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Beta Blockers

David A Springate, Darren M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves

ID
PH642
Version ID
1284
Type
Drug
Data Sources
Doctors Independent Network , CPRD GOLD
Valid event data range
01/01/19997 - 31/12/2006
Sex
♀  Female ♂  Male
Agreement Date
2020-10-08
Coding system
GPRD product codes
Collections
ClinicalCodes Repository Phenotype Library
Tags
No tags

Definition

Objectives:

To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population.

Design:

Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer.

Setting:

Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN).

Participants:

CPRD data for 11 302 patients with cancer compared with published results from DIN for 3462 patients; study period January 1997 to December 2006.

Primary and secondary outcome measures:

All-cause mortality: overall; by treatment subgroup (β-blockers only, β-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer site.

Results:

Using CPRD, β-blocker use was not associated with mortality (HR=1.03, 95% CI 0.93 to 1.14, vs patients prescribed other BPLMs only), but DIN β-blocker users had significantly higher mortality (HR=1.18, 95% CI 1.04 to 1.33). However, these HRs were not statistically different (p=0.063), but did differ for patients on β-blockers alone (CPRD=0.94, 95% CI 0.82 to 1.07; DIN=1.37, 95% CI 1.16 to 1.61; p<0.001). Results for individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases.

Conclusions:

We found a complex pattern of similarities and differences between databases. Overall treatment effect estimates were not statistically different, adding to a growing body of evidence that different UK PCDs produce comparable effect estimates. However, individually the two studies lead to different conclusions regarding the safety of β-blockers and some subgroup effects differed significantly. Single studies using even internally wellvalidated databases do not guarantee generalisable results, especially for subgroups, and confirmatory studies using at least one other independent data source are strongly recommended.

Publications

  • David A Springate, Darrent M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves, Can analyses of electronic patient records be independently and externally validated? Study 2—the effect of β-adrenoceptor blocker therapy on cancer survival a retrospective cohort study. BMJ Open, 5(e007299), 2014.

