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Diabetes Mellitus Type II (DMII)

Evangelos Kontopantelis, Ivan Olier, Claire Planner, David Reeves, Darren M Ashcroft, Linda Gask, Tim Doran, Sioban Reilly

Type
Disease or Syndrome
ID
PH522
Version ID
1044
Data Sources
Valid event data range
01/04/2000 - 31/03/2012
Sex
Female, Male
Agreement Date
2015-12-16
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

The database:

The CPRD is a large computerised database of anonymised primary care medical records. It contains complete patient information for participating practices, with the healthcare events (diagnoses, treatments, referrals, tests and prescriptions) recorded using coding systems (Read coding for diagnoses). Practice characteristics are described in detail elsewhere. The database is broadly representative of the UK population, although larger practices are over-represented. Practices need to meet prespecified data entry quality criteria to be defined as ‘up to research standard’, and for each study year, our main sample included all CPRD practices that were classed as such for the whole year. We also generated two data sets to test the sensitivity of our findings. First, we included all practices contributing data across the entire study period. Second, we included a subsample of 50 practices, representative of UK practices in terms of area deprivation, and practice list size.

Defining people with SMI and controls:

Information was extracted for the period 1 April 2000 to 31 March 2012 and aggregated into 12 yearly ‘bins’, to correspond with financial years 2000/2001–2011/2012. We used Read codes to identify the presence of SMI. First, we identified relevant keywords (or key-stubs) and codes, for example ‘paranoi’ and ‘E100.00’ (simple schizophrenia). Next, the CPRD was searched for codes that matched the list in either the code or the description field. Finally, the matched code list was reviewed by clinical experts and a final conservative list of codes was agreed. A similar process was used to define comorbidities (hypertension, asthma, hypothyroidism, osteoarthritis, chronic kidney disease, coronary heart disease, epilepsy, chronic obstructive pulmonary disease, cancer, stroke, heart failure, rheumatoid arthritis, dementia and psoriasis). All code lists we used are available from http://www.clinicalcodes.org. All conditions, bar asthma, were treated as unresolvable (ie, permanent). Within each year, all patients registered with a CPRD practice for the whole year and aged 18 or over were eligible for inclusion. The final SMI Read code list was used to identify cases of SMI, which were then grouped into three broad subcategories, in line with the diagnoses used when compiling primary care QOF SMI registers: schizophrenia; affective psychoses (bipolar disorder or other unspecified affective psychosis); other types of psychosis. In the event that an individual received more than one SMI diagnosis over the study period, we used the last available diagnosis to retrospectively ‘correct’ the original diagnosis (ie, we assumed that the latest diagnosis was the correct one). Within each year, each SMI case was then matched on age, sex and practice to five randomly selected patients not associated with SMI up until that time point. More details on the extraction of the cohort have been provided elsewhere,21 and a flow chart of the data extraction process is available in the online appendix figure A2.

Defining consultation type:

We defined a ‘consultation’ as involving direct contact between a patient and a healthcare professional within the primary care setting. We divided consultations into two main categories: face-to-face (our primary outcome), and by telephone (see online appendix table A1). We also constructed a third ‘other’ grouping of all other activities that are captured by the ‘consultation type’ codes within the CPRD. This includes mail/email contact, third party consultations (including referrals), secondary care episodes, other administrative tasks and consultations of unknown content. This group is highly heterogeneous and includes many activities that cannot be classed as consultations. However, we decided to use this grouping as an aggregate secondary outcome since it can potentially provide insight into the overall workload associated with patient care in the primary care context. We decided against breaking down the ‘other’ group in more subcategories as we are very doubtful regarding the reliability and across practice consistency of the coding within these ‘other’ categories. In instances where a patient had two or more consultations within a day, we conservatively assumed a single consultation took place, to reduce the likelihood of including duplicate records.

Publications

  • Evangelos Kontopantelis, Ivan Olier, Claire Panner, David Reeves, Darren M Ashcroft, Linda Gask, Tim Doran, Siobhan Reilly, Primary care consultation rates among people with and without severe mental illness a UK cohort study using the Clinical Practice Research Datalink. BMJ Open, 5 (e008650), 2015.

