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Other Antihypertensives

David A Springate, Darren M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves

Type
Drug
ID
PH650
Version ID
1300
Data Sources
CPRD GOLD , Doctors Independent Network
Valid event data range
01/01/19997 - 31/12/2006
Sex
Female, Male
Agreement Date
2020-10-08
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objectives:

To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population.

Design:

Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer.

Setting:

Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN).

Participants:

CPRD data for 11 302 patients with cancer compared with published results from DIN for 3462 patients; study period January 1997 to December 2006.

Primary and secondary outcome measures:

All-cause mortality: overall; by treatment subgroup (β-blockers only, β-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer site.

Results:

Using CPRD, β-blocker use was not associated with mortality (HR=1.03, 95% CI 0.93 to 1.14, vs patients prescribed other BPLMs only), but DIN β-blocker users had significantly higher mortality (HR=1.18, 95% CI 1.04 to 1.33). However, these HRs were not statistically different (p=0.063), but did differ for patients on β-blockers alone (CPRD=0.94, 95% CI 0.82 to 1.07; DIN=1.37, 95% CI 1.16 to 1.61; p<0.001). Results for individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases.

Conclusions:

We found a complex pattern of similarities and differences between databases. Overall treatment effect estimates were not statistically different, adding to a growing body of evidence that different UK PCDs produce comparable effect estimates. However, individually the two studies lead to different conclusions regarding the safety of β-blockers and some subgroup effects differed significantly. Single studies using even internally wellvalidated databases do not guarantee generalisable results, especially for subgroups, and confirmatory studies using at least one other independent data source are strongly recommended.

Publications

  • David A Springate, Darrent M Aschroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves, Can analyses of electronic patient records be independently and externally validated? Study 2—the effect of β-adrenoceptor blocker therapy on cancer survival a retrospective cohort study. BMJ Open, 5(e007299), 2014.

