Study question:
What is the prevalence of different types of potentially hazardous prescribing in general practice in the United Kingdom, and what is the variation between practices?
Methods:
A cross sectional study included all adult patients potentially at risk of a prescribing or monitoring error defined by a combination of diagnoses and prescriptions in 526 general practices contributing to the Clinical Practice Research Datalink (CPRD) up to 1 April 2013. Primary outcomes were the prevalence of potentially hazardous prescriptions of anticoagulants, anti-platelets, NSAIDs, β blockers, glitazones, metformin, digoxin, antipsychotics, combined hormonal contraceptives, and oestrogens and monitoring by blood test less frequently than recommended for patients with repeated prescriptions of angiotensin converting enzyme inhibitors and loop diuretics, amiodarone, methotrexate, lithium, or warfarin.
Study answer and limitations:
49 927 of 949 552 patients at risk triggered at least one prescribing indicator (5.26%, 95% confidence interval 5.21% to 5.30%) and 21 501 of 182 721 (11.8%, 11.6% to 11.9%) triggered at least one monitoring indicator. The prevalence of different types of potentially hazardous prescribing ranged from almost zero to 10.2%, and for inadequate monitoring ranged from 10.4% to 41.9%. Older patients and those prescribed multiple repeat medications had significantly higher risks of triggering a prescribing indicator whereas younger patients with fewer repeat prescriptions had significantly higher risk of triggering a monitoring indicator. There was high variation between practices for some indicators. Though prescribing safety indicators describe prescribing patterns that can increase the risk of harm to the patient and should generally be avoided, there will always be exceptions where the indicator is clinically justified. Furthermore there is the possibility that some information is not captured by CPRD for some practices—for example, INR results in patients receiving warfarin.
What this study adds:
The high prevalence for certain indicators emphasises existing prescribing risks and the need for their appropriate consideration within primary care, particularly for older patients and those taking multiple medications. The high variation between practices indicates potential for improvement through targeted practice level intervention.
S Jill Stocks, Evangelos Kontopantelis, Artur Akbarov, Sarah Rodgers, Anthony J Avery, Darren M Ashcroft, Examining variations in prescribing safety in UK general practice cross sectional study using the Clinical Practice Research Datalink. BMJ, 351(h5501), 2015.
Code | Description | Coding System (CPRD_product_code) | Entity type | Category |
---|---|---|---|---|
10098 | Zoton 30mg gastro-resistant granules sachets (Wyeth Pharmaceuticals) | CPRD_product_code | res25: gastroprotection | drug |
10555 | Famotidine 40mg tablets | CPRD_product_code | res25: gastroprotection | drug |
10556 | Algitec Liquid (GlaxoSmithKline Consumer Healthcare) | CPRD_product_code | res25: gastroprotection | drug |
10622 | Algitec Chewable tablet (GlaxoSmithKline Consumer Healthcare) | CPRD_product_code | res25: gastroprotection | drug |
10746 | Pepcid 40mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1229 | Zantac 150mg tablets (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1230 | Cimetidine 800mg tablets | CPRD_product_code | res25: gastroprotection | drug |
1232 | Losec 20mg gastro-resistant capsules (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
13015 | Losec MUPS 10mg gastro-resistant tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
13282 | Omeprazole 5mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
13378 | Zantac 300mg effervescent tablets (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
13579 | Zinga 150mg capsules (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1367 | Ranitidine 150mg effervescent tablets | CPRD_product_code | res25: gastroprotection | drug |
1394 | Ranitidine 75mg/5ml oral solution sugar free | CPRD_product_code | res25: gastroprotection | drug |
1451 | Omeprazole 40mg gastro-resistant capsules | CPRD_product_code | res25: gastroprotection | drug |
15275 | Omeprazole 10mg gastro-resistant capsules (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
15277 | Gavilast-P 75mg tablets (Reckitt Benckiser Healthcare (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1556 | Ranitidine 300mg tablets | CPRD_product_code | res25: gastroprotection | drug |
16034 | Gavilast 75mg tablets (Reckitt Benckiser Healthcare (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
16092 | Ranitidine 75mg effervescent tablets sugar free | CPRD_product_code | res25: gastroprotection | drug |
16195 | Zinga 300mg capsules (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
162 | Arthrotec 50 gastro-resistant tablets (Pfizer Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1692 | Diclofenac sodium 50mg gastro-resistant / Misoprostol 200microgram tablets | CPRD_product_code | res25: gastroprotection | drug |
17108 | Zantac 75 tablets (Omega Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
