Study question:
What is the prevalence of different types of potentially hazardous prescribing in general practice in the United Kingdom, and what is the variation between practices?
Methods:
A cross sectional study included all adult patients potentially at risk of a prescribing or monitoring error defined by a combination of diagnoses and prescriptions in 526 general practices contributing to the Clinical Practice Research Datalink (CPRD) up to 1 April 2013. Primary outcomes were the prevalence of potentially hazardous prescriptions of anticoagulants, anti-platelets, NSAIDs, β blockers, glitazones, metformin, digoxin, antipsychotics, combined hormonal contraceptives, and oestrogens and monitoring by blood test less frequently than recommended for patients with repeated prescriptions of angiotensin converting enzyme inhibitors and loop diuretics, amiodarone, methotrexate, lithium, or warfarin.
Study answer and limitations:
49 927 of 949 552 patients at risk triggered at least one prescribing indicator (5.26%, 95% confidence interval 5.21% to 5.30%) and 21 501 of 182 721 (11.8%, 11.6% to 11.9%) triggered at least one monitoring indicator. The prevalence of different types of potentially hazardous prescribing ranged from almost zero to 10.2%, and for inadequate monitoring ranged from 10.4% to 41.9%. Older patients and those prescribed multiple repeat medications had significantly higher risks of triggering a prescribing indicator whereas younger patients with fewer repeat prescriptions had significantly higher risk of triggering a monitoring indicator. There was high variation between practices for some indicators. Though prescribing safety indicators describe prescribing patterns that can increase the risk of harm to the patient and should generally be avoided, there will always be exceptions where the indicator is clinically justified. Furthermore there is the possibility that some information is not captured by CPRD for some practices—for example, INR results in patients receiving warfarin.
What this study adds:
The high prevalence for certain indicators emphasises existing prescribing risks and the need for their appropriate consideration within primary care, particularly for older patients and those taking multiple medications. The high variation between practices indicates potential for improvement through targeted practice level intervention.
S Jill Stocks, Evangelos Kontopantelis, Artur Akbarov, Sarah Rodgers, Anthony J Avery, Darren M Ashcroft, Examining variations in prescribing safety in UK general practice cross sectional study using the Clinical Practice Research Datalink. BMJ, 351(h5501), 2015.
Code | Description | Coding System (CPRD_product_code) | Entity type | Category |
---|---|---|---|---|
1006 | Half Inderal LA 80mg capsules (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
10191 | Atenix 50 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
10429 | Lopresor 50mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1048 | Inderal 80mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1050 | Inderal 40mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
10627 | Co-Betaloc tablets (Pfizer Ltd) | CPRD_product_code | res25: P1betablockers | drug |
10716 | Corgard 80mg tablets (Sanofi) | CPRD_product_code | res25: P1betablockers | drug |
10777 | Trasicor 160mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
10892 | Emcor 10mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1124 | Tenoretic 100mg/25mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
11338 | Bendroflumethiazide 5mg with Nadolol 40mg tablets | CPRD_product_code | res25: P1betablockers | drug |
11380 | Sotacor 160mg tablets (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
11432 | TIMOPTOL preservative free unit dose eye drops 0.5% [M S D] | CPRD_product_code | res25: P1betablockers | drug |
11454 | timolol maleate gel-forming eye drops 0.5% | CPRD_product_code | res25: P1betablockers | drug |
11711 | Propranolol 50mg/5ml oral solution | CPRD_product_code | res25: P1betablockers | drug |
11793 | Metoprolol 50mg/5ml oral suspension | CPRD_product_code | res25: P1betablockers | drug |
12037 | Betim 10mg Tablet (ICN Pharmaceuticals France S.A.) | CPRD_product_code | res25: P1betablockers | drug |
12054 | Propranolol 80mg / Bendroflumethiazide 2.5mg capsules | CPRD_product_code | res25: P1betablockers | drug |
12141 | Betaxolol 20mg tablets | CPRD_product_code | res25: P1betablockers | drug |
12191 | GLAULINE eye drops 0.6% [S & N] | CPRD_product_code | res25: P1betablockers | drug |
12296 | Sectral 100mg capsules (Sanofi) | CPRD_product_code | res25: P1betablockers | drug |
12456 | Sotazide Tablet (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
12495 | Berkolol 10mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