Clinical Code List

Rows: 102
Code Description Entity type Category Coding System (Read)
66Ao.00 Diabetes type 2 review res21: DMII diagnostic Read
66At100 Type II diabetic dietary review res21: DMII diagnostic Read
66At111 Type 2 diabetic dietary review res21: DMII diagnostic Read
C100112 Non-insulin dependent diabetes mellitus res21: DMII diagnostic Read
C109.00 Non-insulin dependent diabetes mellitus res21: DMII diagnostic Read
C109.11 NIDDM - Non-insulin dependent diabetes mellitus res21: DMII diagnostic Read
C109.12 Type 2 diabetes mellitus res21: DMII diagnostic Read
C109.13 Type II diabetes mellitus res21: DMII diagnostic Read
C109000 Non-insulin-dependent diabetes mellitus with renal comps res21: DMII diagnostic Read
C109011 Type II diabetes mellitus with renal complications res21: DMII diagnostic Read
C109012 Type 2 diabetes mellitus with renal complications res21: DMII diagnostic Read
C109100 Non-insulin-dependent diabetes mellitus with ophthalm comps res21: DMII diagnostic Read
C109111 Type II diabetes mellitus with ophthalmic complications res21: DMII diagnostic Read
C109112 Type 2 diabetes mellitus with ophthalmic complications res21: DMII diagnostic Read
C109200 Non-insulin-dependent diabetes mellitus with neuro comps res21: DMII diagnostic Read
C109211 Type II diabetes mellitus with neurological complications res21: DMII diagnostic Read
C109212 Type 2 diabetes mellitus with neurological complications res21: DMII diagnostic Read
C109300 Non-insulin-dependent diabetes mellitus with multiple comps res21: DMII diagnostic Read
C109400 Non-insulin dependent diabetes mellitus with ulcer res21: DMII diagnostic Read
C109411 Type II diabetes mellitus with ulcer res21: DMII diagnostic Read
C109412 Type 2 diabetes mellitus with ulcer res21: DMII diagnostic Read
C109500 Non-insulin dependent diabetes mellitus with gangrene res21: DMII diagnostic Read
C109511 Type II diabetes mellitus with gangrene res21: DMII diagnostic Read
C109512 Type 2 diabetes mellitus with gangrene res21: DMII diagnostic Read
C109600 Non-insulin-dependent diabetes mellitus with retinopathy res21: DMII diagnostic Read
C109611 Type II diabetes mellitus with retinopathy res21: DMII diagnostic Read
C109612 Type 2 diabetes mellitus with retinopathy res21: DMII diagnostic Read
C109700 Non-insulin dependent diabetes mellitus - poor control res21: DMII diagnostic Read
C109711 Type II diabetes mellitus - poor control res21: DMII diagnostic Read
C109712 Type 2 diabetes mellitus - poor control res21: DMII diagnostic Read
C109900 Non-insulin-dependent diabetes mellitus without complication res21: DMII diagnostic Read
C109A00 Non-insulin dependent diabetes mellitus with mononeuropathy res21: DMII diagnostic Read
C109A11 Type II diabetes mellitus with mononeuropathy res21: DMII diagnostic Read
C109B00 Non-insulin dependent diabetes mellitus with polyneuropathy res21: DMII diagnostic Read
C109B11 Type II diabetes mellitus with polyneuropathy res21: DMII diagnostic Read
C109C00 Non-insulin dependent diabetes mellitus with nephropathy res21: DMII diagnostic Read
C109C11 Type II diabetes mellitus with nephropathy res21: DMII diagnostic Read
C109C12 Type 2 diabetes mellitus with nephropathy res21: DMII diagnostic Read
C109D00 Non-insulin dependent diabetes mellitus with hypoglyca coma res21: DMII diagnostic Read
C109D11 Type II diabetes mellitus with hypoglycaemic coma res21: DMII diagnostic Read
C109D12 Type 2 diabetes mellitus with hypoglycaemic coma res21: DMII diagnostic Read
C109E00 Non-insulin depend diabetes mellitus with diabetic cataract res21: DMII diagnostic Read
C109E11 Type II diabetes mellitus with diabetic cataract res21: DMII diagnostic Read
C109E12 Type 2 diabetes mellitus with diabetic cataract res21: DMII diagnostic Read
C109F11 Type II diabetes mellitus with peripheral angiopathy res21: DMII diagnostic Read
C109F12 Type 2 diabetes mellitus with peripheral angiopathy res21: DMII diagnostic Read
C109G00 Non-insulin dependent diabetes mellitus with arthropathy res21: DMII diagnostic Read
C109G11 Type II diabetes mellitus with arthropathy res21: DMII diagnostic Read
C109G12 Type 2 diabetes mellitus with arthropathy res21: DMII diagnostic Read
C109H11 Type II diabetes mellitus with neuropathic arthropathy res21: DMII diagnostic Read
C109H12 Type 2 diabetes mellitus with neuropathic arthropathy res21: DMII diagnostic Read
C109J00 Insulin treated Type 2 diabetes mellitus res21: DMII diagnostic Read
C109J11 Insulin treated non-insulin dependent diabetes mellitus res21: DMII diagnostic Read
C109J12 Insulin treated Type II diabetes mellitus res21: DMII diagnostic Read
