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Ace Inhibitors

David A Springate, Darren M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves

Type
Drug
ID
PH641
Version ID
1282
Data Sources
Doctors Independent Network , CPRD GOLD
Valid event data range
01/01/19997 - 31/12/2006
Sex
Female, Male
Agreement Date
2020-10-08
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objectives:

To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population.

Design:

Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer.

Setting:

Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN).

Participants:

CPRD data for 11 302 patients with cancer compared with published results from DIN for 3462 patients; study period January 1997 to December 2006.

Primary and secondary outcome measures:

All-cause mortality: overall; by treatment subgroup (β-blockers only, β-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer site.

Results:

Using CPRD, β-blocker use was not associated with mortality (HR=1.03, 95% CI 0.93 to 1.14, vs patients prescribed other BPLMs only), but DIN β-blocker users had significantly higher mortality (HR=1.18, 95% CI 1.04 to 1.33). However, these HRs were not statistically different (p=0.063), but did differ for patients on β-blockers alone (CPRD=0.94, 95% CI 0.82 to 1.07; DIN=1.37, 95% CI 1.16 to 1.61; p<0.001). Results for individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases.

Conclusions:

We found a complex pattern of similarities and differences between databases. Overall treatment effect estimates were not statistically different, adding to a growing body of evidence that different UK PCDs produce comparable effect estimates. However, individually the two studies lead to different conclusions regarding the safety of β-blockers and some subgroup effects differed significantly. Single studies using even internally wellvalidated databases do not guarantee generalisable results, especially for subgroups, and confirmatory studies using at least one other independent data source are strongly recommended.

Publications

  • David A Springate, Darrent M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves, Can analyses of electronic patient records be independently and externally validated? Study 2—the effect of β-adrenoceptor blocker therapy on cancer survival a retrospective cohort study. BMJ Open, 5(e007299), 2014.

