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End-Stage Renal Disease (ESRD)

Kethryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaram, Laurie A Tomlinson

Type
Disease or Syndrome
ID
PH574
Version ID
1148
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2015-12-31
Coding system
Read codes v2 ICD10 codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objective:

To investigate whether there is an association between use of ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB), and risk of acute kidney injury (AKI).

Design:

A time-updated, new-user cohort study among people initiating common antihypertensives (ACEI/ARB, beta-blockers, calcium channel blockers and thiazide diuretics) in primary care between April 1997 and March 2014.

Participants:

Adults initiating antihypertensive drug treatment, with at least one year of registration prior to first prescription, identified from UK primary care practices contributing to the Clinical Practice Research Datalink and eligible for linkage to hospital records data from the Hospital Episode Statistics database.

Main outcome measures:

Incidence rate ratio (RR) for first episode of AKI during time exposed to ACEI/ARB compared to time unexposed, estimated using Poisson regression adjusted for age, sex, comorbidities, use of other antihypertensive drugs, and calendar period.

Results:

Among 570,443 participants with a median follow-up of 2.8 years (IQR 0.4 to 7) there were 15,004 first cases of AKI. The overall crude rate of AKI was 6.4/1,000 person years at risk (95% CI 6.30 to 6.50) but varied from 1.63 (1.43 to 1.86) to 662.53 (538.98 to 814.40) depending on, age, comorbidities, and other prescribed drugs. The adjusted RR of AKI during time exposed to ACEI/ARB compared to time unexposed was 1.18 (95% CI 1.13 to 1.23) which was attenuated to 1.12 (95% CI 1.08 to 1.17) after adjustment for non-thiazide diuretic therapy. There was an interaction for the risk of AKI between people using loop diuretics and ACEI/ARB. For those taking loop diuretics, the adjusted RR of AKI during time exposed to ACEI/ARB compared to time unexposed was 0.99 (95% CI 0.92 to 1.06) but it was 1.18 (95% CI 1.13 to 1.24) among people not-exposed to loop diuretics (p<0.001).

Conclusions:

Treatment with ACEI/ARB alone appears to be associated with a small increase in the rate of AKI which is largely seen among people with low absolute risk of AKI. Among people requiring loop diuretics, who have a high absolute risk of AKI, treatment with ACEI/ARB had no measurable association with AKI.

Publications

  • Kethryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaram, Laurie A Tomlinson, Renin-angiostensin system blockage and risk of acute kidney injury. 2015.