Clinical Code List

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Rows: 403
Code Description Coding System (CPRD_product_code) Entity type Category
1006 HALF-INDERAL LA capsules 80mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
10191 ATENIX tablets 50mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
10294 INDERAL injection 1mg/ml [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
10429 LOPRESOR tablets 50mg [NOVARTIS] CPRD_product_code res24: beta_blockers drug
1048 INDERAL tablets 80mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
1050 INDERAL tablets 40mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
10627 CO-BETALOC tablets 100mg + 12.5mg [PHARMACIA] CPRD_product_code res24: beta_blockers drug
10716 CORGARD tablets 80mg [SANOFI/AVE] CPRD_product_code res24: beta_blockers drug
10777 TRASICOR tablets 160mg [NOVARTIS] CPRD_product_code res24: beta_blockers drug
10892 EMCOR tablets 10mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
1124 TENORETIC tablets 100mg + 25mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
11338 bendroflumethiazide with nadolol tablets 5mg + 40mg CPRD_product_code res24: beta_blockers drug
11380 SOTACOR tablets 160mg [BRISTOL] CPRD_product_code res24: beta_blockers drug
11711 propranolol oral solution 50mg/5ml CPRD_product_code res24: beta_blockers drug
11793 metoprolol tartrate suspension 50mg/5ml CPRD_product_code res24: beta_blockers drug
12037 BETIM tablets 10mg [ICN] CPRD_product_code res24: beta_blockers drug
12054 propranolol with bendroflumethiazide capsules 80mg + 2.5mg CPRD_product_code res24: beta_blockers drug
12141 betaxolol hydrochloride tablets 20mg CPRD_product_code res24: beta_blockers drug
12296 SECTRAL capsules 100mg [AVENTIS] CPRD_product_code res24: beta_blockers drug
12456 SOTAZIDE tablets [BRISTOL] CPRD_product_code res24: beta_blockers drug
12495 BERKOLOL tablets 10mg [BERK] CPRD_product_code res24: beta_blockers drug
12517 timolol maleate with bendroflumethiazide tablets 20mg + 5mg CPRD_product_code res24: beta_blockers drug
12519 KERLONE tablets 20mg [SANOFI S] CPRD_product_code res24: beta_blockers drug
12651 timolol maleate with bendroflumethiazide tablets 10mg + 2.5mg CPRD_product_code res24: beta_blockers drug
1288 TENORET tablets 50mg + 12.5mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
1290 bisoprolol tablets 10mg CPRD_product_code res24: beta_blockers drug
1295 labetalol hydrochloride tablets 400mg CPRD_product_code res24: beta_blockers drug
13051 sotalol tablets 200mg CPRD_product_code res24: beta_blockers drug
1333 oxprenolol tablets 40mg CPRD_product_code res24: beta_blockers drug
1334 oxprenolol modified release tablet 160mg CPRD_product_code res24: beta_blockers drug
13394 TENORMIN syrup 25mg/5ml [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
13415 CORGARD tablets 40mg [SANOFI/AVE] CPRD_product_code res24: beta_blockers drug
13487 BETA-CARDONE tablets 200mg [FOCUS] CPRD_product_code res24: beta_blockers drug
13499 LOPRESOR tablets 100mg [NOVARTIS] CPRD_product_code res24: beta_blockers drug
13526 ATENIXCO tablets 100mg + 25mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
13871 co-prenozide (oxprenolol and cyclopenthiazide) modified release tablet 160mg + 0.25mg CPRD_product_code res24: beta_blockers drug
14030 CARDICOR tablets 2.5mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
14057 pindolol with clopamide tablets 10mg + 5mg CPRD_product_code res24: beta_blockers drug
14058 CARDICOR tablets 1.25mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
14117 EUCARDIC tablets 3.125mg [ROCHE] CPRD_product_code res24: beta_blockers drug
14126 acebutolol hydrochloride and hydrochlorothiazide tablets 200mg + 12.5mg CPRD_product_code res24: beta_blockers drug
14146 EUCARDIC tablets 6.25mg [ROCHE] CPRD_product_code res24: beta_blockers drug
14438 CORGARETIC 80 tablets [SANOFI S] CPRD_product_code res24: beta_blockers drug
1448 propranolol modified release capsules 160mg CPRD_product_code res24: beta_blockers drug
14502 metoprolol tartrate injection 5mg/5ml CPRD_product_code res24: beta_blockers drug
14552 PROPANIX tablets 10mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