Clinical Code List

Rows: 176
Code Description Coding System (CPRD_product_code) Entity type Category
10088 DOXADURA tablets 4mg [DISCOVERY] CPRD_product_code res24: other_antihypertensives drug
10134 FLOMAXTRA XL modified release tablet 400micrograms [ASTELLAS] CPRD_product_code res24: other_antihypertensives drug
10253 moxonidine tablets 300micrograms CPRD_product_code res24: other_antihypertensives drug
10713 DECASERPYL tablets 5mg [ROUSSEL] CPRD_product_code res24: other_antihypertensives drug
10714 methoserpidine tablets 5mg CPRD_product_code res24: other_antihypertensives drug
11177 PHYSIOTENS tablets 200micrograms [ABBOTT] CPRD_product_code res24: other_antihypertensives drug
11394 BARATOL tablets 25mg [SHIRE] CPRD_product_code res24: other_antihypertensives drug
119 doxazosin tablets 1mg CPRD_product_code res24: other_antihypertensives drug
12518 HYPOVASE BD starter pack [PFIZER] CPRD_product_code res24: other_antihypertensives drug
12545 phentolamine mesilate injection 10mg/ml CPRD_product_code res24: other_antihypertensives drug
1292 HYPOVASE tablets 1mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
1294 doxazosin tablets 4mg CPRD_product_code res24: other_antihypertensives drug
13610 ALPHAVASE tablets 2mg [ASHBOURNE] CPRD_product_code res24: other_antihypertensives drug
14390 ALDOMET suspension 250mg/5ml [M S D] CPRD_product_code res24: other_antihypertensives drug
1455 prazosin tablets 500 micrograms CPRD_product_code res24: other_antihypertensives drug
14932 TABPHYN MR capsules 400micrograms [PROSTRAKAN] CPRD_product_code res24: other_antihypertensives drug
15493 reserpine with hydrochlorothiazide tablets CPRD_product_code res24: other_antihypertensives drug
16198 BARATOL tablets 50mg [SHIRE] CPRD_product_code res24: other_antihypertensives drug
16201 HYTRIN BPH tablets 2mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
16248 clonidine injection 150micrograms/ml CPRD_product_code res24: other_antihypertensives drug
1707 methyldopa tablets 250mg CPRD_product_code res24: other_antihypertensives drug
18252 METALPHA tablets 250mg [ASHBOURNE] CPRD_product_code res24: other_antihypertensives drug
19193 DOXAZOSIN tablets 2mg [TEVA] CPRD_product_code res24: other_antihypertensives drug
19216 DOXAZOSIN tablets 4mg [IVAX] CPRD_product_code res24: other_antihypertensives drug
19823 ALPHAVASE tablets 5mg [ASHBOURNE] CPRD_product_code res24: other_antihypertensives drug
19892 SERPASIL -ESIDREX tablets [NOV/CIBA] CPRD_product_code res24: other_antihypertensives drug
20369 doxazosin oral suspension 1mg/5ml CPRD_product_code res24: other_antihypertensives drug
20656 SERPASIL tablets 250micrograms [NOV/CIBA] CPRD_product_code res24: other_antihypertensives drug
20690 reserpine tablets 250micrograms CPRD_product_code res24: other_antihypertensives drug
2104 RAUWILOID tablets 2mg [3M] CPRD_product_code res24: other_antihypertensives drug
2117 DORALESE TILTAB tablets 20mg [CHEMIDEX] CPRD_product_code res24: other_antihypertensives drug
21346 HYDROMET tablets [MSD MORSON] CPRD_product_code res24: other_antihypertensives drug
21502 SERPASIL tablets 100micrograms [NOV/CIBA] CPRD_product_code res24: other_antihypertensives drug
22454 DEMSER capsules 250mg [M S D] CPRD_product_code res24: other_antihypertensives drug
22853 reserpine tablets 100micrograms CPRD_product_code res24: other_antihypertensives drug
23010 ROGITINE injection 10mg/ml [ALLIANCE] CPRD_product_code res24: other_antihypertensives drug
23345 HYPERCAL tablets 2mg [CARLTON] CPRD_product_code res24: other_antihypertensives drug
23380 CATAPRES tablets 300micrograms [BOEH INGL] CPRD_product_code res24: other_antihypertensives drug
2345 HYTRIN BPH starter pack [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
23459 HYPOVASE BENIGN PROSTATIC HYPERPLASIA tablets 2mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
2346 HYTRIN tablets 5mg [ABBOTT] CPRD_product_code res24: other_antihypertensives drug
2347 HYTRIN tablets 10mg [ABBOTT] CPRD_product_code res24: other_antihypertensives drug
2348 HYTRIN BPH tablets 10mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
23761 methyldopa suspension 250mg/5ml CPRD_product_code res24: other_antihypertensives drug
24196 DOPAMET tablets 250mg [BERK] CPRD_product_code res24: other_antihypertensives drug
