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Lipid Lowering Other

Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Matthias Pierce, Darren M. Ashcroft

Type
Drug
ID
PH540
Version ID
1080
Data Sources
Valid event data range
01/04/2006 - 31/03/2012
Sex
Female, Male
Agreement Date
2014-12-16
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Data source:

We used the Clinical Practice Research Datalink (CPRD), a large primary care database that holds complete electronic patient records (including diagnoses, prescriptions and referrals) from participating family practices across the UK. A hierarchical clinical coding system (Read) is used to record the data. In July 2012, data were available for 644 practices and 13,772,992 patients. Full details of the database have been provided elsewhere.

Diabetes cohort:

We extracted data from 1 April 2006 to 31 March 2012 and, for ease of reporting and analysing, aggregated information into six financial years. Within each year, practice inclusion eligibility was determined by a CPRD assessment algorithm, which informs on practices considered to be of research standard; therefore, our cohort of practices varied over time. For each research standard practice and year, we defined as eligible patients those who were registered with the practice for the full year and were aged 18 years or over in that year. From these patients, using relevant Read codes for type 2 diabetes (e.g. C10F.00: Type 2 diabetes mellitus) and excluding those treated with insulin within 2 years of diagnosis, we identified 246,544 patients over the study period. Diagnoses were not constrained to the study period and a relevant code prior to the study as well as during the study period would flag a patient from the respective year onwards. Data on sex, age and removal from the database due to deaths were available and complete for all patients.We extracted data on diabetes-related macrovascular (myocardial infarction, stroke, peripheral vascular disease or amputation) and microvascular (retinopathy, neuropathy, nephropathy [chronic kidney disease stages 4–5] or foot ulcer) complications as well as comorbidities (asthma, coronary heart disease, chronic kidney disease [excluded from microvascular analysis], chronic obstructive pulmonary disease, depression, dementia, severe mental illness, heart failure, hypertension, stroke [excluded from macrovascular analysis], cancer, epilepsy, osteoarthritis, osteoporosis and hypothyroidism). Although we aimed to include all conditions associated with diabetes, the choice was partially determined by the domains incentivised under the Quality and Outcomes Framework (QOF), for which accuracy of diagnosis is considered high. Information was also extracted on smoking (never smoked, current, exsmoker and missing data),BMI, HbA1c levels (%), cholesterol levels (mmol/l) and systolic/diastolic BP (mmHg). Biometric measurement data were cleaned and we calculated patient means for each year when more than one relevant record was available. Using product lists we determined prescription prevalence (at least one) for relevant medications: ACE inhibitors, acarbose, α-blockers, anticoagulants, antiplatelet agents, β-blockers, calcium-channel blockers, thiazide diuretics, loop diuretics, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide- 1 agonists, statins and other lipid-lowering drugs, meglitinides , metformin, sulfonylureas and thiazolidinediones. For approximately 60% of the practices, records were linked to Office of National Statistics (ONS) mortality data and we had access to death dates for all their patients. For these, using ICD-10 codes (www.who.int/classifications/icd/en/) we were able to estimate deathslinked to specific causes (underlying or in the top three): diabetes (E10–E16), ischaemic heart disease (I21–I22), stroke (I60–I64) or stroke excluding bleeds (excluding I63).

Publications

  • Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, 58:505-518, 2015.