14673 pindolol tablets 15mg CPRD_product_code res24: beta_blockers drug
14808 BEDRANOL modified release capsules 80mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
15042 TOLERZIDE tablets [BMS] CPRD_product_code res24: beta_blockers drug
15117 nifedipine with atenolol capsules 20mg + 50mg CPRD_product_code res24: beta_blockers drug
15176 TOTAMOL tablets 50mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
15488 metoprolol tartrate with chlortalidone tablets CPRD_product_code res24: beta_blockers drug
15619 HALF-BETADUR CR capsules 80mg [MONMOUTH] CPRD_product_code res24: beta_blockers drug
1572 sotalol tablets 80mg CPRD_product_code res24: beta_blockers drug
15730 TOTAMOL tablets 100mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
1597 labetalol hydrochloride tablets 100mg CPRD_product_code res24: beta_blockers drug
16645 LABROCOL tablets 400mg [LAGAP] CPRD_product_code res24: beta_blockers drug
16776 CELECTOL tablets 400mg [PANTHEON] CPRD_product_code res24: beta_blockers drug
16786 chlortalidone with atenolol tablets 25mg+100mg CPRD_product_code res24: beta_blockers drug
1684 BETA-ADALAT capsules 50mg + 20mg [BAYER] CPRD_product_code res24: beta_blockers drug
17082 SYPROL oral solution 5mg/5ml [ROSEMONT] CPRD_product_code res24: beta_blockers drug
17149 MONOZIDE 10 tablets 10mg + 6.25mg [WYETH PHAR] CPRD_product_code res24: beta_blockers drug
17322 ATENIX tablets 25mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
17462 bisoprolol and hydrochlorothiazide tablets 10mg + 6.25mg CPRD_product_code res24: beta_blockers drug
17615 CARDICOR tablets 5mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
17679 sotalol injection 10mg/ml CPRD_product_code res24: beta_blockers drug
17783 SPIROPROP tablets [PHARMACIA] CPRD_product_code res24: beta_blockers drug
1788 atenolol with chlortalidone tablets 100mg+25mg CPRD_product_code res24: beta_blockers drug
18185 CARDICOR tablets 7.5mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
18287 CO-BETALOC SA tablets 200mg + 25mg [PHARMACIA] CPRD_product_code res24: beta_blockers drug
18414 EUCARDIC tablets 12.5mg [ROCHE] CPRD_product_code res24: beta_blockers drug
18743 TENBEN capsules 25mg + 1.25mg [GALEN] CPRD_product_code res24: beta_blockers drug
18950 TOTAMOL tablets 25mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
19055 chlortalidone with atenolol tablets 12.5mg+50mg CPRD_product_code res24: beta_blockers drug
19068 labetalol hydrochloride injection 5mg/ml CPRD_product_code res24: beta_blockers drug
19142 bendroflumethiazide with timolol maleate tablets 2.5mg + 10mg CPRD_product_code res24: beta_blockers drug
19172 ATENOLOL tablets 25mg [IVAX] CPRD_product_code res24: beta_blockers drug
19178 BISOPROLOL tablets 10mg [RANBAXY] CPRD_product_code res24: beta_blockers drug
19182 ATENOLOL tablets 50mg [IVAX] CPRD_product_code res24: beta_blockers drug
19191 ATENOLOL tablets 100mg [TEVA] CPRD_product_code res24: beta_blockers drug
19200 BISOPROLOL tablets 5mg [IVAX] CPRD_product_code res24: beta_blockers drug
19202 CARVEDILOL tablets 6.25mg [TEVA] CPRD_product_code res24: beta_blockers drug
19437 EUCARDIC tablets 25mg [ROCHE] CPRD_product_code res24: beta_blockers drug
197 atenolol injection 5mg/10ml CPRD_product_code res24: beta_blockers drug
19853 CARDICOR tablets 3.75mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
19858 CARDICOR tablets 10mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
19998 TRANDATE injection 100mg/20ml [FOCUS] CPRD_product_code res24: beta_blockers drug
20012 VISKEN tablets 15mg [SOVEREIGN] CPRD_product_code res24: beta_blockers drug
20082 LOPRESOR SR tablets 200mg [RECORDATI] CPRD_product_code res24: beta_blockers drug
20093 metoprolol tartrate with hydrochlorothiazide modified release tablet 200mg + 25mg CPRD_product_code res24: beta_blockers drug
20169 practolol injection 2mg/ml CPRD_product_code res24: beta_blockers drug
20468 HALF BETA-PROGRANE sustained release capsules 80mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
20502 ATENIX tablets 100mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
20728 ATENAMIN tablets 25mg [OPD] CPRD_product_code res24: beta_blockers drug
21025 PRESTIM FORTE tablets [LEO] CPRD_product_code res24: beta_blockers drug