Clinical Code List

Rows: 423
Code Description Coding System (CPRD_product_code) Entity type Category
1021 INNOZIDE tablets [M S D] CPRD_product_code res24: ACE_inhibitors drug
10316 COAPROVEL tablets 150mg + 12.5mg [SANOFI BMS] CPRD_product_code res24: ACE_inhibitors drug
10323 losartan with hydrochlorothiazide tablets 100mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
10882 CARACE tablets 2.5mg [BMS] CPRD_product_code res24: ACE_inhibitors drug
10902 captopril with hydrochlorothiazide tablets 50mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
11133 hydrochlorothiazide with captopril tablets 25mg + 50mg CPRD_product_code res24: ACE_inhibitors drug
11197 INNOVACE MELT wafer 5mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
1121 captopril tablets 12.5mg CPRD_product_code res24: ACE_inhibitors drug
11251 DIOVAN capsules 40mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
11252 DIOVAN capsules 80mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
11348 APROVEL tablets 300mg [SANOFI/AVE] CPRD_product_code res24: ACE_inhibitors drug
11351 co-zidocapt (hydrochlorothiazide and captopril) tablets 25mg + 50mg CPRD_product_code res24: ACE_inhibitors drug
1143 captopril tablets 25mg CPRD_product_code res24: ACE_inhibitors drug
1144 CAPOTEN tablets 25mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
11448 irbesartan with hydrochlorothiazide tablets 150mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
11469 irbesartan with hydrochlorothiazide tablets 300mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
11526 COAPROVEL tablets 300mg + 12.5mg [SANOFI BMS] CPRD_product_code res24: ACE_inhibitors drug
11561 co-zidocapt (hydrochlorothiazide and captopril) tablets 12.5mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
11567 ramipril with felodipine modified release tablet 5mg + 5mg CPRD_product_code res24: ACE_inhibitors drug
11641 captopril with hydrochlorothiazide tablets 25mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
11864 valsartan with hydrochlorothiazide tablets 160mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
11937 ramipril oral suspension 2.5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
11965 ramipril with felodipine modified release tablet 2.5mg + 2.5mg CPRD_product_code res24: ACE_inhibitors drug
11983 perindopril erbumine oral suspension 4mg/5ml CPRD_product_code res24: ACE_inhibitors drug
11987 lisinopril oral solution 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
12313 CARACE tablets 20mg [BMS] CPRD_product_code res24: ACE_inhibitors drug
12411 cilazapril tablets 500 micrograms CPRD_product_code res24: ACE_inhibitors drug
12412 cilazapril tablets 2.5mg CPRD_product_code res24: ACE_inhibitors drug
12574 cilazapril tablets 1mg CPRD_product_code res24: ACE_inhibitors drug
12815 TANATRIL tablets 10mg [CHIESI] CPRD_product_code res24: ACE_inhibitors drug
12836 eprosartan tablets 600mg CPRD_product_code res24: ACE_inhibitors drug
12858 imidapril hydrochloride tablets 10mg CPRD_product_code res24: ACE_inhibitors drug
12874 telmisartan tablets 80mg CPRD_product_code res24: ACE_inhibitors drug
1293 irbesartan tablets 150mg CPRD_product_code res24: ACE_inhibitors drug
1299 enalapril tablets 10mg CPRD_product_code res24: ACE_inhibitors drug
13026 cilazapril tablets 5mg CPRD_product_code res24: ACE_inhibitors drug
13123 eprosartan tablets 400mg CPRD_product_code res24: ACE_inhibitors drug
13589 STARIL tablets 20mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
13755 enalapril wafer 10mg CPRD_product_code res24: ACE_inhibitors drug
13821 MICARDIS tablets 40mg [BOEH INGL] CPRD_product_code res24: ACE_inhibitors drug
14228 COVERSYL PLUS tablets [SERVIER] CPRD_product_code res24: ACE_inhibitors drug
14283 valsartan with hydrochlorothiazide tablets 160mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
14387 CARACE tablets 5mg [BMS] CPRD_product_code res24: ACE_inhibitors drug
14477 ACCUPRO tablets 10mg [PFIZER] CPRD_product_code res24: ACE_inhibitors drug
14478 ACCUPRO tablets 20mg [PFIZER] CPRD_product_code res24: ACE_inhibitors drug
147 ramipril capsules 1.25mg CPRD_product_code res24: ACE_inhibitors drug
14738 hydrochlorothiazide with losartan tablets 12.5mg + 50mg CPRD_product_code res24: ACE_inhibitors drug
