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Ca Channel Blocker

David A Springate, Darren M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves

ID
PH644
Version ID
1288
Type
Drug
Data Sources
Doctors Independent Network , CPRD GOLD
Valid event data range
01/01/19997 - 31/12/2006
Sex
♀  Female ♂  Male
Agreement Date
2020-10-08
Coding system
GPRD product codes
Collections
ClinicalCodes Repository Phenotype Library
Tags
No tags

Definition

Objectives:

To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population.

Design:

Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer.

Setting:

Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN).

Participants:

CPRD data for 11 302 patients with cancer compared with published results from DIN for 3462 patients; study period January 1997 to December 2006.

Primary and secondary outcome measures:

All-cause mortality: overall; by treatment subgroup (β-blockers only, β-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer site.

Results:

Using CPRD, β-blocker use was not associated with mortality (HR=1.03, 95% CI 0.93 to 1.14, vs patients prescribed other BPLMs only), but DIN β-blocker users had significantly higher mortality (HR=1.18, 95% CI 1.04 to 1.33). However, these HRs were not statistically different (p=0.063), but did differ for patients on β-blockers alone (CPRD=0.94, 95% CI 0.82 to 1.07; DIN=1.37, 95% CI 1.16 to 1.61; p<0.001). Results for individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases.

Conclusions:

We found a complex pattern of similarities and differences between databases. Overall treatment effect estimates were not statistically different, adding to a growing body of evidence that different UK PCDs produce comparable effect estimates. However, individually the two studies lead to different conclusions regarding the safety of β-blockers and some subgroup effects differed significantly. Single studies using even internally wellvalidated databases do not guarantee generalisable results, especially for subgroups, and confirmatory studies using at least one other independent data source are strongly recommended.

Publications

  • David A Springate, Darrent M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves, Can analyses of electronic patient records be independently and externally validated? Study 2—the effect of β-adrenoceptor blocker therapy on cancer survival a retrospective cohort study. BMJ Open, 5(e007299), 2014.