12517 | Timolol maleate with bendroflumethiazide 20mg + 5mg Tablet | CPRD_product_code | res25: P1betablockers | drug |
12519 | Kerlone 20mg tablets (Sanofi-Synthelabo Ltd) | CPRD_product_code | res25: P1betablockers | drug |
12651 | Timolol 10mg / Bendroflumethiazide 2.5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
12678 | BETOPTIC ophthalmic suspension 0.25% [ALCON] | CPRD_product_code | res25: P1betablockers | drug |
12749 | metipranolol preservative free eye drops 0.1% | CPRD_product_code | res25: P1betablockers | drug |
1288 | Tenoret 50mg/12.5mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1290 | Bisoprolol 10mg tablets | CPRD_product_code | res25: P1betablockers | drug |
1295 | Labetalol 400mg tablets | CPRD_product_code | res25: P1betablockers | drug |
13051 | Sotalol 200mg tablets | CPRD_product_code | res25: P1betablockers | drug |
1333 | Oxprenolol 40mg tablets | CPRD_product_code | res25: P1betablockers | drug |
1334 | Oxprenolol 160mg modified-release tablets | CPRD_product_code | res25: P1betablockers | drug |
13394 | Tenormin 25mg/5ml syrup (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
13487 | Beta-Cardone 200mg tablets (Focus Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
13499 | Lopresor 100mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
13526 | Atenix Co 100 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
13871 | Co-prenozide 160mg/0.25mg modified-release tablets | CPRD_product_code | res25: P1betablockers | drug |
14030 | Cardicor 2.5mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
14057 | Pindolol 10mg / Clopamide 5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
14058 | Cardicor 1.25mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
14117 | Eucardic 3.125mg tablets (Roche Products Ltd) | CPRD_product_code | res25: P1betablockers | drug |
14126 | Acebutolol 200mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
14146 | Eucardic 6.25mg tablets (Roche Products Ltd) | CPRD_product_code | res25: P1betablockers | drug |
14211 | MINIMS METIPRANOLOL eye drops 0.1% [BAUSCH & L] | CPRD_product_code | res25: P1betablockers | drug |
14286 | timolol with travoprost eye drops 0.5% + 0.004% | CPRD_product_code | res25: P1betablockers | drug |
14319 | DUOTRAV eye drops [ALCON] | CPRD_product_code | res25: P1betablockers | drug |
14438 | Corgaretic 80mg tablets (Sanofi-Synthelabo Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1448 | Propranolol 160mg modified-release capsules | CPRD_product_code | res25: P1betablockers | drug |
14552 | Propanix 10mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
14673 | Pindolol 15mg tablets | CPRD_product_code | res25: P1betablockers | drug |
14808 | Bedranol SR 80mg capsules (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
14877 | NYOGEL eye gel 0.1% [ALCON] | CPRD_product_code | res25: P1betablockers | drug |
14952 | COMBIGAN eye drops [ALLERGAN] | CPRD_product_code | res25: P1betablockers | drug |
15042 | Tolerzide Tablet (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
15117 | Nifedipine with atenolol 20mg + 50mg Capsule | CPRD_product_code | res25: P1betablockers | drug |
15176 | Totamol 50mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
15488 | Metoprolol tartrate with chlortalidone Tablet | CPRD_product_code | res25: P1betablockers | drug |
15619 | Half-betadur cr 80mg Capsule (Monmouth Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1572 | Sotalol 80mg tablets | CPRD_product_code | res25: P1betablockers | drug |
15730 | Totamol 100mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1597 | Labetalol 100mg tablets | CPRD_product_code | res25: P1betablockers | drug |
16032 | timolol maleate eye gel 0.1% | CPRD_product_code | res25: P1betablockers | drug |
16156 | timolol with bimatoprost eye drops 0.5% + 0.03% | CPRD_product_code | res25: P1betablockers | drug |
16645 | Labrocol 400mg Tablet (Lagap) | CPRD_product_code | res25: P1betablockers | drug |
16776 | Celectol 400mg Tablet (Pantheon Healthcare Ltd) | CPRD_product_code | res25: P1betablockers | drug |
16786 | Chlortalidone 25mg with Atenolol 100mg tablets | CPRD_product_code | res25: P1betablockers | drug |
1684 | Beta-Adalat modified-release capsules (Bayer Plc) | CPRD_product_code | res25: P1betablockers | drug |
17082 | Syprol 5mg/5ml oral solution (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
17115 | timolol maleate with dorzolamide eye drops 0.5% + 2% | CPRD_product_code | res25: P1betablockers | drug |
17149 | Monozide 10 tablets (Wyeth Pharmaceuticals) | CPRD_product_code | res25: P1betablockers | drug |
17322 | Atenix 25 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
17462 | Bisoprolol 10mg / Hydrochlorothiazide 6.25mg tablets | CPRD_product_code | res25: P1betablockers | drug |
