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Antiplatelets

Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Matthias Pierce, Darren M. Ashcroft

Type
Drug
ID
PH496
Version ID
992
Data Sources
Valid event data range
01/04/2006 - 31/03/2012
Sex
Female, Male
Agreement Date
2014-12-16
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Data source:

We used the Clinical Practice Research Datalink (CPRD), a large primary care database that holds complete electronic patient records (including diagnoses, prescriptions and referrals) from participating family practices across the UK. A hierarchical clinical coding system (Read) is used to record the data. In July 2012, data were available for 644 practices and 13,772,992 patients. Full details of the database have been provided elsewhere.

Diabetes cohort:

We extracted data from 1 April 2006 to 31 March 2012 and, for ease of reporting and analysing, aggregated information into six financial years. Within each year, practice inclusion eligibility was determined by a CPRD assessment algorithm, which informs on practices considered to be of research standard; therefore, our cohort of practices varied over time. For each research standard practice and year, we defined as eligible patients those who were registered with the practice for the full year and were aged 18 years or over in that year. From these patients, using relevant Read codes for type 2 diabetes (e.g. C10F.00: Type 2 diabetes mellitus) and excluding those treated with insulin within 2 years of diagnosis, we identified 246,544 patients over the study period. Diagnoses were not constrained to the study period and a relevant code prior to the study as well as during the study period would flag a patient from the respective year onwards. Data on sex, age and removal from the database due to deaths were available and complete for all patients.We extracted data on diabetes-related macrovascular (myocardial infarction, stroke, peripheral vascular disease or amputation) and microvascular (retinopathy, neuropathy, nephropathy [chronic kidney disease stages 4–5] or foot ulcer) complications as well as comorbidities (asthma, coronary heart disease, chronic kidney disease [excluded from microvascular analysis], chronic obstructive pulmonary disease, depression, dementia, severe mental illness, heart failure, hypertension, stroke [excluded from macrovascular analysis], cancer, epilepsy, osteoarthritis, osteoporosis and hypothyroidism). Although we aimed to include all conditions associated with diabetes, the choice was partially determined by the domains incentivised under the Quality and Outcomes Framework (QOF), for which accuracy of diagnosis is considered high. Information was also extracted on smoking (never smoked, current, exsmoker and missing data),BMI, HbA1c levels (%), cholesterol levels (mmol/l) and systolic/diastolic BP (mmHg). Biometric measurement data were cleaned and we calculated patient means for each year when more than one relevant record was available. Using product lists we determined prescription prevalence (at least one) for relevant medications: ACE inhibitors, acarbose, α-blockers, anticoagulants, antiplatelet agents, β-blockers, calcium-channel blockers, thiazide diuretics, loop diuretics, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide- 1 agonists, statins and other lipid-lowering drugs, meglitinides , metformin, sulfonylureas and thiazolidinediones. For approximately 60% of the practices, records were linked to Office of National Statistics (ONS) mortality data and we had access to death dates for all their patients. For these, using ICD-10 codes (www.who.int/classifications/icd/en/) we were able to estimate deathslinked to specific causes (underlying or in the top three): diabetes (E10–E16), ischaemic heart disease (I21–I22), stroke (I60–I64) or stroke excluding bleeds (excluding I63).

Publications

  • Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, 58:505-518, 2015.

