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Cancer

David Reeves, David A Springate, Darren M Ashcroft, Ronan Ryan, Tim Doran, Richard Morris, Ivan Olier, Evangelos Kontopantelis

Type
Disease or Syndrome
ID
PH616
Version ID
1232
Data Sources
Valid event data range
01/01/1996 - 17/12/20003
Sex
Female, Male
Agreement Date
2014-04-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Data:

CPRD and THIN obtain their data from practices using the Vision electronic record system, while QResearch obtains data from practices using EMIS software. We felt that comparisons would be most informative between databases drawing data from different capture systems. Across the time-period studied, two versions of EMIS were in use, the more common being the text-based EMIS LV system with navigation and data entry mainly via the keyboard; EMIS PCS, which is Windows-based with mouse control and drop-down menus, was introduced from 1999. Vision was Windows-based throughout the study period. A small-scale direct comparison of EMIS LV and Vision indicated that coded data entry, excepting prescribing information, was faster with Vision and that more items were likely to be coded. Practices running Vision have slightly higher achievement rates for most Quality and Outcomes Framework (QOF) indicators than practices running either version of EMIS, even after controlling for differences in practice and area characteristics. We had access to CPRD, and therefore chose to replicate a study previously conducted using QResearch. CPRD and QResearch both draw data from general practices spread throughout the UK—currently more than 600 practices each—and comparisons to the national age-gender structure and prevalence rates for common conditions mostly show good correspondence for both datasets. For practical reasons, we focused on studies of the effectiveness of medicinal interventions and, after assessing the available studies, chose to replicate an investigation into the effects of statins on the mortality of patients with ischaemic heart disease (IHD) by Hippisley-Cox and Coupland (H-C&C). The methodological details provided in the published paper were insufficient on their own to allow a close replication to be conducted, and we therefore obtained additional details from the authors. We requested purely factual information about the methods used and did not share any of our analyses or results. We replicated the methods of H-C&C as closely as possible, given the differences between the two databases. All of the methods described below, including the study period, variable specifications and analytical procedures, are exact replications of those used in the original study, unless indicated otherwise. We selected all practices in CPRD that provided up to standard (UTS) data (UTS is CPRD’s designation for data meeting their internal quality standards) for the whole of the period from 1 January 1996 to 17 December 2003. We next identified all patients with a first diagnosis of IHD within this period, based on the QOF business rules for 2004. We excluded patients whose IHD diagnosis fell within the first 3 months of registration with their general practice or was on or subsequent to their recorded date of death, or who were prescribed statins prior to first diagnosis. We extracted data for these patients from the date of IHD diagnosis up until 17 December 2003, or until the date of death or exit from the practice, or the last recorded date for practices that stopped providing data before 17 December 2003, giving a maximum possible length of follow-up postdiagnosis of just under 8 years.

Analysis:

The main outcome was all-cause mortality, identified through a record of death in the CPRD. Following H-C&C, we conducted two main analyses: (1) a cohort analysis and (2) a case-control analysis nested within the full cohort. All analyses were conducted using R. Following H-C&C, statistical significance was assessed using p<0.01 (two tailed), but 95% CIs are reported in tables and figures. We made an a priori decision not to attempt to ‘improve’ on the analysis conducted by H-C&C, as our specific aim was to determine whether the same results and conclusions would emerge from using identical methods on a different underlying dataset targeting the same population.

Cohort analysis:

The cohort analysis used a Cox proportional hazards model to examine the effect of statin use on patient survival, with survival time determined by the time (in days) between the date of first diagnosis and date of death. Patients who transferred out of their practice before death or who were still alive at the end of the study period were treated as censored observations. Statin exposure was used as a time-varying covariate, with the period of exposure from the date of first prescription to when the statin was stopped (estimated as the date of last prescription plus 90 days; intervening breaks in the use of statins were ignored), or if not stopped until the end of the study period, date of death or date of transfer out of practice. Covariates adjusted for in the analysis were year of diagnosis, gender, comorbidities (diabetes, hypertension, myocardial infarction, congestive cardiac failure and cancer), and age (coded as 0–44, 45–54, 55–64, 65–74, 75–84, 85–94 or ≥95), smoking (ever smoked, never smoked, not recorded) and body mass index (BMI; coded as <25, 25–30, >30 kg/m2) all at the date of diagnosis. The presence of each comorbidity was indicated by a diagnosis in the patient record (using the 2004 QOF business rules) and coded as present/not present at the date of IHD diagnosis. If smoking status or BMI was not recorded within 4 years prior to diagnosis of IHD, we coded it as missing. The analysis was undertaken using the R survival analysis package accounting for the clustering of patients by practice and using the Huber-White robust estimate of SE. The proportional hazards assumption was checked graphically and with a test for proportional hazards.