21133 ATENAMIN tablets 50mg [OPD] CPRD_product_code res24: beta_blockers drug
21182 hydrochlorothiazide with timolol and amiloride tablets 25mg + 10mg + 2.5mg CPRD_product_code res24: beta_blockers drug
21838 PROPANIX tablets 80mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
21839 BERKOLOL tablets 80mg [BERK] CPRD_product_code res24: beta_blockers drug
21866 BERKOLOL tablets 40mg [BERK] CPRD_product_code res24: beta_blockers drug
21873 ATENIXCO tablets 50mg+12.5mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
21885 OXYPRENIX SR tablets 160mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
21905 BIPRANIX tablets 10mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
21966 BIPRANIX tablets 5mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
220 propranolol oral solution 5mg/5ml CPRD_product_code res24: beta_blockers drug
22208 HALF PROPANIX LA sustained release capsules 80mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
22793 LABROCOL tablets 200mg [LAGAP] CPRD_product_code res24: beta_blockers drug
22912 bendroflumethiazide with propranolol capsules 2.5mg + 80mg CPRD_product_code res24: beta_blockers drug
23131 bendroflumethiazide with propranolol modified release capsules 5mg + 160mg CPRD_product_code res24: beta_blockers drug
23134 nadolol with bendroflumethiazide tablets 40mg + 5mg CPRD_product_code res24: beta_blockers drug
23326 BETADUR CR sustained release capsules 160mg [MONMOUTH] CPRD_product_code res24: beta_blockers drug
23587 SLOPROLOL capsules 160mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
2361 TRASICOR tablets 80mg [NOVARTIS] CPRD_product_code res24: beta_blockers drug
24 atenolol tablets 100mg CPRD_product_code res24: beta_blockers drug
24083 BISOPROLOL tablets 5mg [TEVA] CPRD_product_code res24: beta_blockers drug
24094 TRASICOR tablets 40mg [AMDIPHARM] CPRD_product_code res24: beta_blockers drug
2414 INDERAL tablets 10mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
24191 ANTIPRESSAN tablets 50mg [BERK] CPRD_product_code res24: beta_blockers drug
24195 ANTIPRESSAN tablets 100mg [BERK] CPRD_product_code res24: beta_blockers drug
24218 BERKOLOL tablets 160mg [BERK] CPRD_product_code res24: beta_blockers drug
24280 TOTARETIC tablets 100mg+25mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
2432 TENORMIN LS tablets 50mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
24461 BETALOC IV injection 5mg/5ml [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
24635 SOTACOR injection 10mg/ml [BRISTOL] CPRD_product_code res24: beta_blockers drug
24832 LASIPRESSIN tablets [HOECHST] CPRD_product_code res24: beta_blockers drug
2499 nadolol tablets 80mg CPRD_product_code res24: beta_blockers drug
25359 RAPRANOL SR capsules 160mg [RANBAXY] CPRD_product_code res24: beta_blockers drug
25363 PRESTIM tablets [MEDA] CPRD_product_code res24: beta_blockers drug
25367 RAPRANOL SR capsules 80mg [RANBAXY] CPRD_product_code res24: beta_blockers drug
25462 clopamide with pindolol tablets 5mg + 10mg CPRD_product_code res24: beta_blockers drug
25644 APSOLOX tablets 80mg [APS] CPRD_product_code res24: beta_blockers drug
25730 timolol maleate with amiloride and hydrochlorothiazide tablets CPRD_product_code res24: beta_blockers drug
2587 TENORMIN tablets 100mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
2590 TENORMIN 25 tablets [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
26 atenolol tablets 25mg CPRD_product_code res24: beta_blockers drug
26211 ANTIPRESSAN tablets 25mg [BERK] CPRD_product_code res24: beta_blockers drug
26228 PROPANIX LA modified release capsules 160mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
26229 BETA-PROGRANE capsules 160mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
26248 TENCHLOR tablets 100mg + 25mg [BERK] CPRD_product_code res24: beta_blockers drug
26255 LOPRANOL LA capsules 160mg [OPUS] CPRD_product_code res24: beta_blockers drug
2629 carvedilol tablets 12.5mg CPRD_product_code res24: beta_blockers drug
26529 furosemide with penbutolol tablets CPRD_product_code res24: beta_blockers drug
26741 TOTARETIC tablets 50mg+12.5mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
