Methicillin-resistant Staphylococcus Aureus (Mrsa)
Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa
PH640 / 1280 Clinical-Coded Phenotype
Overview
Phenotype TypeDisease or syndromeSexBothValid Event Date Range01/01/1993 - 31/12/2007Coding SystemRead codes v2OXMIS codesData SourcesCollectionsClinicalCodes RepositoryPhenotype LibraryTagsNo dataDefinition
Design:
Population-based case-control study in children 1 to 19 years of age.
Setting:
Primary care, General Practice Research Database, United Kingdom, 1994-2007.
Participants:
Cases were children who had MRSA diagnosed as outpatients, and controls were individually matched on age and practice, with the matched case’s diagnosis date as the index date for both.
Main Exposures:
Antibacterial agents prescribed 180 to 30 days prior to the index date, excluding prescriptions 30 days before the index date to prevent protopathic bias.
Outcome Measures:
Rate ratios (RRs) estimated from the odds ratios of exposure in cases compared with controls using conditional logistic regression, adjusted for comorbid conditions, other prescription drug use, and hospitalization.
Results:
The rate of MRSA was 4.5 per 100 000 per year. Of 297 cases and 9357 controls, 52.5% and 13.6%, respectively, received antibacterial drug prescriptions during the 150-day exposure window. The adjusted RR with any antibacterial drug was 3.5 (95% confidence interval [CI], 2.6-4.8). The RRs increased with the number of prescriptions (2.2 [95% CI, 1.5-3.2], 3.3 [95% CI, 1.9-5.6], 11.0 [95% CI, 5.6-21.6], and 18.2 [95% CI, 9.4-35.4] for 1, 2, 3, and >=4 prescriptions, respectively). The RR was particularly elevated for quinolones at 14.8 (95% CI, 3.9- 55.8), with wide variation among antibacterial classes.
Implementation
No dataImplementation
Clinical Code List
PUBLISHED - 5 Codes
PUBLISHED - 1 Codes
Publication
Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa, Antibacterial Drugs and the Risk of Community-Associated Methicillin-Resistant Staphylococcus aureus in Children. Arch Pediatr Adolesc Med, 165(12), 2011.
Citation Example
Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa. PH640 / 1280 - Methicillin-resistant Staphylococcus Aureus (Mrsa). Phenotype Library [Online]. 06 October 2021. Available from: http://phenotypes.healthdatagateway.org/phenotypes/PH640/version/1280/detail/. [Accessed 02 December 2024]
API
To Export Phenotype Details:
Format API JSON site_root/api/v1/phenotypes/PH640/version/1280/detail/?format=json R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get details of phenotype
phenotype_details = client$phenotypes$get_detail(
'PH640',
version_id=1280
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_detail(
'PH640',
version_id=1280
)To Export Phenotype Code List:
Format API JSON site_root/api/v1/phenotypes/PH640/version/1280/export/codes/?format=json CSV site_root/phenotypes/PH640/version/1280/export/codes/ R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get codelist of phenotype
phenotype_codelist = client$phenotypes$get_codelist(
'PH640',
version_id=1280
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_codelist(
'PH640',
version_id=1280
)Version History