Nested case-control study:

The nested case-control analysis compared all patients from the cohort who died during the follow-up period (the cases) with a group of matched control patients (also with IHD) who did not die. For each case, we defined an ‘index date’ as the date of death. We then used an incidence density sampling procedure (as per the original study; personal correspondence) to randomly select four control patients for each case matched on gender, year of IHD diagnosis and age (coded in 5-year age-bands). General practice was not used as a matching variable. Controls were patients with IHD alive at the time their matched case died (including patients who themselves became cases at a later time-point). The incidence sampling procedure allowed the same patient to be selected as a control for more than one case, thus providing a full set of four controls for each case, while still producing unbiased estimates of risk. Statin exposure was based on the first and last prescription dates prior to the index date and coded into: (1) currently taking statins (last prescription was within 90 days of the index date); (2) previously took statins (last prescription more than 90 days prior to the index date) and (3) has never taken statins. We did this for all statins as a group and also separately for five different types of statin (atorvastatin, cerivastatin, fluvastatin, pravastatin and simvastatin). For ‘all statins’, the last prescription could be for a different statin type than the first; for individual statins, it had to be the same type. One further formulation, rosuvastatin, was in use that did not appear in the QResearch study. We included this in the ‘all statins’ group but did not analyse it individually as only 22 patients had received the statin. Analysis of the case-control study used conditional logistic regression accounting for the matching of cases with controls, to obtain ORs for the risk of death in relation to use of statins. We allowed for clustering by general practice and used a robust estimate of SE, in line with the cohort analysis. Covariates in the analysis were smoking status, BMI and comorbidities, specified as in the Cohort analysis but based on the index date rather than the date of diagnosis. Additional covariates in this analysis were the Townsend deprivation score for the practice postcode (in national quintiles; H-C&C used quintiles of patient-level Townsend scores) and use of β-blockers, aspirin, ACE inhibitors and calcium channel blockers, identified through the British National Formulary chapter codes in the patient record. Each medication was coded as either used or not used prior to the index date but after the date of IHD diagnosis. Interactions between use of statins and each of gender, age (less than 75 vs 75 and over) and diabetes were tested by adding interaction terms into the model.

Publications

  • David Reeves, David A Springate, Darren M Ashcroft, Ronan Ryan, Tim Doran, Richard Morris, Ivan Olier, Evangelos Kontopantelis, Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case–control analysis. BMJ Open, 4:e004952 2014.

Clinical Code List

Rows: 1227
Code Description Entity type Category Coding System (Read)
B0...00 Malignant neoplasm of lip; oral cavity and pharynx Cancer diagnostic Read
B0...11 Carcinoma of lip; oral cavity and pharynx Cancer diagnostic Read
B00..00 Malignant neoplasm of lip Cancer diagnostic Read
B00..11 Carcinoma of lip Cancer diagnostic Read
B000.00 Malignant neoplasm of upper lip; vermilion border Cancer diagnostic Read
B000000 Malignant neoplasm of upper lip; external Cancer diagnostic Read
B000100 Malignant neoplasm of upper lip; lipstick area Cancer diagnostic Read
B000z00 Malignant neoplasm of upper lip; vermilion border NOS Cancer diagnostic Read
B001.00 Malignant neoplasm of lower lip; vermilion border Cancer diagnostic Read
B001000 Malignant neoplasm of lower lip; external Cancer diagnostic Read
B001100 Malignant neoplasm of lower lip; lipstick area Cancer diagnostic Read