Clinical Code List

Rows: 131
Code Description Entity type Category Coding System (ICD-10 Read)
14S2.00 h/o: kidney recipient res30: ESRD diagnostic Read
14V2.00 h/o: renal dialysis res30: ESRD diagnostic Read
14V2.11 h/o: kidney dialysis res30: ESRD diagnostic Read
1Z14.00 chronic kidney disease stage 5 res30: ESRD diagnostic Read
1Z1K.00 chronic kidney disease stage 5 with proteinuria res30: ESRD diagnostic Read
1Z1K.11 ckd stage 5 with proteinuria res30: ESRD diagnostic Read
1Z1L.00 chronic kidney disease stage 5 without proteinuria res30: ESRD diagnostic Read
1Z1L.11 ckd stage 5 without proteinuria res30: ESRD diagnostic Read
4I29.00 peritoneal dialysis sample res30: ESRD diagnostic Read
4N0..00 dialysis fluid urea level res30: ESRD diagnostic Read
4N2..00 dialysis fluid glucose level res30: ESRD diagnostic Read
67P4100 discussion about kidney transplantation res30: ESRD diagnostic Read
7A60.00 arteriovenous shunt res30: ESRD diagnostic Read
7A60000 insertion of arteriovenous prosthesis res30: ESRD diagnostic Read
7A60100 creation of arteriovenous fistula nec res30: ESRD diagnostic Read
7A60111 creation of radial-cephalic fistula res30: ESRD diagnostic Read
7A60112 creation of brachial-cephalic fistula res30: ESRD diagnostic Read
7A60200 attention to arteriovenous shunt res30: ESRD diagnostic Read
7A60300 removal of infected arteriovenous shunt res30: ESRD diagnostic Read
7A60400 banding of arteriovenous fistula res30: ESRD diagnostic Read
7A60500 thrombectomy of arteriovenous fistula res30: ESRD diagnostic Read
7A60600 creation of graft fistula for dialysis res30: ESRD diagnostic Read
7A60y00 other specified arteriovenous shunt res30: ESRD diagnostic Read
7A60z00 arteriovenous shunt nos res30: ESRD diagnostic Read
7A61100 repair of acquired arteriovenous fistula res30: ESRD diagnostic Read
7A61111 ligation of acquired arteriovenous fistula res30: ESRD diagnostic Read
7A61400 ligation of acquired arteriovenous fistula res30: ESRD diagnostic Read
7A61900 ligation of arteriovenous dialysis fistula res30: ESRD diagnostic Read
7A61A00 ligation of arteriovenous dialysis graft res30: ESRD diagnostic Read
7B00.00 transplantation of kidney res30: ESRD diagnostic Read
7B00100 transplantation of kidney from live donor res30: ESRD diagnostic Read
7B00111 allotransplantation of kidney from live donor res30: ESRD diagnostic Read
7B00200 transplantation of kidney from cadaver res30: ESRD diagnostic Read
7B00211 allotransplantation of kidney from cadaver res30: ESRD diagnostic Read
7B00212 cadaveric renal transplant res30: ESRD diagnostic Read
7B00300 allotransplantation of kidney from cadaver heart-beating res30: ESRD diagnostic Read
7B00400 allotransplantation kidney from cadaver heart non-beating res30: ESRD diagnostic Read
7B00600 xenograft renal transplant res30: ESRD diagnostic Read
7B00y00 other specified transplantation of kidney res30: ESRD diagnostic Read
7B00z00 transplantation of kidney nos res30: ESRD diagnostic Read
7B01500 transplant nephrectomy res30: ESRD diagnostic Read
7B01511 excision of rejected transplanted kidney res30: ESRD diagnostic Read
7B06300 exploration of renal transplant res30: ESRD diagnostic Read
7B0F.00 interventions associated with transplantation of kidney res30: ESRD diagnostic Read
7B0F100 pre-transplantation of kidney work-up, recipient res30: ESRD diagnostic Read
7B0F300 post-transplantation of kidney examination, recipient res30: ESRD diagnostic Read
7B0Fy00 os interventions associated with transplantation of kidney res30: ESRD diagnostic Read
7B0Fz00 interventions associated with transplantation of kidney nos res30: ESRD diagnostic Read
7L1A.00 compensation for renal failure res30: ESRD diagnostic Read
7L1A.11 dialysis for renal failure res30: ESRD diagnostic Read
7L1A000 renal dialysis res30: ESRD diagnostic Read
7L1A011 thomas intravascular shunt for dialysis res30: ESRD diagnostic Read
7L1A100 peritoneal dialysis res30: ESRD diagnostic Read