26895 SYPROL oral solution 10mg/5ml [ROSEMONT] CPRD_product_code res24: beta_blockers drug
26922 BREVIBLOC injection 10mg/ml [BAXTER] CPRD_product_code res24: beta_blockers drug
27357 OXPRENOLOL tablets 40mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
27486 propranolol injection 1mg/ml CPRD_product_code res24: beta_blockers drug
27700 PROPRANOLOL tablets 40mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
27719 METOROS LS tablets 95mg [GEIGY] CPRD_product_code res24: beta_blockers drug
27727 sotalol injection 2mg/ml CPRD_product_code res24: beta_blockers drug
2775 labetalol hydrochloride tablets 200mg CPRD_product_code res24: beta_blockers drug
2780 oxprenolol tablets 80mg CPRD_product_code res24: beta_blockers drug
27946 nadolol with bendroflumethiazide tablets 80mg + 5mg CPRD_product_code res24: beta_blockers drug
27964 APSOLOL tablets 40mg [APS] CPRD_product_code res24: beta_blockers drug
28048 ANGILOL tablets 10mg [DDSA] CPRD_product_code res24: beta_blockers drug
28128 PROPRANOLOL sustained release capsules 80mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
28177 hydrochlorothiazide with atenolol and amiloride capsules CPRD_product_code res24: beta_blockers drug
28700 CARTROL tablets 10mg [NOVARTIS] CPRD_product_code res24: beta_blockers drug
28788 HALF PROPATARD LA modified release capsules 80mg [GALEN] CPRD_product_code res24: beta_blockers drug
28996 BEDRANOL modified release capsules 160mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
29180 TRASICOR tablets 80mg [AMDIPHARM] CPRD_product_code res24: beta_blockers drug
29230 SLOW-PREN tablets 160mg [IVAX] CPRD_product_code res24: beta_blockers drug
29368 ATENOLOL tablets 25mg [TEVA] CPRD_product_code res24: beta_blockers drug
29398 ATENAMIN tablets 100mg [OPD] CPRD_product_code res24: beta_blockers drug
29427 hydrochlorothiazide with metoprolol tartrate tablets 12.5mg + 100mg CPRD_product_code res24: beta_blockers drug
29610 BETIM tablets 10mg [MEDA] CPRD_product_code res24: beta_blockers drug
297 propranolol tablets 10mg CPRD_product_code res24: beta_blockers drug
29762 MEPRANIX tablets 50mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
29763 PROPANIX tablets 160mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
29827 carteolol hydrochloride tablets 10mg CPRD_product_code res24: beta_blockers drug
29998 METOROS tablets 190mg [NOV/GEIGY] CPRD_product_code res24: beta_blockers drug
3005 INDERAL LA capsules 160mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
30400 MEPRANIX tablets 100mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
30519 amiloride hydrochloride with timolol and hydrochlorothiazide tablets CPRD_product_code res24: beta_blockers drug
30541 esmolol hydrochloride concentrate for solution for infusion 250mg/ml CPRD_product_code res24: beta_blockers drug
30636 VASATEN tablets 50mg [SHIRE] CPRD_product_code res24: beta_blockers drug
30770 LABETALOL tablets 200mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
3087 propranolol oral solution 40mg/5ml CPRD_product_code res24: beta_blockers drug
31214 PROPRANOLOL tablets 80mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
31470 TENCHLOR tablets 50mg+12.5mg [BERK] CPRD_product_code res24: beta_blockers drug
31536 ATENOLOL tablets 25mg [KENT] CPRD_product_code res24: beta_blockers drug
3167 propranolol tablets 160mg CPRD_product_code res24: beta_blockers drug
31708 CO-TENIDONE tablets 50mg+12.5mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
31776 PROPRANOLOL tablets 40mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
31833 ANGILOL tablets 80mg [DDSA] CPRD_product_code res24: beta_blockers drug
31934 ATENOLOL tablets 100mg [IVAX] CPRD_product_code res24: beta_blockers drug
32094 CO-TENIDONE tablets 50mg+12.5mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
32114 BISOPROLOL tablets 5mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
32135 BREVIBLOC concentrate for solution for infusion 250mg/ml [BAXTER] CPRD_product_code res24: beta_blockers drug
32162 PROPRANOLOL modified release capsules 80mg [LAGAP] CPRD_product_code res24: beta_blockers drug
32552 CONGESCOR tablets 2.5mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