B001z00 Malignant neoplasm of lower lip; vermilion border NOS Cancer diagnostic Read
B002.00 Malignant neoplasm of upper lip; inner aspect Cancer diagnostic Read
B002100 Malignant neoplasm of upper lip; frenulum Cancer diagnostic Read
B002200 Malignant neoplasm of upper lip; mucosa Cancer diagnostic Read
B002300 Malignant neoplasm of upper lip; oral aspect Cancer diagnostic Read
B002z00 Malignant neoplasm of upper lip; inner aspect NOS Cancer diagnostic Read
B003.00 Malignant neoplasm of lower lip; inner aspect Cancer diagnostic Read
B003000 Malignant neoplasm of lower lip; buccal aspect Cancer diagnostic Read
B003100 Malignant neoplasm of lower lip; frenulum Cancer diagnostic Read
B003200 Malignant neoplasm of lower lip; mucosa Cancer diagnostic Read
B003300 Malignant neoplasm of lower lip; oral aspect Cancer diagnostic Read
B003z00 Malignant neoplasm of lower lip; inner aspect NOS Cancer diagnostic Read
B004.00 Malignant neoplasm of lip unspecified; inner aspect Cancer diagnostic Read
B004000 Malignant neoplasm of lip unspecified; buccal aspect Cancer diagnostic Read
B004200 Malignant neoplasm of lip unspecified; mucosa Cancer diagnostic Read
B004300 Malignant neoplasm of lip; oral aspect Cancer diagnostic Read
B005.00 Malignant neoplasm of commissure of lip Cancer diagnostic Read
B006.00 Malignant neoplasm of overlapping lesion of lip Cancer diagnostic Read
B007.00 Malignant neoplasm of lip; unspecified Cancer diagnostic Read
B00z000 Malignant neoplasm of lip; unspecified; external Cancer diagnostic Read
B00z100 Malignant neoplasm of lip; unspecified; lipstick area Cancer diagnostic Read
B00zz00 Malignant neoplasm of lip; vermilion border NOS Cancer diagnostic Read
B01..00 Malignant neoplasm of tongue Cancer diagnostic Read
B010.00 Malignant neoplasm of base of tongue Cancer diagnostic Read
B010.11 Malignant neoplasm of posterior third of tongue Cancer diagnostic Read
B010000 Malignant neoplasm of base of tongue dorsal surface Cancer diagnostic Read
B010z00 Malignant neoplasm of fixed part of tongue NOS Cancer diagnostic Read
B011.00 Malignant neoplasm of dorsal surface of tongue Cancer diagnostic Read
B011z00 Malignant neoplasm of dorsum of tongue NOS Cancer diagnostic Read
B012.00 Malignant neoplasm of tongue; tip and lateral border Cancer diagnostic Read
B013.00 Malignant neoplasm of ventral surface of tongue Cancer diagnostic Read
B013000 Malignant neoplasm of anterior 2/3 of tongue ventral surface Cancer diagnostic Read
B013100 Malignant neoplasm of frenulum linguae Cancer diagnostic Read
B013z00 Malignant neoplasm of ventral tongue surface NOS Cancer diagnostic Read
B014.00 Malignant neoplasm of anterior 2/3 of tongue unspecified Cancer diagnostic Read
B015.00 Malignant neoplasm of tongue; junctional zone Cancer diagnostic Read
B016.00 Malignant neoplasm of lingual tonsil Cancer diagnostic Read
B017.00 Malignant overlapping lesion of tongue Cancer diagnostic Read
B01y.00 Malignant neoplasm of other sites of tongue Cancer diagnostic Read
B01z.00 Malignant neoplasm of tongue NOS Cancer diagnostic Read
B02..00 Malignant neoplasm of major salivary glands Cancer diagnostic Read
B020.00 Malignant neoplasm of parotid gland Cancer diagnostic Read
B021.00 Malignant neoplasm of submandibular gland Cancer diagnostic Read
B022.00 Malignant neoplasm of sublingual gland Cancer diagnostic Read
B02y.00 Malignant neoplasm of other major salivary glands Cancer diagnostic Read
B02z.00 Malignant neoplasm of major salivary gland NOS Cancer diagnostic Read
B03..00 Malignant neoplasm of gum Cancer diagnostic Read
B030.00 Malignant neoplasm of upper gum Cancer diagnostic Read
B031.00 Malignant neoplasm of lower gum Cancer diagnostic Read
B03y.00 Malignant neoplasm of other sites of gum Cancer diagnostic Read
B03z.00 Malignant neoplasm of gum NOS Cancer diagnostic Read
B04..00 Malignant neoplasm of floor of mouth Cancer diagnostic Read
B040.00 Malignant neoplasm of anterior portion of floor of mouth Cancer diagnostic Read
B041.00 Malignant neoplasm of lateral portion of floor of mouth Cancer diagnostic Read