7L1A200 haemodialysis nec res30: ESRD diagnostic Read
7L1A300 haemofiltration res30: ESRD diagnostic Read
7L1A400 automated peritoneal dialysis res30: ESRD diagnostic Read
7L1A500 continuous ambulatory peritoneal dialysis res30: ESRD diagnostic Read
7L1A600 peritoneal dialysis nec res30: ESRD diagnostic Read
7L1Ay00 other specified compensation for renal failure res30: ESRD diagnostic Read
7L1Az00 compensation for renal failure nos res30: ESRD diagnostic Read
7L1B.00 placement ambulatory apparatus compensation renal failure res30: ESRD diagnostic Read
7L1B.11 placement ambulatory dialysis apparatus - compens renal fail res30: ESRD diagnostic Read
7L1B000 insertion of ambulatory peritoneal dialysis catheter res30: ESRD diagnostic Read
7L1B100 removal of ambulatory peritoneal dialysis catheter res30: ESRD diagnostic Read
7L1B200 flushing of peritoneal dialysis catheter res30: ESRD diagnostic Read
7L1By00 placement ambulatory apparatus- compensate renal failure os res30: ESRD diagnostic Read
7L1C.00 placement other apparatus for compensation for renal failure res30: ESRD diagnostic Read
7L1C000 insertion of temporary peritoneal dialysis catheter res30: ESRD diagnostic Read
7L1Cy00 placement other apparatus- compensate for renal failure os res30: ESRD diagnostic Read
7L1Cz00 placement other apparatus- compensate for renal failure nos res30: ESRD diagnostic Read
8L50.00 renal transplant planned res30: ESRD diagnostic Read
9Ot5.00 predicted stage chronic kidney disease res30: ESRD diagnostic Read
9b8K.00 transplantation surgery res30: ESRD diagnostic Read
G72C.00 ruptured aneurysm of dialysis vascular access res30: ESRD diagnostic Read
G72D.00 aneurysm of dialysis arteriovenous fistula res30: ESRD diagnostic Read
G72D100 aneurysm of needle site of dialysis arteriovenous fistula res30: ESRD diagnostic Read
G72D200 aneurysm of anastomotic site of dialysis av fistula res30: ESRD diagnostic Read
G760.00 acquired arteriovenous fistula res30: ESRD diagnostic Read
Gy1..00 stenosis of dialysis vascular access res30: ESRD diagnostic Read
Gy21.00 thrombosis of dialysis arteriovenous fistula res30: ESRD diagnostic Read
Gy3..00 occlusion of dialysis vascular access res30: ESRD diagnostic Read
Gy31.00 occlusion of dialysis arteriovenous fistula res30: ESRD diagnostic Read
Gy40.00 infection of dialysis arteriovenous graft res30: ESRD diagnostic Read
Gy41.00 infection of dialysis arteriovenous fistula res30: ESRD diagnostic Read
Gy51.00 haemorrhage of dialysis arteriovenous fistula res30: ESRD diagnostic Read
Gy60.00 rupture of dialysis arteriovenous graft res30: ESRD diagnostic Read
K05..12 end stage renal failure res30: ESRD diagnostic Read
K050.00 end stage renal failure res30: ESRD diagnostic Read
K055.00 chronic kidney disease stage 5 res30: ESRD diagnostic Read
K0B5.00 renal tubulo-interstitial disordrs in transplant rejectn res30: ESRD diagnostic Read
K0D..00 end-stage renal disease res30: ESRD diagnostic Read
Kyu1C00 [x]renal tubulo-interstitial disorders/transplant rejection res30: ESRD diagnostic Read
SP01500 mechanical complication of dialysis catheter res30: ESRD diagnostic Read
SP01700 mechanical complication of arterio-venous surgical fistula res30: ESRD diagnostic Read
SP05613 [x] peritoneal dialysis associated peritonitis res30: ESRD diagnostic Read
SP06B00 continuous ambulatory peritoneal dialysis associated perit res30: ESRD diagnostic Read
SP07G00 stenosis of arteriovenous dialysis fistula res30: ESRD diagnostic Read
SP07N00 arteriovenous fistula thrombosis res30: ESRD diagnostic Read
SP08011 det.ren.func.after ren.transpl res30: ESRD diagnostic Read
SP08300 kidney transplant failure and rejection res30: ESRD diagnostic Read
SP08J00 chronic rejection of renal transplant res30: ESRD diagnostic Read
SP08N00 unexplained episode of renal transplant dysfunction res30: ESRD diagnostic Read
SP08R00 renal transplant rejection res30: ESRD diagnostic Read
