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Dementia

Evangelos Kontopantelis, Ivan Olier, Claire Planner, David Reeves, Darren M Ashcroft, Linda Gask, Tim Doran, Sioban Reilly

Type
Disease or Syndrome
ID
PH515
Version ID
1030
Data Sources
Valid event data range
01/04/2000 - 31/03/2012
Sex
Female, Male
Agreement Date
2015-12-16
Coding system
Read codes v2 OXMIS codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

The database:

The CPRD is a large computerised database of anonymised primary care medical records. It contains complete patient information for participating practices, with the healthcare events (diagnoses, treatments, referrals, tests and prescriptions) recorded using coding systems (Read coding for diagnoses). Practice characteristics are described in detail elsewhere. The database is broadly representative of the UK population, although larger practices are over-represented. Practices need to meet prespecified data entry quality criteria to be defined as ‘up to research standard’, and for each study year, our main sample included all CPRD practices that were classed as such for the whole year. We also generated two data sets to test the sensitivity of our findings. First, we included all practices contributing data across the entire study period. Second, we included a subsample of 50 practices, representative of UK practices in terms of area deprivation, and practice list size.

Defining people with SMI and controls:

Information was extracted for the period 1 April 2000 to 31 March 2012 and aggregated into 12 yearly ‘bins’, to correspond with financial years 2000/2001–2011/2012. We used Read codes to identify the presence of SMI. First, we identified relevant keywords (or key-stubs) and codes, for example ‘paranoi’ and ‘E100.00’ (simple schizophrenia). Next, the CPRD was searched for codes that matched the list in either the code or the description field. Finally, the matched code list was reviewed by clinical experts and a final conservative list of codes was agreed. A similar process was used to define comorbidities (hypertension, asthma, hypothyroidism, osteoarthritis, chronic kidney disease, coronary heart disease, epilepsy, chronic obstructive pulmonary disease, cancer, stroke, heart failure, rheumatoid arthritis, dementia and psoriasis). All code lists we used are available from http://www.clinicalcodes.org. All conditions, bar asthma, were treated as unresolvable (ie, permanent). Within each year, all patients registered with a CPRD practice for the whole year and aged 18 or over were eligible for inclusion. The final SMI Read code list was used to identify cases of SMI, which were then grouped into three broad subcategories, in line with the diagnoses used when compiling primary care QOF SMI registers: schizophrenia; affective psychoses (bipolar disorder or other unspecified affective psychosis); other types of psychosis. In the event that an individual received more than one SMI diagnosis over the study period, we used the last available diagnosis to retrospectively ‘correct’ the original diagnosis (ie, we assumed that the latest diagnosis was the correct one). Within each year, each SMI case was then matched on age, sex and practice to five randomly selected patients not associated with SMI up until that time point. More details on the extraction of the cohort have been provided elsewhere,21 and a flow chart of the data extraction process is available in the online appendix figure A2.

Defining consultation type:

We defined a ‘consultation’ as involving direct contact between a patient and a healthcare professional within the primary care setting. We divided consultations into two main categories: face-to-face (our primary outcome), and by telephone (see online appendix table A1). We also constructed a third ‘other’ grouping of all other activities that are captured by the ‘consultation type’ codes within the CPRD. This includes mail/email contact, third party consultations (including referrals), secondary care episodes, other administrative tasks and consultations of unknown content. This group is highly heterogeneous and includes many activities that cannot be classed as consultations. However, we decided to use this grouping as an aggregate secondary outcome since it can potentially provide insight into the overall workload associated with patient care in the primary care context. We decided against breaking down the ‘other’ group in more subcategories as we are very doubtful regarding the reliability and across practice consistency of the coding within these ‘other’ categories. In instances where a patient had two or more consultations within a day, we conservatively assumed a single consultation took place, to reduce the likelihood of including duplicate records.