14870 telmisartan with hydrochlorothiazide tablets 40mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
14943 valsartan tablets 40mg CPRD_product_code res24: ACE_inhibitors drug
14960 COVERSYL tablets 8mg [SERVIER] CPRD_product_code res24: ACE_inhibitors drug
14965 COZAAR tablets 100mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
14983 OLMETEC tablets 10mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
15031 ACCURETIC tablets 10mg + 12.5mg [PFIZER] CPRD_product_code res24: ACE_inhibitors drug
15085 INNOVACE titration pack [M S D] CPRD_product_code res24: ACE_inhibitors drug
15096 ACCUPRO tablets 40mg [PFIZER] CPRD_product_code res24: ACE_inhibitors drug
15108 quinapril and hydrochlorothiazide tablets 10mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
15121 moexipril hydrochloride tablets 7.5mg CPRD_product_code res24: ACE_inhibitors drug
15135 hydrochlorothiazide with captopril tablets 12.5mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
1520 CAPOZIDE tablets [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
15605 cilazapril tablets 250micrograms CPRD_product_code res24: ACE_inhibitors drug
15958 captopril tablets 2mg CPRD_product_code res24: ACE_inhibitors drug
16060 valsartan with hydrochlorothiazide tablets 80mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
16161 telmisartan with hydrochlorothiazide tablets 80mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
16196 VASCACE tablets 5mg [ROCHE] CPRD_product_code res24: ACE_inhibitors drug
16197 VASCACE tablets 2.5mg [ROCHE] CPRD_product_code res24: ACE_inhibitors drug
16212 VASCACE tablets 1mg [ROCHE] CPRD_product_code res24: ACE_inhibitors drug
16285 TEVETEN tablets 400mg [ABBOTT] CPRD_product_code res24: ACE_inhibitors drug
16371 TEVETEN tablets 600mg [ABBOTT] CPRD_product_code res24: ACE_inhibitors drug
16701 CARACE tablets 10mg [BMS] CPRD_product_code res24: ACE_inhibitors drug
16708 enalapril titration pack CPRD_product_code res24: ACE_inhibitors drug
16710 GOPTEN capsules 0.5mg [ABBOTT] CPRD_product_code res24: ACE_inhibitors drug
16924 imidapril hydrochloride tablets 5mg CPRD_product_code res24: ACE_inhibitors drug
17006 TRIAPIN modified release tablet 5mg + 5mg [AVENTIS] CPRD_product_code res24: ACE_inhibitors drug
17120 moexipril hydrochloride tablets 15mg CPRD_product_code res24: ACE_inhibitors drug
17474 felodipine with ramipril modified release tablet 5mg + 5mg CPRD_product_code res24: ACE_inhibitors drug
17545 MICARDIS tablets 80mg [BOEH INGL] CPRD_product_code res24: ACE_inhibitors drug
17624 captopril oral suspension 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
17633 captopril oral liquid 3mg/5ml CPRD_product_code res24: ACE_inhibitors drug
17655 CARACE 10 plus tablets [BMS] CPRD_product_code res24: ACE_inhibitors drug
17686 MICARDIS tablets 20mg [BOEH INGL] CPRD_product_code res24: ACE_inhibitors drug
17689 MICARDIS PLUS tablets 80mg + 12.5mg [BOEH INGL] CPRD_product_code res24: ACE_inhibitors drug
1780 losartan tablets 50mg CPRD_product_code res24: ACE_inhibitors drug
1807 captopril tablets 50mg CPRD_product_code res24: ACE_inhibitors drug
18200 olmesartan medoxomil with hydrochlorothiazide tablets 20mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
18202 MICARDIS PLUS tablets 40mg + 12.5mg [BOEH INGL] CPRD_product_code res24: ACE_inhibitors drug
18219 imidapril hydrochloride tablets 20mg CPRD_product_code res24: ACE_inhibitors drug
18223 trandolapril with verapamil modified release capsules 2mg + 180mg CPRD_product_code res24: ACE_inhibitors drug
18263 ACEZIDE tablets [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
18269 ACEPRIL tablets 12.5mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
18325 ACEPRIL tablets 50mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
18903 olmesartan medoxomil with hydrochlorothiazide tablets 20mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
18910 OLMETEC tablets 20mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
1904 enalapril tablets 20mg CPRD_product_code res24: ACE_inhibitors drug
19198 LISINOPRIL tablets 20mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
19204 LISINOPRIL tablets 5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