SP08T00 urological complication of renal transplant res30: ESRD diagnostic Read
SP08W00 vascular complication of renal transplant res30: ESRD diagnostic Read
SP0E.00 disorders associated with peritoneal dialysis res30: ESRD diagnostic Read
SP0G.00 anaphylactoid reaction due to haemodialysis res30: ESRD diagnostic Read
TA02000 accid cut,puncture,perf,h'ge - kidney dialysis res30: ESRD diagnostic Read
TA22.00 failure of sterile precautions during perfusion res30: ESRD diagnostic Read
TA22000 failure of sterile precautions during kidney dialysis res30: ESRD diagnostic Read
TB00100 kidney transplant with complication, without blame res30: ESRD diagnostic Read
TB00111 renal transplant with complication, without blame res30: ESRD diagnostic Read
TB11.00 kidney dialysis with complication, without blame res30: ESRD diagnostic Read
TB11.11 renal dialysis with complication, without blame res30: ESRD diagnostic Read
U612200 [x]failure sterile precautions dur kidney dialys/other perf res30: ESRD diagnostic Read
Z1A..00 dialysis training res30: ESRD diagnostic Read
Z1A1.00 peritoneal dialysis training res30: ESRD diagnostic Read
Z1A2.00 haemodialysis training res30: ESRD diagnostic Read
Z919.00 care of haemodialysis equipment res30: ESRD diagnostic Read
Z919100 priming haemodialysis lines res30: ESRD diagnostic Read
Z919300 reversing haemodialysis lines res30: ESRD diagnostic Read
Z91A.00 peritoneal dialysis bag procedure res30: ESRD diagnostic Read
ZV42000 [v]kidney transplanted res30: ESRD diagnostic Read
ZV45100 [v]renal dialysis status res30: ESRD diagnostic Read
ZV56.00 [v]aftercare involving intermittent dialysis res30: ESRD diagnostic Read
ZV56000 [v]aftercare involving extracorporeal dialysis res30: ESRD diagnostic Read
ZV56011 [v]aftercare involving renal dialysis nos res30: ESRD diagnostic Read
ZV56100 [v]preparatory care for dialysis res30: ESRD diagnostic Read
ZV56y00 [v]other specified aftercare involving intermittent dialysis res30: ESRD diagnostic Read
ZV56y11 [v]aftercare involving peritoneal dialysis res30: ESRD diagnostic Read
ZVu3G00 [x]other dialysis res30: ESRD diagnostic Read
Rows: 15
Code Description Entity type Category Coding System (ICD-10 Read)
I77.0 arteriovenous fistula, acquired res30: ESRD diagnostic ICD-10
N16.5 renal tubulo-interstitial disorders in transplant rejection res30: ESRD diagnostic ICD-10
N18.5 chronic kidney disease, stage 5 res30: ESRD diagnostic ICD-10
T82.4 mechanical complication of vascular dialysis catheter res30: ESRD diagnostic ICD-10
T86.1 kidney transplant failure and rejection res30: ESRD diagnostic ICD-10
Y60.2 during kidney dialysis or other perfusion res30: ESRD diagnostic ICD-10
Y61.2 during kidney dialysis or other perfusion res30: ESRD diagnostic ICD-10
Y62.2 during kidney dialysis or other perfusion res30: ESRD diagnostic ICD-10
Y84.1 kidney dialysis res30: ESRD diagnostic ICD-10
Z49 care involving dialysis res30: ESRD diagnostic ICD-10
Z49.0 preparatory care for dialysis res30: ESRD diagnostic ICD-10
Z49.1 extracorporeal dialysis res30: ESRD diagnostic ICD-10
Z49.2 other dialysis res30: ESRD diagnostic ICD-10
Z94.0 kidney transplant status res30: ESRD diagnostic ICD-10
Z99.2 dependence on renal dialysis res30: ESRD diagnostic ICD-10

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH574/version/1148/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH574/version/1148/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH574', '1148', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH574/version/1148/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH574/version/1148/export/codes/?format=json
CSV site_root/phenotypes/PH574/version/1148/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH574', '1148', api_client=client)

Version History

Version
ID
Name Owner Publish date
1148 End-Stage Renal Disease (ESRD) ieuan.scanlon 2021-10-06 currently shown

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