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Hypertension

Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Matthias Pierce, Darren M. Ashcroft

Type
Disease or Syndrome
ID
PH534
Version ID
1068
Data Sources
Valid event data range
01/04/2006 - 31/03/2012
Sex
Female, Male
Agreement Date
2014-12-16
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Data source:

We used the Clinical Practice Research Datalink (CPRD), a large primary care database that holds complete electronic patient records (including diagnoses, prescriptions and referrals) from participating family practices across the UK. A hierarchical clinical coding system (Read) is used to record the data. In July 2012, data were available for 644 practices and 13,772,992 patients. Full details of the database have been provided elsewhere.

Diabetes cohort:

We extracted data from 1 April 2006 to 31 March 2012 and, for ease of reporting and analysing, aggregated information into six financial years. Within each year, practice inclusion eligibility was determined by a CPRD assessment algorithm, which informs on practices considered to be of research standard; therefore, our cohort of practices varied over time. For each research standard practice and year, we defined as eligible patients those who were registered with the practice for the full year and were aged 18 years or over in that year. From these patients, using relevant Read codes for type 2 diabetes (e.g. C10F.00: Type 2 diabetes mellitus) and excluding those treated with insulin within 2 years of diagnosis, we identified 246,544 patients over the study period. Diagnoses were not constrained to the study period and a relevant code prior to the study as well as during the study period would flag a patient from the respective year onwards. Data on sex, age and removal from the database due to deaths were available and complete for all patients.We extracted data on diabetes-related macrovascular (myocardial infarction, stroke, peripheral vascular disease or amputation) and microvascular (retinopathy, neuropathy, nephropathy [chronic kidney disease stages 4–5] or foot ulcer) complications as well as comorbidities (asthma, coronary heart disease, chronic kidney disease [excluded from microvascular analysis], chronic obstructive pulmonary disease, depression, dementia, severe mental illness, heart failure, hypertension, stroke [excluded from macrovascular analysis], cancer, epilepsy, osteoarthritis, osteoporosis and hypothyroidism). Although we aimed to include all conditions associated with diabetes, the choice was partially determined by the domains incentivised under the Quality and Outcomes Framework (QOF), for which accuracy of diagnosis is considered high. Information was also extracted on smoking (never smoked, current, exsmoker and missing data),BMI, HbA1c levels (%), cholesterol levels (mmol/l) and systolic/diastolic BP (mmHg). Biometric measurement data were cleaned and we calculated patient means for each year when more than one relevant record was available. Using product lists we determined prescription prevalence (at least one) for relevant medications: ACE inhibitors, acarbose, α-blockers, anticoagulants, antiplatelet agents, β-blockers, calcium-channel blockers, thiazide diuretics, loop diuretics, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide- 1 agonists, statins and other lipid-lowering drugs, meglitinides , metformin, sulfonylureas and thiazolidinediones. For approximately 60% of the practices, records were linked to Office of National Statistics (ONS) mortality data and we had access to death dates for all their patients. For these, using ICD-10 codes (www.who.int/classifications/icd/en/) we were able to estimate deathslinked to specific causes (underlying or in the top three): diabetes (E10–E16), ischaemic heart disease (I21–I22), stroke (I60–I64) or stroke excluding bleeds (excluding I63).

Publications

  • Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, 58:505-518, 2015.