Publications

  • Evangelos Kontopantelis, Ivan Olier, Claire Panner, David Reeves, Darren M Ashcroft, Linda Gask, Tim Doran, Siobhan Reilly, Primary care consultation rates among people with and without severe mental illness a UK cohort study using the Clinical Practice Research Datalink. BMJ Open, 5 (e008650), 2015.

Clinical Code List

Rows: 73
Code Description Entity type Coding System (OXMIS Read) Category
E00..00 Senile and presenile organic psychotic conditions res21: Dementia Read diagnostic
E00..11 Senile dementia res21: Dementia Read diagnostic
E00..12 Senile/presenile dementia res21: Dementia Read diagnostic
E000.00 Uncomplicated senile dementia res21: Dementia Read diagnostic
E001.00 Presenile dementia res21: Dementia Read diagnostic
E001000 Uncomplicated presenile dementia res21: Dementia Read diagnostic
E001100 Presenile dementia with delirium res21: Dementia Read diagnostic
E001200 Presenile dementia with paranoia res21: Dementia Read diagnostic
E001300 Presenile dementia with depression res21: Dementia Read diagnostic
E001z00 Presenile dementia NOS res21: Dementia Read diagnostic
E002.00 Senile dementia with depressive or paranoid features res21: Dementia Read diagnostic
E002000 Senile dementia with paranoia res21: Dementia Read diagnostic
E002100 Senile dementia with depression res21: Dementia Read diagnostic
E002z00 Senile dementia with depressive or paranoid features NOS res21: Dementia Read diagnostic
E003.00 Senile dementia with delirium res21: Dementia Read diagnostic
E004.00 Arteriosclerotic dementia res21: Dementia Read diagnostic
E004.11 Multi infarct dementia res21: Dementia Read diagnostic
E004000 Uncomplicated arteriosclerotic dementia res21: Dementia Read diagnostic
E004100 Arteriosclerotic dementia with delirium res21: Dementia Read diagnostic
E004200 Arteriosclerotic dementia with paranoia res21: Dementia Read diagnostic
E004300 Arteriosclerotic dementia with depression res21: Dementia Read diagnostic
E004z00 Arteriosclerotic dementia NOS res21: Dementia Read diagnostic
E00y.00 Other senile and presenile organic psychoses res21: Dementia Read diagnostic
E00y.11 Presbyophrenic psychosis res21: Dementia Read diagnostic
E00z.00 Senile or presenile psychoses NOS res21: Dementia Read diagnostic
E012.00 Other alcoholic dementia res21: Dementia Read diagnostic
E012.11 Alcoholic dementia NOS res21: Dementia Read diagnostic
E012000 Chronic alcoholic brain syndrome res21: Dementia Read diagnostic
E041.00 Dementia in conditions EC res21: Dementia Read diagnostic
Eu00.00 [X]Dementia in Alzheimer's disease res21: Dementia Read diagnostic
Eu00000 [X]Dementia in Alzheimer's disease with early onset res21: Dementia Read diagnostic
Eu00011 [X]Presenile dementia,Alzheimer's type res21: Dementia Read diagnostic
Eu00012 [X]Primary degen dementia, Alzheimer's type, presenile onset res21: Dementia Read diagnostic
Eu00013 [X]Alzheimer's disease type 2 res21: Dementia Read diagnostic
Eu00100 [X]Dementia in Alzheimer's disease with late onset res21: Dementia Read diagnostic
Eu00111 [X]Alzheimer's disease type 1 res21: Dementia Read diagnostic
Eu00112 [X]Senile dementia,Alzheimer's type res21: Dementia Read diagnostic
Eu00113 [X]Primary degen dementia of Alzheimer's type, senile onset res21: Dementia Read diagnostic
Eu00200 [X]Dementia in Alzheimer's dis, atypical or mixed type res21: Dementia Read diagnostic
Eu00z00 [X]Dementia in Alzheimer's disease, unspecified res21: Dementia Read diagnostic
Eu00z11 [X]Alzheimer's dementia unspec res21: Dementia Read diagnostic