Clinical Code List

Rows: 76
Code Description Coding System (CPRD_product_code) Entity type Category
10094 NIASPAN TITRATION PACK modified release tablet 375mg + 500mg + 750mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
11785 colestyramine powder sugar-free 4g CPRD_product_code res9: lipid_lowering_other drug
11976 NIASPAN modified release tablet 500mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
1212 colestipol granules CPRD_product_code res9: lipid_lowering_other drug
1214 BEZALIP mono-tablets 400mg [ROCHE] CPRD_product_code res9: lipid_lowering_other drug
1215 fenofibrate capsules 100mg CPRD_product_code res9: lipid_lowering_other drug
1217 LIPANTIL MICRO 200 capsules 200mg [FOURNIER] CPRD_product_code res9: lipid_lowering_other drug
12211 nicotinic acid tablets 50mg CPRD_product_code res9: lipid_lowering_other drug
1324 BEZALIP tablets 200mg [ROCHE] CPRD_product_code res9: lipid_lowering_other drug
14379 LIPANTIL MICRO capsules 67mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
14963 nicotinic acid modified release tablet 500mg CPRD_product_code res9: lipid_lowering_other drug
1716 QUESTRAN sachets 4g [BRISTOL] CPRD_product_code res9: lipid_lowering_other drug
17614 ZIMBACOL XL modified release tablet 400mg [ARCHIMEDES] CPRD_product_code res9: lipid_lowering_other drug
1764 QUESTRAN LIGHT sachets 4g [BRISTOL] CPRD_product_code res9: lipid_lowering_other drug
17813 nicotinic acid tablets 100mg CPRD_product_code res9: lipid_lowering_other drug
17824 nicotinic acid tablets 25mg CPRD_product_code res9: lipid_lowering_other drug
18081 COLESTID ORANGE granules [PHARMACIA] CPRD_product_code res9: lipid_lowering_other drug
18098 nicotinic acid modified release tablet 375mg + 500mg + 750mg CPRD_product_code res9: lipid_lowering_other drug
18126 nicotinic acid modified release tablet 1000mg CPRD_product_code res9: lipid_lowering_other drug
184 bezafibrate tablets 200mg CPRD_product_code res9: lipid_lowering_other drug
19938 colestipol with aspartame granules CPRD_product_code res9: lipid_lowering_other drug
2215 LOPID capsules 300mg [PFIZER] CPRD_product_code res9: lipid_lowering_other drug
23153 LIPAROL XL modified release tablet 400mg [ASHBOURNE] CPRD_product_code res9: lipid_lowering_other drug
23956 MAXEPA emulsion [SEVEN SEAS] CPRD_product_code res9: lipid_lowering_other drug
24084 COLESTYRAMINE sachets 4g [PLIVA] CPRD_product_code res9: lipid_lowering_other drug
2435 LIPANTIL capsules 100mg [FOURNIER] CPRD_product_code res9: lipid_lowering_other drug
24583 nicotinic acid modified release tablet 750mg CPRD_product_code res9: lipid_lowering_other drug
2662 MAXEPA capsules 1g [SEVEN SEAS] CPRD_product_code res9: lipid_lowering_other drug
29213 BEZAGEN XL modified release tablet 400mg [GEN (UK)] CPRD_product_code res9: lipid_lowering_other drug
29328 BEZAFIBRATE tablets 200mg [HILLCROSS] CPRD_product_code res9: lipid_lowering_other drug
3089 ciprofibrate tablets 100mg CPRD_product_code res9: lipid_lowering_other drug
31221 BEZAFIBRATE tablets 200mg [GEN (UK)] CPRD_product_code res9: lipid_lowering_other drug
3159 fenofibrate capsules 200mg CPRD_product_code res9: lipid_lowering_other drug
31783 FENOGAL capsules 200mg [GENUS] CPRD_product_code res9: lipid_lowering_other drug
3204 MAXEPA liquid [SEVEN SEAS] CPRD_product_code res9: lipid_lowering_other drug
32110 COLESTYRAMINE sachets 4g [DOMINION] CPRD_product_code res9: lipid_lowering_other drug
3318 gemfibrozil capsules 300mg CPRD_product_code res9: lipid_lowering_other drug
33603 FIBRAZATE XL tablets 400mg [SANDOZ] CPRD_product_code res9: lipid_lowering_other drug
33944 BEZAFIBRATE tablets 200mg [TEVA] CPRD_product_code res9: lipid_lowering_other drug
34181 BEZAFIBRATE modified release tablet 400mg [HILLCROSS] CPRD_product_code res9: lipid_lowering_other drug
34201 COLESTYRAMINE sachets 4g [ACTAVIS] CPRD_product_code res9: lipid_lowering_other drug