Clinical Code List

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Rows: 443
Code Description Coding System (CPRD_product_code) Entity type Category
10135 NIFEDIPRESS MR modified release tablet 10mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
10136 NIFEDIPRESS MR modified release tablet 20mg [DEXCEL] CPRD_product_code res24: ca_channel_blockers drug
10153 FELENDIL XL modified release tablet 5mg [RATIOPHARM] CPRD_product_code res24: ca_channel_blockers drug
10246 ADIPINE XL tablets 60mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
10267 ADIZEM XL capsules 200mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
10595 NIMOTOP tablets 30mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
10688 verapamil hydrochloride tablets 160mg CPRD_product_code res24: ca_channel_blockers drug
10832 SECURON tablets 80mg [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
1118 verapamil hydrochloride tablets 40mg CPRD_product_code res24: ca_channel_blockers drug
1120 verapamil hydrochloride tablets 80mg CPRD_product_code res24: ca_channel_blockers drug
11223 ANGITIL SR capsules 90mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
1130 VIAZEM XL capsules 300mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
11512 NIFEDIPRESS MR modified release tablet 10mg [DEXCEL] CPRD_product_code res24: ca_channel_blockers drug
11547 nimodipine tablets 30mg CPRD_product_code res24: ca_channel_blockers drug
11567 ramipril with felodipine modified release tablet 5mg + 5mg CPRD_product_code res24: ca_channel_blockers drug
11769 CALCHAN MR tablets 20mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
11770 DILZEM SR capsules 60mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
11777 verapamil hydrochloride sugar free solution 40mg/5ml CPRD_product_code res24: ca_channel_blockers drug
11922 diltiazem oral suspension 60mg/5ml CPRD_product_code res24: ca_channel_blockers drug
11943 CARDENE capsules 20mg [ASTELLAS] CPRD_product_code res24: ca_channel_blockers drug
11965 ramipril with felodipine modified release tablet 2.5mg + 2.5mg CPRD_product_code res24: ca_channel_blockers drug
11966 MOTENS tablets 2mg [BOEH INGL] CPRD_product_code res24: ca_channel_blockers drug
11972 VERTAB SR tablets 240mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
11973 CALCICARD CR controlled release tablet 120mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
12104 CORDILOX tablets 160mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
12392 UNIVER sustained release capsules 180mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
12606 NIFELEASE modified release tablet 20mg [EASTERN] CPRD_product_code res24: ca_channel_blockers drug
12613 UNIPINE XL modified release tablet 30mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
1262 nifedipine 12 hour modified release tablets 20mg CPRD_product_code res24: ca_channel_blockers drug
12639 DILTIAZEM HYDROCHLORIDE modified release tablet 90mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
12705 ANGIOZEM CR slow-release tablets 90mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
12875 CARDENE SR capsules 45mg [ASTELLAS] CPRD_product_code res24: ca_channel_blockers drug
1289 TILDIEM RETARD tablets 120mg [SANOFI/AVE] CPRD_product_code res24: ca_channel_blockers drug
1298 verapamil hydrochloride modified release tablet 240mg CPRD_product_code res24: ca_channel_blockers drug
1300 NIFENSAR XL sustained release tablets 20mg [RHONE] CPRD_product_code res24: ca_channel_blockers drug
13027 VIAZEM XL capsules 240mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
13033 ANGITIL XL capsules 240mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
13075 DILZEM XL capsules 180mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
13127 DILZEM XL capsules 240mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
13139 ADIPINE XL tablets 30mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
13240 DILZEM XL capsules 120mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
13243 lercanidipine hydrochloride tablets 20mg CPRD_product_code res24: ca_channel_blockers drug
13251 VERA-TIL SR tablets 240mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
13302 DILZEM SR capsules 90mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
13410 ANGIOZEM tablets 60mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
13672 ANGIOPINE MR modified release tablet 10mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
13699 ANGIOPINE LA tablets 40mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
13856 VERAPRESS MR tablets 240mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
