Print

Diuretics

David A Springate, Darren M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves

Type
Drug
ID
PH647
Version ID
1294
Data Sources
CPRD GOLD , Doctors Independent Network
Valid event data range
01/01/19997 - 31/12/2006
Sex
Female, Male
Agreement Date
2020-10-08
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objectives:

To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population.

Design:

Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer.

Setting:

Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN).

Participants:

CPRD data for 11 302 patients with cancer compared with published results from DIN for 3462 patients; study period January 1997 to December 2006.

Primary and secondary outcome measures:

All-cause mortality: overall; by treatment subgroup (β-blockers only, β-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer site.

Results:

Using CPRD, β-blocker use was not associated with mortality (HR=1.03, 95% CI 0.93 to 1.14, vs patients prescribed other BPLMs only), but DIN β-blocker users had significantly higher mortality (HR=1.18, 95% CI 1.04 to 1.33). However, these HRs were not statistically different (p=0.063), but did differ for patients on β-blockers alone (CPRD=0.94, 95% CI 0.82 to 1.07; DIN=1.37, 95% CI 1.16 to 1.61; p<0.001). Results for individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases.

Conclusions:

We found a complex pattern of similarities and differences between databases. Overall treatment effect estimates were not statistically different, adding to a growing body of evidence that different UK PCDs produce comparable effect estimates. However, individually the two studies lead to different conclusions regarding the safety of β-blockers and some subgroup effects differed significantly. Single studies using even internally wellvalidated databases do not guarantee generalisable results, especially for subgroups, and confirmatory studies using at least one other independent data source are strongly recommended.

Publications

  • David A Springate, Darrent M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves, Can analyses of electronic patient records be independently and externally validated? Study 2—the effect of β-adrenoceptor blocker therapy on cancer survival a retrospective cohort study. BMJ Open, 5(e007299), 2014.