Clinical Code List

Rows: 45
Code Description Coding System (CPRD_product_code) Entity type Category
16 aspirin tablets 75mg CPRD_product_code res9: antiplatelets drug
18329 ENPRIN enteric coated tablets 75mg [GALPHARM] CPRD_product_code res9: antiplatelets drug
19189 MICROPIRIN enteric coated tablets 75mg [RATIOPHARM] CPRD_product_code res9: antiplatelets drug
22618 SOLPRIN tablets 75mg [RECKITT B] CPRD_product_code res9: antiplatelets drug
23593 POSTMI dispersible tablet 75mg [ASHBOURNE] CPRD_product_code res9: antiplatelets drug
23878 NU-SEALS CARDIO EC tablets 75mg [GENUS] CPRD_product_code res9: antiplatelets drug
25335 POSTMI EC tablets 75mg [ASHBOURNE] CPRD_product_code res9: antiplatelets drug
25718 ANGETTES tablets 75mg [BRISTOL] CPRD_product_code res9: antiplatelets drug
2607 PAYNOCIL tablets [BEECHAM] CPRD_product_code res9: antiplatelets drug
2628 NU-SEALS ASPIRIN EC tablets 75mg [LILLY] CPRD_product_code res9: antiplatelets drug
3 aspirin dispersible tablet 75mg CPRD_product_code res9: antiplatelets drug
31211 ASPIRIN dispersible tablet 75mg [AAH(VANT)] CPRD_product_code res9: antiplatelets drug
31938 ASPIRIN EC tablets 75mg [SANDOZ] CPRD_product_code res9: antiplatelets drug
31953 ASPIRIN dispersible tablet 75mg [IVAX] CPRD_product_code res9: antiplatelets drug
31954 ASPIRIN dispersible tablet 75mg [TEVA] CPRD_product_code res9: antiplatelets drug
31956 ASPIRIN enteric coated tablets 75mg [KENT] CPRD_product_code res9: antiplatelets drug
32036 ASPIRIN dispersible tablet 75mg [ACTAVIS] CPRD_product_code res9: antiplatelets drug
32992 ASPIRIN enteric coated tablets 75mg [GEN (UK)] CPRD_product_code res9: antiplatelets drug
33293 ASPIRIN enteric coated tablets 75mg [STERWIN] CPRD_product_code res9: antiplatelets drug
33320 ASPIRIN dispersible tablet 75mg [SOVEREIGN] CPRD_product_code res9: antiplatelets drug
33656 ASPIRIN dispersible tablet 75mg [HILLCROSS] CPRD_product_code res9: antiplatelets drug
33676 ASPIRIN dispersible tablet 75mg [KENT] CPRD_product_code res9: antiplatelets drug
34 aspirin gastro-resistant tablets 75mg CPRD_product_code res9: antiplatelets drug
34385 ASPIRIN soluble tablet 75mg [CO-OPERATI] CPRD_product_code res9: antiplatelets drug
34434 ASPIRIN dispersible tablet 75mg [T & R] CPRD_product_code res9: antiplatelets drug
34485 ASPIRIN enteric coated tablets 75mg [IVAX] CPRD_product_code res9: antiplatelets drug
34611 ASPIRIN enteric coated tablets 75mg [CP PHARM] CPRD_product_code res9: antiplatelets drug
34796 ASPIRIN enteric coated tablets 75mg [GALEN] CPRD_product_code res9: antiplatelets drug
34797 ASPIRIN enteric coated tablets 75mg [ACTAVIS] CPRD_product_code res9: antiplatelets drug
34942 ASPIRIN dispersible tablet 75mg [NUCARE] CPRD_product_code res9: antiplatelets drug
40381 ASPIRIN soluble tablet 75mg [CP PHARM] CPRD_product_code res9: antiplatelets drug
40913 GREPID film coated tablets 75mg [BEACON] CPRD_product_code res9: antiplatelets drug
41512 ASPIRIN enteric coated tablets 75mg [TEVA] CPRD_product_code res9: antiplatelets drug
42750 CLOPIDOGREL film coated tablets 75mg [ACTAVIS] CPRD_product_code res9: antiplatelets drug
43709 ASPIRIN enteric coated tablets 75mg [ALMUS] CPRD_product_code res9: antiplatelets drug
45643 ASPIRIN soluble tablet 75mg [CELLTECH] CPRD_product_code res9: antiplatelets drug
46891 clopidogrel oral suspension 75mg/5ml CPRD_product_code res9: antiplatelets drug
47937 ASPIRIN dispersible tablet 75mg [WOCKHARDT] CPRD_product_code res9: antiplatelets drug
47992 ASPIRIN enteric coated tablets 75mg [HILLCROSS] CPRD_product_code res9: antiplatelets drug
48021 ASPIRIN tablets 75mg [HILLCROSS] CPRD_product_code res9: antiplatelets drug
489 clopidogrel film coated tablets 75mg CPRD_product_code res9: antiplatelets drug
6006 NU-SEALS ASPIRIN EC tablets 75mg [ALLIANCE] CPRD_product_code res9: antiplatelets drug
6696 MICROPIRIN enteric coated tablets 75mg [DEXCEL] CPRD_product_code res9: antiplatelets drug
836 PLAVIX film coated tablets 75mg [SANOFI BMS] CPRD_product_code res9: antiplatelets drug
9144 CAPRIN EC tablets 75mg [WOCKHARDT] CPRD_product_code res9: antiplatelets drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH496/version/992/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH496/version/992/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH496', '992', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH496/version/992/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH496/version/992/export/codes/?format=json
CSV site_root/phenotypes/PH496/version/992/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH496', '992', api_client=client)

Version History

Version
ID
Name Owner Publish date
992 Antiplatelets ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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