Objective:
To quantify how a period of intense media coverage of controversy over the risk:benefit balance of statins affected their use.
Design:
Interrupted time series analysis of prospectively collected electronic data from primary care.
Setting:
Clinical Practice Research Datalink (CPRD) in the United Kingdom.
Participants:
Patients newly eligible for or currently taking statins for primary and secondary cardiovascular disease prevention in each month in January 2011-March 2015.
Main Outcome Measures:
Adjusted odds ratios for starting/stopping taking statins after the media coverage (October 2013-March 2014).
Results:
There was no evidence that the period of high media coverage was associated with changes in statin initiation among patients with a high recorded risk score for cardiovascular disease (primary prevention) or a recent cardiovascular event (secondary prevention) (odds ratio 0.99 (95% confidence interval 0.87 to 1.13; P=0.92) and 1.04 (0.92 to 1.18; P=0.54), respectively), though there was a decrease in the overall proportion of patients with a recorded risk score. Patients already taking statins were more likely to stop taking them for both primary and secondary prevention after the high media coverage period (1.11 (1.05 to 1.18; P<0.001) and 1.12 (1.04 to 1.21; P=0.003), respectively). Stratified analyses showed that older patients and those with a longer continuous prescription were more likely to stop taking statins after the media coverage. In post hoc analyses, the increased rates of cessation were no longer observed after six months.
Conclusions:
A period of intense public discussion over the risks: benefit balance of statins, covered widely in the media, was followed by a transient rise in the proportion of people who stopped taking statins. This research highlights the potential for widely covered health stories in the lay media to impact on healthcare related behaviour.
Anthony Mathews, Emily Herret, Antonio Gassparrini, Tjeerd Van Staa, Ben Goldacre, Liam Smeeth, Krishnan Bhaskaran, Impact of statin related media coverage on use of statins interrupted time series analysis with UK primary care data. BMJ, 353(i3283),2016.
| Code | Description | Entity type | Category | Coding System (Read) |
|---|---|---|---|---|
| 14O7.00 | At risk of heart disease | res46: CVD Risk Score | test | Read |
| 14O7000 | High risk of heart disease | res46: CVD Risk Score | test | Read |
| 14OF.00 | Low risk of primary heart disease | res46: CVD Risk Score | test | Read |
| 14OG.00 | Moderate risk of primary heart disease | res46: CVD Risk Score | test | Read |
| 14OH.00 | High risk of primary heart disease | res46: CVD Risk Score | test | Read |
| 14Oh.00 | At risk of cardiovascular disease | res46: CVD Risk Score | test | Read |
| 14Oh000 | High risk of cardiovascular disease | res46: CVD Risk Score | test | Read |
| 33BC.00 | Cardiovascular event risk | res46: CVD Risk Score | test | Read |
| 3888 | Framingham coronary heart disease 10 year risk score | res46: CVD Risk Score | test | Read |
| 388A.00 | Coronary heart disease risk | res46: CVD Risk Score | test | Read |
| 388R.00 | Framingham coronary heart disease 10 yr adjusted risk score | res46: CVD Risk Score | test | Read |
| 388W.00 | Joint British Societies cardiac risk score | res46: CVD Risk Score | test | Read |
| 388Y.00 | UKPDS 10yr coronary heart disease risk score | res46: CVD Risk Score | test | Read |
| 38B1.11 | Cardiovascular disease risk assessment | res46: CVD Risk Score | test | Read |
| 38B1000 | CVD (cardiovascular disease) risk assessment by third party | res46: CVD Risk Score | test | Read |
| 38D6.00 | Assessing cardiovascular risk using SIGN score | res46: CVD Risk Score | test | Read |
| 38D6.11 | ASSIGN score | res46: CVD Risk Score | test | Read |
| 38DF.00 | QRISK cardiovascular disease 10 year risk score | res46: CVD Risk Score | test | Read |
| 38DP.00 | QRISK2 cardiovascular disease 10 year risk score | res46: CVD Risk Score | test | Read |
| 38DR.00 | Framingham 1991 cardiovascular disease 10 year risk score | res46: CVD Risk Score | test | Read |
| 38G6.00 | Joint British Societies cardiovascular disease risk score | res46: CVD Risk Score | test | Read |
| 662k.00 | JBS cardiovascular disease risk <10% over next 10 years | res46: CVD Risk Score | test | Read |
| 662l.00 | JBS cardiovascular disease risk 10-20% over next 10 years | res46: CVD Risk Score | test | Read |
| 662m.00 | JBS cardiovascular disease risk >20% up to 30% ov next 10 yr | res46: CVD Risk Score | test | Read |
| 662n.00 | JBS cardiovascular disease risk >30% over next 10 years | res46: CVD Risk Score | test | Read |
| 66f2.00 | Cardiovascular disease high risk review | res46: CVD Risk Score | test | Read |
| 6A40.00 | Review of patient at risk from coronary heart disease | res46: CVD Risk Score | test | Read |
| 8BR1.00 | Cardiovascular disease risk assessment indicated | res46: CVD Risk Score | test | Read |
| 8CR6.00 | Coronary heart disease risk clinical management plan | res46: CVD Risk Score | test | Read |
| 9NdT.00 | Consent given for cardiovascular health risk assessment | res46: CVD Risk Score | test | Read |
| 9OhA.00 | Cardiovascular disease risk assessment done | res46: CVD Risk Score | test | Read |
| ZR3r.00 | Coronary heart disease risk | res46: CVD Risk Score | test | Read |
| ZRB2.00 | Framingham coronary heart disease 10 year risk score | res46: CVD Risk Score | test | Read |
To Export Phenotype Details:
| Format | API |
|---|---|
| XML | site_root/api/v1/public/phenotypes/PH579/version/1158/detail/?format=xml |
| JSON | site_root/api/v1/public/phenotypes/PH579/version/1158/detail/?format=json |
| R Package |
|
To Export Phenotype Code List:
| Format | API |
|---|---|
| XML | site_root/api/v1/public/phenotypes/PH579/version/1158/export/codes/?format=xml |
| JSON | site_root/api/v1/public/phenotypes/PH579/version/1158/export/codes/?format=json |
| CSV | site_root/phenotypes/PH579/version/1158/export/codes/ |
| R Package |
|
| Version ID |
Name | Owner | Publish date | |
|---|---|---|---|---|
| 1158 | Cardiovascular Disease (CVD) Risk Score | ieuan.scanlon | 2021-10-06 | currently shown |
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