B042.00 Malignant neoplasm; overlapping lesion of floor of mouth Cancer diagnostic Read
B04y.00 Malignant neoplasm of other sites of floor of mouth Cancer diagnostic Read
B04z.00 Malignant neoplasm of floor of mouth NOS Cancer diagnostic Read
B05..00 Malignant neoplasm of other and unspecified parts of mouth Cancer diagnostic Read
B050.00 Malignant neoplasm of cheek mucosa Cancer diagnostic Read
B050.11 Malignant neoplasm of buccal mucosa Cancer diagnostic Read
B051.00 Malignant neoplasm of vestibule of mouth Cancer diagnostic Read
B051000 Malignant neoplasm of upper buccal sulcus Cancer diagnostic Read
B051100 Malignant neoplasm of lower buccal sulcus Cancer diagnostic Read
B052.00 Malignant neoplasm of hard palate Cancer diagnostic Read
B053.00 Malignant neoplasm of soft palate Cancer diagnostic Read
B054.00 Malignant neoplasm of uvula Cancer diagnostic Read
B055.00 Malignant neoplasm of palate unspecified Cancer diagnostic Read
B055000 Malignant neoplasm of junction of hard and soft palate Cancer diagnostic Read
B055100 Malignant neoplasm of roof of mouth Cancer diagnostic Read
B055z00 Malignant neoplasm of palate NOS Cancer diagnostic Read
B056.00 Malignant neoplasm of retromolar area Cancer diagnostic Read
B057.00 Overlapping lesion of other and unspecified parts of mouth Cancer diagnostic Read
B05y.00 Malignant neoplasm of other specified mouth parts Cancer diagnostic Read
B05z.00 Malignant neoplasm of mouth NOS Cancer diagnostic Read
B05z000 Kaposi's sarcoma of palate Cancer diagnostic Read
B06..00 Malignant neoplasm of oropharynx Cancer diagnostic Read
B060.00 Malignant neoplasm of tonsil Cancer diagnostic Read
B060000 Malignant neoplasm of faucial tonsil Cancer diagnostic Read
B060100 Malignant neoplasm of palatine tonsil Cancer diagnostic Read
B060200 Malignant neoplasm of overlapping lesion of tonsil Cancer diagnostic Read
B060z00 Malignant neoplasm tonsil NOS Cancer diagnostic Read
B061.00 Malignant neoplasm of tonsillar fossa Cancer diagnostic Read
B062.00 Malignant neoplasm of tonsillar pillar Cancer diagnostic Read
B062000 Malignant neoplasm of faucial pillar Cancer diagnostic Read
B062100 Malignant neoplasm of glossopalatine fold Cancer diagnostic Read
B062200 Malignant neoplasm of palatoglossal arch Cancer diagnostic Read
B062300 Malignant neoplasm of palatopharyngeal arch Cancer diagnostic Read
B062z00 Malignant neoplasm of tonsillar fossa NOS Cancer diagnostic Read
B063.00 Malignant neoplasm of vallecula Cancer diagnostic Read
B064.00 Malignant neoplasm of anterior epiglottis Cancer diagnostic Read
B064000 Malignant neoplasm of epiglottis; free border Cancer diagnostic Read
B064100 Malignant neoplasm of glossoepiglottic fold Cancer diagnostic Read
B064z00 Malignant neoplasm of anterior epiglottis NOS Cancer diagnostic Read
B065.00 Malignant neoplasm of junctional region of epiglottis Cancer diagnostic Read
B066.00 Malignant neoplasm of lateral wall of oropharynx Cancer diagnostic Read
B067.00 Malignant neoplasm of posterior wall of oropharynx Cancer diagnostic Read
B06y.00 Malignant neoplasm of oropharynx; other specified sites Cancer diagnostic Read
B06yz00 Malignant neoplasm of other specified site of oropharynx NOS Cancer diagnostic Read
B06z.00 Malignant neoplasm of oropharynx NOS Cancer diagnostic Read
B07..00 Malignant neoplasm of nasopharynx Cancer diagnostic Read
B070.00 Malignant neoplasm of roof of nasopharynx Cancer diagnostic Read
B071.00 Malignant neoplasm of posterior wall of nasopharynx Cancer diagnostic Read
B071000 Malignant neoplasm of adenoid Cancer diagnostic Read
B071100 Malignant neoplasm of pharyngeal tonsil Cancer diagnostic Read
B071z00 Malignant neoplasm of posterior wall of nasopharynx NOS Cancer diagnostic Read
B072.00 Malignant neoplasm of lateral wall of nasopharynx Cancer diagnostic Read
B072000 Malignant neoplasm of pharyngeal recess Cancer diagnostic Read
B072z00 Malignant neoplasm of lateral wall of nasopharynx NOS Cancer diagnostic Read