17615 | Cardicor 5mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
17759 | metipranolol eye drops 0.1% | CPRD_product_code | res25: P1betablockers | drug |
17783 | Spiroprop Tablet (Pharmacia Ltd) | CPRD_product_code | res25: P1betablockers | drug |
1788 | Atenolol 100mg with Chlortalidone 25mg tablets | CPRD_product_code | res25: P1betablockers | drug |
18114 | metipranolol preservative free eye drops 0.3% | CPRD_product_code | res25: P1betablockers | drug |
18185 | Cardicor 7.5mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
18287 | Co-Betaloc SA tablets (Pfizer Ltd) | CPRD_product_code | res25: P1betablockers | drug |
18414 | Eucardic 12.5mg tablets (Roche Products Ltd) | CPRD_product_code | res25: P1betablockers | drug |
18743 | Tenben 25mg/1.25mg capsules (Galen Ltd) | CPRD_product_code | res25: P1betablockers | drug |
18950 | Totamol 25mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
18956 | MINIMS METIPRANOLOL eye drops 0.6% [BAUSCH & L] | CPRD_product_code | res25: P1betablockers | drug |
19055 | Chlortalidone 12.5mg with Atenolol 50mg tablets | CPRD_product_code | res25: P1betablockers | drug |
1910 | levobunolol eye drops 0.5% | CPRD_product_code | res25: P1betablockers | drug |
19142 | Bendroflumethiazide 2.5mg with Timolol maleate 10mg tablets | CPRD_product_code | res25: P1betablockers | drug |
19149 | betaxolol hydrochloride preservative free ophthalmic suspension 0.25% | CPRD_product_code | res25: P1betablockers | drug |
19172 | Atenolol 25mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19178 | Bisoprolol 10mg tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19182 | Atenolol 50mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19191 | Atenolol 100mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19200 | Bisoprolol 5mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19202 | Carvedilol 6.25mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19437 | Eucardic 25mg tablets (Roche Products Ltd) | CPRD_product_code | res25: P1betablockers | drug |
197 | Atenolol 5mg/10ml solution for injection ampoules | CPRD_product_code | res25: P1betablockers | drug |
19853 | Cardicor 3.75mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
19858 | Cardicor 10mg tablets (Merck Serono Ltd) | CPRD_product_code | res25: P1betablockers | drug |
20012 | Visken 15mg Tablet (Sovereign Medical Ltd) | CPRD_product_code | res25: P1betablockers | drug |
20015 | MINIMS METIPRANOLOL eye drops 0.3% [BAUSCH & L] | CPRD_product_code | res25: P1betablockers | drug |
20082 | Lopresor SR 200mg tablets (Recordati Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
20093 | Metoprolol 200mg modified-release / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res25: P1betablockers | drug |
20363 | GANFORT eye drops [ALLERGAN] | CPRD_product_code | res25: P1betablockers | drug |
20468 | Half Beta-Prograne 80mg modified-release capsules (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
20502 | Atenix 100 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
20728 | Atenamin 25mg Tablet (OPD Pharm) | CPRD_product_code | res25: P1betablockers | drug |
21025 | Prestim forte Tablet (LEO Pharma) | CPRD_product_code | res25: P1betablockers | drug |
21133 | Atenamin 50mg Tablet (OPD Pharm) | CPRD_product_code | res25: P1betablockers | drug |
21182 | Hydrochlorothiazide with timolol and amiloride 25mg with 10mg with 2.5mg Tablet | CPRD_product_code | res25: P1betablockers | drug |
21506 | GLAU-OPT eye drops 0.25% [OPUS] | CPRD_product_code | res25: P1betablockers | drug |
21508 | GLAU-OPT eye drops 0.5% [OPUS] | CPRD_product_code | res25: P1betablockers | drug |
21706 | BETOPTIC preservative free ophthalmic suspension 0.25% [ALCON] | CPRD_product_code | res25: P1betablockers | drug |
21838 | Propanix 80mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
21839 | Berkolol 80mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
21866 | Berkolol 40mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
21873 | Atenix Co 50 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
21885 | Oxyprenix SR 160mg tablets | CPRD_product_code | res25: P1betablockers | drug |
21905 | Bipranix 10mg tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
21966 | Bipranix 5mg tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
220 | Propranolol 5mg/5ml oral solution | CPRD_product_code | res25: P1betablockers | drug |
22208 | Half propanix la 80mg Modified-release capsule (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
22793 | Labrocol 200mg Tablet (Lagap) | CPRD_product_code | res25: P1betablockers | drug |
22912 | Bendroflumethiazide 2.5mg with Propanolol 80mg capsules | CPRD_product_code | res25: P1betablockers | drug |