19208 ENALAPRIL tablets 10mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
19223 LISINOPRIL tablets 10mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
196 enalapril tablets 5mg CPRD_product_code res24: ACE_inhibitors drug
19690 verapamil hydrochloride with trandolapril modified release capsules 180mg + 2mg CPRD_product_code res24: ACE_inhibitors drug
20117 OLMETEC tablets 40mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
20188 enalapril wafer 2.5mg CPRD_product_code res24: ACE_inhibitors drug
20579 TARKA capsules 180mg + 2mg [ABBOTT] CPRD_product_code res24: ACE_inhibitors drug
20849 TENSOPRIL tablets 12.5mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
20975 lisinopril oral suspension 7.5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
21053 VASCACE tablets 0.5mg [ROCHE] CPRD_product_code res24: ACE_inhibitors drug
21162 felodipine with ramipril modified release tablet 2.5mg + 2.5mg CPRD_product_code res24: ACE_inhibitors drug
21231 CARALPHA tablets 20mg + 12.5mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
21423 COZAAR-COMP tablets 100mg + 25mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
21943 KAPLON tablets 12.5mg [APS] CPRD_product_code res24: ACE_inhibitors drug
22439 EDNYT tablets 20mg [DOMINION] CPRD_product_code res24: ACE_inhibitors drug
22708 enalapril wafer 5mg CPRD_product_code res24: ACE_inhibitors drug
23252 PRALENAL tablets 10mg [OPUS] CPRD_product_code res24: ACE_inhibitors drug
23456 hydrochlorothiazide with valsartan tablets 25mg + 160mg CPRD_product_code res24: ACE_inhibitors drug
23478 TENSOPRIL tablets 50mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
23642 VASCACE tablets 0.25mg [ROCHE] CPRD_product_code res24: ACE_inhibitors drug
24041 enalapril wafer 20mg CPRD_product_code res24: ACE_inhibitors drug
24268 hydrochlorothiazide with valsartan tablets 12.5mg + 80mg CPRD_product_code res24: ACE_inhibitors drug
24359 DIOVAN tablets 40mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
24482 CAPTOMEX tablets 50mg [DUMEX] CPRD_product_code res24: ACE_inhibitors drug
24484 hydrochlorothiazide with valsartan tablets 12.5mg + 160mg CPRD_product_code res24: ACE_inhibitors drug
24632 hydrochlorothiazide with losartan tablets 25mg + 100mg CPRD_product_code res24: ACE_inhibitors drug
25382 CO-DIOVAN tablets 160mg + 25mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
25998 CAPTOMEX tablets 12.5mg [DUMEX] CPRD_product_code res24: ACE_inhibitors drug
26995 KAPLON tablets 25mg [APS] CPRD_product_code res24: ACE_inhibitors drug
27520 OLMETEC PLUS tablets 20mg + 25mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
277 lisinopril tablets 2.5mg CPRD_product_code res24: ACE_inhibitors drug
27871 INNOVACE MELT wafer 10mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
28127 ENALAPRIL tablets 2.5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
28438 TRIAPIN MITE modified release tablet 2.5mg + 2.5mg [AVENTIS] CPRD_product_code res24: ACE_inhibitors drug
28486 captopril oral suspension 6.25mg/5ml CPRD_product_code res24: ACE_inhibitors drug
28586 LOPACE capsules 5mg [DISCOVERY] CPRD_product_code res24: ACE_inhibitors drug
28724 PERDIX tablets 7.5mg [UCB] CPRD_product_code res24: ACE_inhibitors drug
28725 PERDIX tablets 15mg [UCB] CPRD_product_code res24: ACE_inhibitors drug
28820 CAPTOMEX tablets 25mg [DUMEX] CPRD_product_code res24: ACE_inhibitors drug
28902 ODRIK capsules 2mg [AVENTIS] CPRD_product_code res24: ACE_inhibitors drug
29130 GOPTEN capsules 4mg [ABBOTT] CPRD_product_code res24: ACE_inhibitors drug
29530 INNOVACE MELT wafer 2.5mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
29627 LOPACE capsules 2.5mg [DISCOVERY] CPRD_product_code res24: ACE_inhibitors drug
29634 OLMETEC PLUS tablets 20mg + 12.5mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
2971 irbesartan tablets 300mg CPRD_product_code res24: ACE_inhibitors drug
2982 ZESTORETIC 20-tablets 20mg + 12.5mg [ASTRAZENEC] CPRD_product_code res24: ACE_inhibitors drug
30039 TENSOPRIL tablets 25mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
3069 ACEPRIL tablets 25mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
30921 LISINOPRIL tablets 2.5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