B073.00 Malignant neoplasm of anterior wall of nasopharynx Cancer diagnostic Read
B073200 Malignant neoplasm posterior margin nasal septum and choanae Cancer diagnostic Read
B073z00 Malignant neoplasm of anterior wall of nasopharynx NOS Cancer diagnostic Read
B074.00 Malignant neoplasm; overlapping lesion of nasopharynx Cancer diagnostic Read
B07y.00 Malignant neoplasm of other specified site of nasopharynx Cancer diagnostic Read
B07z.00 Malignant neoplasm of nasopharynx NOS Cancer diagnostic Read
B08..00 Malignant neoplasm of hypopharynx Cancer diagnostic Read
B080.00 Malignant neoplasm of postcricoid region Cancer diagnostic Read
B081.00 Malignant neoplasm of pyriform sinus Cancer diagnostic Read
B082.00 Malignant neoplasm aryepiglottic fold; hypopharyngeal aspect Cancer diagnostic Read
B083.00 Malignant neoplasm of posterior pharynx Cancer diagnostic Read
B08y.00 Malignant neoplasm of other specified hypopharyngeal site Cancer diagnostic Read
B08z.00 Malignant neoplasm of hypopharynx NOS Cancer diagnostic Read
B0z..00 Malig neop other/ill-defined sites lip; oral cavity; pharynx Cancer diagnostic Read
B0z0.00 Malignant neoplasm of pharynx unspecified Cancer diagnostic Read
B0z1.00 Malignant neoplasm of Waldeyer's ring Cancer diagnostic Read
B0z2.00 Malignant neoplasm of laryngopharynx Cancer diagnostic Read
B0zy.00 Malignant neoplasm of other sites lip; oral cavity; pharynx Cancer diagnostic Read
B0zz.00 Malignant neoplasm of lip; oral cavity and pharynx NOS Cancer diagnostic Read
B1...00 Malignant neoplasm of digestive organs and peritoneum Cancer diagnostic Read
B1...11 Carcinoma of digestive organs and peritoneum Cancer diagnostic Read
B10..00 Malignant neoplasm of oesophagus Cancer diagnostic Read
B100.00 Malignant neoplasm of cervical oesophagus Cancer diagnostic Read
B101.00 Malignant neoplasm of thoracic oesophagus Cancer diagnostic Read
B102.00 Malignant neoplasm of abdominal oesophagus Cancer diagnostic Read
B103.00 Malignant neoplasm of upper third of oesophagus Cancer diagnostic Read
B104.00 Malignant neoplasm of middle third of oesophagus Cancer diagnostic Read
B105.00 Malignant neoplasm of lower third of oesophagus Cancer diagnostic Read
B106.00 Malignant neoplasm; overlapping lesion of oesophagus Cancer diagnostic Read
B107.00 Siewert type I adenocarcinoma Cancer diagnostic Read
B10y.00 Malignant neoplasm of other specified part of oesophagus Cancer diagnostic Read
B10z.00 Malignant neoplasm of oesophagus NOS Cancer diagnostic Read
B10z.11 Oesophageal cancer Cancer diagnostic Read
B11..00 Malignant neoplasm of stomach Cancer diagnostic Read
B11..11 Gastric neoplasm Cancer diagnostic Read
B110.00 Malignant neoplasm of cardia of stomach Cancer diagnostic Read
B110000 Malignant neoplasm of cardiac orifice of stomach Cancer diagnostic Read
B110100 Malignant neoplasm of cardio-oesophageal junction of stomach Cancer diagnostic Read
B110111 Malignant neoplasm of gastro-oesophageal junction Cancer diagnostic Read
B110z00 Malignant neoplasm of cardia of stomach NOS Cancer diagnostic Read
B111.00 Malignant neoplasm of pylorus of stomach Cancer diagnostic Read
B111000 Malignant neoplasm of prepylorus of stomach Cancer diagnostic Read
B111100 Malignant neoplasm of pyloric canal of stomach Cancer diagnostic Read
B111z00 Malignant neoplasm of pylorus of stomach NOS Cancer diagnostic Read
B112.00 Malignant neoplasm of pyloric antrum of stomach Cancer diagnostic Read
B113.00 Malignant neoplasm of fundus of stomach Cancer diagnostic Read
B114.00 Malignant neoplasm of body of stomach Cancer diagnostic Read
B115.00 Malignant neoplasm of lesser curve of stomach unspecified Cancer diagnostic Read
B116.00 Malignant neoplasm of greater curve of stomach unspecified Cancer diagnostic Read
B117.00 Malignant neoplasm; overlapping lesion of stomach Cancer diagnostic Read
B118.00 Siewert type II adenocarcinoma Cancer diagnostic Read
B119.00 Siewert type III adenocarcinoma Cancer diagnostic Read
B11y.00 Malignant neoplasm of other specified site of stomach Cancer diagnostic Read