23131 | Bendroflumethiazide 5mg with Propanolol 160mg modified-release capsules | CPRD_product_code | res25: P1betablockers | drug |
23134 | Nadolol 40mg / Bendroflumethiazide 5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
23326 | Betadur cr 160mg Modified-release capsule (Monmouth Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
23587 | Sloprolol 160mg Capsule (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
2361 | Trasicor 80mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
2378 | TIMOPTOL eye drops 0.5% [M S D] | CPRD_product_code | res25: P1betablockers | drug |
2380 | GLAUCOL unit dose eye drops 0.5% [IVAX] | CPRD_product_code | res25: P1betablockers | drug |
2381 | timolol maleate preservative free unit dose eye drops 0.5% | CPRD_product_code | res25: P1betablockers | drug |
24 | Atenolol 100mg tablets | CPRD_product_code | res25: P1betablockers | drug |
24083 | Bisoprolol 5mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
24094 | Trasicor 40mg tablets (Amdipharm Plc) | CPRD_product_code | res25: P1betablockers | drug |
2414 | Inderal 10mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
24191 | Antipressan 50mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
24195 | Antipressan 100mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
24218 | Berkolol 160mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
24280 | Totaretic 100mg+25mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
2432 | Tenormin LS 50mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
24832 | Lasipressin Tablet (Hoechst UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
2499 | Nadolol 80mg tablets | CPRD_product_code | res25: P1betablockers | drug |
2523 | BETOPTIC eye drops 0.5% [ALCON] | CPRD_product_code | res25: P1betablockers | drug |
25359 | Rapranol SR 160mg capsules (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
25363 | Prestim tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
25367 | Rapranol SR 80mg capsules (Ranbaxy (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
25462 | Clopamide 5mg with Pindolol 10mg tablets | CPRD_product_code | res25: P1betablockers | drug |
25644 | Apsolox 80mg Tablet (Approved Prescription Services Ltd) | CPRD_product_code | res25: P1betablockers | drug |
25730 | Timolol maleate with amiloride and hydrochlorothiazide Tablet | CPRD_product_code | res25: P1betablockers | drug |
2587 | Tenormin 100mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
2590 | Tenormin 25mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
26 | Atenolol 25mg tablets | CPRD_product_code | res25: P1betablockers | drug |
26211 | Antipressan 25mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
26228 | Propanix LA 160mg Modified-release capsule (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
26229 | Beta-Prograne 160mg modified-release capsules (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
26248 | Tenchlor 100mg/25mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
26255 | Lopranol la 160mg Capsule (Opus Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
2629 | Carvedilol 12.5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
26529 | Furosemide with penbutolol Tablet | CPRD_product_code | res25: P1betablockers | drug |
26741 | Totaretic 50mg+12.5mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
26895 | Syprol 10mg/5ml oral solution (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
27141 | COSOPT preservative free eye drops [M S D] | CPRD_product_code | res25: P1betablockers | drug |
27357 | Oxprenolol 40mg Tablet (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
27700 | Propranolol 40mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
27719 | Metoros ls 95mg Tablet (Geigy Pharmaceuticals) | CPRD_product_code | res25: P1betablockers | drug |
2774 | GLAUCOL unit dose eye drops 0.25% [IVAX] | CPRD_product_code | res25: P1betablockers | drug |
2775 | Labetalol 200mg tablets | CPRD_product_code | res25: P1betablockers | drug |
2780 | Oxprenolol 80mg tablets | CPRD_product_code | res25: P1betablockers | drug |
27946 | Nadolol 80mg / Bendroflumethiazide 5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
27964 | Apsolol 40mg Tablet (Approved Prescription Services Ltd) | CPRD_product_code | res25: P1betablockers | drug |
28048 | Angilol 10mg Tablet (DDSA Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
28128 | Propranolol 80mg Modified-release capsule (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
28177 | Hydrochlorothiazide with atenolol and amiloride Capsule | CPRD_product_code | res25: P1betablockers | drug |
28700 | Cartrol 10mg Tablet (Novartis Consumer Health UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
28788 | Half propatard la 80mg Modified-release capsule (Galen Ltd) | CPRD_product_code | res25: P1betablockers | drug |