Clinical Code List

Rows: 271
Code Description Coding System (CPRD_product_code) Entity type Category
1021 INNOZIDE tablets [M S D] CPRD_product_code res24: diuretics drug
10316 COAPROVEL tablets 150mg + 12.5mg [SANOFI BMS] CPRD_product_code res24: diuretics drug
10323 losartan with hydrochlorothiazide tablets 100mg + 25mg CPRD_product_code res24: diuretics drug
10627 CO-BETALOC tablets 100mg + 12.5mg [PHARMACIA] CPRD_product_code res24: diuretics drug
10902 captopril with hydrochlorothiazide tablets 50mg + 25mg CPRD_product_code res24: diuretics drug
11133 hydrochlorothiazide with captopril tablets 25mg + 50mg CPRD_product_code res24: diuretics drug
1124 TENORETIC tablets 100mg + 25mg [ASTRAZENEC] CPRD_product_code res24: diuretics drug
1125 NAVIDREX -K tablets [NOV/CIBA] CPRD_product_code res24: diuretics drug
11338 bendroflumethiazide with nadolol tablets 5mg + 40mg CPRD_product_code res24: diuretics drug
11351 co-zidocapt (hydrochlorothiazide and captopril) tablets 25mg + 50mg CPRD_product_code res24: diuretics drug
11384 co-flumactone (hydroflumethiazide and spironolactone) tablets 50mg+50mg CPRD_product_code res24: diuretics drug
11448 irbesartan with hydrochlorothiazide tablets 150mg + 12.5mg CPRD_product_code res24: diuretics drug
11469 irbesartan with hydrochlorothiazide tablets 300mg + 12.5mg CPRD_product_code res24: diuretics drug
11526 COAPROVEL tablets 300mg + 12.5mg [SANOFI BMS] CPRD_product_code res24: diuretics drug
11561 co-zidocapt (hydrochlorothiazide and captopril) tablets 12.5mg + 25mg CPRD_product_code res24: diuretics drug
11641 captopril with hydrochlorothiazide tablets 25mg + 12.5mg CPRD_product_code res24: diuretics drug
1170 cyclopenthiazide tablets 0.5mg CPRD_product_code res24: diuretics drug
11864 valsartan with hydrochlorothiazide tablets 160mg + 12.5mg CPRD_product_code res24: diuretics drug
12054 propranolol with bendroflumethiazide capsules 80mg + 2.5mg CPRD_product_code res24: diuretics drug
1209 NEO-NACLEX tablets 5mg [GOLDSHIELD] CPRD_product_code res24: diuretics drug
12110 hydroflumethiazide tablets 50mg CPRD_product_code res24: diuretics drug
12360 NEPHRIL tablets 1mg [PFIZER] CPRD_product_code res24: diuretics drug
12440 HYDROSALURIC tablets 25mg [M S D] CPRD_product_code res24: diuretics drug
1251 MODURET 25 tablets [M S D] CPRD_product_code res24: diuretics drug
12517 timolol maleate with bendroflumethiazide tablets 20mg + 5mg CPRD_product_code res24: diuretics drug
12546 KALSPARE tablets [DOMINION] CPRD_product_code res24: diuretics drug
12547 triamterene with chlortalidone tablets 50mg + 50mg CPRD_product_code res24: diuretics drug
12651 timolol maleate with bendroflumethiazide tablets 10mg + 2.5mg CPRD_product_code res24: diuretics drug
1288 TENORET tablets 50mg + 12.5mg [ASTRAZENEC] CPRD_product_code res24: diuretics drug
12926 polythiazide tablets 1mg CPRD_product_code res24: diuretics drug
1297 ALDACTIDE film coated tablets 50mg + 50mg [PHARMACIA] CPRD_product_code res24: diuretics drug
13246 chlorothiazide oral suspension 150mg/5ml CPRD_product_code res24: diuretics drug
13363 ESIDREX tablets 50mg [NOV/CIBA] CPRD_product_code res24: diuretics drug
13525 HYDRENOX tablets 50mg [KNOLL] CPRD_product_code res24: diuretics drug
13526 ATENIXCO tablets 100mg + 25mg [ASHBOURNE] CPRD_product_code res24: diuretics drug
13871 co-prenozide (oxprenolol and cyclopenthiazide) modified release tablet 160mg + 0.25mg CPRD_product_code res24: diuretics drug
14126 acebutolol hydrochloride and hydrochlorothiazide tablets 200mg + 12.5mg CPRD_product_code res24: diuretics drug
14228 COVERSYL PLUS tablets [SERVIER] CPRD_product_code res24: diuretics drug