24369 PETYME MR capsules 400micrograms [TEVA] CPRD_product_code res24: other_antihypertensives drug
25047 HYPOVASE BENIGN PROSTATIC HYPERPLASIA tablets 500 micrograms [PFIZER] CPRD_product_code res24: other_antihypertensives drug
25275 METALPHA tablets 500mg [ASHBOURNE] CPRD_product_code res24: other_antihypertensives drug
25289 DOPAMET tablets 500mg [BERK] CPRD_product_code res24: other_antihypertensives drug
25393 DECASERPYL tablets 10mg [ROUSSEL] CPRD_product_code res24: other_antihypertensives drug
25487 CASCOR tablets 2mg [RANBAXY] CPRD_product_code res24: other_antihypertensives drug
25551 CASCOR tablets 4mg [RANBAXY] CPRD_product_code res24: other_antihypertensives drug
25645 SEOMINAL tablets [STERLING] CPRD_product_code res24: other_antihypertensives drug
26237 ALPHAVASE tablets 500 micrograms [ASHBOURNE] CPRD_product_code res24: other_antihypertensives drug
26238 ALPHAVASE tablets 1mg [ASHBOURNE] CPRD_product_code res24: other_antihypertensives drug
2630 DIXARIT tablets 25micrograms [BOEH INGL] CPRD_product_code res24: other_antihypertensives drug
26693 HYPOVASE BENIGN PROSTATIC HYPERPLASIA BD starter pack [PFIZER] CPRD_product_code res24: other_antihypertensives drug
26919 methyldopa injection 50mg/ml CPRD_product_code res24: other_antihypertensives drug
27403 OMNIC MR capsules 400micrograms [ASTELLAS] CPRD_product_code res24: other_antihypertensives drug
2816 indoramin tablets 20mg CPRD_product_code res24: other_antihypertensives drug
28441 PAMSVAX XL capsules 400micrograms [ARROW] CPRD_product_code res24: other_antihypertensives drug
28738 methyldopa with hydrochlorothiazide tablets CPRD_product_code res24: other_antihypertensives drug
2878 clonidine tablets 100micrograms CPRD_product_code res24: other_antihypertensives drug
29187 methoserpidine tablets 10mg CPRD_product_code res24: other_antihypertensives drug
29570 DOPAMET tablets 125mg [BERK] CPRD_product_code res24: other_antihypertensives drug
29696 methoserpidine with benzthiazide tablets CPRD_product_code res24: other_antihypertensives drug
30129 ABICOL tablets [KNOLL] CPRD_product_code res24: other_antihypertensives drug
30293 CATAPRES injection 150micrograms/ml [BOEH INGL] CPRD_product_code res24: other_antihypertensives drug
3049 methyldopa tablets 125mg CPRD_product_code res24: other_antihypertensives drug
30691 HYPERCAL B tablets [CARLTON] CPRD_product_code res24: other_antihypertensives drug
3070 methyldopa tablets 500mg CPRD_product_code res24: other_antihypertensives drug
31109 PROSURIN XL capsules 400micrograms [GEN (UK)] CPRD_product_code res24: other_antihypertensives drug
32913 METHYLDOPA tablets 250mg [ACTAVIS] CPRD_product_code res24: other_antihypertensives drug
33093 CLONIDINE tablets 25micrograms [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
33094 DOXAZOSIN tablets 2mg [GEN (UK)] CPRD_product_code res24: other_antihypertensives drug
33322 MOXONIDINE tablets 200micrograms [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
33788 metirosine capsules 250mg CPRD_product_code res24: other_antihypertensives drug
338 clonidine tablets 25micrograms CPRD_product_code res24: other_antihypertensives drug
34080 STRONAZON MR capsules 400micrograms [ACTAVIS] CPRD_product_code res24: other_antihypertensives drug
34342 DOXAZOSIN tablets 1mg [TEVA] CPRD_product_code res24: other_antihypertensives drug
34553 DOXAZOSIN tablets 4mg [GEN (UK)] CPRD_product_code res24: other_antihypertensives drug
34601 DOXAZOSIN tablets 1mg [GEN (UK)] CPRD_product_code res24: other_antihypertensives drug
34625 DOXAZOSIN tablets 2mg [HILLCROSS] CPRD_product_code res24: other_antihypertensives drug
3470 terazosin tablets 1mg CPRD_product_code res24: other_antihypertensives drug
34715 DOXAZOSIN tablets 1mg [HILLCROSS] CPRD_product_code res24: other_antihypertensives drug
35058 DIFFUNDOX XL capsules 400micrograms [ZENTIVA] CPRD_product_code res24: other_antihypertensives drug
35272 DOXADURA XL tablets 4mg [GENUS] CPRD_product_code res24: other_antihypertensives drug
35312 BAZETHAM MR capsules 400micrograms [PLIVA] CPRD_product_code res24: other_antihypertensives drug
35466 ALPHACARD MR capsules 400micrograms [RATIOPHARM] CPRD_product_code res24: other_antihypertensives drug
35603 doxazosin oral suspension 4mg/5ml CPRD_product_code res24: other_antihypertensives drug
35925 CONTIFLO XL capsules 400micrograms [RANBAXY] CPRD_product_code res24: other_antihypertensives drug