28996 | Bedranol SR 160mg capsules (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
29180 | Trasicor 80mg tablets (Amdipharm Plc) | CPRD_product_code | res25: P1betablockers | drug |
29230 | Slow-pren 160mg Tablet (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
29368 | Atenolol 25mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
29398 | Atenamin 100mg Tablet (OPD Pharm) | CPRD_product_code | res25: P1betablockers | drug |
29427 | Hydrochlorothiazide with metoprolol tartrate 12.5mg with 100mg tablet | CPRD_product_code | res25: P1betablockers | drug |
29610 | Betim 10mg tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
297 | Propranolol 10mg tablets | CPRD_product_code | res25: P1betablockers | drug |
29762 | Mepranix 50mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
29763 | Propanix 160mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
29827 | Carteolol HCl 10mg tablets | CPRD_product_code | res25: P1betablockers | drug |
29998 | Metoros 190mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3005 | Inderal LA 160mg capsules (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
30400 | Mepranix 100mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
30519 | Amiloride with timolol with hydrochlorothiazide tablets | CPRD_product_code | res25: P1betablockers | drug |
30636 | Vasaten 50mg Tablet (Shire Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
30770 | Labetalol 200mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3084 | betaxolol hydrochloride eye drops 0.5% | CPRD_product_code | res25: P1betablockers | drug |
3085 | carteolol hydrochloride eye drops 1% | CPRD_product_code | res25: P1betablockers | drug |
3087 | Propranolol 40mg/5ml oral solution sugar free | CPRD_product_code | res25: P1betablockers | drug |
3112 | TEOPTIC eye drops 1% [SPECTRUM] | CPRD_product_code | res25: P1betablockers | drug |
31214 | Propranolol 80mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
313 | TIMOPTOL eye drops 0.25% [M S D] | CPRD_product_code | res25: P1betablockers | drug |
31470 | Tenchlor 50mg/12.5mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
31536 | Atenolol 25mg tablets (Kent Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3167 | Propranolol 160mg tablets | CPRD_product_code | res25: P1betablockers | drug |
31708 | Co-tenidone 50mg/12.5mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
31776 | Propranolol 40mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
31833 | Angilol 80mg Tablet (DDSA Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
31934 | Atenolol 100mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
32094 | Co-tenidone 50mg/12.5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
32114 | Bisoprolol 5mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
32162 | Propranolol 80mg Modified-release capsule (Lagap) | CPRD_product_code | res25: P1betablockers | drug |
32552 | Congescor 2.5mg tablets (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
32630 | Vivacor 10mg tablets (Lexon (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
32634 | TIMOLOL eye drops 0.25% [TEVA] | CPRD_product_code | res25: P1betablockers | drug |
32787 | Visken 15mg tablets (AMCo) | CPRD_product_code | res25: P1betablockers | drug |
32836 | Metoprolol 50mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33079 | Atenolol 100mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33085 | Atenolol 100mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33092 | Atenolol 50mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33184 | Atenolol 100mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33374 | Carvedilol 12.5mg tablets (Genus Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33376 | Probeta LA 160mg Capsule (Trinity Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33403 | TIMOLOL eye drops 0.25% [LENNON] | CPRD_product_code | res25: P1betablockers | drug |
3344 | Betaloc 100mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33569 | Oxprenolol sr 160mg Modified-release tablet (Hillcross Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33602 | Slo-Pro 160mg capsules (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33644 | Propranolol 80mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33650 | Atenolol 50mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33657 | Atenolol 25mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33659 | Hydrochlorothiazide with metoprolol tartrate 25mg with 200mg Modified-release tablet | CPRD_product_code | res25: P1betablockers | drug |
33836 | Apsolol 160mg Tablet (Approved Prescription Services Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33839 | Bisoprolol 10mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33850 | Atenolol 50mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