32630 VIVACOR tablets 10mg [LEXON] CPRD_product_code res24: beta_blockers drug
32787 VISKEN tablets 15mg [AMDIPHARM] CPRD_product_code res24: beta_blockers drug
32836 METOPROLOL tablets 50mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
33079 ATENOLOL tablets 100mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
33085 ATENOLOL tablets 100mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
33092 ATENOLOL tablets 50mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
33184 ATENOLOL tablets 100mg [WOCKHARDT] CPRD_product_code res24: beta_blockers drug
33374 CARVEDILOL tablets 12.5mg [GENUS] CPRD_product_code res24: beta_blockers drug
33376 PROBETA LA capsules 160mg [TRINITY] CPRD_product_code res24: beta_blockers drug
3344 BETALOC tablets 100mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
33569 OXPRENOLOL SR tablets 160mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
33578 SOTACOR injection 40mg/4ml [BMS] CPRD_product_code res24: beta_blockers drug
33602 SLO-PRO modified release capsules 160mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
33644 PROPRANOLOL tablets 80mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
33650 ATENOLOL tablets 50mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
33657 ATENOLOL tablets 25mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
33659 hydrochlorothiazide with metoprolol tartrate modified release tablet 25mg + 200mg CPRD_product_code res24: beta_blockers drug
33836 APSOLOL tablets 160mg [APS] CPRD_product_code res24: beta_blockers drug
33839 BISOPROLOL tablets 10mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
33850 ATENOLOL tablets 50mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
33909 CONGESCOR tablets 1.25mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
34012 CO-TENIDONE tablets 100mg+25mg [IVAX] CPRD_product_code res24: beta_blockers drug
34034 CO-TENIDONE tablets 50mg+12.5mg [IVAX] CPRD_product_code res24: beta_blockers drug
34092 METOPROLOL tablets 100mg [TEVA] CPRD_product_code res24: beta_blockers drug
34094 METOPROLOL tablets 50mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
34125 METOPROLOL tablets 100mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
34171 LABETALOL tablets 100mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
34177 LABETALOL tablets 100mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
34185 PROPRANOLOL LA modified release capsules 80mg [APS] CPRD_product_code res24: beta_blockers drug
34188 LABETALOL tablets 200mg [CELLTECH] CPRD_product_code res24: beta_blockers drug
34208 PROPRANOLOL SR capsules 160mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
34214 PROPRANOLOL tablets 160mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34265 ATENOLOL tablets 50mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
34365 ATENOLOL tablets 50mg [TEVA] CPRD_product_code res24: beta_blockers drug
34371 SOTALOL tablets 40mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
34378 PROPRANOLOL tablets 10mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
34407 METOPROLOL tablets 50mg [TEVA] CPRD_product_code res24: beta_blockers drug
34430 METOPROLOL tablets 50mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34443 ATENOLOL tablets 50mg [WOCKHARDT] CPRD_product_code res24: beta_blockers drug
34449 CO-TENIDONE tablets 50mg+12.5mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
34492 ATENOLOL tablets 25mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
34501 CARVEDILOL tablets 12.5mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34509 METOPROLOL tablets 100mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
34520 SOTALOL tablets 80mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
34575 ATENOLOL tablets 25mg [WOCKHARDT] CPRD_product_code res24: beta_blockers drug
34584 METOPROLOL tablets 50mg [IVAX] CPRD_product_code res24: beta_blockers drug
34585 ATENOLOL tablets 25mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
34600 SOTALOL tablets 40mg [TEVA] CPRD_product_code res24: beta_blockers drug
34640 SOTALOL tablets 40mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
34690 SOTALOL tablets 80mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