17162 | Galenamet 400mg tablets (Galen Ltd) | CPRD_product_code | res25: gastroprotection | drug |
18 | Omeprazole 20mg gastro-resistant capsules | CPRD_product_code | res25: gastroprotection | drug |
18225 | Esomeprazole 40mg powder for solution for injection vials | CPRD_product_code | res25: gastroprotection | drug |
18426 | Acid-Eze 200mg tablets (Manx Healthcare Ltd) | CPRD_product_code | res25: gastroprotection | drug |
18489 | Zantac 75 Relief tablets (Omega Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
19249 | Ranitidine 300mg tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
19272 | Ranitidine 150mg tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
19277 | Axid 300mg capsules (Flynn Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1941 | Pariet 20mg gastro-resistant tablets (Eisai Ltd) | CPRD_product_code | res25: gastroprotection | drug |
1947 | Zoton 15mg gastro-resistant capsules (Wyeth Pharmaceuticals) | CPRD_product_code | res25: gastroprotection | drug |
1963 | Ranitidine 75mg tablets | CPRD_product_code | res25: gastroprotection | drug |
1977 | Rabeprazole 10mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
1986 | Pantoprazole 40mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
20011 | Galenamet 800mg Tablet (Galen Ltd) | CPRD_product_code | res25: gastroprotection | drug |
20360 | Tagamet 200mg/5ml syrup (Chemidex Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
2057 | Cimetidine 200mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
21 | Ranitidine 150mg tablets | CPRD_product_code | res25: gastroprotection | drug |
2151 | Rabeprazole 20mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
21544 | Rantec 300 tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21565 | Ranitil 150mg tablets (Tillomed Laboratories Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21602 | Raciran 300 tablets (Opus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21823 | Acitak 400mg tablets (Opus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21825 | Ultec 400mg tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21853 | Peptimax 400 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21871 | Peptimax 200mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21893 | Raciran 150 tablets (Opus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21894 | Zaedoc 150 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21901 | Zaedoc 300 300mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21988 | Ultec 200mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
21991 | Tagadine 400mg Tablet (OPD Pharm) | CPRD_product_code | res25: gastroprotection | drug |
22037 | Tagamet 400mg tablets (Chemidex Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
225 | Nizatidine 300mg capsules | CPRD_product_code | res25: gastroprotection | drug |
22635 | Galenamet 200mg Tablet (Galen Ltd) | CPRD_product_code | res25: gastroprotection | drug |
22643 | Zita 400mg tablets (LPC Medical (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
23132 | Pepcid AC 10mg Chewable tablet (MSD Thomas Morson Pharmaceuticals) | CPRD_product_code | res25: gastroprotection | drug |
2387 | Arthrotec 75 gastro-resistant tablets (Pfizer Ltd) | CPRD_product_code | res25: gastroprotection | drug |
24049 | Cimetidine 100mg with Sodium alginate 250mg/5ml suspension | CPRD_product_code | res25: gastroprotection | drug |
24092 | Tagamet 200mg tablets (Chemidex Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
24301 | Tagamet 100mg Tablet (GlaxoSmithKline Consumer Healthcare) | CPRD_product_code | res25: gastroprotection | drug |
24302 | Rantec 150 tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
24360 | Heartburn relief 10mg Tablet (Galpharm International Ltd) | CPRD_product_code | res25: gastroprotection | drug |
24704 | Tagamet dual action 100mg + 250mg/5ml Liquid (GlaxoSmithKline Consumer Healthcare) | CPRD_product_code | res25: gastroprotection | drug |
25271 | Peptimax 800mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
25360 | Histac 150mg tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
25404 | Famotidine 10mg Tablet | CPRD_product_code | res25: gastroprotection | drug |
25596 | Nexium I.V 40mg powder for solution for injection vials (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
25873 | Cimetidine 200mg with alginic acid 500mg tablets | CPRD_product_code | res25: gastroprotection | drug |
26170 | Ranitidine 150mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
26208 | Acitak 200mg Tablet (Opus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
26537 | Omeran 20mg gastro-resistant tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
26699 | Tagamet 100mg Tablet (AHA Sales Services Ltd) | CPRD_product_code | res25: gastroprotection | drug |
26949 | Ranitil 300mg tablets (Tillomed Laboratories Ltd) | CPRD_product_code | res25: gastroprotection | drug |
27024 | Ultec 800mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
27288 | Axid 150mg capsules (Flynn Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
27465 | Zita 800mg Tablet (Eastern Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
276 | Losec 10mg gastro-resistant capsules (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
