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Depression

Catherine Morgan, Roger T Webb, Mathew J Carr, Evangelos Kontopantelis, Jonathan Green, Carolyn A Chew-Graham, Nav Kapur, Darren M Aschcroft

Type
Disease or Syndrome
ID
PH586
Version ID
1172
Data Sources
Valid event data range
01/01/2001 - 31/12/2014
Sex
Female, Male
Agreement Date
2017-10-18
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objectives:

To examine temporal trends in sex and age specific incidence of self harm in children and adolescents, clinical management patterns, and risk of cause specific mortality following an index self harm episode at a young age.

Design:

Population based cohort study.

Setting:

UK Clinical Practice Research Datalink—electronic health records from 674 general practices, with practice level deprivation measured ecologically using the index of multiple deprivation. Patients from eligible English practices were linked to hospital episode statistics (HES) and Office for National Statistics (ONS) mortality records.

Participants:

For the descriptive analytical phases we examined data pertaining to 16 912 patients aged 10-19 who harmed themselves during 2001-14. For analysis of cause specific mortality following self harm, 8638 patients eligible for HES and ONS linkage were matched by age, sex, and general practice with up to 20 unaffected children and adolescents (n=170 274).

Main outcome measures:

In the first phase, temporal trends in sex and age specific annual incidence were examined. In the second phase, clinical management was assessed according to the likelihood of referral to mental health services and psychotropic drug prescribing. In the third phase, relative risks of all cause mortality, unnatural death (including suicide and accidental death), and fatal acute alcohol or drug poisoning were estimated as hazard ratios derived from stratified Cox proportional hazards models for the self harm cohort versus the matched unaffected comparison cohort.

Results:

The annual incidence of self harm was observed to increase in girls (37.4 per 10 000) compared with boys (12.3 per 10 000), and a sharp 68% increase occurred among girls aged 13-16, from 45.9 per 10 000 in 2011 to 77.0 per 10 000 in 2014. Referrals within 12 months of the index self harm episode were 23% less likely for young patients registered at the most socially deprived practices, even though incidences were considerably higher in these localities. Children and adolescents who harmed themselves were approximately nine times more likely to die unnaturally during follow-up, with especially noticeable increases in risks of suicide (deprivation adjusted hazard ratio 17.5, 95% confidence interval 7.6 to 40.5) and fatal acute alcohol or drug poisoning (34.3, 10.2 to 115.7).

Conclusions:

Gaining a better understanding of the mechanisms responsible for the recent apparent increase in the incidence of self harm among early-mid teenage girls, and coordinated initiatives to tackle health inequalities in the provision of services to distressed children and adolescents, represent urgent priorities for multiple public agencies.

Publications

  • Catherine Morgan, Roger T Webb, Mathew J Carr, Evangelos Kontopantelis, Jonathan Green, Carolyn A Chew-Graham, Nav Kapur, Darren M Aschcroft, Incidence, clinical management, and mortality risk following self harm among children and adolescents cohort study in primary care. BMJ, 359(j4351), 2017.