31072 AMIAS tablets 32mg [TAKEDA] CPRD_product_code res24: ACE_inhibitors drug
31307 ODRIK capsules 0.5mg [AVENTIS] CPRD_product_code res24: ACE_inhibitors drug
31587 INNOVACE MELT wafer 20mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
31716 ENALAPRIL tablets 20mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
31810 ODRIK capsules 1mg [AVENTIS] CPRD_product_code res24: ACE_inhibitors drug
3203 CAPOZIDE LS tablets [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
32048 KAPLON tablets 50mg [APS] CPRD_product_code res24: ACE_inhibitors drug
32166 CAPTO-CO tablets 25mg+50mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
3222 valsartan capsules 80mg CPRD_product_code res24: ACE_inhibitors drug
32241 ENALAPRIL tablets 10mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
32514 ECOPACE tablets 25mg [GOLDSHIELD] CPRD_product_code res24: ACE_inhibitors drug
32560 TANATRIL tablets 20mg [CHIESI] CPRD_product_code res24: ACE_inhibitors drug
32597 LISINOPRIL tablets 10mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
32857 RAMIPRIL capsules 1.25mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
32934 LOPACE capsules 10mg [DISCOVERY] CPRD_product_code res24: ACE_inhibitors drug
33057 EDNYT tablets 5mg [DOMINION] CPRD_product_code res24: ACE_inhibitors drug
33078 ENALAPRIL tablets 20mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
33095 PERINDOPRIL tablets 4mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
3310 CAPOTEN tablets 12.5mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
33336 CAPTOPRIL oral suspension 5mg/5ml [ELDON] CPRD_product_code res24: ACE_inhibitors drug
33353 LISINOPRIL AND HYDROCHLOROTHIAZIDE tablets 20mg + 12.5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
33646 CAPTOPRIL tablets 12.5mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
33811 RAMIPRIL capsules 2.5mg [RANBAXY] CPRD_product_code res24: ACE_inhibitors drug
33894 RAMIPRIL capsules 10mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
33977 LISINOPRIL tablets 10mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34357 RAMIPRIL capsules 10mg [GENUS] CPRD_product_code res24: ACE_inhibitors drug
34382 RAMIPRIL capsules 5mg [WINTHROP] CPRD_product_code res24: ACE_inhibitors drug
34390 RAMIPRIL capsules 5mg [GENUS] CPRD_product_code res24: ACE_inhibitors drug
34400 ENALAPRIL tablets 5mg [DOWELHURST] CPRD_product_code res24: ACE_inhibitors drug
34412 RAMIPRIL capsules 5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
34429 RAMIPRIL capsules 5mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34431 RAMIPRIL capsules 2.5mg [WINTHROP] CPRD_product_code res24: ACE_inhibitors drug
34432 RAMIPRIL capsules 2.5mg [GENUS] CPRD_product_code res24: ACE_inhibitors drug
34453 ENALAPRIL tablets 20mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34471 LISINOPRIL tablets 5mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34490 RAMIPRIL capsules 2.5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
34505 RAMIPRIL capsules 2.5mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
34528 RAMIPRIL capsules 2.5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
34539 RAMIPRIL capsules 5mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
34540 RAMIPRIL capsules 5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
34544 CAPTOPRIL tablets 12.5mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
34562 CAPTOPRIL tablets 25mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
34567 RAMIPRIL capsules 2.5mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34583 RAMIPRIL capsules 10mg [DEXCEL] CPRD_product_code res24: ACE_inhibitors drug
34589 RAMIPRIL capsules 5mg [DEXCEL] CPRD_product_code res24: ACE_inhibitors drug
34651 RAMIPRIL capsules 10mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34652 RAMIPRIL capsules 5mg [SOVEREIGN] CPRD_product_code res24: ACE_inhibitors drug
34657 RAMIPRIL capsules 10mg [WINTHROP] CPRD_product_code res24: ACE_inhibitors drug
34696 LISINOPRIL tablets 20mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34698 RAMIPRIL capsules 1.25mg [WINTHROP] CPRD_product_code res24: ACE_inhibitors drug
34710 RAMIPRIL capsules 10mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