27698 | Zantac 75 Dissolve tablets (GlaxoSmithKline Consumer Healthcare) | CPRD_product_code | res25: gastroprotection | drug |
27808 | Phimetin 800mg Tablet (BHR Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
28047 | Cimetidine 200mg/5ml oral solution sugar free | CPRD_product_code | res25: gastroprotection | drug |
28050 | Zita 200mg Tablet (Eastern Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
28787 | Phimetin 200mg Tablet (BHR Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
29048 | Tagamet 800mg tablets (Chemidex Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
29148 | Phimetin 400mg Tablet (BHR Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
29457 | Omeprazole 20mg gastro-resistant capsules (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
29468 | Omeprazole 40mg gastro-resistant capsules (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
30 | Lansoprazole 15mg gastro-resistant capsules | CPRD_product_code | res25: gastroprotection | drug |
30241 | Ranitidine 150mg dispersible tablet | CPRD_product_code | res25: gastroprotection | drug |
30863 | Ranitidine 150mg Tablet (Genus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
30926 | Omeprazole 10mg gastro-resistant capsules (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
31213 | Omeran 10mg gastro-resistant tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
31492 | Histac 300mg tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
31533 | Ranitidine 150mg Tablet (Genus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
31846 | Cimetidine 4mg/ml infusion | CPRD_product_code | res25: gastroprotection | drug |
32342 | Ranitidine indigestion relief 75mg Tablet (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
32747 | Cimetidine 400mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
3276 | Tagamet 800mg Tablet (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
32859 | Zantac 75 Relief Dissolve tablets (Omega Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
32914 | Omeprazole 10mg gastro-resistant tablets (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
32919 | Omeprazole 20mg gastro-resistant tablets (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
32924 | Omeprazole 20mg gastro-resistant tablets (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
33022 | Zanprol 10mg gastro-resistant tablets (Omega Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
33088 | Cimetidine 400mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
33325 | Cimetidine 400mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
33326 | Omeprazole 10mg gastro-resistant tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
33565 | Omeprazole 20mg Tablet (Neo Laboratories Ltd) | CPRD_product_code | res25: gastroprotection | drug |
33667 | Cimetidine 400mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34276 | Ranitidine 75mg/5ml oral solution sugar free (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34295 | Ranitidine 150mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34301 | Ranitidine 150mg effervescent tablets (Sovereign Medical Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34302 | Omeprazole 20mg gastro-resistant capsules (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34321 | Nizatidine 150mg capsules (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34332 | Omeprazole 10mg gastro-resistant capsules (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34403 | Ranitidine 150mg tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34411 | Omeprazole 20mg gastro-resistant capsules (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34433 | Ranitidine 150mg Tablet (Dominion Pharma) | CPRD_product_code | res25: gastroprotection | drug |
34450 | Ranitidine 150mg effervescent tablets (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34480 | Ranitidine 150mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34511 | Nizatidine 150mg capsules (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34531 | Ranitidine 300mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34556 | Cimetidine 200mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34568 | Omeprazole 10mg gastro-resistant capsules (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34571 | Omeprazole 10mg gastro-resistant capsules (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34577 | Omeprazole 20mg gastro-resistant capsules (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34708 | Ranitidine 150mg Tablet (Warrick) | CPRD_product_code | res25: gastroprotection | drug |
34788 | Cimetidine 200mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34791 | Omeprazole 40mg gastro-resistant capsules (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34792 | Omeprazole 10mg gastro-resistant capsules (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34812 | Omeprazole 20mg Gastro-resistant capsule (Niche Generics Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34841 | Omeprazole 20mg gastro-resistant capsules (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34843 | Omeprazole 20mg gastro-resistant capsules (Dexcel-Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34886 | Ranitidine 150mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34967 | Omeprazole 20mg gastro-resistant capsules (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