14283 valsartan with hydrochlorothiazide tablets 160mg + 25mg CPRD_product_code res24: diuretics drug
14438 CORGARETIC 80 tablets [SANOFI S] CPRD_product_code res24: diuretics drug
14738 hydrochlorothiazide with losartan tablets 12.5mg + 50mg CPRD_product_code res24: diuretics drug
14870 telmisartan with hydrochlorothiazide tablets 40mg + 12.5mg CPRD_product_code res24: diuretics drug
15031 ACCURETIC tablets 10mg + 12.5mg [PFIZER] CPRD_product_code res24: diuretics drug
15108 quinapril and hydrochlorothiazide tablets 10mg + 12.5mg CPRD_product_code res24: diuretics drug
15127 hydrochlorothiazide with triamterene tablets 25mg+50mg CPRD_product_code res24: diuretics drug
15135 hydrochlorothiazide with captopril tablets 12.5mg + 25mg CPRD_product_code res24: diuretics drug
1520 CAPOZIDE tablets [SQUIBB] CPRD_product_code res24: diuretics drug
15457 BAYCARON tablets 25mg [BAYER] CPRD_product_code res24: diuretics drug
15488 metoprolol tartrate with chlortalidone tablets CPRD_product_code res24: diuretics drug
15811 co-flumactone (hydroflumethiazide and spironolactone) tablets 25mg+25mg CPRD_product_code res24: diuretics drug
16060 valsartan with hydrochlorothiazide tablets 80mg + 12.5mg CPRD_product_code res24: diuretics drug
16161 telmisartan with hydrochlorothiazide tablets 80mg + 12.5mg CPRD_product_code res24: diuretics drug
16498 KALSPARE tablets [DHP] CPRD_product_code res24: diuretics drug
16632 HYDROSALURIC tablets 50mg [M S D] CPRD_product_code res24: diuretics drug
16786 chlortalidone with atenolol tablets 25mg+100mg CPRD_product_code res24: diuretics drug
17143 mefruside tablets 25mg CPRD_product_code res24: diuretics drug
1721 DYAZIDE tablets [GOLDSHIELD] CPRD_product_code res24: diuretics drug
17252 ESIDREX tablets 25mg [NOV/CIBA] CPRD_product_code res24: diuretics drug
17655 CARACE 10 plus tablets [BMS] CPRD_product_code res24: diuretics drug
17689 MICARDIS PLUS tablets 80mg + 12.5mg [BOEH INGL] CPRD_product_code res24: diuretics drug
17720 SALURIC tablets 500mg [M S D] CPRD_product_code res24: diuretics drug
1788 atenolol with chlortalidone tablets 100mg+25mg CPRD_product_code res24: diuretics drug
18200 olmesartan medoxomil with hydrochlorothiazide tablets 20mg + 12.5mg CPRD_product_code res24: diuretics drug
18202 MICARDIS PLUS tablets 40mg + 12.5mg [BOEH INGL] CPRD_product_code res24: diuretics drug
18263 ACEZIDE tablets [SQUIBB] CPRD_product_code res24: diuretics drug
18267 ENDURON tablets 5mg [ABBOTT] CPRD_product_code res24: diuretics drug
18287 CO-BETALOC SA tablets 200mg + 25mg [PHARMACIA] CPRD_product_code res24: diuretics drug
18361 AMILMAXCO tablets [ASHBOURNE] CPRD_product_code res24: diuretics drug
18606 diltiazem and hydrochlorothiazide modified release capsules 150mg + 12.5mg CPRD_product_code res24: diuretics drug
18726 TRIAMAXCO tablets [ASHBOURNE] CPRD_product_code res24: diuretics drug
18733 co-amilozide (amiloride and hydrochlorothiazide) oral solution 5mg + 50mg/5ml CPRD_product_code res24: diuretics drug
18743 TENBEN capsules 25mg + 1.25mg [GALEN] CPRD_product_code res24: diuretics drug
18903 olmesartan medoxomil with hydrochlorothiazide tablets 20mg + 25mg CPRD_product_code res24: diuretics drug
18973 CENTYL tablets 2.5mg [BURGESS] CPRD_product_code res24: diuretics drug
19055 chlortalidone with atenolol tablets 12.5mg+50mg CPRD_product_code res24: diuretics drug
19142 bendroflumethiazide with timolol maleate tablets 2.5mg + 10mg CPRD_product_code res24: diuretics drug
19352 XURET low dose tablets 0.5mg [GALEN] CPRD_product_code res24: diuretics drug