C109K00 Hyperosmolar non-ketotic state in type 2 diabetes mellitus res21: DMII diagnostic Read
C10D.00 Diabetes mellitus autosomal dominant type 2 res21: DMII diagnostic Read
C10F.00 Type 2 diabetes mellitus res21: DMII diagnostic Read
C10F.11 Type II diabetes mellitus res21: DMII diagnostic Read
C10F000 Type 2 diabetes mellitus with renal complications res21: DMII diagnostic Read
C10F011 Type II diabetes mellitus with renal complications res21: DMII diagnostic Read
C10F100 Type 2 diabetes mellitus with ophthalmic complications res21: DMII diagnostic Read
C10F111 Type II diabetes mellitus with ophthalmic complications res21: DMII diagnostic Read
C10F200 Type 2 diabetes mellitus with neurological complications res21: DMII diagnostic Read
C10F211 Type II diabetes mellitus with neurological complications res21: DMII diagnostic Read
C10F300 Type 2 diabetes mellitus with multiple complications res21: DMII diagnostic Read
C10F311 Type II diabetes mellitus with multiple complications res21: DMII diagnostic Read
C10F400 Type 2 diabetes mellitus with ulcer res21: DMII diagnostic Read
C10F411 Type II diabetes mellitus with ulcer res21: DMII diagnostic Read
C10F500 Type 2 diabetes mellitus with gangrene res21: DMII diagnostic Read
C10F511 Type II diabetes mellitus with gangrene res21: DMII diagnostic Read
C10F600 Type 2 diabetes mellitus with retinopathy res21: DMII diagnostic Read
C10F611 Type II diabetes mellitus with retinopathy res21: DMII diagnostic Read
C10F700 Type 2 diabetes mellitus - poor control res21: DMII diagnostic Read
C10F711 Type II diabetes mellitus - poor control res21: DMII diagnostic Read
C10F900 Type 2 diabetes mellitus without complication res21: DMII diagnostic Read
C10F911 Type II diabetes mellitus without complication res21: DMII diagnostic Read
C10FA00 Type 2 diabetes mellitus with mononeuropathy res21: DMII diagnostic Read
C10FA11 Type II diabetes mellitus with mononeuropathy res21: DMII diagnostic Read
C10FB00 Type 2 diabetes mellitus with polyneuropathy res21: DMII diagnostic Read
C10FB11 Type II diabetes mellitus with polyneuropathy res21: DMII diagnostic Read
C10FC00 Type 2 diabetes mellitus with nephropathy res21: DMII diagnostic Read
C10FC11 Type II diabetes mellitus with nephropathy res21: DMII diagnostic Read
C10FD00 Type 2 diabetes mellitus with hypoglycaemic coma res21: DMII diagnostic Read
C10FD11 Type II diabetes mellitus with hypoglycaemic coma res21: DMII diagnostic Read
C10FE00 Type 2 diabetes mellitus with diabetic cataract res21: DMII diagnostic Read
C10FE11 Type II diabetes mellitus with diabetic cataract res21: DMII diagnostic Read
C10FF00 Type 2 diabetes mellitus with peripheral angiopathy res21: DMII diagnostic Read
C10FG00 Type 2 diabetes mellitus with arthropathy res21: DMII diagnostic Read
C10FG11 Type II diabetes mellitus with arthropathy res21: DMII diagnostic Read
C10FH00 Type 2 diabetes mellitus with neuropathic arthropathy res21: DMII diagnostic Read
C10FJ00 Insulin treated Type 2 diabetes mellitus res21: DMII diagnostic Read
C10FJ11 Insulin treated Type II diabetes mellitus res21: DMII diagnostic Read
C10FK00 Hyperosmolar non-ketotic state in type 2 diabetes mellitus res21: DMII diagnostic Read
C10FL00 Type 2 diabetes mellitus with persistent proteinuria res21: DMII diagnostic Read
C10FL11 Type II diabetes mellitus with persistent proteinuria res21: DMII diagnostic Read
C10FM00 Type 2 diabetes mellitus with persistent microalbuminuria res21: DMII diagnostic Read
C10FM11 Type II diabetes mellitus with persistent microalbuminuria res21: DMII diagnostic Read
C10FN00 Type 2 diabetes mellitus with ketoacidosis res21: DMII diagnostic Read
C10FP00 Type 2 diabetes mellitus with ketoacidotic coma res21: DMII diagnostic Read
C10FQ00 Type 2 diabetes mellitus with exudative maculopathy res21: DMII diagnostic Read
C10FR00 Type 2 diabetes mellitus with gastroparesis res21: DMII diagnostic Read
ZC2CA00 Dietary advice for type II diabetes res21: DMII diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH522/version/1044/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH522/version/1044/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH522', '1044', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH522/version/1044/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH522/version/1044/export/codes/?format=json
CSV site_root/phenotypes/PH522/version/1044/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH522', '1044', api_client=client)

Version History

Version
ID
Name Owner Publish date
1044 Diabetes Mellitus Type II (DMII) ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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