B11y000 Malignant neoplasm of anterior wall of stomach NEC Cancer diagnostic Read
B11y100 Malignant neoplasm of posterior wall of stomach NEC Cancer diagnostic Read
B11yz00 Malignant neoplasm of other specified site of stomach NOS Cancer diagnostic Read
B11z.00 Malignant neoplasm of stomach NOS Cancer diagnostic Read
B12..00 Malignant neoplasm of small intestine and duodenum Cancer diagnostic Read
B120.00 Malignant neoplasm of duodenum Cancer diagnostic Read
B121.00 Malignant neoplasm of jejunum Cancer diagnostic Read
B122.00 Malignant neoplasm of ileum Cancer diagnostic Read
B123.00 Malignant neoplasm of Meckel's diverticulum Cancer diagnostic Read
B124.00 Malignant neoplasm; overlapping lesion of small intestine Cancer diagnostic Read
B12y.00 Malignant neoplasm of other specified site small intestine Cancer diagnostic Read
B12z.00 Malignant neoplasm of small intestine NOS Cancer diagnostic Read
B13..00 Malignant neoplasm of colon Cancer diagnostic Read
B130.00 Malignant neoplasm of hepatic flexure of colon Cancer diagnostic Read
B131.00 Malignant neoplasm of transverse colon Cancer diagnostic Read
B132.00 Malignant neoplasm of descending colon Cancer diagnostic Read
B133.00 Malignant neoplasm of sigmoid colon Cancer diagnostic Read
B134.00 Malignant neoplasm of caecum Cancer diagnostic Read
B134.11 Carcinoma of caecum Cancer diagnostic Read
B135.00 Malignant neoplasm of appendix Cancer diagnostic Read
B136.00 Malignant neoplasm of ascending colon Cancer diagnostic Read
B137.00 Malignant neoplasm of splenic flexure of colon Cancer diagnostic Read
B138.00 Malignant neoplasm; overlapping lesion of colon Cancer diagnostic Read
B139.00 Hereditary nonpolyposis colon cancer Cancer diagnostic Read
B13y.00 Malignant neoplasm of other specified sites of colon Cancer diagnostic Read
B13z.00 Malignant neoplasm of colon NOS Cancer diagnostic Read
B13z.11 Colonic cancer Cancer diagnostic Read
B14..00 Malignant neoplasm of rectum; rectosigmoid junction and anus Cancer diagnostic Read
B140.00 Malignant neoplasm of rectosigmoid junction Cancer diagnostic Read
B141.00 Malignant neoplasm of rectum Cancer diagnostic Read
B141.11 Carcinoma of rectum Cancer diagnostic Read
B141.12 Rectal carcinoma Cancer diagnostic Read
B142.00 Malignant neoplasm of anal canal Cancer diagnostic Read
B142.11 Anal carcinoma Cancer diagnostic Read
B142000 Malignant neoplasm of cloacogenic zone Cancer diagnostic Read
B143.00 Malignant neoplasm of anus unspecified Cancer diagnostic Read
B14y.00 Malig neop other site rectum; rectosigmoid junction and anus Cancer diagnostic Read
B14z.00 Malignant neoplasm rectum;rectosigmoid junction and anus NOS Cancer diagnostic Read
B15..00 Malignant neoplasm of liver and intrahepatic bile ducts Cancer diagnostic Read
B150.00 Primary malignant neoplasm of liver Cancer diagnostic Read
B150000 Primary carcinoma of liver Cancer diagnostic Read
B150100 Hepatoblastoma of liver Cancer diagnostic Read
B150200 Primary angiosarcoma of liver Cancer diagnostic Read
B150300 Hepatocellular carcinoma Cancer diagnostic Read
B150z00 Primary malignant neoplasm of liver NOS Cancer diagnostic Read
B151.00 Malignant neoplasm of intrahepatic bile ducts Cancer diagnostic Read
B151000 Malignant neoplasm of interlobular bile ducts Cancer diagnostic Read
B151200 Malignant neoplasm of intrahepatic biliary passages Cancer diagnostic Read
B151400 Malignant neoplasm of intrahepatic gall duct Cancer diagnostic Read
B151z00 Malignant neoplasm of intrahepatic bile ducts NOS Cancer diagnostic Read
B152.00 Malignant neoplasm of liver unspecified Cancer diagnostic Read
B153.00 Secondary malignant neoplasm of liver Cancer diagnostic Read
B15z.00 Malignant neoplasm of liver and intrahepatic bile ducts NOS Cancer diagnostic Read
B16..00 Malignant neoplasm gallbladder and extrahepatic bile ducts Cancer diagnostic Read
B160.00 Malignant neoplasm of gallbladder Cancer diagnostic Read
B160.11 Carcinoma gallbladder Cancer diagnostic Read
B161.00 Malignant neoplasm of extrahepatic bile ducts Cancer diagnostic Read