19890 hydrochlorothiazide with amiloride tablets 25mg+2.5mg CPRD_product_code res24: diuretics drug
2 bendroflumethiazide tablets 2.5mg CPRD_product_code res24: diuretics drug
2001 ALDACTIDE film coated tablets 25mg + 25mg [PHARMACIA] CPRD_product_code res24: diuretics drug
2002 amiloride hydrochloride with hydrochlorothiazide tablets 5mg + 50mg CPRD_product_code res24: diuretics drug
20057 methyclothiazide tablets 5mg CPRD_product_code res24: diuretics drug
20066 AMIL-CO tablets 5mg + 50mg [IVAX] CPRD_product_code res24: diuretics drug
20093 metoprolol tartrate with hydrochlorothiazide modified release tablet 200mg + 25mg CPRD_product_code res24: diuretics drug
2046 NAVIDREX tablets 0.5mg [GOLDSHIELD] CPRD_product_code res24: diuretics drug
21025 PRESTIM FORTE tablets [LEO] CPRD_product_code res24: diuretics drug
21182 hydrochlorothiazide with timolol and amiloride tablets 25mg + 10mg + 2.5mg CPRD_product_code res24: diuretics drug
21231 CARALPHA tablets 20mg + 12.5mg [ACTAVIS] CPRD_product_code res24: diuretics drug
21423 COZAAR-COMP tablets 100mg + 25mg [M S D] CPRD_product_code res24: diuretics drug
21803 BERKOZIDE tablets 2.5mg [BERK] CPRD_product_code res24: diuretics drug
21867 BERKOZIDE tablets 5mg [BERK] CPRD_product_code res24: diuretics drug
21873 ATENIXCO tablets 50mg+12.5mg [ASHBOURNE] CPRD_product_code res24: diuretics drug
2255 NAVISPARE tablets [GOLDSHIELD] CPRD_product_code res24: diuretics drug
22912 bendroflumethiazide with propranolol capsules 2.5mg + 80mg CPRD_product_code res24: diuretics drug
22923 hydrochlorothiazide with amiloride tablets 50mg + 5mg CPRD_product_code res24: diuretics drug
23131 bendroflumethiazide with propranolol modified release capsules 5mg + 160mg CPRD_product_code res24: diuretics drug
23134 nadolol with bendroflumethiazide tablets 40mg + 5mg CPRD_product_code res24: diuretics drug
23427 BENDROFLUMETHIAZIDE tablets 5mg [HILLCROSS] CPRD_product_code res24: diuretics drug
23456 hydrochlorothiazide with valsartan tablets 25mg + 160mg CPRD_product_code res24: diuretics drug
23505 ADIZEM XL PLUS controlled release capsules 150mg + 12.5mg [NAPP] CPRD_product_code res24: diuretics drug
24008 VASETIC tablets [SHIRE] CPRD_product_code res24: diuretics drug
24189 NEO-BENDROMAX tablets 2.5mg [ASHBOURNE] CPRD_product_code res24: diuretics drug
24190 NEO-BENDROMAX tablets 5mg [ASHBOURNE] CPRD_product_code res24: diuretics drug
24268 hydrochlorothiazide with valsartan tablets 12.5mg + 80mg CPRD_product_code res24: diuretics drug
24280 TOTARETIC tablets 100mg+25mg [CP PHARM] CPRD_product_code res24: diuretics drug
24484 hydrochlorothiazide with valsartan tablets 12.5mg + 160mg CPRD_product_code res24: diuretics drug
24632 hydrochlorothiazide with losartan tablets 25mg + 100mg CPRD_product_code res24: diuretics drug
25363 PRESTIM tablets [MEDA] CPRD_product_code res24: diuretics drug
25382 CO-DIOVAN tablets 160mg + 25mg [NOVARTIS] CPRD_product_code res24: diuretics drug
25500 HYPERTANE 50 tablets [SCHWARZ] CPRD_product_code res24: diuretics drug
25505 SPIRO-CO tablets 50mg+50mg [IVAX] CPRD_product_code res24: diuretics drug
25730 timolol maleate with amiloride and hydrochlorothiazide tablets CPRD_product_code res24: diuretics drug
2612 indapamide tablets 2.5mg CPRD_product_code res24: diuretics drug
26219 ZIDA-CO tablets 5mg + 50mg [OPUS] CPRD_product_code res24: diuretics drug
26220 DELVAS tablets [BERK] CPRD_product_code res24: diuretics drug
26248 TENCHLOR tablets 100mg + 25mg [BERK] CPRD_product_code res24: diuretics drug
26256 OPUMIDE tablets 2.5mg [OPUS] CPRD_product_code res24: diuretics drug
26275 NINDAXA tablets 2.5mg [ASHBOURNE] CPRD_product_code res24: diuretics drug