Eu01.00 [X]Vascular dementia res21: Dementia Read diagnostic
Eu01.11 [X]Arteriosclerotic dementia res21: Dementia Read diagnostic
Eu01000 [X]Vascular dementia of acute onset res21: Dementia Read diagnostic
Eu01100 [X]Multi-infarct dementia res21: Dementia Read diagnostic
Eu01111 [X]Predominantly cortical dementia res21: Dementia Read diagnostic
Eu01200 [X]Subcortical vascular dementia res21: Dementia Read diagnostic
Eu01300 [X]Mixed cortical and subcortical vascular dementia res21: Dementia Read diagnostic
Eu01y00 [X]Other vascular dementia res21: Dementia Read diagnostic
Eu01z00 [X]Vascular dementia, unspecified res21: Dementia Read diagnostic
Eu02.00 [X]Dementia in other diseases classified elsewhere res21: Dementia Read diagnostic
Eu02000 [X]Dementia in Pick's disease res21: Dementia Read diagnostic
Eu02100 [X]Dementia in Creutzfeldt-Jakob disease res21: Dementia Read diagnostic
Eu02200 [X]Dementia in Huntington's disease res21: Dementia Read diagnostic
Eu02300 [X]Dementia in Parkinson's disease res21: Dementia Read diagnostic
Eu02400 [X]Dementia in human immunodef virus [HIV] disease res21: Dementia Read diagnostic
Eu02500 [X]Lewy body dementia res21: Dementia Read diagnostic
Eu02y00 [X]Dementia in other specified diseases classif elsewhere res21: Dementia Read diagnostic
Eu02z00 [X] Unspecified dementia res21: Dementia Read diagnostic
Eu02z11 [X] Presenile dementia NOS res21: Dementia Read diagnostic
Eu02z12 [X] Presenile psychosis NOS res21: Dementia Read diagnostic
Eu02z13 [X] Primary degenerative dementia NOS res21: Dementia Read diagnostic
Eu02z14 [X] Senile dementia NOS res21: Dementia Read diagnostic
Eu02z15 [X] Senile psychosis NOS res21: Dementia Read diagnostic
Eu02z16 [X] Senile dementia, depressed or paranoid type res21: Dementia Read diagnostic
Eu10711 [X]Alcoholic dementia NOS res21: Dementia Read diagnostic
F110.00 Alzheimer's disease res21: Dementia Read diagnostic
F110000 Alzheimer's disease with early onset res21: Dementia Read diagnostic
F110100 Alzheimer's disease with late onset res21: Dementia Read diagnostic
F111.00 Pick's disease res21: Dementia Read diagnostic
F112.00 Senile degeneration of brain res21: Dementia Read diagnostic
F116.00 Lewy body disease res21: Dementia Read diagnostic
Fyu3000 [X]Other Alzheimer's disease res21: Dementia Read diagnostic
Rows: 8
Code Description Entity type Coding System (OXMIS Read) Category
2900 SENILE DEMENTIA res21: Dementia OXMIS diagnostic
2901A PRESENILE DEMENTIA res21: Dementia OXMIS diagnostic
2901B ALZHEIMER'S DISEASE res21: Dementia OXMIS diagnostic
2901D JACOB- CREUZFELDT DISEASE WITH DEMENTIA res21: Dementia OXMIS diagnostic
2919 DEMENTIA ALCOHOLIC res21: Dementia OXMIS diagnostic
2930 DEMENTIA ARTERIOSCLEROTIC res21: Dementia OXMIS diagnostic
299 B DEMENTIA res21: Dementia OXMIS diagnostic
299 G DEMENTIA AGGRESSIVE res21: Dementia OXMIS diagnostic

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH515/version/1030/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH515/version/1030/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH515', '1030', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH515/version/1030/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH515/version/1030/export/codes/?format=json
CSV site_root/phenotypes/PH515/version/1030/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH515', '1030', api_client=client)

Version History

Version
ID
Name Owner Publish date
1030 Dementia ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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