Print

Methicillin-resistant Staphylococcus Aureus (Mrsa)

Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa

Type
Disease or Syndrome
ID
PH640
Version ID
1280
Data Sources
Valid event data range
01/01/1993 - 31/12/2007
Sex
Female, Male
Agreement Date
2011-08-01
Coding system
Read codes v2 OXMIS codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Design:

Population-based case-control study in children 1 to 19 years of age.

Setting:

Primary care, General Practice Research Database, United Kingdom, 1994-2007.

Participants:

Cases were children who had MRSA diagnosed as outpatients, and controls were individually matched on age and practice, with the matched case’s diagnosis date as the index date for both.

Main Exposures:

Antibacterial agents prescribed 180 to 30 days prior to the index date, excluding prescriptions 30 days before the index date to prevent protopathic bias.

Outcome Measures:

Rate ratios (RRs) estimated from the odds ratios of exposure in cases compared with controls using conditional logistic regression, adjusted for comorbid conditions, other prescription drug use, and hospitalization.

Results:

The rate of MRSA was 4.5 per 100 000 per year. Of 297 cases and 9357 controls, 52.5% and 13.6%, respectively, received antibacterial drug prescriptions during the 150-day exposure window. The adjusted RR with any antibacterial drug was 3.5 (95% confidence interval [CI], 2.6-4.8). The RRs increased with the number of prescriptions (2.2 [95% CI, 1.5-3.2], 3.3 [95% CI, 1.9-5.6], 11.0 [95% CI, 5.6-21.6], and 18.2 [95% CI, 9.4-35.4] for 1, 2, 3, and >=4 prescriptions, respectively). The RR was particularly elevated for quinolones at 14.8 (95% CI, 3.9- 55.8), with wide variation among antibacterial classes.

Publications

  • Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa, Antibacterial Drugs and the Risk of Community-Associated Methicillin-Resistant Staphylococcus aureus in Children. Arch Pediatr Adolesc Med, 165(12), 2011.

Clinical Code List

Rows: 5
Code Description Entity type Coding System (OXMIS Read) Category
4JP..00 MRSA positive res16: MRSA Read diagnostic
A3B1100 MRSA infection res16: MRSA Read diagnostic
A3B1111 Multiple-resistane Staphylococcus aureaus infection res16: MRSA Read diagnostic
Sp25800 MRSA infection of postoperative wound res16: MRSA Read diagnostic
ZV02A00 MRSA infection carrier res16: MRSA Read diagnostic
Rows: 1
Code Description Entity type Coding System (OXMIS Read) Category
0399TB S aureus multiresistant infection res16: MRSA OXMIS diagnostic

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH640/version/1280/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH640/version/1280/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH640', '1280', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH640/version/1280/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH640/version/1280/export/codes/?format=json
CSV site_root/phenotypes/PH640/version/1280/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH640', '1280', api_client=client)

Version History

Version
ID
Name Owner Publish date
1280 Methicillin-resistant Staphylococcus Aureus (Mrsa) ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

Print - Print page.