36023 CARDOZIN XL tablets 4mg [HILLCROSS] CPRD_product_code res24: other_antihypertensives drug
36282 MORVESIN XL capsules 400micrograms [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
36649 HYTRIN tablets 2mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
36740 SLOCINX XL tablets 4mg [WINTHROP] CPRD_product_code res24: other_antihypertensives drug
36780 HYTRIN tablets 5mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
3715 prazosin tablets 5mg CPRD_product_code res24: other_antihypertensives drug
37243 CARDOZIN XL tablets 4mg [TEVA] CPRD_product_code res24: other_antihypertensives drug
37428 HYTRIN tablets 10mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
38461 CARDOZIN XL tablets 4mg [ARROW] CPRD_product_code res24: other_antihypertensives drug
3923 terazosin bph starter pack 7 x 1mg + 14 x 2mg + 7 x 5mg CPRD_product_code res24: other_antihypertensives drug
3924 terazosin tablets 5mg CPRD_product_code res24: other_antihypertensives drug
40256 BARATOL tablets 25mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
40310 MOXONIDINE tablets 200micrograms [TEVA] CPRD_product_code res24: other_antihypertensives drug
40678 DOXAZOSIN tablets 4mg [TEVA] CPRD_product_code res24: other_antihypertensives drug
40810 phenoxybenzamine oral suspension 10mg/5ml CPRD_product_code res24: other_antihypertensives drug
40891 DOXAZOSIN tablets 2mg [IVAX] CPRD_product_code res24: other_antihypertensives drug
4111 HYPOVASE tablets 500 micrograms [PFIZER] CPRD_product_code res24: other_antihypertensives drug
41543 DOXAZOSIN tablets 1mg [IVAX] CPRD_product_code res24: other_antihypertensives drug
41651 PRAZOSIN tablets 500 micrograms [APS] CPRD_product_code res24: other_antihypertensives drug
41652 PRAZOSIN tablets 500 micrograms [HILLCROSS] CPRD_product_code res24: other_antihypertensives drug
41661 METHYLDOPA tablets 250mg [CP PHARM] CPRD_product_code res24: other_antihypertensives drug
41721 PRAZOSIN tablets 1mg [HILLCROSS] CPRD_product_code res24: other_antihypertensives drug
4215 CATAPRES tablets 100micrograms [BOEH INGL] CPRD_product_code res24: other_antihypertensives drug
42462 KIRTACAP MR capsules 400micrograms [CONSILIENT] CPRD_product_code res24: other_antihypertensives drug
42936 FLOMAX RELIEF MR modified release capsules 400micrograms [BOEH INGL] CPRD_product_code res24: other_antihypertensives drug
43531 MOXONIDINE tablets 400micrograms [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
43547 PRAZOSIN tablets 500 micrograms [IVAX] CPRD_product_code res24: other_antihypertensives drug
43695 COLIXIL XL tablets 4mg [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
43988 ALDOMET tablets 250mg [SIGMA] CPRD_product_code res24: other_antihypertensives drug
43989 ALDOMET tablets 500mg [SIGMA] CPRD_product_code res24: other_antihypertensives drug
4406 DECASERPYL PLUS tablets [ROUSSEL] CPRD_product_code res24: other_antihypertensives drug
4449 CARDURA tablets 1mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
445 prazosin titration pack 8x500micrograms + 32x1mg CPRD_product_code res24: other_antihypertensives drug
44553 PINEXEL PR capsules 400micrograms [WOCKHARDT] CPRD_product_code res24: other_antihypertensives drug
45040 LARBEX XL prolonged release tablet 4mg [TEVA] CPRD_product_code res24: other_antihypertensives drug
45265 DOXAZOSIN SR tablets 4mg [GEN (UK)] CPRD_product_code res24: other_antihypertensives drug
45328 DOXAZOSIN tablets 1mg [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
45342 DOXAZOSIN tablets 4mg [SANDOZ] CPRD_product_code res24: other_antihypertensives drug
45578 CLONIDINE tablets 25micrograms [HILLCROSS] CPRD_product_code res24: other_antihypertensives drug
45583 DOXAZOSIN tablets 2mg [DEXCEL] CPRD_product_code res24: other_antihypertensives drug
45584 phenoxybenzamine concentrate for solution for infusion 100mg/2ml CPRD_product_code res24: other_antihypertensives drug
460 FLOMAX MR modified release capsules 400micrograms [YAMANOUCHI] CPRD_product_code res24: other_antihypertensives drug
46066 CARDOZIN XL tablets 4mg [ALMUS] CPRD_product_code res24: other_antihypertensives drug
46206 PAMSVAX XL capsules 400micrograms [ALMUS] CPRD_product_code res24: other_antihypertensives drug
4637 terazosin tablets 2mg CPRD_product_code res24: other_antihypertensives drug