Clinical Code List

Rows: 107
Code Description Entity type Category Coding System (Read)
1B17.00 depressed res59: Depression diagnostic Read
2257.00 o/e - depressed res59: Depression diagnostic Read
62T1.00 puerperal depression res59: Depression diagnostic Read
9kQ..00 on full dose long term treatment depression - enh serv admin res59: Depression diagnostic Read
E001300 presenile dementia with depression res59: Depression diagnostic Read
E002100 Senile dementia with depression res59: Depression diagnostic Read
E004300 Arteriosclerotic dementia with depression res59: Depression diagnostic Read
E11..12 depressive psychoses res59: Depression diagnostic Read
E112.00 single major depressive episode res59: Depression diagnostic Read
E112.11 agitated depression res59: Depression diagnostic Read
E112.12 endogenous depression first episode res59: Depression diagnostic Read
E112.13 endogenous depression first episode res59: Depression diagnostic Read
E112.14 endogenous depression res59: Depression diagnostic Read
E112000 single major depressive episode, unspecified res59: Depression diagnostic Read
E112100 single major depressive episode, mild res59: Depression diagnostic Read
E112200 single major depressive episode, moderate res59: Depression diagnostic Read
E112300 single major depressive episode, severe, without psychosis res59: Depression diagnostic Read
E112400 single major depressive episode, severe, with psychosis res59: Depression diagnostic Read
E112z00 single major depressive episode nos res59: Depression diagnostic Read
E113.00 recurrent major depressive episode res59: Depression diagnostic Read
E113.11 endogenous depression - recurrent res59: Depression diagnostic Read
E113000 recurrent major depressive episodes, unspecified res59: Depression diagnostic Read
E113100 recurrent major depressive episodes, mild res59: Depression diagnostic Read
E113200 recurrent major depressive episodes, moderate res59: Depression diagnostic Read
E113300 recurrent major depressive episodes, severe, no psychosis res59: Depression diagnostic Read
E113400 recurrent major depressive episodes, severe, with psychosis res59: Depression diagnostic Read
E113700 recurrent depression res59: Depression diagnostic Read
E113z00 recurrent major depressive episode nos res59: Depression diagnostic Read
E118.00 Seasonal affective disorder res59: Depression diagnostic Read
E11y200 atypical depressive disorder res59: Depression diagnostic Read
E11z200 masked depression res59: Depression diagnostic Read
E130.00 reactive depressive psychosis res59: Depression diagnostic Read
E130.11 psychotic reactive depression res59: Depression diagnostic Read
E135.00 agitated depression res59: Depression diagnostic Read
E200300 anxiety with depression res59: Depression diagnostic Read
E204.00 neurotic depression reactive type res59: Depression diagnostic Read
E204.11 Postnatal depression res59: Depression diagnostic Read
E290.00 brief depressive reaction res59: Depression diagnostic Read
E290z00 brief depressive reaction nos res59: Depression diagnostic Read
E291.00 prolonged depressive reaction res59: Depression diagnostic Read
E2B..00 depressive disorder nec res59: Depression diagnostic Read
E2B0.00 postviral depression res59: Depression diagnostic Read
E2B1.00 chronic depression res59: Depression diagnostic Read
Eu20400 [x]post-schizophrenic depression res59: Depression diagnostic Read
Eu32.00 [x]depressive episode res59: Depression diagnostic Read
Eu32.11 [x]single episode of depressive reaction res59: Depression diagnostic Read
Eu32.12 [x]single episode of psychogenic depression res59: Depression diagnostic Read
Eu32.13 [x]single episode of reactive depression res59: Depression diagnostic Read
Eu32000 [x]mild depressive episode res59: Depression diagnostic Read
Eu32100 [x]moderate depressive episode res59: Depression diagnostic Read
Eu32200 [x]severe depressive episode without psychotic symptoms res59: Depression diagnostic Read
Eu32211 [X]Single episode agitated depressn w'out psychotic symptoms res59: Depression diagnostic Read
Eu32212 [x]single episode major depression w'out psychotic symptoms res59: Depression diagnostic Read
Eu32213 [x]single episode vital depression w'out psychotic symptoms res59: Depression diagnostic Read
Eu32300 [x]severe depressive episode with psychotic symptoms res59: Depression diagnostic Read
Eu32311 [x]single episode of major depression and psychotic symptoms res59: Depression diagnostic Read
Eu32312 [x]single episode of psychogenic depressive psychosis res59: Depression diagnostic Read
Eu32313 [x]single episode of psychotic depression res59: Depression diagnostic Read
Eu32314 [x]single episode of reactive depressive psychosis res59: Depression diagnostic Read