34984 | Heartburn relief 10mg Tablet (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
35101 | Omeprazole 10mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
35257 | Omeprazole 40mg gastro-resistant capsules (Dr Reddy's Laboratories (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
35383 | Omeprazole 20mg gastro-resistant capsules (Dr Reddy's Laboratories (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
35698 | Mepradec 20mg gastro-resistant capsules (Discovery Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
35699 | Mepradec 10mg gastro-resistant capsules (Discovery Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
36046 | Omeprazole 40mg Gastro-resistant capsule (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
36892 | Omeprazole 10mg gastro-resistant tablets (Dexcel-Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
37815 | Lansoprazole 30mg gastro-resistant capsules (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
3857 | Tagamet 200mg Tablet (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
39 | Lansoprazole 30mg gastro-resistant capsules | CPRD_product_code | res25: gastroprotection | drug |
3967 | Zantac 150mg Dispersible tablet (Glaxo Laboratories Ltd) | CPRD_product_code | res25: gastroprotection | drug |
39904 | Lansoprazole 15mg gastro-resistant capsules (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
40152 | Ranitidine 300mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
40430 | Tagamet 4mg/ml Infusion (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
40759 | Lansoprazole 15mg gastro-resistant capsules (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
40896 | Lansoprazole 30mg gastro-resistant capsules (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41364 | Ketoprofen 100mg / Omeprazole 20mg modified-release capsules | CPRD_product_code | res25: gastroprotection | drug |
41365 | Axorid 200mg/20mg modified-release capsules (Meda Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41366 | Axorid 100mg/20mg modified-release capsules (Meda Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41367 | Ketoprofen 200mg / Omeprazole 20mg modified-release capsules | CPRD_product_code | res25: gastroprotection | drug |
41454 | Nexium 10mg gastro-resistant granules sachets (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41501 | Esomeprazole 10mg gastro-resistant granules sachets | CPRD_product_code | res25: gastroprotection | drug |
41534 | Cimetidine 800mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41536 | Ranitidine 300mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41568 | Cimetidine 400mg tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41587 | Cimetidine 200mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41588 | Cimetidine 200mg tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41589 | Cimetidine 200mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41631 | Cimetidine 800mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41648 | Cimetidine 800mg tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41684 | Cimetidine 800mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41895 | Acitak 800mg Tablet (Opus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
41992 | Omeprazole 10mg gastro-resistant tablets (Almus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42088 | Nizatidine 300mg capsules (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42091 | Omeprazole 20mg gastro-resistant tablets (Dexcel-Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42114 | Omeran 40mg gastro-resistant tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42382 | Lansoprazole 30mg gastro-resistant capsules (Almus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42532 | Lansoprazole 30mg gastro-resistant capsules (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42533 | Omeprazole 20mg gastro-resistant capsules (Focus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
4254 | Cytotec 200microgram tablets (Pfizer Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42730 | Lansoprazole 30mg gastro-resistant capsules (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42736 | Omeprazole 20mg gastro-resistant tablets (Kent Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42898 | Omeprazole 10mg gastro-resistant tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
42900 | Omeprazole 20mg gastro-resistant tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
43057 | Lansoprazole 30mg gastro-resistant capsules (Generics (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
43529 | Ranitidine 150mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
43948 | Esomeprazole 40mg gastro-resistant capsules | CPRD_product_code | res25: gastroprotection | drug |
43957 | Omeprazole 20mg gastro-resistant tablets (Almus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
43995 | Esomeprazole 20mg gastro-resistant capsules | CPRD_product_code | res25: gastroprotection | drug |
