Cardiovascular Disease (Psoriasis Association Study with CVD)
Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M Ashcroft
PH6 / 12 Clinical-Coded Phenotype
Overview
Phenotype TypeDisease or syndromeSexBothValid Event Date Range01/01/1994 - 31/12/2009Coding SystemRead codes v2ICD9 codesICD10 codesData SourcesCollectionsPhenotype LibraryTagsNo dataDefinition
The study population included patients with a first diagnosis of psoriasis between 1 January 1994 and 31 December 2009, who were 20 years or older at the time of the diagnosis. A comparison group of up to 5 controls per psoriasis patient was selected. Patients from both cohorts did not have any history of CVD or diabetes before the index date (first diagnosis of psoriasis) or corresponding consulting date and, in order to capture incident not prevalent cases of psoriasis or major CV events, all patients had to have at least 2 years prior registration within their general practice before entry into the study cohort. The control group consisted of patients who never received a diagnostic code for psoriasis. Controls were matched to psoriasis patients by age, gender, and general practice. We assigned control patients the same index date as the patients with psoriasis to whom they were matched. Person-time under observation for each patient was calculated from the corresponding index date up to the end of the study, which was the earliest date of the occurrence of a major CV event (MI, ACS, unstable angina, or stroke), transfer out of the practice, death date, end of follow-up (31 December 2011) or when the practice was no longer up to research data quality standards set by CPRD. Patient consent was not required; all patient data contained in CPRD is anonymised.
Patients with psoriasis were included if they had their first diagnostic code for psoriasis during 1 January 1994–31 December 2009 and received a recognized treatment for psoriasis (emollients, topical treatment, phototherapy, systemic therapy, or biologics (CG153 Psoriasis: NICE guideline; Samarasekera and Smith, 2014)). Patients were classified as having severe psoriasis once they had received a systemic treatment (acitretin, etretinate, ciclosporin, hydroxycarbamide, methotrexate, and fumaric acid), phototherapy, or a biologic therapy (etanercept, adalimumab, infliximab, ustekinumab, and efalizumab); alternatively they were classified as mild psoriasis.
Implementation
No dataImplementation
Clinical Code List
PUBLISHED - 134 Codes
PUBLISHED - 53 Codes
PUBLISHED - 57 Codes
Publication
Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S. Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M. Ashcroft, "Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink". Journal of Investigative Dermatology, 135(9), 2189-2197, 2015.
No dataCitation Requirements
API
To Export Phenotype Details:
Format API JSON site_root/api/v1/phenotypes/PH6/version/12/detail/?format=json R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get details of phenotype
phenotype_details = client$phenotypes$get_detail(
'PH6',
version_id=12
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_detail(
'PH6',
version_id=12
)To Export Phenotype Code List:
Format API JSON site_root/api/v1/phenotypes/PH6/version/12/export/codes/?format=json CSV site_root/phenotypes/PH6/version/12/export/codes/ R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get codelist of phenotype
phenotype_codelist = client$phenotypes$get_codelist(
'PH6',
version_id=12
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_codelist(
'PH6',
version_id=12
)Version History