33909 | Congescor 1.25mg tablets (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34012 | Co-tenidone 100mg/25mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34034 | Co-tenidone 50mg/12.5mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34092 | Metoprolol 100mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34094 | Metoprolol 50mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34125 | Metoprolol 100mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34153 | TIMOLOL eye drops 0.25% [GEN (UK)] | CPRD_product_code | res25: P1betablockers | drug |
34171 | Labetalol 100mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34177 | Labetalol 100mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34185 | Propranolol LA 80mg Modified-release capsule (Approved Prescription Services Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34188 | Labetalol 200mg Tablet (Celltech Pharma Europe Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34208 | Propranolol SR 160mg Modified-release capsule (C P Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34214 | Propranolol 160mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34227 | TIMOLOL eye drops 0.5% [LENNON] | CPRD_product_code | res25: P1betablockers | drug |
34265 | Atenolol 50mg tablets (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34337 | TIMOLOL eye drops 0.25% [ACTAVIS] | CPRD_product_code | res25: P1betablockers | drug |
34365 | Atenolol 50mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34371 | Sotalol 40mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34378 | Propranolol 10mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34407 | Metoprolol 50mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34430 | Metoprolol 50mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34443 | Atenolol 50mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34449 | Co-tenidone 50mg/12.5mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34492 | Atenolol 25mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34501 | Carvedilol 12.5mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34509 | Metoprolol 100mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34520 | Sotalol 80mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34575 | Atenolol 25mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34584 | Metoprolol 50mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34585 | Atenolol 25mg tablets (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34600 | Sotalol 40mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34640 | Sotalol 40mg Tablet (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34690 | Sotalol 80mg tablets (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34695 | Atenolol 50mg tablets (Kent Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3474 | Betaloc-SA 200mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34740 | Carvedilol 6.25mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34741 | Carvedilol 3.125mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34754 | Atenolol 100mg tablets (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34783 | Propranolol 10mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34785 | TIMOLOL eye drops 0.5% [GEN (UK)] | CPRD_product_code | res25: P1betablockers | drug |
34804 | Propranolol 10mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34818 | TIMOLOL eye drops 0.25% [IVAX] | CPRD_product_code | res25: P1betablockers | drug |
34821 | Bisoprolol 10mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34825 | Co-tenidone 50mg/12.5mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34854 | Metoprolol 100mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34867 | Propranolol 80mg Capsule (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34868 | Propranolol 40mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34882 | Atenolol 50mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34884 | Propranolol 160mg Modified-release capsule (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34890 | Metoprolol 50mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34899 | Co-tenidone 100mg/25mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34925 | Metoprolol 50mg tablets (Sandoz Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34945 | Propranolol 160mg Modified-release capsule (Lagap) | CPRD_product_code | res25: P1betablockers | drug |
34949 | Propranolol 160mg Modified-release capsule (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3495 | GLAULINE eye drops 0.1% [S & N] | CPRD_product_code | res25: P1betablockers | drug |
34963 | Bisoprolol 5mg tablets (Actavis UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
34976 | Atenolol 25mg tablets (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