26741 TOTARETIC tablets 50mg+12.5mg [CP PHARM] CPRD_product_code res24: diuretics drug
27256 BENDROFLUMETHIAZIDE tablets 2.5mg [WOCKHARDT] CPRD_product_code res24: diuretics drug
27520 OLMETEC PLUS tablets 20mg + 25mg [DAIIC-SANK] CPRD_product_code res24: diuretics drug
27689 BENDROFLUMETHIAZIDE tablets 2.5mg [IVAX] CPRD_product_code res24: diuretics drug
27946 nadolol with bendroflumethiazide tablets 80mg + 5mg CPRD_product_code res24: diuretics drug
27957 NATRAMID tablets 2.5mg [TRINITY] CPRD_product_code res24: diuretics drug
28157 KALSPARE LS tablets [DOMINION] CPRD_product_code res24: diuretics drug
28177 hydrochlorothiazide with atenolol and amiloride capsules CPRD_product_code res24: diuretics drug
2833 cyclopenthiazide -k tablets CPRD_product_code res24: diuretics drug
29427 hydrochlorothiazide with metoprolol tartrate tablets 12.5mg + 100mg CPRD_product_code res24: diuretics drug
29529 hydroflumethiazide with spironolactone tablets 25mg+25mg CPRD_product_code res24: diuretics drug
29634 OLMETEC PLUS tablets 20mg + 12.5mg [DAIIC-SANK] CPRD_product_code res24: diuretics drug
2982 ZESTORETIC 20-tablets 20mg + 12.5mg [ASTRAZENEC] CPRD_product_code res24: diuretics drug
29991 CENTYL tablets 5mg [BURGESS] CPRD_product_code res24: diuretics drug
30272 benzthiazide with triamterene capsules CPRD_product_code res24: diuretics drug
30519 amiloride hydrochloride with timolol and hydrochlorothiazide tablets CPRD_product_code res24: diuretics drug
3054 HYGROTON tablets 100mg [ALLIANCE] CPRD_product_code res24: diuretics drug
3056 NATRILIX SR sustained release tablets 1.5mg [SERVIER] CPRD_product_code res24: diuretics drug
31131 SPIRO-CO tablets 25mg+25mg [IVAX] CPRD_product_code res24: diuretics drug
31150 CO-AMILOZIDE tablets 5mg+50mg [IVAX] CPRD_product_code res24: diuretics drug
31470 TENCHLOR tablets 50mg+12.5mg [BERK] CPRD_product_code res24: diuretics drug
31670 BENDROFLUMETHIAZIDE tablets 2.5mg [TEVA] CPRD_product_code res24: diuretics drug
31708 CO-TENIDONE tablets 50mg+12.5mg [ACTAVIS] CPRD_product_code res24: diuretics drug
31820 BENDROFLUMETHIAZIDE tablets 5mg [WOCKHARDT] CPRD_product_code res24: diuretics drug
3203 CAPOZIDE LS tablets [SQUIBB] CPRD_product_code res24: diuretics drug
32094 CO-TENIDONE tablets 50mg+12.5mg [HILLCROSS] CPRD_product_code res24: diuretics drug
32166 CAPTO-CO tablets 25mg+50mg [IVAX] CPRD_product_code res24: diuretics drug
3293 MODURETIC solution [BMS] CPRD_product_code res24: diuretics drug
33083 INDAPAMIDE tablets 2.5mg [TEVA] CPRD_product_code res24: diuretics drug
33353 LISINOPRIL AND HYDROCHLOROTHIAZIDE tablets 20mg + 12.5mg [TEVA] CPRD_product_code res24: diuretics drug
33415 BENDROFLUMETHIAZIDE tablets 2.5mg [GEN (UK)] CPRD_product_code res24: diuretics drug
33651 BENDROFLUMETHIAZIDE tablets 2.5mg [HILLCROSS] CPRD_product_code res24: diuretics drug
33659 hydrochlorothiazide with metoprolol tartrate modified release tablet 25mg + 200mg CPRD_product_code res24: diuretics drug
33724 DIURIL oral suspension 250mg/5ml [M S D] CPRD_product_code res24: diuretics drug
34012 CO-TENIDONE tablets 100mg+25mg [IVAX] CPRD_product_code res24: diuretics drug
34034 CO-TENIDONE tablets 50mg+12.5mg [IVAX] CPRD_product_code res24: diuretics drug
34059 BENDROFLUMETHIAZIDE tablets 2.5mg [ACTAVIS] CPRD_product_code res24: diuretics drug
34124 BENDROFLUMETHIAZIDE tablets 5mg [ACTAVIS] CPRD_product_code res24: diuretics drug
34367 CO-AMILOZIDE tablets 2.5mg+25mg [WOCKHARDT] CPRD_product_code res24: diuretics drug
34449 CO-TENIDONE tablets 50mg+12.5mg [GEN (UK)] CPRD_product_code res24: diuretics drug
