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Statins

Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Matthias Pierce, Darren M. Ashcroft

Type
Drug
ID
PH562
Version ID
1124
Data Sources
Valid event data range
01/04/2006 - 31/03/2012
Sex
Female, Male
Agreement Date
2014-12-16
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Data source:

We used the Clinical Practice Research Datalink (CPRD), a large primary care database that holds complete electronic patient records (including diagnoses, prescriptions and referrals) from participating family practices across the UK. A hierarchical clinical coding system (Read) is used to record the data. In July 2012, data were available for 644 practices and 13,772,992 patients. Full details of the database have been provided elsewhere.

Diabetes cohort:

We extracted data from 1 April 2006 to 31 March 2012 and, for ease of reporting and analysing, aggregated information into six financial years. Within each year, practice inclusion eligibility was determined by a CPRD assessment algorithm, which informs on practices considered to be of research standard; therefore, our cohort of practices varied over time. For each research standard practice and year, we defined as eligible patients those who were registered with the practice for the full year and were aged 18 years or over in that year. From these patients, using relevant Read codes for type 2 diabetes (e.g. C10F.00: Type 2 diabetes mellitus) and excluding those treated with insulin within 2 years of diagnosis, we identified 246,544 patients over the study period. Diagnoses were not constrained to the study period and a relevant code prior to the study as well as during the study period would flag a patient from the respective year onwards. Data on sex, age and removal from the database due to deaths were available and complete for all patients.We extracted data on diabetes-related macrovascular (myocardial infarction, stroke, peripheral vascular disease or amputation) and microvascular (retinopathy, neuropathy, nephropathy [chronic kidney disease stages 4–5] or foot ulcer) complications as well as comorbidities (asthma, coronary heart disease, chronic kidney disease [excluded from microvascular analysis], chronic obstructive pulmonary disease, depression, dementia, severe mental illness, heart failure, hypertension, stroke [excluded from macrovascular analysis], cancer, epilepsy, osteoarthritis, osteoporosis and hypothyroidism). Although we aimed to include all conditions associated with diabetes, the choice was partially determined by the domains incentivised under the Quality and Outcomes Framework (QOF), for which accuracy of diagnosis is considered high. Information was also extracted on smoking (never smoked, current, exsmoker and missing data),BMI, HbA1c levels (%), cholesterol levels (mmol/l) and systolic/diastolic BP (mmHg). Biometric measurement data were cleaned and we calculated patient means for each year when more than one relevant record was available. Using product lists we determined prescription prevalence (at least one) for relevant medications: ACE inhibitors, acarbose, α-blockers, anticoagulants, antiplatelet agents, β-blockers, calcium-channel blockers, thiazide diuretics, loop diuretics, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide- 1 agonists, statins and other lipid-lowering drugs, meglitinides , metformin, sulfonylureas and thiazolidinediones. For approximately 60% of the practices, records were linked to Office of National Statistics (ONS) mortality data and we had access to death dates for all their patients. For these, using ICD-10 codes (www.who.int/classifications/icd/en/) we were able to estimate deathslinked to specific causes (underlying or in the top three): diabetes (E10–E16), ischaemic heart disease (I21–I22), stroke (I60–I64) or stroke excluding bleeds (excluding I63).

Publications

  • Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, 58:505-518, 2015.