34695 ATENOLOL tablets 50mg [KENT] CPRD_product_code res24: beta_blockers drug
3474 BETALOC SA DURULE 200mg [ASTRAZENEC] CPRD_product_code res24: beta_blockers drug
34740 CARVEDILOL tablets 6.25mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34741 CARVEDILOL tablets 3.125mg [IVAX] CPRD_product_code res24: beta_blockers drug
34754 ATENOLOL tablets 100mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
34783 PROPRANOLOL tablets 10mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34804 PROPRANOLOL tablets 10mg [TEVA] CPRD_product_code res24: beta_blockers drug
34821 BISOPROLOL tablets 10mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
34825 CO-TENIDONE tablets 50mg+12.5mg [TEVA] CPRD_product_code res24: beta_blockers drug
34854 METOPROLOL tablets 100mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34867 PROPRANOLOL capsules 80mg [IVAX] CPRD_product_code res24: beta_blockers drug
34868 PROPRANOLOL tablets 40mg [TEVA] CPRD_product_code res24: beta_blockers drug
34882 ATENOLOL tablets 50mg [BERK] CPRD_product_code res24: beta_blockers drug
34884 PROPRANOLOL modified release capsules 160mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
34890 METOPROLOL tablets 50mg [BERK] CPRD_product_code res24: beta_blockers drug
34899 CO-TENIDONE tablets 100mg+25mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
34925 METOPROLOL tablets 50mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
34945 PROPRANOLOL sustained release capsules 160mg [LAGAP] CPRD_product_code res24: beta_blockers drug
34949 PROPRANOLOL sustained release capsules 160mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34963 BISOPROLOL tablets 5mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
34976 ATENOLOL tablets 25mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
35054 CELECTOL tablets 200mg [WINTHROP] CPRD_product_code res24: beta_blockers drug
35062 TRASICOR tablets 20mg [AMDIPHARM] CPRD_product_code res24: beta_blockers drug
3516 oxprenolol tablets 20mg CPRD_product_code res24: beta_blockers drug
3526 amiloride hydrochloride with atenolol and hydrochlorothiazide capsules CPRD_product_code res24: beta_blockers drug
35695 VISKEN tablets 5mg [AMDIPHARM] CPRD_product_code res24: beta_blockers drug
35710 sotalol oral suspension 25mg/5ml CPRD_product_code res24: beta_blockers drug
35778 LABROCOL tablets 100mg [LAGAP] CPRD_product_code res24: beta_blockers drug
3588 MONOCOR tablets 5mg [WYETH PHAR] CPRD_product_code res24: beta_blockers drug
35938 PROPRANOLOL SR capsules 80mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
35940 CELECTOL tablets 400mg [WINTHROP] CPRD_product_code res24: beta_blockers drug
36261 ATENOLOL tablets 50mg [TILLOMED] CPRD_product_code res24: beta_blockers drug
36576 PROPRANOLOL tablets 10mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
36603 PROPRANOLOL SR capsules 160mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
3691 sotalol with hydrochlorothiazide tablets 160mg + 25mg CPRD_product_code res24: beta_blockers drug
37118 BISOPROLOL tablets 2.5mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
3748 oxprenolol tablets 160mg CPRD_product_code res24: beta_blockers drug
37725 CO-TENIDONE tablets 100mg+25mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
37837 BISOPROLOL tablets 2.5mg [TEVA] CPRD_product_code res24: beta_blockers drug
3827 PROPANIX tablets 40mg [ASHBOURNE] CPRD_product_code res24: beta_blockers drug
38370 labetalol hydrochloride injection 100mg/20ml CPRD_product_code res24: beta_blockers drug
38433 PROPRANOLOL oral solution 50mg/5ml [ROSEMONT] CPRD_product_code res24: beta_blockers drug
38498 sotalol injection 40mg/4ml CPRD_product_code res24: beta_blockers drug
38991 BISOPROLOL tablets 7.5mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
39233 PROPRANOLOL SR capsules 80mg [TEVA] CPRD_product_code res24: beta_blockers drug
39423 SOTALOL tablets 80mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
39646 bisoprolol oral liquid 0.625mg/5ml CPRD_product_code res24: beta_blockers drug
39819 esmolol hydrochloride solution for infusion 2500mg/250ml CPRD_product_code res24: beta_blockers drug
39846 VIVACOR tablets 5mg [LEXON] CPRD_product_code res24: beta_blockers drug