34551 INDAPAMIDE tablets 2.5mg [GEN (UK)] CPRD_product_code res24: diuretics drug
34602 BENDROFLUMETHIAZIDE tablets 2.5mg [SOVEREIGN] CPRD_product_code res24: diuretics drug
348 MODURETIC tablets [BMS] CPRD_product_code res24: diuretics drug
34803 BENDROFLUMETHIAZIDE tablets 2.5mg [REGENT] CPRD_product_code res24: diuretics drug
34825 CO-TENIDONE tablets 50mg+12.5mg [TEVA] CPRD_product_code res24: diuretics drug
34899 CO-TENIDONE tablets 100mg+25mg [HILLCROSS] CPRD_product_code res24: diuretics drug
3517 hydrochlorothiazide tablets 50mg CPRD_product_code res24: diuretics drug
35196 COAPROVEL tablets 300mg + 25mg [SANOFI BMS] CPRD_product_code res24: diuretics drug
3526 amiloride hydrochloride with atenolol and hydrochlorothiazide capsules CPRD_product_code res24: diuretics drug
35380 hydrochlorothiazide with olmesartan medoxomil tablets 12.5mg + 20mg CPRD_product_code res24: diuretics drug
3548 chlortalidone tablets 100mg CPRD_product_code res24: diuretics drug
35481 irbesartan with hydrochlorothiazide tablets 300mg + 25mg CPRD_product_code res24: diuretics drug
3701 amiloride hydrochloride with hydrochlorothiazide tablets 2.5mg+25mg CPRD_product_code res24: diuretics drug
37294 triamterene with chlortalidone tablets 50mg + 25mg CPRD_product_code res24: diuretics drug
37650 losartan with hydrochlorothiazide tablets 100mg + 12.5mg CPRD_product_code res24: diuretics drug
37710 LISINOPRIL AND HYDROCHLOROTHIAZIDE tablets 10mg + 12.5mg [TEVA] CPRD_product_code res24: diuretics drug
37725 CO-TENIDONE tablets 100mg+25mg [GEN (UK)] CPRD_product_code res24: diuretics drug
37747 COZAAR-COMP tablets 100mg + 12.5mg [M S D] CPRD_product_code res24: diuretics drug
37908 COVERSYL ARGININE PLUS tablets 5mg + 1.25mg [SERVIER] CPRD_product_code res24: diuretics drug
37978 perindopril arginine with indapamide tablets 5mg + 1.25mg CPRD_product_code res24: diuretics drug
38367 hydrochlorothiazide with losartan tablets 12.5mg + 100mg CPRD_product_code res24: diuretics drug
38459 telmisartan with hydrochlorothiazide tablets 80mg + 25mg CPRD_product_code res24: diuretics drug
38889 MICARDIS PLUS tablets 80mg + 25mg [BOEH INGL] CPRD_product_code res24: diuretics drug
38995 ZESTORETIC 20 tablets [ASTRAZENEC] CPRD_product_code res24: diuretics drug
39021 hydrochlorothiazide with olmesartan medoxomil tablets 25mg + 20mg CPRD_product_code res24: diuretics drug
39137 ZESTORETIC 10 tablets [ASTRAZENEC] CPRD_product_code res24: diuretics drug
39147 CARACE 20 PLUS tablets [M S D] CPRD_product_code res24: diuretics drug
39227 CAPOZIDE LS tablets [BMS] CPRD_product_code res24: diuretics drug
39242 CARACE 10 PLUS tablets [M S D] CPRD_product_code res24: diuretics drug
39447 VARBIM XL prolonged release tablet 1.5mg [TEVA] CPRD_product_code res24: diuretics drug
3997 HYGROTON tablets 50mg [ALLIANCE] CPRD_product_code res24: diuretics drug
40149 BENDROFLUMETHIAZIDE tablets 5mg [IVAX] CPRD_product_code res24: diuretics drug
4034 amiloride hydrochloride with hydrochlorothiazide solution 5mg + 50mg/5ml CPRD_product_code res24: diuretics drug
4044 DIUREXAN tablets 20mg [MEDA] CPRD_product_code res24: diuretics drug
40886 BENDROFLUMETHIAZIDE tablets 2.5mg [ALMUS] CPRD_product_code res24: diuretics drug
40907 INDAPAMIDE tablets 2.5mg [GENUS] CPRD_product_code res24: diuretics drug
41517 BENDROFLUMETHIAZIDE tablets 5mg [TEVA] CPRD_product_code res24: diuretics drug
41556 CO-AMILOZIDE tablets 5mg+50mg [TEVA] CPRD_product_code res24: diuretics drug
41572 CO-TENIDONE tablets 100mg+25mg [TEVA] CPRD_product_code res24: diuretics drug
41861 TENSAID XL tablets 1.5mg [GEN (UK)] CPRD_product_code res24: diuretics drug