35054 | Celectol 200mg tablets (Zentiva) | CPRD_product_code | res25: P1betablockers | drug |
35062 | Trasicor 20mg tablets (Amdipharm Plc) | CPRD_product_code | res25: P1betablockers | drug |
3516 | Oxprenolol 20mg tablets | CPRD_product_code | res25: P1betablockers | drug |
35256 | dorzolamide hydrochloride with timolol maleate preservative free eye drops 2% + 0.5% | CPRD_product_code | res25: P1betablockers | drug |
3526 | Amiloride with atenolol with hydrochlorothiazide capsules | CPRD_product_code | res25: P1betablockers | drug |
35695 | Visken 5mg tablets (AMCo) | CPRD_product_code | res25: P1betablockers | drug |
35710 | Sotalol 25mg/5ml oral suspension | CPRD_product_code | res25: P1betablockers | drug |
35778 | Labrocol 100mg Tablet (Lagap) | CPRD_product_code | res25: P1betablockers | drug |
3588 | Monocor 5mg tablets (Wyeth Pharmaceuticals) | CPRD_product_code | res25: P1betablockers | drug |
35933 | LEVOBUNOLOL eye drops 0.5% [CUSI] | CPRD_product_code | res25: P1betablockers | drug |
35938 | Propranolol 80mg modified-release capsules (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
35940 | Celectol 400mg tablets (Zentiva) | CPRD_product_code | res25: P1betablockers | drug |
36261 | Atenolol 50mg tablets (Tillomed Laboratories Ltd) | CPRD_product_code | res25: P1betablockers | drug |
36576 | Propranolol 10mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
36603 | Propranolol SR 160mg Modified-release capsule (Hillcross Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
367 | BETAGAN eye drops 0.5% [ALLERGAN] | CPRD_product_code | res25: P1betablockers | drug |
3691 | Sotalol 160mg with hydrochlorothiazide 25mg tablet | CPRD_product_code | res25: P1betablockers | drug |
37118 | Bisoprolol 2.5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3748 | Oxprenolol 160mg Tablet | CPRD_product_code | res25: P1betablockers | drug |
3765 | BETAGAN preservative free eye drops 0.5% [ALLERGAN] | CPRD_product_code | res25: P1betablockers | drug |
37725 | Co-tenidone 100mg/25mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
37837 | Bisoprolol 2.5mg Tablet (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
3827 | Propanix 40mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
38433 | Propranolol 50mg/5ml Oral solution (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
38991 | Bisoprolol 7.5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
39233 | Propranolol 80mg modified-release capsules (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
39423 | Sotalol 80mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
39646 | Bisoprolol 0.625mg/5ml oral solution | CPRD_product_code | res25: P1betablockers | drug |
3971 | TEOPTIC eye drops 2% w/v [SPECTRUM] | CPRD_product_code | res25: P1betablockers | drug |
39846 | Vivacor 5mg tablets (Lexon (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
4004 | Sotacor 80mg tablets (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
40167 | Metoprolol 100mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
40240 | Labetalol 400mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
40241 | Propranolol LA 160mg Capsule (Approved Prescription Services Ltd) | CPRD_product_code | res25: P1betablockers | drug |
40242 | TIMOLOL eye drops 0.5% [TEVA] | CPRD_product_code | res25: P1betablockers | drug |
4025 | Slow-Trasicor 160mg tablets (AMCo) | CPRD_product_code | res25: P1betablockers | drug |
40257 | AZARGA eye drops 10mg + 5mg/ml [ALCON] | CPRD_product_code | res25: P1betablockers | drug |
40289 | brinzolamide with timolol eye drops 10mg + 5mg/ml | CPRD_product_code | res25: P1betablockers | drug |
4059 | betaxolol hydrochloride ophthalmic suspension 0.25% | CPRD_product_code | res25: P1betablockers | drug |
40761 | Nebivolol 2.5mg tablets | CPRD_product_code | res25: P1betablockers | drug |
41555 | Propranolol 40mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
41572 | Co-tenidone 100mg/25mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
41591 | Bisoprolol 10mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
41740 | Celiprolol 200mg tablets (Teva UK Ltd) | CPRD_product_code | res25: P1betablockers | drug |
41827 | Labetalol 100mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
42152 | Syprol 50mg/5ml oral solution (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res25: P1betablockers | drug |
4265 | Celectol 200mg Tablet (Pantheon Healthcare Ltd) | CPRD_product_code | res25: P1betablockers | drug |
42795 | Celiprolol 200mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
42796 | TIMOLOL eye drops 0.5% [ACTAVIS] | CPRD_product_code | res25: P1betablockers | drug |
43251 | Bisoprolol 1.25mg tablets (Generics (UK) Ltd) | CPRD_product_code | res25: P1betablockers | drug |
43427 | TIMOLOL eye drops 0.25% [HILLCROSS] | CPRD_product_code |