Eu32400 [x]mild depression res59: Depression diagnostic Read
Eu32500 [x]major depression, mild res59: Depression diagnostic Read
Eu32600 [x]major depression, moderately severe res59: Depression diagnostic Read
Eu32700 [x]major depression, severe without psychotic symptoms res59: Depression diagnostic Read
Eu32800 [x]major depression, severe with psychotic symptoms res59: Depression diagnostic Read
Eu32900 [X]Single major depr ep, severe with psych, psych in remiss res59: Depression diagnostic Read
Eu32A00 [X]Recurr major depr ep, severe with psych, psych in remiss res59: Depression diagnostic Read
Eu32y00 [x]other depressive episodes res59: Depression diagnostic Read
Eu32y11 [x]atypical depression res59: Depression diagnostic Read
Eu32y12 [x]single episode of masked depression nos res59: Depression diagnostic Read
Eu32z00 [x]depressive episode, unspecified res59: Depression diagnostic Read
Eu32z11 [x]depression nos res59: Depression diagnostic Read
Eu32z12 [x]depressive disorder nos res59: Depression diagnostic Read
Eu32z13 [x]prolonged single episode of reactive depression res59: Depression diagnostic Read
Eu32z14 [x] reactive depression nos res59: Depression diagnostic Read
Eu33.00 [x]recurrent depressive disorder res59: Depression diagnostic Read
Eu33.11 [x]recurrent episodes of depressive reaction res59: Depression diagnostic Read
Eu33.12 [x]recurrent episodes of psychogenic depression res59: Depression diagnostic Read
Eu33.13 [x]recurrent episodes of reactive depression res59: Depression diagnostic Read
Eu33.14 [x]seasonal depressive disorder res59: Depression diagnostic Read
Eu33.15 [X]SAD - Seasonal affective disorder res59: Depression diagnostic Read
Eu33000 [x]recurrent depressive disorder, current episode mild res59: Depression diagnostic Read
Eu33100 [x]recurrent depressive disorder, current episode moderate res59: Depression diagnostic Read
Eu33200 [X]Recurr depress disorder cur epi severe without psyc sympt res59: Depression diagnostic Read
Eu33211 [x]endogenous depression without psychotic symptoms res59: Depression diagnostic Read
Eu33212 [x]major depression, recurrent without psychotic symptoms res59: Depression diagnostic Read
Eu33214 [x]vital depression, recurrent without psychotic symptoms res59: Depression diagnostic Read
Eu33300 [X]Recurrent depress disorder cur epi severe with psyc symp res59: Depression diagnostic Read
Eu33311 [x]endogenous depression with psychotic symptoms res59: Depression diagnostic Read
Eu33312 [x]manic-depress psychosis,depressed type+psychotic symptoms res59: Depression diagnostic Read
Eu33313 [x]recurr severe episodes/major depression+psychotic symptom res59: Depression diagnostic Read
Eu33314 [x]recurr severe episodes/psychogenic depressive psychosis res59: Depression diagnostic Read
Eu33315 [x]recurrent severe episodes of psychotic depression res59: Depression diagnostic Read
Eu33316 [x]recurrent severe episodes/reactive depressive psychosis res59: Depression diagnostic Read
Eu33400 [x]recurrent depressive disorder, currently in remission res59: Depression diagnostic Read
Eu33y00 [x]other recurrent depressive disorders res59: Depression diagnostic Read
Eu33z00 [x]recurrent depressive disorder, unspecified res59: Depression diagnostic Read
Eu33z11 [x]monopolar depression nos res59: Depression diagnostic Read
Eu34100 [x]dysthymia res59: Depression diagnostic Read
Eu34111 [x]depressive neurosis res59: Depression diagnostic Read
Eu34113 [x]neurotic depression res59: Depression diagnostic Read
Eu34114 [x]persistant anxiety depression res59: Depression diagnostic Read
Eu3y111 [x]recurrent brief depressive episodes res59: Depression diagnostic Read
Eu41200 [x]mixed anxiety and depressive disorder res59: Depression diagnostic Read
Eu41211 [x]mild anxiety depression res59: Depression diagnostic Read
Eu53011 [X]Postnatal depression NOS res59: Depression diagnostic Read
Eu53012 [X]Postpartum depression NOS res59: Depression diagnostic Read
Eu92000 [x]depressive conduct disorder res59: Depression diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH586/version/1172/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH586/version/1172/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH586', '1172', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH586/version/1172/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH586/version/1172/export/codes/?format=json
CSV site_root/phenotypes/PH586/version/1172/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH586', '1172', api_client=client)

Version History

Version
ID
Name Owner Publish date
1172 Depression ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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