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Cardiovascular Events

Rebecca M Joseph, Mohammad Movahedi, William G Dixon, Deborah PM Symmons

Type
Disease or Syndrome
ID
PH485
Version ID
1520
Valid event data range
01/01/1998 - 10/01/2012
Sex
Female, Male
Agreement Date
2017-09-26
Coding system
ICD10 codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objectives:

To investigate the associations between smoking status, smoking cessation and hospitalisations for cardiovascular events (CVE) and respiratory tract infections (RTI ) in an inception cohort of patients with rheumatoid arthritis (RA).

Methods:

The study was set within UK primary care electronic health records (the Clinical Practice Research Datalink) linked to hospital inpatient data (Hospital Episode Statistics). Patients with RA were followed from diagnosis to hospitalisation with a record of CVE or RTI , leaving their general practice, death, or 10 January 2012, whichever was earliest. Smoking status (never, current, former) was defined using primary care data and could vary over time. Survival analysis was performed using Cox regression (first event) and conditional risk set models (multiple RTI s).

Results:

5677 patients were included in the cohort: 68% female, median age 61 years. The age-adjusted and sexadjusted risks of hospitalisation for CVE or RTI were more than twice as high in current vs never smokers (CVE HR (95% CI) 2.19 (1.44 to 3.31); RTI 2.18 (1.71 to 2.78)). The risks for both outcomes were significantly higher in current compared with former smokers (CVE 1.51 (1.04 to 2.19), RTI 1.29 (1.04 to 1.61)). For each additional year of smoking cessation, the risk of first CVE and RTI hospitalisation fell significantly, approximately 25% and 15% respectively in the adjusted models.

Conclusions:

Patients with RA who smoke have an increased risk of hospitalisation with CVE or RTI compared with never and former smokers. The risk decreases for each additional year of smoking cessation. Patients with RA who smoke should be advised to stop smoking.

Publications

  • Rebecca M Joseph, Mohammad Movahedi, William G Dixon, Deborah PM Symmons, Risks of smoking and benefits of smoking cessation on hospitalisations for cardiovascular events and respiratory infection in patients with rheumatoid arthritis a retrospective cohort study using the Clinical Practice Research Datalink. RMD Open, 3(2), e000506, 2017.

Clinical Code List

Rows: 33
Code Description Category Coding System (ICD-10) Entity type
I21 Acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I21.0 Acute transmural myocardial infarction of anterior wall diagnostic ICD-10 res52: cardiovascular events ICD10
I21.1 Acute transmural myocardial infarction of inferior wall diagnostic ICD-10 res52: cardiovascular events ICD10
I21.2 Acute transmural myocardial infarction of other sites diagnostic ICD-10 res52: cardiovascular events ICD10
I21.3 Acute transmural myocardial infarction of unspecified site diagnostic ICD-10 res52: cardiovascular events ICD10
I21.4 Acute subendocardial myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I21.9 Acute myocardial infarction, unspecified diagnostic ICD-10 res52: cardiovascular events ICD10
I22 Subsequent myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I22.0 Subsequent myocardial infarction of anterior wall diagnostic ICD-10 res52: cardiovascular events ICD10
I22.1 Subsequent myocardial infarction of inferior wall diagnostic ICD-10 res52: cardiovascular events ICD10
I22.8 Subsequent myocardial infarction of other sites diagnostic ICD-10 res52: cardiovascular events ICD10
I22.9 Subsequent myocardial infarction of unspecified site diagnostic ICD-10 res52: cardiovascular events ICD10
I23 Certain current complications following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I23.0 Haemopericardium as current complication following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I23.1 Atrial septal defect as current complication following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I23.2 Ventricular septal defect as current complication following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial diagnostic ICD-10 res52: cardiovascular events ICD10
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I23.6 Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute my diagnostic ICD-10 res52: cardiovascular events ICD10
I23.8 Other current complications following acute myocardial infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I63 Cerebral infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I63.0 Cerebral infarction due to thrombosis of precerebral arteries diagnostic ICD-10 res52: cardiovascular events ICD10
I63.1 Cerebral infarction due to embolism of precerebral arteries diagnostic ICD-10 res52: cardiovascular events ICD10
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries diagnostic ICD-10 res52: cardiovascular events ICD10
I63.3 Cerebral infarction due to thrombosis of cerebral arteries diagnostic ICD-10 res52: cardiovascular events ICD10
I63.4 Cerebral infarction due to embolism of cerebral arteries diagnostic ICD-10 res52: cardiovascular events ICD10
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries diagnostic ICD-10 res52: cardiovascular events ICD10
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic diagnostic ICD-10 res52: cardiovascular events ICD10
I63.8 Other cerebral infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I63.9 Cerebral infarction, unspecified diagnostic ICD-10 res52: cardiovascular events ICD10
I64 Stroke, not specified as haemorrhage or infarction diagnostic ICD-10 res52: cardiovascular events ICD10
I64.0 Stroke, not specified as haemorrhage or infarction diagnostic ICD-10 res52: cardiovascular events ICD10

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH485/version/1520/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH485/version/1520/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH485', '1520', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH485/version/1520/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH485/version/1520/export/codes/?format=json
CSV site_root/phenotypes/PH485/version/1520/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH485', '1520', api_client=client)

Version History

Version
ID
Name Owner Publish date
1520 Cardiovascular Events ieuan.scanlon 2021-10-26 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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