Clinical Code List

Rows: 105
Code Description Coding System (CPRD_product_code) Entity type Category
11627 fluvastatin 24 hour modified release tablets 80mg CPRD_product_code res9: statins drug
1219 pravastatin tablets 40mg CPRD_product_code res9: statins drug
1221 LIPOSTAT tablets 10mg [SQUIBB] CPRD_product_code res9: statins drug
1223 LIPOSTAT tablets 40mg [SQUIBB] CPRD_product_code res9: statins drug
13041 SIMVADOR tablets 10mg [DISCOVERY] CPRD_product_code res9: statins drug
15252 CRESTOR tablets 20mg [ASTRAZENEC] CPRD_product_code res9: statins drug
17683 LIPITOR tablets 80mg [PFIZER] CPRD_product_code res9: statins drug
17688 CRESTOR tablets 5mg [ASTRAZENEC] CPRD_product_code res9: statins drug
18442 LIPOBAY tablets 400micrograms [BAYER] CPRD_product_code res9: statins drug
2137 fluvastatin capsules 40mg CPRD_product_code res9: statins drug
22579 ZOCOR tablets 80mg [M S D] CPRD_product_code res9: statins drug
25 simvastatin tablets 20mg CPRD_product_code res9: statins drug
2718 ZOCOR tablets 10mg [M S D] CPRD_product_code res9: statins drug
28 atorvastatin tablets 10mg CPRD_product_code res9: statins drug
2955 LIPITOR tablets 40mg [PFIZER] CPRD_product_code res9: statins drug
31658 cerivastatin tablets 800micrograms CPRD_product_code res9: statins drug
31930 ZOCOR HEART-PRO tablets 10mg [MCNEIL] CPRD_product_code res9: statins drug
32909 SIMVASTATIN tablets 80mg [HILLCROSS] CPRD_product_code res9: statins drug
32921 PRAVASTATIN tablets 10mg [DR REDDY`S] CPRD_product_code res9: statins drug
33082 SIMVASTATIN tablets 20mg [HILLCROSS] CPRD_product_code res9: statins drug
3411 LIPITOR tablets 10mg [PFIZER] CPRD_product_code res9: statins drug
34312 SIMVASTATIN tablets 20mg [GEN (UK)] CPRD_product_code res9: statins drug
34316 SIMVASTATIN tablets 20mg [TEVA] CPRD_product_code res9: statins drug
34353 SIMVASTATIN tablets 40mg [GEN (UK)] CPRD_product_code res9: statins drug
34366 SIMVASTATIN tablets 20mg [IVAX] CPRD_product_code res9: statins drug
34376 SIMVASTATIN tablets 40mg [TEVA] CPRD_product_code res9: statins drug
34381 SIMVASTATIN tablets 40mg [IVAX] CPRD_product_code res9: statins drug
34476 SIMVASTATIN tablets 20mg [RATIOPHARM] CPRD_product_code res9: statins drug
34481 SIMVASTATIN tablets 10mg [IVAX] CPRD_product_code res9: statins drug
34502 SIMVASTATIN tablets 40mg [HILLCROSS] CPRD_product_code res9: statins drug
34535 SIMVASTATIN tablets 10mg [GEN (UK)] CPRD_product_code res9: statins drug
34545 SIMVASTATIN tablets 40mg [RATIOPHARM] CPRD_product_code res9: statins drug
34560 SIMVASTATIN tablets 10mg [RATIOPHARM] CPRD_product_code res9: statins drug
34746 SIMVASTATIN tablets 20mg [NICHE] CPRD_product_code res9: statins drug
34814 SIMVASTATIN tablets 20mg [WOCKHARDT] CPRD_product_code res9: statins drug
34820 PRAVASTATIN tablets 40mg [HILLCROSS] CPRD_product_code res9: statins drug
34879 SIMVASTATIN tablets 40mg [NICHE] CPRD_product_code res9: statins drug
34891 SIMVASTATIN tablets 20mg [KENT] CPRD_product_code res9: statins drug
34907 SIMVASTATIN tablets 40mg [WOCKHARDT] CPRD_product_code res9: statins drug
34955 SIMVASTATIN tablets 10mg [HILLCROSS] CPRD_product_code res9: statins drug
34969 SIMVASTATIN tablets 40mg [ACTAVIS] CPRD_product_code res9: statins drug
36377 PRAVASTATIN tablets 20mg [TEVA] CPRD_product_code res9: statins drug
3690 LIPOSTAT tablets 20mg [SQUIBB] CPRD_product_code res9: statins drug
37434 SIMVASTATIN tablets 40mg [SANDOZ] CPRD_product_code res9: statins drug
379 fluvastatin capsules 20mg CPRD_product_code res9: statins drug
39060 SIMVASTATIN tablets 20mg [DEXCEL] CPRD_product_code res9: statins drug
39652 simvastatin oral suspension sugar-free 40mg/5ml CPRD_product_code res9: statins drug
39675 SIMVASTATIN oral suspension 20mg/5ml [MARTINDALE] CPRD_product_code res9: statins drug
39870 SIMVADOR tablets 80mg [DISCOVERY] CPRD_product_code res9: statins drug
40340 SIMVASTATIN tablets 10mg [TEVA] CPRD_product_code res9: statins drug
40382 PRAVASTATIN tablets 20mg [HILLCROSS] CPRD_product_code res9: statins drug
40601 SIMVASTATIN tablets 20mg [RANBAXY] CPRD_product_code res9: statins drug
41657 SIMVASTATIN tablets 80mg [TEVA] CPRD_product_code res9: statins drug
42 simvastatin tablets 10mg CPRD_product_code res9: statins drug
420 cerivastatin tablets 100micrograms CPRD_product_code res9: statins drug
43218 PRAVASTATIN tablets 10mg [TEVA] CPRD_product_code res9: statins drug