13926 diltiazem 24 hour modified release capsules 360mg CPRD_product_code res24: ca_channel_blockers drug
13965 CORDILOX MR tablets 240mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
14300 ZANIDIP tablets 20mg [RECORDATI] CPRD_product_code res24: ca_channel_blockers drug
14305 VASCALPHA prolonged release tablet 10mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
1449 nifedipine 24 hour modified release tablets 30mg CPRD_product_code res24: ca_channel_blockers drug
14861 CALCHAN MR tablets 10mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
15117 nifedipine with atenolol capsules 20mg + 50mg CPRD_product_code res24: ca_channel_blockers drug
15221 DILCARDIA XL modified release capsules 180mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
15288 ANGITIL XL capsules 300mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
1529 POSICOR tablets 50mg [ROCHE] CPRD_product_code res24: ca_channel_blockers drug
1538 diltiazem tablets 60mg CPRD_product_code res24: ca_channel_blockers drug
15652 mibefradil tablets 50mg CPRD_product_code res24: ca_channel_blockers drug
15715 GENALAT RETARD modified release tablet 20mg [WYETH PHAR] CPRD_product_code res24: ca_channel_blockers drug
1574 verapamil hydrochloride modified release capsules 120mg CPRD_product_code res24: ca_channel_blockers drug
16038 DILZEM SR capsules 120mg [CEPHALON] CPRD_product_code res24: ca_channel_blockers drug
16073 NIFEDIPRESS MR modified release tablet 10mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
16162 amlodipine oral suspension 5mg/5ml CPRD_product_code res24: ca_channel_blockers drug
16328 VERAPRESS modified release tablet 240mg [DEXCEL] CPRD_product_code res24: ca_channel_blockers drug
16677 CORDILOX tablets 80mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
1684 BETA-ADALAT capsules 50mg + 20mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
16850 ANGIOZEM CR slow-release tablets 120mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
1686 diltiazem 12 hour modified release capsules 90mg CPRD_product_code res24: ca_channel_blockers drug
17006 TRIAPIN modified release tablet 5mg + 5mg [AVENTIS] CPRD_product_code res24: ca_channel_blockers drug
17325 CARDILATE MR tablets 10mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
17338 NIFEDOTARD 20 MR modified release tablet 20mg [GALEN] CPRD_product_code res24: ca_channel_blockers drug
17342 NIVATEN RETARD modified release tablet 10mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
17406 ZEMTARD XL capsules 180mg [GALEN] CPRD_product_code res24: ca_channel_blockers drug
17425 ZEMTARD XL capsules 120mg [GALEN] CPRD_product_code res24: ca_channel_blockers drug
17448 NIFEDIPRESS MR modified release tablet 10mg [STERWIN] CPRD_product_code res24: ca_channel_blockers drug
1747 verapamil hydrochloride tablets 120mg CPRD_product_code res24: ca_channel_blockers drug
17474 felodipine with ramipril modified release tablet 5mg + 5mg CPRD_product_code res24: ca_channel_blockers drug
1748 CORDILOX tablets 120mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
17492 ZEMTARD XL capsules 300mg [GALEN] CPRD_product_code res24: ca_channel_blockers drug
17557 FELOTENS XL tablets 5mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
17566 FELOTENS XL tablets 10mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
17586 SLOZEM capsules 300mg [MERCK SER] CPRD_product_code res24: ca_channel_blockers drug
17599 VERAPRESS MR tablets 240mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
17640 AMLOSTIN tablets 5mg [DISCOVERY] CPRD_product_code res24: ca_channel_blockers drug
17666 VIAZEM XL capsules 180mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
18038 nisoldipine modified release tablet 20mg CPRD_product_code res24: ca_channel_blockers drug
18223 trandolapril with verapamil modified release capsules 2mg + 180mg CPRD_product_code res24: ca_channel_blockers drug
1836 diltiazem 8 hour modified release tablets 60mg CPRD_product_code res24: ca_channel_blockers drug
18379 DILCARDIA SR modified release capsules 90mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
18403 DILTIAZEM HYDROCHLORIDE modified release capsules 180mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
18404 DILTIAZEM HYDROCHLORIDE SR capsules 60mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
1854 ADALAT LA tablets 30mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
18606 diltiazem and hydrochlorothiazide modified release capsules 150mg + 12.5mg CPRD_product_code res24: ca_channel_blockers drug