46526 RAPORSIN XL prolonged release tablet 4mg [ACTAVIS] CPRD_product_code res24: other_antihypertensives drug
46922 PRAZOSIN tablets 1mg [IVAX] CPRD_product_code res24: other_antihypertensives drug
4694 terazosin starter pack 7 x 1mg + 21 x 2mg CPRD_product_code res24: other_antihypertensives drug
4802 CARDURA tablets 2mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
4875 terazosin tablets 10mg CPRD_product_code res24: other_antihypertensives drug
493 doxazosin tablets 2mg CPRD_product_code res24: other_antihypertensives drug
4993 moxonidine tablets 200micrograms CPRD_product_code res24: other_antihypertensives drug
5183 HYPOVASE tablets 2mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
5289 clonidine modified release capsules 0.25mg CPRD_product_code res24: other_antihypertensives drug
5337 HYTRIN BPH tablets 5mg [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
5496 doxazosin modified release tablet 8mg CPRD_product_code res24: other_antihypertensives drug
5618 CARDURA XL modified release tablet 8mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
5815 indoramin tablets 25mg CPRD_product_code res24: other_antihypertensives drug
582 doxazosin modified release tablet 4mg CPRD_product_code res24: other_antihypertensives drug
591 prazosin tablets 1mg CPRD_product_code res24: other_antihypertensives drug
6008 OMNIC MR capsules 400micrograms [P & B] CPRD_product_code res24: other_antihypertensives drug
634 tamsulosin hydrochloride modified release capsules 400micrograms CPRD_product_code res24: other_antihypertensives drug
6694 clonidine tablets 300micrograms CPRD_product_code res24: other_antihypertensives drug
7056 tamsulosin hydrochloride modified release tablet 400micrograms CPRD_product_code res24: other_antihypertensives drug
7174 moxonidine tablets 400micrograms CPRD_product_code res24: other_antihypertensives drug
726 prazosin tablets 2mg CPRD_product_code res24: other_antihypertensives drug
7416 ALDOMET injection 50mg/ml [M S D] CPRD_product_code res24: other_antihypertensives drug
7547 DOXADURA tablets 2mg [DISCOVERY] CPRD_product_code res24: other_antihypertensives drug
7549 DOXADURA tablets 1mg [DISCOVERY] CPRD_product_code res24: other_antihypertensives drug
755 CARDURA XL modified release tablet 4mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
7626 ALDOMET tablets 250mg [M S D] CPRD_product_code res24: other_antihypertensives drug
7642 ALDOMET tablets 500mg [M S D] CPRD_product_code res24: other_antihypertensives drug
7759 phenoxybenzamine capsules 10mg CPRD_product_code res24: other_antihypertensives drug
8033 ALDOMET tablets 125mg [M S D] CPRD_product_code res24: other_antihypertensives drug
8076 HYTRIN starter pack [AMDIPHARM] CPRD_product_code res24: other_antihypertensives drug
8077 HYTRIN tablets 2mg [ABBOTT] CPRD_product_code res24: other_antihypertensives drug
8086 CARDURA tablets 4mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
8198 HYPOVASE tablets 5mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
8296 CATAPRES PL PERLONGETS 0.25mg [BOEH INGL] CPRD_product_code res24: other_antihypertensives drug
8863 HYPOVASE BENIGN PROSTATIC HYPERPLASIA tablets 1mg [PFIZER] CPRD_product_code res24: other_antihypertensives drug
8942 DIBENYLINE capsules 10mg [GOLDSHIELD] CPRD_product_code res24: other_antihypertensives drug
9019 indoramin tablets 50mg CPRD_product_code res24: other_antihypertensives drug
9225 methyldopa capsules 250mg CPRD_product_code res24: other_antihypertensives drug
9749 PHYSIOTENS tablets 400micrograms [ABBOTT] CPRD_product_code res24: other_antihypertensives drug
9876 PHYSIOTENS tablets 300micrograms [ABBOTT] CPRD_product_code res24: other_antihypertensives drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH650/version/1300/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH650/version/1300/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH650', '1300', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH650/version/1300/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH650/version/1300/export/codes/?format=json
CSV site_root/phenotypes/PH650/version/1300/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH650', '1300', api_client=client)

Version History

Version
ID
Name Owner Publish date
1300 Other Antihypertensives ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

Print - Print page.