B161000 Malignant neoplasm of cystic duct Cancer diagnostic Read
B161100 Malignant neoplasm of hepatic duct Cancer diagnostic Read
B161200 Malignant neoplasm of common bile duct Cancer diagnostic Read
B161211 Carcinoma common bile duct Cancer diagnostic Read
B161z00 Malignant neoplasm of extrahepatic bile ducts NOS Cancer diagnostic Read
B162.00 Malignant neoplasm of ampulla of Vater Cancer diagnostic Read
B163.00 Malignant neoplasm; overlapping lesion of biliary tract Cancer diagnostic Read
B16y.00 Malignant neoplasm other gallbladder/extrahepatic bile duct Cancer diagnostic Read
B16z.00 Malignant neoplasm gallbladder/extrahepatic bile ducts NOS Cancer diagnostic Read
B17..00 Malignant neoplasm of pancreas Cancer diagnostic Read
B170.00 Malignant neoplasm of head of pancreas Cancer diagnostic Read
B171.00 Malignant neoplasm of body of pancreas Cancer diagnostic Read
B172.00 Malignant neoplasm of tail of pancreas Cancer diagnostic Read
B173.00 Malignant neoplasm of pancreatic duct Cancer diagnostic Read
B174.00 Malignant neoplasm of Islets of Langerhans Cancer diagnostic Read
B175.00 Malignant neoplasm; overlapping lesion of pancreas Cancer diagnostic Read
B17y.00 Malignant neoplasm of other specified sites of pancreas Cancer diagnostic Read
B17y000 Malignant neoplasm of ectopic pancreatic tissue Cancer diagnostic Read
B17yz00 Malignant neoplasm of specified site of pancreas NOS Cancer diagnostic Read
B17z.00 Malignant neoplasm of pancreas NOS Cancer diagnostic Read
B18..00 Malignant neoplasm of retroperitoneum and peritoneum Cancer diagnostic Read
B180.00 Malignant neoplasm of retroperitoneum Cancer diagnostic Read
B180100 Malignant neoplasm of perinephric tissue Cancer diagnostic Read
B180200 Malignant neoplasm of retrocaecal tissue Cancer diagnostic Read
B180z00 Malignant neoplasm of retroperitoneum NOS Cancer diagnostic Read
B181.00 Mesothelioma of peritoneum Cancer diagnostic Read
B182.00 Overlapping malign lesion of retroperitoneum and peritoneum Cancer diagnostic Read
B18y.00 Malignant neoplasm of specified parts of peritoneum Cancer diagnostic Read
B18y100 Malignant neoplasm of mesocaecum Cancer diagnostic Read
B18y200 Malignant neoplasm of mesorectum Cancer diagnostic Read
B18y300 Malignant neoplasm of omentum Cancer diagnostic Read
B18y400 Malignant neoplasm of parietal peritoneum Cancer diagnostic Read
B18y500 Malignant neoplasm of pelvic peritoneum Cancer diagnostic Read
B18y600 Malignant neoplasm of the pouch of Douglas Cancer diagnostic Read
B18y700 Malignant neoplasm of mesentery Cancer diagnostic Read
B18yz00 Malignant neoplasm of specified parts of peritoneum NOS Cancer diagnostic Read
B18z.00 Malignant neoplasm of retroperitoneum and peritoneum NOS Cancer diagnostic Read
B1z..00 Malig neop oth/ill-defined sites digestive tract/peritoneum Cancer diagnostic Read
B1z0.00 Malignant neoplasm of intestinal tract; part unspecified Cancer diagnostic Read
B1z0.11 Cancer of bowel Cancer diagnostic Read
B1z1.00 Malignant neoplasm of spleen NEC Cancer diagnostic Read
B1z1100 Fibrosarcoma of spleen Cancer diagnostic Read
B1z1z00 Malignant neoplasm of spleen NOS Cancer diagnostic Read
B1z2.00 Malignant neoplasm; overlapping lesion of digestive system Cancer diagnostic Read
B1zy.00 Malignant neoplasm other spec digestive tract and peritoneum Cancer diagnostic Read
B1zz.00 Malignant neoplasm of digestive tract and peritoneum NOS Cancer diagnostic Read
B2...00 Malig neop of respiratory tract and intrathoracic organs Cancer diagnostic Read
B2...11 Carcinoma of respiratory tract and intrathoracic organs Cancer diagnostic Read
B20..00 Malig neop nasal cavities; middle ear and accessory sinuses Cancer diagnostic Read
B200.00 Malignant neoplasm of nasal cavities Cancer diagnostic Read
B200000 Malignant neoplasm of cartilage of nose Cancer diagnostic Read
B200100 Malignant neoplasm of nasal conchae Cancer diagnostic Read
B200200 Malignant neoplasm of septum of nose Cancer diagnostic Read
B200300 Malignant neoplasm of vestibule of nose Cancer diagnostic Read