18830 DISOGRAM SR capsules 90mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
18834 DISOGRAM SR capsules 60mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
18852 DISOGRAM SR capsules 120mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
18874 DISOGRAM SR capsules 180mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
18975 CALCICARD tablets 60mg [3M] CPRD_product_code res24: ca_channel_blockers drug
19013 CLINIUM tablets 120mg [LEO] CPRD_product_code res24: ca_channel_blockers drug
19129 SYSCOR MR modified release tablet 10mg [FOREST] CPRD_product_code res24: ca_channel_blockers drug
19170 TENSIPINE MR tablets 10mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
19175 VERAPAMIL HYDROCHLORIDE tablets 40mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
19325 CORDILOX injection 2.5mg/ml [IVAX] CPRD_product_code res24: ca_channel_blockers drug
19426 DISOGRAM SR capsules 240mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
19440 DISOGRAM SR capsules 300mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
19457 RANVERA MR tablets 240mg [RANBAXY] CPRD_product_code res24: ca_channel_blockers drug
19459 VERAPAMIL HYDROCHLORIDE modified release tablet 240mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
19690 verapamil hydrochloride with trandolapril modified release capsules 180mg + 2mg CPRD_product_code res24: ca_channel_blockers drug
1995 diltiazem 12 hour modified release capsules 120mg CPRD_product_code res24: ca_channel_blockers drug
20257 CARDILATE MR tablets 20mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
20311 NIFEDIPRESS MR modified release tablet 20mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
20459 FELENDIL XL modified release tablet 10mg [RATIOPHARM] CPRD_product_code res24: ca_channel_blockers drug
20579 TARKA capsules 180mg + 2mg [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
20591 NIFEDIPRESS MR modified release tablet 20mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
20642 BI-CARZEM SR capsules 60mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
20878 ANGIOPINE capsules 10mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
20890 ZEMTARD XL capsules 240mg [GALEN] CPRD_product_code res24: ca_channel_blockers drug
21145 DILCARDIA SR modified release capsules 60mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
21162 felodipine with ramipril modified release tablet 2.5mg + 2.5mg CPRD_product_code res24: ca_channel_blockers drug
21216 HYPOLAR RETARD-10 modified release tablet 10mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
21245 NIFEDIPRESS MR modified release tablet 10mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
21763 DILTIAZEM HYDROCHLORIDE tablets 60mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
21773 DILTIAZEM HYDROCHLORIDE tablets 60mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
21778 DILTIAZEM HYDROCHLORIDE tablets 60mg [APS] CPRD_product_code res24: ca_channel_blockers drug
21795 RETALZEM modified release tablet 60mg [KENT] CPRD_product_code res24: ca_channel_blockers drug
21872 ANGIOPINE capsules 5mg [ASHBOURNE] CPRD_product_code res24: ca_channel_blockers drug
21886 NIFEDIPRESS MR modified release tablet 20mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
219 diltiazem 12 hour modified release tablets 120mg CPRD_product_code res24: ca_channel_blockers drug
21918 OPTIL modified release tablet 60mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
22019 CALANIF capsules 10mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
22142 CALCILAT capsules 10mg [EASTERN] CPRD_product_code res24: ca_channel_blockers drug
22217 NIMODREL MR tablets 10mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
22241 mibefradil tablets 100mg CPRD_product_code res24: ca_channel_blockers drug
22619 BRITIAZIM modified release tablet 60mg [THAMES] CPRD_product_code res24: ca_channel_blockers drug
22696 SLOFEDIPINE SR modified release tablet 20mg [STERWIN] CPRD_product_code res24: ca_channel_blockers drug
2280 ADALAT RETARD tablets 10mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
22826 SECURON tablets 160mg [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
23233 BI-CARZEM SR capsules 90mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
2343 ADALAT RETARD tablets 20mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
23505 ADIZEM XL PLUS controlled release capsules 150mg + 12.5mg [NAPP] CPRD_product_code res24: ca_channel_blockers drug
23733 OPTIL SR sustained release capsules 90mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