34712 ENALAPRIL tablets 20mg [KENT] CPRD_product_code res24: ACE_inhibitors drug
34719 CAPTOPRIL tablets 50mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34732 RAMIPRIL capsules 2.5mg [DEXCEL] CPRD_product_code res24: ACE_inhibitors drug
34768 ENALAPRIL tablets 20mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
34798 ENALAPRIL tablets 20mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
34799 LISINOPRIL tablets 20mg [STERWIN] CPRD_product_code res24: ACE_inhibitors drug
34877 RAMIPRIL capsules 10mg [SOVEREIGN] CPRD_product_code res24: ACE_inhibitors drug
34893 RAMIPRIL capsules 10mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
34936 CAPTOPRIL tablets 25mg [LAGAP] CPRD_product_code res24: ACE_inhibitors drug
34937 CAPTOPRIL tablets 50mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
34943 RAMIPRIL capsules 10mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
34952 ENALAPRIL tablets 10mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
34953 ENALAPRIL tablets 20mg [WINTHROP] CPRD_product_code res24: ACE_inhibitors drug
35007 ramipril oral suspension 10mg/5ml CPRD_product_code res24: ACE_inhibitors drug
35096 EXFORGE tablets 10mg + 160mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
35173 valsartan with amlodipine tablets 160mg + 5mg CPRD_product_code res24: ACE_inhibitors drug
35174 valsartan with amlodipine tablets 80mg + 5mg CPRD_product_code res24: ACE_inhibitors drug
35189 amlodipine with valsartan tablets 10mg + 160mg CPRD_product_code res24: ACE_inhibitors drug
35196 COAPROVEL tablets 300mg + 25mg [SANOFI BMS] CPRD_product_code res24: ACE_inhibitors drug
35302 captopril oral suspension 12.5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
35304 valsartan with amlodipine tablets 160mg + 10mg CPRD_product_code res24: ACE_inhibitors drug
35317 EXFORGE tablets 5mg + 80mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
35329 amlodipine with valsartan tablets 5mg + 80mg CPRD_product_code res24: ACE_inhibitors drug
35343 amlodipine with valsartan tablets 5mg + 160mg CPRD_product_code res24: ACE_inhibitors drug
35380 hydrochlorothiazide with olmesartan medoxomil tablets 12.5mg + 20mg CPRD_product_code res24: ACE_inhibitors drug
35481 irbesartan with hydrochlorothiazide tablets 300mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
35697 EXFORGE tablets 5mg + 160mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
35731 PERINDOPRIL tablets 8mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
35794 ENALAPRIL tablets 5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
36742 captopril oral suspension 2mg/5ml CPRD_product_code res24: ACE_inhibitors drug
36753 EDNYT tablets 10mg [DOMINION] CPRD_product_code res24: ACE_inhibitors drug
36939 irbesartan sugar-free suspension 300mg/5ml CPRD_product_code res24: ACE_inhibitors drug
37080 enalapril oral solution 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
37087 enalapril oral suspension 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
3720 ZESTRIL tablets 2.5mg [ASTRAZENEC] CPRD_product_code res24: ACE_inhibitors drug
37573 valsartan tablets 320mg CPRD_product_code res24: ACE_inhibitors drug
37650 losartan with hydrochlorothiazide tablets 100mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
37655 CAPTOPRIL tablets 25mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
37710 LISINOPRIL AND HYDROCHLOROTHIAZIDE tablets 10mg + 12.5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
37747 COZAAR-COMP tablets 100mg + 12.5mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
37778 lisinopril oral suspension 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
37908 COVERSYL ARGININE PLUS tablets 5mg + 1.25mg [SERVIER] CPRD_product_code res24: ACE_inhibitors drug
37930 perindopril arginine tablets 5mg CPRD_product_code res24: ACE_inhibitors drug
37964 perindopril arginine tablets 2.5mg CPRD_product_code res24: ACE_inhibitors drug
37965 COVERSYL ARGININE tablets 5mg [SERVIER] CPRD_product_code res24: ACE_inhibitors drug
37971 perindopril arginine tablets 10mg CPRD_product_code res24: ACE_inhibitors drug
37978 perindopril arginine with indapamide tablets 5mg + 1.25mg CPRD_product_code res24: ACE_inhibitors drug