41885 ETHIBIDE XL prolonged release tablet 1.5mg [GENUS] CPRD_product_code res24: diuretics drug
42142 MODURETIC tablets [M S D] CPRD_product_code res24: diuretics drug
42906 INDAPAMIDE tablets 2.5mg [NICHE] CPRD_product_code res24: diuretics drug
43184 MAPEMID XL prolonged release tablet 1.5mg [RATIOPHARM] CPRD_product_code res24: diuretics drug
4332 metolazone tablets 5mg CPRD_product_code res24: diuretics drug
43322 olmesartan medoxomil with hydrochlorothiazide tablets 40mg + 12.5mg CPRD_product_code res24: diuretics drug
4334 metolazone low dose tablets 500micrograms CPRD_product_code res24: diuretics drug
43516 INDAPAMIDE tablets 2.5mg [ACTAVIS] CPRD_product_code res24: diuretics drug
43915 OLMETEC PLUS tablets 40mg + 12.5mg [DAIIC-SANK] CPRD_product_code res24: diuretics drug
44168 INDIPAM XL prolonged release tablet 1.5mg [ACTAVIS] CPRD_product_code res24: diuretics drug
4429 TRASIDREX tablets [GOLDSHIELD] CPRD_product_code res24: diuretics drug
4540 COZAAR-COMP tablets 50mg + 12.5mg [M S D] CPRD_product_code res24: diuretics drug
45916 hydroflumethiazide with spironolactone tablets 50mg+50mg CPRD_product_code res24: diuretics drug
4605 MODUCREN tablets [M S D] CPRD_product_code res24: diuretics drug
46302 NEO-NACLEX tablets 2.5mg [GOLDSHIELD] CPRD_product_code res24: diuretics drug
46355 SEVIKAR HCT tablets 20mg + 5mg + 12.5mg [DAIIC-SANK] CPRD_product_code res24: diuretics drug
46675 INDAPAMIDE SR tablets 1.5mg [HILLCROSS] CPRD_product_code res24: diuretics drug
46687 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 20mg + 5mg + 12.5mg CPRD_product_code res24: diuretics drug
46715 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 10mg + 12.5mg CPRD_product_code res24: diuretics drug
46792 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 5mg + 12.5mg CPRD_product_code res24: diuretics drug
46916 CO-AMILOZIDE tablets 5mg+50mg [HILLCROSS] CPRD_product_code res24: diuretics drug
46952 CO-TENIDONE tablets 100mg+25mg [ACTAVIS] CPRD_product_code res24: diuretics drug
47467 olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 5mg + 25mg CPRD_product_code res24: diuretics drug
4796 INDERETIC capsules [ASTRAZENEC] CPRD_product_code res24: diuretics drug
4983 atenolol with amiloride and hydrochlorothiazide capsules CPRD_product_code res24: diuretics drug
5112 indapamide modified release tablet 1.5mg CPRD_product_code res24: diuretics drug
5189 enalapril with hydrochlorothiazide tablets 20mg + 12.5mg CPRD_product_code res24: diuretics drug
5330 CORGARETIC 40 tablets [SANOFI S] CPRD_product_code res24: diuretics drug
5416 co-triamterzide (triamterene and hydrochlorothiazide) tablets 50mg+25mg CPRD_product_code res24: diuretics drug
542 hydrochlorothiazide tablets 25mg CPRD_product_code res24: diuretics drug
5721 co-tenidone (atenolol and chlortalidone) tablets 100mg+25mg CPRD_product_code res24: diuretics drug
5727 cyclopenthiazide with amiloride tablets 250micrograms + 2.5mg CPRD_product_code res24: diuretics drug
58 bendroflumethiazide tablets 5mg CPRD_product_code res24: diuretics drug
581 atenolol with chlortalidone tablets 50mg+12.5mg CPRD_product_code res24: diuretics drug
605 chlortalidone tablets 50mg CPRD_product_code res24: diuretics drug
6359 ZESTORETIC 10-tablets 10mg + 12.5mg [ASTRAZENEC] CPRD_product_code res24: diuretics drug
6437 losartan with hydrochlorothiazide tablets 50mg + 12.5mg CPRD_product_code res24: diuretics drug
6468 lisinopril with hydrochlorothiazide tablets 20mg + 12.5mg CPRD_product_code res24: diuretics drug
6786 lisinopril with hydrochlorothiazide tablets 10mg + 12.5mg CPRD_product_code res24: diuretics drug