23736 HYPOLAR XL extra modified release tablet 30mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
23805 nisoldipine modified release tablet 10mg CPRD_product_code res24: ca_channel_blockers drug
23823 nisoldipine modified release tablet 30mg CPRD_product_code res24: ca_channel_blockers drug
23872 BERKATENS tablets 40mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
24228 NIMODREL MR tablets 20mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
24365 CARDIOPLEN XL tablets 5mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
24366 CARDIOPLEN XL tablets 10mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
2453 diltiazem modified release capsules 60mg CPRD_product_code res24: ca_channel_blockers drug
25059 BERKATENS tablets 80mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
25132 NIFOPRESS MR tablets 20mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
2521 ADALAT capsules 10mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
2528 SLOZEM capsules 120mg [MERCK SER] CPRD_product_code res24: ca_channel_blockers drug
25572 FELOGEN XL tablets 5mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
25646 NIVATEN RETARD modified release tablet 20mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
25777 DILCARDIA SR modified release capsules 120mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
25919 NIFEDIPINE modified release tablet 20mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
2592 VIAZEM XL capsules 120mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
2605 nifedipine 12 hour modified release capsules 10mg CPRD_product_code res24: ca_channel_blockers drug
26252 BERKATENS tablets 160mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
26265 CALANIF capsules 5mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
26267 OPTIL SR sustained release capsules 120mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
26269 OPTIL SR sustained release capsules 180mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
26270 OPTIL XL extra sustained release capsules 300mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
26309 OPTIL XL extra sustained release capsules 240mg [OPUS] CPRD_product_code res24: ca_channel_blockers drug
26337 CABREN SR tablets 10mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
26460 DILCARDIA XL modified release capsules 240mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
26463 ZEMRET XL capsules 240mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
2663 diltiazem modified release capsules 240mg CPRD_product_code res24: ca_channel_blockers drug
26674 verapamil hydrochloride injection 5mg/2ml CPRD_product_code res24: ca_channel_blockers drug
26759 ZILDIL SR modified release capsules 60mg [CHANELLE] CPRD_product_code res24: ca_channel_blockers drug
26774 nifedipine oral suspension 10mg/5ml CPRD_product_code res24: ca_channel_blockers drug
2686 DILZEM XL MR capsules 240mg [ELANPHARMA] CPRD_product_code res24: ca_channel_blockers drug
269 nifedipine capsules 5mg CPRD_product_code res24: ca_channel_blockers drug
27135 DILTIAZEM SR capsules 90mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
27136 DILTIAZEM HYDROCHLORIDE modified release tablet 90mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
27295 SECURON IV injection 5mg/2ml [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
27401 KENZEM SR capsules 90mg [KENT] CPRD_product_code res24: ca_channel_blockers drug
2746 CORACTEN SR modified release capsules 10mg [UCB] CPRD_product_code res24: ca_channel_blockers drug
27685 DILTIAZEM HYDROCHLORIDE XL capsules 300mg [PLIVA] CPRD_product_code res24: ca_channel_blockers drug
2811 ADIZEM SR capsules 180mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
28438 TRIAPIN MITE modified release tablet 2.5mg + 2.5mg [AVENTIS] CPRD_product_code res24: ca_channel_blockers drug
28688 NIFEDIPINE modified release tablet 10mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
28721 NEOFEL XL tablets 5mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
28843 VERAPAMIL HYDROCHLORIDE tablets 80mg [CELLTECH] CPRD_product_code res24: ca_channel_blockers drug
28844 BERKATENS tablets 120mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
2888 TILDIEM modified release tablet 60mg [SANOFI/AVE] CPRD_product_code res24: ca_channel_blockers drug
28949 BI-CARZEM SR capsules 120mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
29 amlodipine (as besilate) tablets 5mg CPRD_product_code res24: ca_channel_blockers drug
29044 NEOFEL XL tablets 10mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
29145 FELENDIL XL modified release tablet 2.5mg [RATIOPHARM] CPRD_product_code res24: ca_channel_blockers drug