38026 COVERSYL ARGININE tablets 10mg [SERVIER] CPRD_product_code res24: ACE_inhibitors drug
38034 COVERSYL ARGININE tablets 2.5mg [SERVIER] CPRD_product_code res24: ACE_inhibitors drug
38285 PERINDOPRIL tablets 4mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
38308 ramipril tablets 2.5mg + 5mg + 10mg CPRD_product_code res24: ACE_inhibitors drug
38367 hydrochlorothiazide with losartan tablets 12.5mg + 100mg CPRD_product_code res24: ACE_inhibitors drug
3839 CAPOTEN tablets 50mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
38395 valsartan tablets 80mg CPRD_product_code res24: ACE_inhibitors drug
38459 telmisartan with hydrochlorothiazide tablets 80mg + 25mg CPRD_product_code res24: ACE_inhibitors drug
38510 PERINDOPRIL tablets 4mg [APOTEX] CPRD_product_code res24: ACE_inhibitors drug
38854 quinapril oral suspension 20mg/5ml CPRD_product_code res24: ACE_inhibitors drug
38889 MICARDIS PLUS tablets 80mg + 25mg [BOEH INGL] CPRD_product_code res24: ACE_inhibitors drug
38899 QUINIL tablets 10mg [TILLOMED] CPRD_product_code res24: ACE_inhibitors drug
38995 ZESTORETIC 20 tablets [ASTRAZENEC] CPRD_product_code res24: ACE_inhibitors drug
39021 hydrochlorothiazide with olmesartan medoxomil tablets 25mg + 20mg CPRD_product_code res24: ACE_inhibitors drug
39137 ZESTORETIC 10 tablets [ASTRAZENEC] CPRD_product_code res24: ACE_inhibitors drug
39147 CARACE 20 PLUS tablets [M S D] CPRD_product_code res24: ACE_inhibitors drug
39199 DIOVAN tablets 320mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
39227 CAPOZIDE LS tablets [BMS] CPRD_product_code res24: ACE_inhibitors drug
39242 CARACE 10 PLUS tablets [M S D] CPRD_product_code res24: ACE_inhibitors drug
3929 quinapril tablets 10mg CPRD_product_code res24: ACE_inhibitors drug
39355 TRITACE tablets 10mg [STERWIN] CPRD_product_code res24: ACE_inhibitors drug
39421 TRITACE TITRATION PACK tablets 2.5mg + 5mg + 10mg [SANOFI/AVE] CPRD_product_code res24: ACE_inhibitors drug
39512 captopril oral suspension 25mg/5ml CPRD_product_code res24: ACE_inhibitors drug
39786 olmesartan medoxomil oral suspension 10mg/5ml CPRD_product_code res24: ACE_inhibitors drug
39944 losartan tablets 12.5mg CPRD_product_code res24: ACE_inhibitors drug
39984 SEVIKAR film coated tablets 20mg + 5mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
40316 olmesartan medoxomil with amlodipine tablets 20mg + 5mg CPRD_product_code res24: ACE_inhibitors drug
40355 QUINIL tablets 5mg [TILLOMED] CPRD_product_code res24: ACE_inhibitors drug
40384 RAMIPRIL tablets 10mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
40571 COZAAR tablets 12.5mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
40639 olmesartan medoxomil with amlodipine tablets 40mg + 5mg CPRD_product_code res24: ACE_inhibitors drug
40668 olmesartan medoxomil with amlodipine tablets 40mg + 10mg CPRD_product_code res24: ACE_inhibitors drug
40711 losartan oral suspension 2.5mg/1ml CPRD_product_code res24: ACE_inhibitors drug
4103 trandolapril capsules 1mg CPRD_product_code res24: ACE_inhibitors drug
41203 SEVIKAR film coated tablets 40mg + 10mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
41205 SEVIKAR film coated tablets 40mg + 5mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
41232 COZAAR oral suspension 2.5mg/1ml [M S D] CPRD_product_code res24: ACE_inhibitors drug
41417 ENALAPRIL tablets 2.5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
41522 LISINOPRIL tablets 20mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
41532 LISINOPRIL tablets 5mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
41538 LISINOPRIL tablets 2.5mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
4155 AMIAS tablets 2mg [TAKEDA] CPRD_product_code res24: ACE_inhibitors drug
41573 LISINOPRIL tablets 10mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
41617 CAPTOPRIL tablets 25mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
41633 CAPTOPRIL tablets 12.5mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
41694 ENALAPRIL tablets 2.5mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
41743 CAPTOPRIL tablets 50mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
41746 ENALAPRIL tablets 10mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