44528 SIMVASTATIN oral suspension sugar-free 20mg/5ml [ROSEMONT] CPRD_product_code res9: statins drug
44650 SIMVASTATIN tablets 40mg [DEXCEL] CPRD_product_code res9: statins drug
44878 RANZOLONT tablets 10mg [RANBAXY] CPRD_product_code res9: statins drug
45219 SIMVASTATIN tablets 40mg [KENT] CPRD_product_code res9: statins drug
45235 SIMVASTATIN tablets 20mg [SANDOZ] CPRD_product_code res9: statins drug
45245 SIMVASTATIN tablets 20mg [ACTAVIS] CPRD_product_code res9: statins drug
45346 SIMVASTATIN tablets 40mg [ARROW] CPRD_product_code res9: statins drug
46878 SIMVASTATIN tablets 40mg [ALMUS] CPRD_product_code res9: statins drug
46956 SIMVASTATIN tablets 80mg [ARROW] CPRD_product_code res9: statins drug
47065 atorvastatin chewable tablet 20mg CPRD_product_code res9: statins drug
47090 atorvastatin chewable tablet 10mg CPRD_product_code res9: statins drug
47630 LIPITOR chewable tablet 20mg [PFIZER] CPRD_product_code res9: statins drug
47721 LIPITOR chewable tablet 10mg [PFIZER] CPRD_product_code res9: statins drug
47774 SIMVASTATIN tablets 10mg [ARROW] CPRD_product_code res9: statins drug
47948 SIMVASTATIN tablets 10mg [TILLOMED] CPRD_product_code res9: statins drug
47988 PRAVASTATIN tablets 40mg [GEN (UK)] CPRD_product_code res9: statins drug
48018 SIMVASTATIN tablets 20mg [ARROW] CPRD_product_code res9: statins drug
48051 SIMVASTATIN tablets 10mg [KENT] CPRD_product_code res9: statins drug
48058 SIMVASTATIN tablets 10mg [RANBAXY] CPRD_product_code res9: statins drug
48078 SIMVASTATIN tablets 10mg [ACTAVIS] CPRD_product_code res9: statins drug
48097 PRAVASTATIN tablets 40mg [TEVA] CPRD_product_code res9: statins drug
490 pravastatin tablets 10mg CPRD_product_code res9: statins drug
4961 LIPOBAY tablets 300micrograms [BAYER] CPRD_product_code res9: statins drug
5009 cerivastatin tablets 200micrograms CPRD_product_code res9: statins drug
51 simvastatin tablets 40mg CPRD_product_code res9: statins drug
5148 simvastatin tablets 80mg CPRD_product_code res9: statins drug
5251 cerivastatin tablets 300micrograms CPRD_product_code res9: statins drug
5278 cerivastatin tablets 400micrograms CPRD_product_code res9: statins drug
5775 atorvastatin tablets 80mg CPRD_product_code res9: statins drug
5985 LESCOL XL tablets 80mg [NOVARTIS] CPRD_product_code res9: statins drug
6168 ZOCOR tablets 40mg [M S D] CPRD_product_code res9: statins drug
6213 rosuvastatin tablets 20mg CPRD_product_code res9: statins drug
713 rosuvastatin tablets 10mg CPRD_product_code res9: statins drug
7196 ZOCOR tablets 20mg [M S D] CPRD_product_code res9: statins drug
730 pravastatin tablets 20mg CPRD_product_code res9: statins drug
7347 CRESTOR tablets 10mg [ASTRAZENEC] CPRD_product_code res9: statins drug
7374 LIPITOR tablets 20mg [PFIZER] CPRD_product_code res9: statins drug
745 atorvastatin tablets 40mg CPRD_product_code res9: statins drug
75 atorvastatin tablets 20mg CPRD_product_code res9: statins drug
7554 rosuvastatin tablets 5mg CPRD_product_code res9: statins drug
802 SIMVADOR tablets 40mg [DISCOVERY] CPRD_product_code res9: statins drug
818 simvastatin oral suspension sugar-free 20mg/5ml CPRD_product_code res9: statins drug
8380 LESCOL capsules 20mg [NOV/SANDOZ] CPRD_product_code res9: statins drug
9153 LESCOL capsules 40mg [NOV/SANDOZ] CPRD_product_code res9: statins drug
9315 LIPOBAY tablets 100micrograms [BAYER] CPRD_product_code res9: statins drug
9316 LIPOBAY tablets 200micrograms [BAYER] CPRD_product_code res9: statins drug
9897 rosuvastatin tablets 40mg CPRD_product_code res9: statins drug
9920 SIMVADOR tablets 20mg [DISCOVERY] CPRD_product_code res9: statins drug
9930 CRESTOR tablets 40mg [ASTRAZENEC] CPRD_product_code res9: statins drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH562/version/1124/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH562/version/1124/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH562', '1124', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH562/version/1124/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH562/version/1124/export/codes/?format=json
CSV site_root/phenotypes/PH562/version/1124/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH562', '1124', api_client=client)

Version History

Version
ID
Name Owner Publish date
1124 Statins ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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