6794 perindopril erbumine with indapamide tablets 4mg + 1.25mg CPRD_product_code res24: diuretics drug
6816 chlorothiazide oral suspension 250mg/5ml CPRD_product_code res24: diuretics drug
6877 CO-DIOVAN tablets 160mg + 12.5mg [NOVARTIS] CPRD_product_code res24: diuretics drug
7066 metoprolol tartrate with hydrochlorothiazide tablets 100mg + 12.5mg CPRD_product_code res24: diuretics drug
7136 DYTIDE capsules 50mg+25mg [GOLDSHIELD] CPRD_product_code res24: diuretics drug
7351 bendroflumethiazide oral suspension 2.5mg/5ml CPRD_product_code res24: diuretics drug
7543 KALTEN capsules [M&A PHARM] CPRD_product_code res24: diuretics drug
7618 xipamide tablets 20mg CPRD_product_code res24: diuretics drug
764 CO-DIOVAN tablets 80mg + 12.5mg [NOVARTIS] CPRD_product_code res24: diuretics drug
7641 NATRILIX tablets 2.5mg [SERVIER] CPRD_product_code res24: diuretics drug
7698 APRINOX tablets 5mg [SOVEREIGN] CPRD_product_code res24: diuretics drug
7740 triamterene with benzthiazide capsules 50mg+25mg CPRD_product_code res24: diuretics drug
7961 spironolactone with hydroflumethiazide tablets 50mg+50mg CPRD_product_code res24: diuretics drug
8058 NORMETIC tablets [ABBOTT] CPRD_product_code res24: diuretics drug
8147 LOPRESORETIC tablets [NOV/GEIGY] CPRD_product_code res24: diuretics drug
8189 SECADREX tablets [AVENTIS] CPRD_product_code res24: diuretics drug
8303 TENAVOID tablets [BURGESS] CPRD_product_code res24: diuretics drug
8369 INDEREX capsules [ASTRAZENEC] CPRD_product_code res24: diuretics drug
8464 meprobamate with bendroflumethiazide tablets CPRD_product_code res24: diuretics drug
8521 spironolactone with hydroflumethiazide tablets 25mg+25mg CPRD_product_code res24: diuretics drug
8526 APRINOX tablets 2.5mg [SOVEREIGN] CPRD_product_code res24: diuretics drug
8602 METENIX tablets 5mg [SANOFI/AVE] CPRD_product_code res24: diuretics drug
8623 PRESTIM tablets [ICN] CPRD_product_code res24: diuretics drug
8673 oxprenolol with cyclopenthiazide modified release tablet 160mg+0.25mg CPRD_product_code res24: diuretics drug
8836 chlorothiazide tablets 500mg CPRD_product_code res24: diuretics drug
8891 HYGROTON -K tablets [NOV/GEIGY] CPRD_product_code res24: diuretics drug
8897 TRIAM-CO tablets 50mg+25mg [IVAX] CPRD_product_code res24: diuretics drug
8987 propranolol with bendroflumethiazide modified release capsules 160mg + 5mg CPRD_product_code res24: diuretics drug
9178 atenolol with bendroflumethiazide capsules 25mg + 1.25mg CPRD_product_code res24: diuretics drug
9223 triamterene with hydrochlorothiazide tablets 50mg+25mg CPRD_product_code res24: diuretics drug
923 co-amilozide (amiloride and hydrochlorothiazide) tablets 5mg+50mg CPRD_product_code res24: diuretics drug
924 co-amilozide (amiloride and hydrochlorothiazide) tablets 2.5mg+25mg CPRD_product_code res24: diuretics drug
9764 CARACE 20 plus tablets [BMS] CPRD_product_code res24: diuretics drug
9783 co-tenidone (atenolol and chlortalidone) tablets 50mg+12.5mg CPRD_product_code res24: diuretics drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH647/version/1294/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH647/version/1294/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH647', '1294', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH647/version/1294/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH647/version/1294/export/codes/?format=json
CSV site_root/phenotypes/PH647/version/1294/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH647', '1294', api_client=client)

Version History

Version
ID
Name Owner Publish date
1294 Diuretics ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

Print - Print page.