2926 nicardipine hydrochloride capsules 20mg CPRD_product_code res24: ca_channel_blockers drug
29637 VERAPRESS MR tablets 240mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
29676 CALAZEM modified release tablet 60mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
30197 diltiazem modified release capsules 120mg CPRD_product_code res24: ca_channel_blockers drug
30199 nifedipine modified release tablet 30mg CPRD_product_code res24: ca_channel_blockers drug
30242 diltiazem modified release capsules 180mg CPRD_product_code res24: ca_channel_blockers drug
30462 ETHIMIL modified release tablet 240mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
30473 CORODAY modified release tablet 20mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
30557 FELOGEN XL tablets 10mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
3057 SECURON tablets 120mg [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
3061 diltiazem 12 hour modified release capsules 180mg CPRD_product_code res24: ca_channel_blockers drug
30758 lidoflazine tablets 120mg CPRD_product_code res24: ca_channel_blockers drug
30915 CABREN SR tablets 2.5mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
30991 CABREN SR tablets 5mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
3118 ADIZEM SR capsules 90mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
31336 SYSCOR MR modified release tablet 30mg [FOREST] CPRD_product_code res24: ca_channel_blockers drug
31337 SYSCOR MR modified release tablet 20mg [FOREST] CPRD_product_code res24: ca_channel_blockers drug
31489 BI-CARZEM XL capsules 240mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
31490 ZOLVERA oral solution 40mg/5ml [ROSEMONT] CPRD_product_code res24: ca_channel_blockers drug
31676 DILTIAZEM HYDROCHLORIDE modified release tablet 120mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
31711 VERAPAMIL HYDROCHLORIDE tablets 80mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
31737 ZILDIL SR modified release capsules 120mg [CHANELLE] CPRD_product_code res24: ca_channel_blockers drug
31761 AMLOSTIN tablets 10mg [DISCOVERY] CPRD_product_code res24: ca_channel_blockers drug
32089 DILTIAZEM HYDROCHLORIDE SR capsules 120mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
3221 lacidipine tablets 4mg CPRD_product_code res24: ca_channel_blockers drug
32262 DILTIAZEM HYDROCHLORIDE tablets 60mg [CP PHARM] CPRD_product_code res24: ca_channel_blockers drug
32590 VERAPAMIL HYDROCHLORIDE tablets 40mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
32595 AMLODIPINE tablets 5mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
32658 DILCARDIA XL modified release capsules 120mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
32870 DILTIAZEM HYDROCHLORIDE tablets 60mg [STERWIN] CPRD_product_code res24: ca_channel_blockers drug
32917 AMLODIPINE tablets 5mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
32922 FELODIPINE modified release tablet 10mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
3302 CARDENE SR capsules 30mg [ASTELLAS] CPRD_product_code res24: ca_channel_blockers drug
33025 NIMODREL XL tablets 30mg [ZURICH] CPRD_product_code res24: ca_channel_blockers drug
33091 FELODIPINE modified release tablet 10mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
3342 SECURON SR tablets 240mg [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
3343 HALF SECURON SR tablets 120mg [ABBOTT] CPRD_product_code res24: ca_channel_blockers drug
33471 VERAPAMIL HYDROCHLORIDE tablets 40mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
3370 DILZEM XL MR capsules 120mg [ELANPHARMA] CPRD_product_code res24: ca_channel_blockers drug
33932 PARMID XL tablets 5mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
34093 AMLODIPINE tablets 10mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
34101 NIFEDIPINE MR modified release tablet 20mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
34115 nifedipine modified release tablet 60mg CPRD_product_code res24: ca_channel_blockers drug
34146 NIFEDIPINE MR modified release tablet 10mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
34187 NIFEDIPINE modified release tablet 10mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
34247 NIFEDIPINE capsules 10mg [BERK] CPRD_product_code res24: ca_channel_blockers drug
34377 DILTIAZEM HYDROCHLORIDE SR capsules 90mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
34475 DILTIAZEM HYDROCHLORIDE modified release tablet 90mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
