychostimulant abuse in remission res55: substance_misuse diagnostic Read
E257z00 Nondependent amphetamine or psychostimulant abuse NOS res55: substance_misuse diagnostic Read
E258.00 Nondependent antidepressant type drug abuse res55: substance_misuse diagnostic Read
E258z00 Nondependent antidepressant type drug abuse NOS res55: substance_misuse diagnostic Read
E259.00 Nondependent mixed drug abuse res55: substance_misuse diagnostic Read
E259000 Nondependent mixed drug abuse, unspecified res55: substance_misuse diagnostic Read
E259100 Nondependent mixed drug abuse, continuous res55: substance_misuse diagnostic Read
E259200 Nondependent mixed drug abuse, episodic res55: substance_misuse diagnostic Read
E259300 Nondependent mixed drug abuse in remission res55: substance_misuse diagnostic Read
E259400 Misuse of prescription only drugs res55: substance_misuse diagnostic Read
E259z00 Nondependent mixed drug abuse NOS res55: substance_misuse diagnostic Read
E25y.00 Nondependent other drug abuse res55: substance_misuse diagnostic Read
E25y.11 Analgesic abuse res55: substance_misuse diagnostic Read
E25y.13 Steroid abuse res55: substance_misuse diagnostic Read
E25y000 Nondependent other drug abuse, unspecified res55: substance_misuse diagnostic Read
E25y100 Nondependent other drug abuse, continuous res55: substance_misuse diagnostic Read
E25y200 Nondependent other drug abuse, episodic res55: substance_misuse diagnostic Read
E25y300 Nondependent other drug abuse in remission res55: substance_misuse diagnostic Read
E25yz00 Nondependent other drug abuse NOS res55: substance_misuse diagnostic Read
E25z.00 Misuse of drugs NOS res55: substance_misuse diagnostic Read
E29y500 Other adjustment reaction with withdrawal res55: substance_misuse diagnostic Read
Eu11200 [X]Mental and behav dis due to use opioids: dependence syndr res55: substance_misuse diagnostic Read
Eu11211 [X]Drug addiction - opioids res55: substance_misuse diagnostic Read
Eu11212 [X]Heroin addiction res55: substance_misuse diagnostic Read
Eu11300 [X]Mental and behav dis due to use opioids: withdrawal state res55: substance_misuse diagnostic Read
Eu11311 [X]Cold turkey, opiate withdrawal res55: substance_misuse diagnostic Read
Eu11400 [X]Men & behav dis due opioid: withdrawl state with delirium res55: substance_misuse diagnostic Read
Eu11500 [X]Mental & behav dis due to use opioids: psychotic disorder res55: substance_misuse diagnostic Read
Eu11600 [X]Mental and behav dis due to use opioids: amnesic syndrome res55: substance_misuse diagnostic Read
Eu11700 [X]Men & beh dis due opioids: resid & late-onset psychot dis res55: substance_misuse diagnostic Read
Eu11y00 [X]Men & behav dis due to use opioids: oth men & behav dis res55: substance_misuse diagnostic Read
Eu11z00 [X]Ment & behav dis due use opioids: unsp ment & behav dis res55: substance_misuse diagnostic Read
Eu12.00 [X]Mental and behavioural disorders due to use cannabinoids res55: substance_misuse diagnostic Read
Eu12000 [X]Mental & behav dis due cannabinoids: acute intoxication res55: substance_misuse diagnostic Read
Eu12100 [X]Mental and behav dis due to use cannabinoids: harmful use res55: substance_misuse diagnostic Read
Eu12200 [X]Mental and behav dis due to cannabinoids: dependence synd res55: substance_misuse diagnostic Read
Eu12211 [X]Drug addiction - cannabis res55: substance_misuse diagnostic Read
Eu12300 [X]Mental and behav dis due cannabinoids: withdrawal state res55: substance_misuse diagnostic Read
Eu12500 [X]Mental & behav dis due to cannabinoids: psychotic disordr res55: substance_misuse diagnostic Read
Eu12600 [X]Mental and behav dis due to use cannabinoids: amnesic syn res55: substance_misuse diagnostic Read
Eu12700 [X]Mnt/bh dis due cannabinds: resid & late-onset psychot dis res55: substance_misuse diagnostic Read
Eu12y00 [X]Men/behav dis due to use cannabinoids: oth men/behav disd res55: substance_misuse diagnostic Read