34277 GEMFIBROZIL tablets 600mg [TEVA] CPRD_product_code res9: lipid_lowering_other drug
37266 colesevelam hydrochloride tablets 625mg CPRD_product_code res9: lipid_lowering_other drug
37953 CHOLESTAGEL tablets 625mg [GENZYME] CPRD_product_code res9: lipid_lowering_other drug
39420 BEZALIP MONO modified release tablet 400mg [ACTAVIS] CPRD_product_code res9: lipid_lowering_other drug
39576 BEZALIP tablets 200mg [ACTAVIS] CPRD_product_code res9: lipid_lowering_other drug
4062 LOPID tablets 600mg [PFIZER] CPRD_product_code res9: lipid_lowering_other drug
4067 OLBETAM capsules 250mg [PHARMACIA] CPRD_product_code res9: lipid_lowering_other drug
40729 TREDAPTIVE modified release tablet 1g + 20mg [M S D] CPRD_product_code res9: lipid_lowering_other drug
40885 nicotinic acid with laropiprant modified release tablet 1g + 20mg CPRD_product_code res9: lipid_lowering_other drug
41396 FENOFIBRATE MICRO capsules 200mg [HILLCROSS] CPRD_product_code res9: lipid_lowering_other drug
42801 BEZAFIBRATE XL modified release tablet 400mg [GEN (UK)] CPRD_product_code res9: lipid_lowering_other drug
47935 FENOFIBRATE capsules 200mg [TEVA] CPRD_product_code res9: lipid_lowering_other drug
4920 fenofibrate micronised capsules 200mg CPRD_product_code res9: lipid_lowering_other drug
4928 LIPANTIL MICRO capsules 200mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
5216 BEZALIP MONO modified release tablet 400mg [ROCHE] CPRD_product_code res9: lipid_lowering_other drug
5390 fenofibrate micronised capsules 267mg CPRD_product_code res9: lipid_lowering_other drug
5564 COLESTID orange sachets [PHARMACIA] CPRD_product_code res9: lipid_lowering_other drug
602 bezafibrate modified release tablet 400mg CPRD_product_code res9: lipid_lowering_other drug
6120 EZETROL tablets 10mg [M S D] CPRD_product_code res9: lipid_lowering_other drug
6155 colestyramine with aspartame powder sugar-free 4g CPRD_product_code res9: lipid_lowering_other drug
6365 COLESTID granules [PHARMACIA] CPRD_product_code res9: lipid_lowering_other drug
644 colestyramine powder 4g CPRD_product_code res9: lipid_lowering_other drug
653 ezetimibe tablets 10mg CPRD_product_code res9: lipid_lowering_other drug
6572 OMACOR capsules [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
7540 LIPANTIL MICRO capsules 267mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
7544 NIASPAN modified release tablet 750mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
7551 NIASPAN modified release tablet 1000mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug
8082 gemfibrozil tablets 600mg CPRD_product_code res9: lipid_lowering_other drug
8104 acipimox capsules 250mg CPRD_product_code res9: lipid_lowering_other drug
8366 probucol tablets 250mg CPRD_product_code res9: lipid_lowering_other drug
8706 MODALIM tablets 100mg [SANOFI/AVE] CPRD_product_code res9: lipid_lowering_other drug
8834 LURSELLE tablets 250mg [HOECHSTMAR] CPRD_product_code res9: lipid_lowering_other drug
9491 fenofibrate micronised capsules 67mg CPRD_product_code res9: lipid_lowering_other drug
9639 fenofibrate micronised tablets 160mg CPRD_product_code res9: lipid_lowering_other drug
9716 SUPRALIP tablets 160mg [ABBOTT] CPRD_product_code res9: lipid_lowering_other drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH540/version/1080/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH540/version/1080/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH540', '1080', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH540/version/1080/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH540/version/1080/export/codes/?format=json
CSV site_root/phenotypes/PH540/version/1080/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH540', '1080', api_client=client)

Version History

Version
ID
Name Owner Publish date
1080 Lipid Lowering Other ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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