Clinical Code List

Rows: 69
Code Description Entity type Category Coding System (Read)
2126100 Hypertension resolved hypertension diagnostic Read
212K.00 Hypertension resolved hypertension diagnostic Read
G2...00 Hypertensive disease hypertension diagnostic Read
G2...11 BP - hypertensive disease hypertension diagnostic Read
G20..00 Essential hypertension hypertension diagnostic Read
G200.00 Malignant essential hypertension hypertension diagnostic Read
G201.00 Benign essential hypertension hypertension diagnostic Read
G202.00 Systolic hypertension hypertension diagnostic Read
G20z.00 Essential hypertension NOS hypertension diagnostic Read
G20z.11 Hypertension NOS hypertension diagnostic Read
G21..00 Hypertensive heart disease hypertension diagnostic Read
G210.00 Malignant hypertensive heart disease hypertension diagnostic Read
G210000 Malignant hypertensive heart disease without CCF hypertension diagnostic Read
G210100 Malignant hypertensive heart disease with CCF hypertension diagnostic Read
G210z00 Malignant hypertensive heart disease NOS hypertension diagnostic Read
G211.00 Benign hypertensive heart disease hypertension diagnostic Read
G211000 Benign hypertensive heart disease without CCF hypertension diagnostic Read
G211100 Benign hypertensive heart disease with CCF hypertension diagnostic Read
G21z.00 Hypertensive heart disease NOS hypertension diagnostic Read
G21z000 Hypertensive heart disease NOS without CCF hypertension diagnostic Read
G21z011 Cardiomegaly - hypertensive hypertension diagnostic Read
G21z100 Hypertensive heart disease NOS with CCF hypertension diagnostic Read
G21zz00 Hypertensive heart disease NOS hypertension diagnostic Read
G22..00 Hypertensive renal disease hypertension diagnostic Read
G220.00 Malignant hypertensive renal disease hypertension diagnostic Read
G221.00 Benign hypertensive renal disease hypertension diagnostic Read
G222.00 Hypertensive renal disease with renal failure hypertension diagnostic Read
G22z.00 Hypertensive renal disease NOS hypertension diagnostic Read
G22z.11 Renal hypertension hypertension diagnostic Read
G23..00 Hypertensive heart and renal disease hypertension diagnostic Read
G230.00 Malignant hypertensive heart and renal disease hypertension diagnostic Read
G231.00 Benign hypertensive heart and renal disease hypertension diagnostic Read
G232.00 Hypertensive heart&renal dis wth (congestive) heart failure hypertension diagnostic Read
G233.00 Hypertensive heart and renal disease with renal failure hypertension diagnostic Read
G234.00 Hyperten heart&renal dis+both(congestv)heart and renal fail hypertension diagnostic Read
G23z.00 Hypertensive heart and renal disease NOS hypertension diagnostic Read
G24..00 Secondary hypertension hypertension diagnostic Read
G240.00 Secondary malignant hypertension hypertension diagnostic Read
G240000 Secondary malignant renovascular hypertension hypertension diagnostic Read
G240z00 Secondary malignant hypertension NOS hypertension diagnostic Read
G241.00 Secondary benign hypertension hypertension diagnostic Read
G241000 Secondary benign renovascular hypertension hypertension diagnostic Read
G241z00 Secondary benign hypertension NOS hypertension diagnostic Read
G244.00 Hypertension secondary to endocrine disorders hypertension diagnostic Read
G24z.00 Secondary hypertension NOS hypertension diagnostic Read
G24z000 Secondary renovascular hypertension NOS hypertension diagnostic Read
G24zz00 Secondary hypertension NOS hypertension diagnostic Read
G2y..00 Other specified hypertensive disease hypertension diagnostic Read
G2z..00 Hypertensive disease NOS hypertension diagnostic Read
Gyu2000 [X]Other secondary hypertension hypertension diagnostic Read
Gyu2100 [X]Hypertension secondary to other renal disorders hypertension diagnostic Read
L120.00 Benign essential hypertension in pregnancy/childbirth/puerp hypertension diagnostic Read
L120000 Benign essential hypertension in preg/childb/puerp unspec hypertension diagnostic Read
L120100 Benign essential hypertension in preg/childb/puerp - deliv hypertension diagnostic Read
L120300 Benign essential hypertension in preg/childb/puerp-not deliv hypertension diagnostic Read
L120400 Benign essential hypertension in preg/childb/puerp +p/n comp hypertension diagnostic Read
L120z00 Benign essential hypertension in preg/childb/puerp NOS hypertension diagnostic Read
L121.00 Renal hypertension in pregnancy/childbirth/puerperium hypertension diagnostic Read
L121000 Renal hypertension in pregnancy/childbirth/puerp unspecified hypertension diagnostic Read
L121100 Renal hypertension in pregnancy/childbirth/puerp - delivered hypertension diagnostic Read
L121300 Renal hypertension in preg/childbirth/puerp - not delivered hypertension diagnostic Read
L121z00 Renal hypertension in pregnancy/childbirth/puerperium NOS hypertension diagnostic Read
L122.00 Other pre-existing hypertension in preg/childbirth/puerp hypertension diagnostic Read
L122000 Other pre-existing hypertension in preg/childb/puerp unspec hypertension diagnostic Read
L122100 Other pre-existing hypertension in preg/childb/puerp - deliv hypertension diagnostic Read
L122300 Other pre-exist hypertension in preg/childb/puerp-not deliv hypertension diagnostic Read
L122z00 Other pre-existing hypertension in preg/childb/puerp NOS hypertension diagnostic Read
L128.00 Pre-exist hypertension compl preg childbirth and puerperium hypertension diagnostic Read
L128200 Pre-exist 2ndry hypertens comp preg childbth and puerperium hypertension diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH534/version/1068/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH534/version/1068/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH534', '1068', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH534/version/1068/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH534/version/1068/export/codes/?format=json
CSV site_root/phenotypes/PH534/version/1068/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH534', '1068', api_client=client)

Version History

Version
ID
Name Owner Publish date
1068 Hypertension ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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