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Myocardial Infarction

Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah PM Symmons, Christopher EM Griffiths, Darren M Ashcroft

Type
Disease or Syndrome
ID
PH611
Version ID
1222
Data Sources
Valid event data range
01/01/1994 - 31/12/2009
Sex
Female, Male
Agreement Date
2014-12-31
Coding system
ICD10 codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Study population:

The study population included patients with a first diagnosis of psoriasis between January 1, 1994 and December 31, 2009, who were 20 years or older at the time of the diagnosis. A comparison group of up to 5 controls per psoriasis patient was selected. Patients from both cohorts did not have any history of CVD or diabetes before index date (first diagnosis of psoriasis) or corresponding consulting date and, in order to capture incident not prevalent cases of psoriasis or MI, all patients had to have at least 2 years prior registration within their general practice before entry into the study cohort. The control group consisted of patients who never received a diagnostic code for psoriasis. Controls were matched to psoriasis patients by age, gender, general practice and then by calendar time (date of first diagnosis of psoriasis). Person-time under observation for each patient was calculated from the corresponding index date up to end of the study which was the earliest date of the occurrence of the MI event, transfer out of the practice or death date, end of follow-up (December 31, 2011) or if the practice was no longer up to research data quality standards set by CPRD.

Definition of exposure:

Patients with psoriasis were included if they had their first diagnostic code for psoriasis during January 1, 1994-December 31, 2009 and received a recognised treatment for psoriasis (emollients, topical treatment, phototherapy, systemic therapy or biologics (CG153 Psoriasis: NICE guideline) (Samarasekera and Smith, 2014)). Patients were classified as having severe psoriasis once they had received a systemic treatment (acitretin, etretinate, ciclosporin, hydroxycarbamide, methotrexate, fumaric acid), phototherapy or a biologic therapy (etanercept, adalimumab, infliximab, ustekinumab, efalizumab); alternatively they were classified as mild psoriasis.

Outcome of interest:

The outcome of interest was fatal and non-fatal incident MI events. In our main analysis, MI events were identified using Read codes in CPRD. In sensitivity analysis, we identified MI events recorded in both CPRD and national mortality records (ONS) for those patients registered in practices that provided linked data between CPRD and ONS.

Publications

  • Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah PM Symmons, Christopher EM Griffiths, Darren M. Ashcroft, Psoriasis and the risk of myocardial infarction Cohort study using the clinical practive research datalink. 2014.

Clinical Code List

Rows: 21
Code Description Entity type Category Coding System (ICD-10)
I21 Acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I21.0 Acute transmural myocardial infarction of anterior wall myocardial infarction - icd10 diagnostic ICD-10
I21.1 Acute transmural myocardial infarction of inferior wall myocardial infarction - icd10 diagnostic ICD-10
I21.2 Acute transmural myocardial infarction of other sites myocardial infarction - icd10 diagnostic ICD-10
I21.3 Acute transmural myocardial infarction of unspecified site myocardial infarction - icd10 diagnostic ICD-10
I21.4 Acute subendocardial myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I21.9 Acute myocardial infarction, unspecified myocardial infarction - icd10 diagnostic ICD-10
I22 Subsequent myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I22.0 Subsequent myocardial infarction of anterior wall myocardial infarction - icd10 diagnostic ICD-10
I22.1 Subsequent myocardial infarction of inferior wall myocardial infarction - icd10 diagnostic ICD-10
I22.8 Subsequent myocardial infarction of other sites myocardial infarction - icd10 diagnostic ICD-10
I22.9 Subsequent myocardial infarction of unspecified site myocardial infarction - icd10 diagnostic ICD-10
I23 Certain current complications following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I23.0 Haemopericardium as current complication following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I23.1 Atrial septal defect as current complication following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I23.2 Ventricular septal defect as current complication following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial myocardial infarction - icd10 diagnostic ICD-10
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10
I23.6 Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute my myocardial infarction - icd10 diagnostic ICD-10
I23.8 Other current complications following acute myocardial infarction myocardial infarction - icd10 diagnostic ICD-10

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH611/version/1222/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH611/version/1222/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH611', '1222', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH611/version/1222/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH611/version/1222/export/codes/?format=json
CSV site_root/phenotypes/PH611/version/1222/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH611', '1222', api_client=client)

Version History

Version
ID
Name Owner Publish date
1222 Myocardial Infarction ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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