B200z00 Malignant neoplasm of nasal cavities NOS Cancer diagnostic Read
B201.00 Malig neop auditory tube; middle ear and mastoid air cells Cancer diagnostic Read
B201100 Malignant neoplasm of tympanic cavity Cancer diagnostic Read
B201200 Malignant neoplasm of tympanic antrum Cancer diagnostic Read
B201300 Malignant neoplasm of mastoid air cells Cancer diagnostic Read
B201z00 Malig neop auditory tube; middle ear; mastoid air cells NOS Cancer diagnostic Read
B202.00 Malignant neoplasm of maxillary sinus Cancer diagnostic Read
B203.00 Malignant neoplasm of ethmoid sinus Cancer diagnostic Read
B204.00 Malignant neoplasm of frontal sinus Cancer diagnostic Read
B205.00 Malignant neoplasm of sphenoidal sinus Cancer diagnostic Read
B206.00 Malignant neoplasm; overlapping lesion of accessory sinuses Cancer diagnostic Read
B20y.00 Malig neop other site nasal cavity; middle ear and sinuses Cancer diagnostic Read
B20z.00 Malignant neoplasm of accessory sinus NOS Cancer diagnostic Read
B21..00 Malignant neoplasm of larynx Cancer diagnostic Read
B210.00 Malignant neoplasm of glottis Cancer diagnostic Read
B211.00 Malignant neoplasm of supraglottis Cancer diagnostic Read
B212.00 Malignant neoplasm of subglottis Cancer diagnostic Read
B213.00 Malignant neoplasm of laryngeal cartilage Cancer diagnostic Read
B213000 Malignant neoplasm of arytenoid cartilage Cancer diagnostic Read
B213100 Malignant neoplasm of cricoid cartilage Cancer diagnostic Read
B213300 Malignant neoplasm of thyroid cartilage Cancer diagnostic Read
B213z00 Malignant neoplasm of laryngeal cartilage NOS Cancer diagnostic Read
B214.00 Malignant neoplasm; overlapping lesion of larynx Cancer diagnostic Read
B215.00 Malignant neoplasm of epiglottis NOS Cancer diagnostic Read
B21y.00 Malignant neoplasm of larynx; other specified site Cancer diagnostic Read
B21z.00 Malignant neoplasm of larynx NOS Cancer diagnostic Read
B22..00 Malignant neoplasm of trachea; bronchus and lung Cancer diagnostic Read
B220.00 Malignant neoplasm of trachea Cancer diagnostic Read
B220100 Malignant neoplasm of mucosa of trachea Cancer diagnostic Read
B220z00 Malignant neoplasm of trachea NOS Cancer diagnostic Read
B221.00 Malignant neoplasm of main bronchus Cancer diagnostic Read
B221000 Malignant neoplasm of carina of bronchus Cancer diagnostic Read
B221100 Malignant neoplasm of hilus of lung Cancer diagnostic Read
B221z00 Malignant neoplasm of main bronchus NOS Cancer diagnostic Read
B222.00 Malignant neoplasm of upper lobe; bronchus or lung Cancer diagnostic Read
B222.11 Pancoast's syndrome Cancer diagnostic Read
B222000 Malignant neoplasm of upper lobe bronchus Cancer diagnostic Read
B222100 Malignant neoplasm of upper lobe of lung Cancer diagnostic Read
B222z00 Malignant neoplasm of upper lobe; bronchus or lung NOS Cancer diagnostic Read
B223.00 Malignant neoplasm of middle lobe; bronchus or lung Cancer diagnostic Read
B223000 Malignant neoplasm of middle lobe bronchus Cancer diagnostic Read
B223100 Malignant neoplasm of middle lobe of lung Cancer diagnostic Read
B223z00 Malignant neoplasm of middle lobe; bronchus or lung NOS Cancer diagnostic Read
B224.00 Malignant neoplasm of lower lobe; bronchus or lung Cancer diagnostic Read
B224000 Malignant neoplasm of lower lobe bronchus Cancer diagnostic Read
B224100 Malignant neoplasm of lower lobe of lung Cancer diagnostic Read
B224z00 Malignant neoplasm of lower lobe; bronchus or lung NOS Cancer diagnostic Read
B225.00 Malignant neoplasm of overlapping lesion of bronchus & lung Cancer diagnostic Read
B226.00 Mesothelioma Cancer diagnostic Read
B22y.00 Malignant neoplasm of other sites of bronchus or lung Cancer diagnostic Read
B22z.00 Malignant neoplasm of bronchus or lung NOS Cancer diagnostic Read
B22z.11 Lung cancer Cancer diagnostic Read
B23..00 Malignant neoplasm of pleura Cancer diagnostic Read
B230.00 Malignant neoplasm of parietal pleura Cancer diagnostic Read
B232.00 Mesothelioma of pleura Cancer diagnostic Read
B23y.00 Malignant neoplasm of other specified pleura Cancer diagnostic Read
B23z.0