Eu12z00 [X]Ment/behav dis due use cannabinoids: unsp ment/behav disd res55: substance_misuse diagnostic Read
Eu13.00 [X]Mental and behavioural dis due use sedatives/hypnotics res55: substance_misuse diagnostic Read
Eu13000 [X]Mental & behav dis due seds/hypntcs: acute intoxication res55: substance_misuse diagnostic Read
Eu13100 [X]Mental and behav dis due to use seds/hypntcs: harmful use res55: substance_misuse diagnostic Read
Eu13200 [X]Mental and behav dis due to seds/hypntcs: dependence synd res55: substance_misuse diagnostic Read
Eu13211 [X]Drug addiction- sedative / hypnotics res55: substance_misuse diagnostic Read
Eu13300 [X]Mental and behav dis due seds/hypntcs: withdrawal state res55: substance_misuse diagnostic Read
Eu13400 [X]Men & beh dis due seds/hypns: withdrwl state wth delirium res55: substance_misuse diagnostic Read
Eu13500 [X]Mental & behav dis due to seds/hypntcs: psychotic disordr res55: substance_misuse diagnostic Read
Eu14.00 [X]Mental and behavioural disorders due to use of cocaine res55: substance_misuse diagnostic Read
Eu14000 [X]Mental & behav dis due to use cocaine: acute intoxication res55: substance_misuse diagnostic Read
Eu14100 [X]Mental and behav dis due to use of cocaine: harmful use res55: substance_misuse diagnostic Read
Eu14200 [X]Mental and behav dis due to use cocaine: dependence syndr res55: substance_misuse diagnostic Read
Eu14211 [X]Drug addiction - cocaine res55: substance_misuse diagnostic Read
Eu14300 [X]Mental and behav dis due to use cocaine: withdrawal state res55: substance_misuse diagnostic Read
Eu14500 [X]Mental & behav dis due to use cocaine: psychotic disorder res55: substance_misuse diagnostic Read
Eu14700 [X]Men & beh dis due cocaine: resid & late-onset psychot dis res55: substance_misuse diagnostic Read
Eu15.00 [X]Mental & behav disorder due other stimulants inc caffein res55: substance_misuse diagnostic Read
Eu15000 [X]Mnt/beh dis due oth stim inc caffein: acute intoxication res55: substance_misuse diagnostic Read
Eu15100 [X]Ment/behav dis due to use oth stims inc caff: harmful use res55: substance_misuse diagnostic Read
Eu15200 [X]Mental and behav dis oth stim inc caffein: dependnce synd res55: substance_misuse diagnostic Read
Eu15211 [X]Drug addiction-other stimul res55: substance_misuse diagnostic Read
Eu15300 [X]Mnt/behav dis other stimlnts inc caffeine: withdrwl state res55: substance_misuse diagnostic Read
Eu15500 [X]Mental/behav dis oth stims inc caffeine: psychotic dis res55: substance_misuse diagnostic Read
Eu15700 [X]Mnt/bh dis oth stm inc caffne resid/late-onset psycht dis res55: substance_misuse diagnostic Read
Eu15z00 [X]Ment/beh dis oth stims inc caffeine: unsp ment/behav disd res55: substance_misuse diagnostic Read
Eu16.00 [X]Mental and behavioural disorders due to use hallucinogens res55: substance_misuse diagnostic Read
Eu16000 [X]Mental & behav dis due hallucinogens: acute intoxicatn res55: substance_misuse diagnostic Read
Eu16100 [X]Mental and behav dis due to use hallucinogens: harmfl use res55: substance_misuse diagnostic Read
Eu16200 [X]Mental and behav dis due to hallucinogens: dependence syn res55: substance_misuse diagnostic Read
Eu16211 [X]Drug addiction - hallucinogen res55: substance_misuse diagnostic Read
Eu16300 [X]Mental and behav dis due hallucinogens: withdrawal state res55: substance_misuse diagnostic Read
Eu16500 [X]Mental & behav dis due to hallucinogens: psychotic disord res55: substance_misuse diagnostic Read
Eu16700 [X]Mnt/bh dis due hallucngns: resid & late-onset psychot dis res55: substance_misuse diagnostic Read
Eu16711 [X]Post hallucinogen perception disorder res55: substance_misuse diagnostic Read
Eu16z00 [X]Ment/behav dis due use hallucinogens: unsp ment/behav dis res55: substance_misuse diagnostic Read
Eu17200 [X]Mental and behav dis due to use tobacco: dependence syndr res55: substance_misuse diagnostic Read
Eu17300 [X]Mental and behav dis due to use tobacco: withdrawal state res55: substance_misuse diagnostic