34522 NIFEDIPINE capsules 5mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
34581 DILTIAZEM HYDROCHLORIDE modified release tablet 60mg [KENT] CPRD_product_code res24: ca_channel_blockers drug
34607 NIFEDIPINE capsules 5mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
34824 DILTIAZEM HYDROCHLORIDE modified release tablet 120mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
34959 VERAPAMIL HYDROCHLORIDE tablets 40mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
34975 NIFEDIPINE capsules 5mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
35084 VASCALPHA prolonged release tablet 5mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
35096 EXFORGE tablets 10mg + 160mg [NOVARTIS] CPRD_product_code res24: ca_channel_blockers drug
35173 valsartan with amlodipine tablets 160mg + 5mg CPRD_product_code res24: ca_channel_blockers drug
35174 valsartan with amlodipine tablets 80mg + 5mg CPRD_product_code res24: ca_channel_blockers drug
35189 amlodipine with valsartan tablets 10mg + 160mg CPRD_product_code res24: ca_channel_blockers drug
35304 valsartan with amlodipine tablets 160mg + 10mg CPRD_product_code res24: ca_channel_blockers drug
35317 EXFORGE tablets 5mg + 80mg [NOVARTIS] CPRD_product_code res24: ca_channel_blockers drug
35329 amlodipine with valsartan tablets 5mg + 80mg CPRD_product_code res24: ca_channel_blockers drug
35343 amlodipine with valsartan tablets 5mg + 160mg CPRD_product_code res24: ca_channel_blockers drug
35592 CARDIOPLEN XL tablets 2.5mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
35646 NEOZIPINE XL tablets 60mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
35696 KENZEM SR capsules 120mg [KENT] CPRD_product_code res24: ca_channel_blockers drug
35697 EXFORGE tablets 5mg + 160mg [NOVARTIS] CPRD_product_code res24: ca_channel_blockers drug
35729 VERAPAMIL HYDROCHLORIDE tablets 80mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
36202 AMLODIPINE tablets 10mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
36583 ZEMRET XL capsules 180mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
36620 PARMID XL tablets 10mg [SANDOZ] CPRD_product_code res24: ca_channel_blockers drug
36664 ZEMRET XL capsules 300mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
3676 DILZEM XL MR capsules 180mg [ELANPHARMA] CPRD_product_code res24: ca_channel_blockers drug
37025 nifedipine modified release tablet 20mg CPRD_product_code res24: ca_channel_blockers drug
3711 ADIPINE MR 20 modified release tablet 20mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
3712 CORACTEN XL modified release capsules 30mg [UCB] CPRD_product_code res24: ca_channel_blockers drug
37184 VALNI XL tablets 30mg [WINTHROP] CPRD_product_code res24: ca_channel_blockers drug
37530 NEOZIPINE XL tablets 30mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
37726 nifedipine oral suspension 100mg/5ml CPRD_product_code res24: ca_channel_blockers drug
37774 KENZEM SR capsules 60mg [KENT] CPRD_product_code res24: ca_channel_blockers drug
37897 FELOTENS XL tablets 2.5mg [GENUS] CPRD_product_code res24: ca_channel_blockers drug
38066 DILTIAZEM HYDROCHLORIDE modified release tablet 60mg [LAGAP] CPRD_product_code res24: ca_channel_blockers drug
38107 NIFEDIPINE SR tablets 30mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
38434 KELOC SR tablets 10mg [APS] CPRD_product_code res24: ca_channel_blockers drug
38545 TILDIEM LA capsules 200mg [SANOFI/AVE] CPRD_product_code res24: ca_channel_blockers drug
38632 ADIZEM SR capsules 90mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38634 ADIZEM XL capsules 300mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38818 ADIZEM SR capsules 120mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38831 ADIZEM SR capsules 180mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38855 ADIZEM XL capsules 180mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38865 ADIZEM XL capsules 120mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38876 TILDIEM LA capsules 300mg [SANOFI/AVE] CPRD_product_code res24: ca_channel_blockers drug
38882 ADIZEM XL capsules 240mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
38964 ADIZEM SR tablets 120mg [NAPPPHARM] CPRD_product_code res24: ca_channel_blockers drug
39009 VERAPAMIL HYDROCHLORIDE tablets 40mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
3917 ISTIN tablets 5mg [PFIZER] CPRD_product_code res24: ca_channel_blockers drug
39171 BI-CARZEM SR capsules 60mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
39298 BI-CARZEM SR capsules 90mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