44023 | Pantoloc Control 20mg gastro-resistant tablets (Novartis Consumer Health UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
44252 | Omeprazole 20mg/5ml Oral suspension (Martindale Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
4451 | Dyspamet chewtab 200 200mg Chewable tablet (Goldshield Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
446 | Cimetidine 200mg tablets | CPRD_product_code | res25: gastroprotection | drug |
4468 | Ranitidine 300mg effervescent tablets | CPRD_product_code | res25: gastroprotection | drug |
44753 | Lansoprazole 30mg gastro-resistant capsules (Consilient Health Ltd) | CPRD_product_code | res25: gastroprotection | drug |
44800 | Naproxen 500mg / Esomeprazole 20mg modified-release tablets | CPRD_product_code | res25: gastroprotection | drug |
44986 | Vimovo 500mg/20mg modified-release tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
45173 | Omeprazole 20mg gastro-resistant capsules (Almus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
45214 | Ranitidine 150mg tablets (Sterwin Medicines) | CPRD_product_code | res25: gastroprotection | drug |
45232 | Ranitidine 150mg tablets (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
45294 | Ranitidine 300mg Effervescent tablet (Ratiopharm UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
45322 | Ranitidine 300mg Tablet (Galen Ltd) | CPRD_product_code | res25: gastroprotection | drug |
4654 | Losec 40mg gastro-resistant capsules (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
46744 | Emozul 20mg gastro-resistant capsules (Consilient Health Ltd) | CPRD_product_code | res25: gastroprotection | drug |
46745 | Emozul 40mg gastro-resistant capsules (Consilient Health Ltd) | CPRD_product_code | res25: gastroprotection | drug |
4742 | Axid 300mg Capsule (Eli Lilly and Company Ltd) | CPRD_product_code | res25: gastroprotection | drug |
47511 | Omeprazole 5mg/5ml Oral suspension (Martindale Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
47909 | Lansoprazole 30mg gastro-resistant capsules (Arrow Generics Ltd) | CPRD_product_code | res25: gastroprotection | drug |
47934 | Cimetidine 400mg tablets (Dexcel-Pharma Ltd) | CPRD_product_code | res25: gastroprotection | drug |
48063 | Lansoprazole 30mg gastro-resistant capsules (Zentiva) | CPRD_product_code | res25: gastroprotection | drug |
4880 | Diclofenac sodium 75mg gastro-resistant / Misoprostol 200microgram tablets | CPRD_product_code | res25: gastroprotection | drug |
4885 | Axid 150mg Capsule (Eli Lilly and Company Ltd) | CPRD_product_code | res25: gastroprotection | drug |
49163 | Omeprazole 20mg gastro-resistant capsules (Zentiva) | CPRD_product_code | res25: gastroprotection | drug |
49209 | Lansoprazole 7.5mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
4921 | Omeprazole 20mg dispersible gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
49375 | Pantoprazole 20mg gastro-resistant tablets (Nycomed UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
49433 | Omeprazole 40mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
4955 | Omeprazole 40mg dispersible gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
49584 | Omeprazole 8mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
50269 | Arthrotec 75 gastro-resistant tablets (Mawdsley-Brooks & Company Ltd) | CPRD_product_code | res25: gastroprotection | drug |
50365 | Omeprazole 8.5mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
50372 | Omeprazole 15mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
50492 | Lansoprazole 30mg gastro-resistant capsules (Sigma Pharmaceuticals Plc) | CPRD_product_code | res25: gastroprotection | drug |
51260 | Omeprazole 20mg gastro-resistant capsules (Arrow Generics Ltd) | CPRD_product_code | res25: gastroprotection | drug |
51290 | Zoton FasTab 15mg (Mawdsley-Brooks & Company Ltd) | CPRD_product_code | res25: gastroprotection | drug |
51357 | Omeprazole 15mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
51548 | Nexium 20mg gastro-resistant tablets (Mawdsley-Brooks & Company Ltd) | CPRD_product_code | res25: gastroprotection | drug |
51549 | Ranitidine 5mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
5178 | Esomeprazole 20mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
51801 | Ranitidine 300mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
51804 | Pantoprazole 20mg gastro-resistant tablets (Arrow Generics Ltd) | CPRD_product_code | res25: gastroprotection | drug |
519 | Zoton 30mg gastro-resistant capsules (Wyeth Pharmaceuticals) | CPRD_product_code | res25: gastroprotection | drug |
5232 | Omeprazole 10mg dispersible gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
5236 | Losec MUPS 20mg gastro-resistant tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
52379 | Omeprazole 25mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
52612 | Losec 20mg gastro-resistant capsules (Lexon (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
5269 | Nexium 20mg gastro-resistant tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
52691 | Ranitidine 18mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
52866 | Omeprazole 4mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