42081 TRITACE tablets 1.25mg [STERWIN] CPRD_product_code res24: ACE_inhibitors drug
4226 COZAAR tablets 25mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
42285 QUINIL tablets 40mg [TILLOMED] CPRD_product_code res24: ACE_inhibitors drug
42723 PRALENAL tablets 5mg [OPUS] CPRD_product_code res24: ACE_inhibitors drug
42894 ENALAPRIL tablets 10mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
42901 ENALAPRIL tablets 5mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
42902 ENALAPRIL tablets 20mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
42908 ENALAPRIL tablets 5mg [IVAX] CPRD_product_code res24: ACE_inhibitors drug
43012 perindopril erbumine oral liquid CPRD_product_code res24: ACE_inhibitors drug
43322 olmesartan medoxomil with hydrochlorothiazide tablets 40mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
43411 ENALAPRIL tablets 5mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
43412 LISINOPRIL tablets 2.5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
43413 LISINOPRIL tablets 20mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
43416 LISINOPRIL tablets 10mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
43418 LISINOPRIL tablets 5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
43432 captopril (roi) tablets 6.25mg CPRD_product_code res24: ACE_inhibitors drug
43507 CAPTOPRIL tablets 25mg [GEN (UK)] CPRD_product_code res24: ACE_inhibitors drug
43563 ENALAPRIL tablets 2.5mg [WINTHROP] CPRD_product_code res24: ACE_inhibitors drug
43566 LISINOPRIL tablets 2.5mg [SANDOZ] CPRD_product_code res24: ACE_inhibitors drug
43649 CAPTOPRIL tablets 25mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
43813 PERINDOPRIL tablets 2mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
43915 OLMETEC PLUS tablets 40mg + 12.5mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
44527 captopril oral solution 5mg/ml CPRD_product_code res24: ACE_inhibitors drug
44657 EDNYT tablets 2.5mg [DOMINION] CPRD_product_code res24: ACE_inhibitors drug
44778 valsartan tablets 160mg CPRD_product_code res24: ACE_inhibitors drug
448 enalapril tablets 2.5mg CPRD_product_code res24: ACE_inhibitors drug
45217 ENALAPRIL tablets 5mg [KENT] CPRD_product_code res24: ACE_inhibitors drug
45228 captopril capsules CPRD_product_code res24: ACE_inhibitors drug
45264 RAMIPRIL capsules 1.25mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
45300 LISINOPRIL tablets 10mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
45319 PERINDOPRIL tablets 2mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors drug
45324 LISINOPRIL tablets 20mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
45337 LISINOPRIL tablets 5mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
45340 RAMIPRIL capsules 10mg [ACTAVIS] CPRD_product_code res24: ACE_inhibitors drug
4540 COZAAR-COMP tablets 50mg + 12.5mg [M S D] CPRD_product_code res24: ACE_inhibitors drug
45554 ramipril oral solution 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
45600 DIOVAN tablets 160mg [NOVARTIS] CPRD_product_code res24: ACE_inhibitors drug
4571 STARIL tablets 10mg [SQUIBB] CPRD_product_code res24: ACE_inhibitors drug
45816 LISINOPRIL tablets 5mg [ALMUS] CPRD_product_code res24: ACE_inhibitors drug
45938 PERINDOPRIL tablets 8mg [TEVA] CPRD_product_code res24: ACE_inhibitors drug
46355 SEVIKAR HCT tablets 20mg + 5mg + 12.5mg [DAIIC-SANK] CPRD_product_code res24: ACE_inhibitors drug
46365 QUINIL tablets 20mg [TILLOMED] CPRD_product_code res24: ACE_inhibitors drug
4645 valsartan capsules 160mg CPRD_product_code res24: ACE_inhibitors drug
46687 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 20mg + 5mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
46715 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 10mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
46792 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 5mg + 12.5mg CPRD_product_code res24: ACE_inhibitors drug
4685 AMIAS tablets 4mg [TAKEDA] CPRD_product_code res24: ACE_inhibitors drug
46851 captopril oral solution 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
46890 ramipril oral suspension 5mg/5ml CPRD_product_code res24: ACE_inhibitors drug
46951 CAPTOPRIL tablets 12.5mg [HILLCROSS] CPRD_product_code res24: ACE_inhibitors