3930 nifedipine 24 hour modified release tablets 60mg CPRD_product_code res24: ca_channel_blockers drug
3931 POSICOR tablets 100mg [ROCHE] CPRD_product_code res24: ca_channel_blockers drug
39357 NEOFEL XL tablets 2.5mg [NEOLAB] CPRD_product_code res24: ca_channel_blockers drug
3943 verapamil hydrochloride modified release capsules 240mg CPRD_product_code res24: ca_channel_blockers drug
39800 VALNI XL tablets 60mg [WINTHROP] CPRD_product_code res24: ca_channel_blockers drug
39804 AMLODIPINE tablets 5mg [DR REDDY`S] CPRD_product_code res24: ca_channel_blockers drug
39914 AMLODIPINE tablets 5mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
39984 SEVIKAR film coated tablets 20mg + 5mg [DAIIC-SANK] CPRD_product_code res24: ca_channel_blockers drug
40074 nifedipine capsules 20mg CPRD_product_code res24: ca_channel_blockers drug
40316 olmesartan medoxomil with amlodipine tablets 20mg + 5mg CPRD_product_code res24: ca_channel_blockers drug
40405 VERAPAMIL HYDROCHLORIDE tablets 120mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
40633 VASCALPHA prolonged release tablet 5mg [ALMUS] CPRD_product_code res24: ca_channel_blockers drug
40639 olmesartan medoxomil with amlodipine tablets 40mg + 5mg CPRD_product_code res24: ca_channel_blockers drug
40668 olmesartan medoxomil with amlodipine tablets 40mg + 10mg CPRD_product_code res24: ca_channel_blockers drug
410 nifedipine 12 hour modified release tablets 10mg CPRD_product_code res24: ca_channel_blockers drug
41203 SEVIKAR film coated tablets 40mg + 10mg [DAIIC-SANK] CPRD_product_code res24: ca_channel_blockers drug
41205 SEVIKAR film coated tablets 40mg + 5mg [DAIIC-SANK] CPRD_product_code res24: ca_channel_blockers drug
41489 BI-CARZEM SR capsules 120mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
41586 VERAPAMIL HYDROCHLORIDE tablets 80mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
41635 DILTIAZEM HYDROCHLORIDE tablets 60mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
41679 VERAPAMIL HYDROCHLORIDE tablets 80mg [IVAX] CPRD_product_code res24: ca_channel_blockers drug
41693 VERAPAMIL HYDROCHLORIDE tablets 120mg [GEN (UK)] CPRD_product_code res24: ca_channel_blockers drug
41979 ADIPINE LA extra modified release tablet 30mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
42210 AMLODIPINE tablets 10mg [WINTHROP] CPRD_product_code res24: ca_channel_blockers drug
4227 ADALAT LA tablets 60mg [BAYER] CPRD_product_code res24: ca_channel_blockers drug
4239 ADIPINE MR 10 modified release tablet 10mg [CHIESI] CPRD_product_code res24: ca_channel_blockers drug
42625 VERA-TIL SR tablets 120mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
42731 DILTIAZEM SR capsules 120mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
42804 DILTIAZEM HYDROCHLORIDE XL capsules 180mg [PLIVA] CPRD_product_code res24: ca_channel_blockers drug
42819 DILTIAZEM XL capsules 240mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
42912 NIFEDIPINE capsules 10mg [TEVA] CPRD_product_code res24: ca_channel_blockers drug
4308 DILZEM SR capsules 90mg [ELANPHARMA] CPRD_product_code res24: ca_channel_blockers drug
43222 VALNI RETARD tablets 20mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
43394 PINEFELD XL tablets 10mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
43410 nifedipine extra modified release tablet 60mg CPRD_product_code res24: ca_channel_blockers drug
43430 DILTIAZEM HYDROCHLORIDE modified release tablet 120mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
43470 AMLODIPINE tablets 5mg [WOCKHARDT] CPRD_product_code res24: ca_channel_blockers drug
43511 NIFEDIPINE capsules 10mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
43512 FELODIPINE modified release tablet 5mg [HILLCROSS] CPRD_product_code res24: ca_channel_blockers drug
43515 NIFEDIPINE capsules 10mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
43753 ADALAT LA 30 prolonged release tablet [BAYER] CPRD_product_code res24: ca_channel_blockers drug
43790 VASCALPHA prolonged release tablet 10mg [ALMUS] CPRD_product_code res24: ca_channel_blockers drug
43818 ADALAT LA 60 prolonged release tablet [BAYER] CPRD_product_code res24: ca_channel_blockers drug
43879 VERA-TIL SR tablets 240mg [ACTAVIS] CPRD_product_code res24: ca_channel_blockers drug
43880 AMLODIPINE tablets 5mg [ALMUS] CPRD_product_code res24: ca_channel_blockers drug
4408 SLOZEM capsules 240mg [MERCK SER] CPRD_product_code res24: ca_channel_blockers drug
44192 ZEMRET XL capsules 240mg [TILLOMED] CPRD_product_code res24: ca_channel_blockers drug
44859 FELODIPINE SR tablets 5mg [APS] CPRD_product_code