4004 SOTACOR tablets 80mg [BRISTOL] CPRD_product_code res24: beta_blockers drug
40167 METOPROLOL tablets 100mg [IVAX] CPRD_product_code res24: beta_blockers drug
40240 LABETALOL tablets 400mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
40241 PROPRANOLOL LA capsules 160mg [APS] CPRD_product_code res24: beta_blockers drug
4025 SLOW TRASICOR sustained release tablets 160mg [AMDIPHARM] CPRD_product_code res24: beta_blockers drug
40761 nebivolol tablets 2.5mg CPRD_product_code res24: beta_blockers drug
41555 PROPRANOLOL tablets 40mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
41572 CO-TENIDONE tablets 100mg+25mg [TEVA] CPRD_product_code res24: beta_blockers drug
41591 BISOPROLOL tablets 10mg [TEVA] CPRD_product_code res24: beta_blockers drug
41740 CELIPROLOL tablets 200mg [TEVA] CPRD_product_code res24: beta_blockers drug
41827 LABETALOL tablets 100mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
42152 SYPROL oral solution 50mg/5ml [ROSEMONT] CPRD_product_code res24: beta_blockers drug
4265 CELECTOL tablets 200mg [PANTHEON] CPRD_product_code res24: beta_blockers drug
42795 CELIPROLOL tablets 200mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
43251 BISOPROLOL tablets 1.25mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
43525 PROPRANOLOL tablets 10mg [IVAX] CPRD_product_code res24: beta_blockers drug
43549 SOTALOL tablets 40mg [IVAX] CPRD_product_code res24: beta_blockers drug
43564 BISOPROLOL tablets 5mg [PLIVA] CPRD_product_code res24: beta_blockers drug
44000 bisoprolol oral suspension 2.5mg/5ml CPRD_product_code res24: beta_blockers drug
44083 LABETALOL tablets 200mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
4410 carvedilol tablets 6.25mg CPRD_product_code res24: beta_blockers drug
4429 TRASIDREX tablets [GOLDSHIELD] CPRD_product_code res24: beta_blockers drug
44808 NEBIVOLOL tablets 2.5mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
44858 ATENOLOL tablets 25mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
45250 LABETALOL tablets 400mg [SANDOZ] CPRD_product_code res24: beta_blockers drug
45289 metoprolol tartrate oral liquid CPRD_product_code res24: beta_blockers drug
45297 PROPRANOLOL tablets 40mg [IVAX] CPRD_product_code res24: beta_blockers drug
45309 ACEBUTOLOL tablets 400mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
45343 PROPRANOLOL SR capsules 80mg [CP PHARM] CPRD_product_code res24: beta_blockers drug
4542 atenolol with nifedipine capsules 50mg + 20mg CPRD_product_code res24: beta_blockers drug
45494 PROPRANOLOL tablets 10mg [ALMUS] CPRD_product_code res24: beta_blockers drug
45765 SYPROL oral solution 40mg/5ml [ROSEMONT] CPRD_product_code res24: beta_blockers drug
45877 BETA-PROGRANE capsules 160mg [TEVA] CPRD_product_code res24: beta_blockers drug
4588 VISKEN tablets 5mg [SOVEREIGN] CPRD_product_code res24: beta_blockers drug
4605 MODUCREN tablets [M S D] CPRD_product_code res24: beta_blockers drug
46363 HALF BETA-PROGRANE sustained release capsules 80mg [TEVA] CPRD_product_code res24: beta_blockers drug
46614 LOPRESOR tablets 50mg [RECORDATI] CPRD_product_code res24: beta_blockers drug
46740 LOPRESOR tablets 100mg [RECORDATI] CPRD_product_code res24: beta_blockers drug
46908 ATENOLOL tablets 100mg [KENT] CPRD_product_code res24: beta_blockers drug
46931 ATENOLOL tablets 100mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
46935 CARVEDILOL tablets 3.125mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
46936 CARVEDILOL tablets 3.125mg [HILLCROSS] CPRD_product_code res24: beta_blockers drug
46952 CO-TENIDONE tablets 100mg+25mg [ACTAVIS] CPRD_product_code res24: beta_blockers drug
47041 BISOPROLOL tablets 2.5mg [GEN (UK)] CPRD_product_code res24: beta_blockers drug
47107 carvedilol oral suspension 5mg/5ml CPRD_product_code res24: beta_blockers drug
472 bisoprolol tablets 5mg CPRD_product_code res24: beta_blockers drug
4725 labetalol hydrochloride tablets 50mg CPRD_product_code res24: beta_blockers drug
47300 NEBIVOLOL tablets 2.5mg [GLENMARK] CPRD_product_code res24: beta_blockers drug
4771 EMCOR LS tablets 5mg [MERCK SER] CPRD_product_code res24: beta_blockers drug
4796 INDERETIC capsules [ASTRAZENEC] CPRD_product_code res24: beta_blockers