52971 | Losec MUPS 10mg gastro-resistant tablets (Lexon (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
53317 | Ranitidine 75mg/5ml oral solution sugar free (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
53333 | Ranitidine 75mg tablets (Vantage) | CPRD_product_code | res25: gastroprotection | drug |
53335 | Ranitidine 150mg tablets (Accord Healthcare Ltd) | CPRD_product_code | res25: gastroprotection | drug |
53337 | Omeprazole 10mg gastro-resistant capsules (Phoenix Healthcare Distribution Ltd) | CPRD_product_code | res25: gastroprotection | drug |
53518 | Omeprazole 2mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
5358 | Lansoprazole 30mg gastro-resistant granules sachets | CPRD_product_code | res25: gastroprotection | drug |
53616 | Lansoprazole 5mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
53843 | Esomeprazole 40mg gastro-resistant tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
53871 | Lansoprazole 30mg gastro-resistant capsules (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
53947 | Ranitidine 75mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
54101 | Ranitidine 16mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
54121 | Lansoprazole 15mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
54188 | Lansoprazole 30mg gastro-resistant capsules (Phoenix Healthcare Distribution Ltd) | CPRD_product_code | res25: gastroprotection | drug |
5419 | Pantoprazole 20mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
54253 | Ranitidine 75mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
54539 | Ranitidine 10mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
54683 | Mezzopram 10mg gastro-resistant tablets (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
54693 | Pantoprazole 20mg gastro-resistant tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
54746 | Ranitidine 10mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
54784 | Ranitidine 150mg tablets (Medreich Plc) | CPRD_product_code | res25: gastroprotection | drug |
54939 | Lansoprazole 15mg gastro-resistant capsules (Alliance Healthcare (Distribution) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55168 | Omeprazole 10mg dispersible gastro-resistant tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55439 | Lansoprazole 15mg gastro-resistant capsules (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55468 | Omeprazole 20mg gastro-resistant capsules (Alliance Healthcare (Distribution) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55647 | Ranitidine 20mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
55665 | Ranitidine 5mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
55700 | Omeprazole 3mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
55744 | Omeprazole 20mg gastro-resistant capsules (Zanza Laboratories Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55745 | Losec 10mg gastro-resistant capsules (Lexon (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55857 | Ranitidine 75mg tablets (Galpharm International Ltd) | CPRD_product_code | res25: gastroprotection | drug |
55936 | Ranitidine 1.5mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
55991 | Ranitidine 3mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
5604 | Esomeprazole 40mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
56235 | Omeprazole 12.5mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
56414 | Ranitidine 3mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
56432 | Omeprazole 6.8mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
56433 | Omeprazole 35mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
56479 | Losec 20mg gastro-resistant capsules (Waymade Healthcare Plc) | CPRD_product_code | res25: gastroprotection | drug |
56569 | Ranitidine 75mg/5ml oral solution sugar free (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
56614 | Ranitidine 25mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
56816 | Ranitidine 50mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
56895 | Omeprazole 50mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
57158 | Lansoprazole 30mg gastro-resistant capsules (Alliance Healthcare (Distribution) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57177 | Omeprazole 20mg gastro-resistant capsules (Bristol Laboratories Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57236 | Cimetidine 400mg tablets (Almus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57311 | Esomeprazole 20mg gastro-resistant capsules (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57504 | Zoton FasTab 30mg (Waymade Healthcare Plc) | CPRD_product_code | res25: gastroprotection | drug |
57528 | Losec 20mg gastro-resistant capsules (Dowelhurst Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57541 | Omeprazole 10mg gastro-resistant tablets (Sterwin Medicines) | CPRD_product_code | res25: gastroprotection | drug |
57566 | Omeprazole 20mg dispersible gastro-resistant tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57572 | Zoton 15mg gastro-resistant capsules (Dowelhurst Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57648 | Omeprazole 10mg gastro-resistant capsules (Dr Reddy's Laboratories (UK) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
57738 | Omeprazole 4mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
57909 | Ranitidine 150mg effervescent tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58030 | Rabeprazole 10mg gastro-resistant tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58066 | Omeprazole 8mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
58216 | Omeprazole 20mg gastro-resistant capsules (Kent Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58236 | Mezzopram 20mg gastro-resistant tablets (Sandoz Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58244 | Ranitidine 75mg/5ml oral solution sugar free (Almus Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58332 | Omeprazole 20mg gastro-resistant capsules (Somex Pharma) | CPRD_product_code | res25: gastroprotection | drug |
58334 | Ranitidine 75mg tablets (Medreich Plc) | CPRD_product_code | res25: gastroprotection | drug |
5834 | Pariet 10mg gastro-resistant tablets (Eisai Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58344 | Omeprazole 50mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
58415 | Diclofenac sodium 50mg gastro-resistant / Misoprostol 200microgram tablets (A A H Pharmaceuticals Lt | CPRD_product_code | res25: gastroprotection | drug |
58475 | Rabeprazole 20mg gastro-resistant tablets (Zentiva) | CPRD_product_code | res25: gastroprotection | drug |
58679 | Lansoprazole 15mg gastro-resistant capsules (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58711 | Ranitidine 150mg tablets (Boston Healthcare Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58842 | Misofen 75mg / 200microgram gastro-resistant tablets (Morningside Healthcare Ltd) | CPRD_product_code | res25: gastroprotection | drug |
58946 | Omeprazole 10mg gastro-resistant capsules (Waymade Healthcare Plc) | CPRD_product_code | res25: gastroprotection | drug |
59106 | Lansoprazole 30mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
59135 | Omeprazole 2.5mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
59296 | Rabeprazole 10mg gastro-resistant tablets (Zentiva) | CPRD_product_code | res25: gastroprotection | drug |
59390 | Pantoprazole 40mg gastro-resistant tablets (Nycomed UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
59394 | Misoprostol 400microgram tablets | CPRD_product_code | res25: gastroprotection | drug |
59404 | Lansoprazole 30mg gastro-resistant capsules (Sovereign Medical Ltd) | CPRD_product_code | res25: gastroprotection | drug |
59547 | Omeprazole 40mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
59586 | Lansoprazole 30mg gastro-resistant capsules (Kent Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
59711 | Pantoprazole 20mg gastro-resistant tablets (Teva UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
59725 | Omeprazole 25mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
60230 | Omeprazole 10mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
60403 | Omeprazole 20mg/5ml oral solution | CPRD_product_code | res25: gastroprotection | drug |
60409 | Omeprazole 20mg dispersible gastro-resistant tablets (Waymade Healthcare Plc) | CPRD_product_code | res25: gastroprotection | drug |
60537 | Lansoprazole 30mg gastro-resistant capsules (DE Pharmaceuticals) | CPRD_product_code | res25: gastroprotection | drug |
60588 | Rabeprazole 20mg gastro-resistant tablets (Alliance Healthcare (Distribution) Ltd) | CPRD_product_code | res25: gastroprotection | drug |
60590 | Rabeprazole 20mg gastro-resistant tablets (Actavis UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
60615 | Lansoprazole 30mg orodispersible tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: gastroprotection | drug |
6063 | Zoton FasTab 30mg (Pfizer Ltd) | CPRD_product_code | res25: gastroprotection | drug |
6114 | Omeprazole 20mg gastro-resistant tablets | CPRD_product_code | res25: gastroprotection | drug |
6165 | Protium 20mg gastro-resistant tablets (Nycomed UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
6245 | Lansoprazole 15mg orodispersible tablets | CPRD_product_code | res25: gastroprotection | drug |
6291 | Zoton FasTab 15mg (Pfizer Ltd) | CPRD_product_code | res25: gastroprotection | drug |
6300 | Lansoprazole 30mg orodispersible tablets | CPRD_product_code | res25: gastroprotection | drug |
6490 | Nexium 40mg gastro-resistant tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
6727 | Protium 40mg gastro-resistant tablets (Nycomed UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
68 | Cimetidine 400mg tablets | CPRD_product_code | res25: gastroprotection | drug |
690 | Nizatidine 150mg capsules | CPRD_product_code | res25: gastroprotection | drug |
7255 | Omeprazole 20mg/5ml oral suspension | CPRD_product_code | res25: gastroprotection | drug |
7666 | Zantac 300mg tablets (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
773 | Misoprostol 200microgram tablets | CPRD_product_code | res25: gastroprotection | drug |
7848 | Tagamet 400mg Tablet (GlaxoSmithKline UK Ltd) | CPRD_product_code | res25: gastroprotection | drug |
8388 | Pepcid 20mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res25: gastroprotection |