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Anxiolitics

K Windfuhr, D While, N Kapur, D M Ashcroft, E Kontopantelis, M J Carr, J Shaw, L Applyby, R T Webb

Type
Drug
ID
PH695
Version ID
1390
Data Sources
Valid event data range
01/01/2002 - 31/12/2011
Sex
Female, Male
Agreement Date
2016-09-21
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Background:

Little is known about the precursors of suicide risk among primary-care patients. This study aimed to examine suicide risk in relation to patterns of clinical consultation, psychotropic drug prescribing, and psychiatric diagnoses.

Method:

Nested case-control study in the Clinical Practice Research Datalink (CPRD), England. Patients aged516 years who died by suicide during 2002–2011 (N = 2384) were matched on gender, age and practice with up to 20 living control patients (N = 46 899).

Results:

Risk was raised among non-consulting patients, and increased sharply with rising number of consultations in the preceding year [512 consultations v. 1: unadjusted odds ratio (OR) 6.0, 95% confidence interval (CI) 4.9–7.3]. Markedly elevated risk was also associated with the prescribing of multiple psychotropic medication types (55 types v. 0: OR 62.6, CI 44.3–88.4) and with having several psychiatric diagnoses (54 diagnoses v. 0: OR 31.1, CI 19.3–50.1). Risk was also raised among patients living in more socially deprived localities. The confounding effect of multiple psychotropic drug types largely accounted for the rising risk gradient observed with increasing consultation frequency.

Conclusions:

A greater proportion of patients with several psychiatric diagnoses, those prescribed multiple psychotropic medication types, and those who consult at very high frequency might be considered for referral to mental health services by their general practitioners. Non-consulters are also at increased risk, which suggests that conventional models of primary care may not be effective in meeting the needs of all people in the community experiencing major psychosocial difficulties.

Publications

  • K Windfuhr, D While, N Kapur, D M Ashcroft, E Kontopantelis, M J Carr, J Shaw, L Appleby, R T Webb, Suicide risk linked with clinical consultation frequency, psychiatric diagnoses and psychotropic medication prescribing in a national study of primary-care patients. Psychological Medicine, 46, 3407-3417, 2016.

Clinical Code List

Rows: 40
Code Description Entity type Coding System (Multilex) Category
39801020 Zimovane 7.5mg tablets (Lexon (UK) Ltd) res38: Anxiolitics Multilex drug
479021 Zopiclone 3.75mg/5ml oral solution res38: Anxiolitics Multilex drug
59209020 Zopiclone 7.5mg tablets (Actavis UK Ltd) res38: Anxiolitics Multilex drug
59210020 Zopiclone 3.75mg tablets (Actavis UK Ltd) res38: Anxiolitics Multilex drug
59236020 Zopiclone 3.75mg tablets (IVAX Pharmaceuticals UK Ltd) res38: Anxiolitics Multilex drug
59237020 Zopiclone 7.5mg tablets (IVAX Pharmaceuticals UK Ltd) res38: Anxiolitics Multilex drug
59593020 Zopiclone 3.75mg tablets (Teva UK Ltd) res38: Anxiolitics Multilex drug
59594020 Zopiclone 7.5mg tablets (Teva UK Ltd) res38: Anxiolitics Multilex drug
59784020 Zopiclone 7.5mg tablets (Generics (UK) Ltd) res38: Anxiolitics Multilex drug
59785020 Zopiclone 3.75mg tablets (Generics (UK) Ltd) res38: Anxiolitics Multilex drug
60509020 Zopiclone 3.75mg tablets (A A H Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
60510020 Zopiclone 7.5mg tablets (A A H Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
62715020 Zopiclone 7.5mg tablets (Sandoz Ltd) res38: Anxiolitics Multilex drug
63436020 Zopiclone 7.5mg tablets (Kent Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
63765020 Zopiclone 7.5mg tablets (PLIVA Pharma Ltd) res38: Anxiolitics Multilex drug
63881020 Zolpidem 5mg Tablet (Winthrop Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
63882020 Zolpidem 10mg Tablet (Winthrop Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
64484020 Zolpidem 5mg tablets (Teva UK Ltd) res38: Anxiolitics Multilex drug
64487020 Zolpidem 10mg tablets (Teva UK Ltd) res38: Anxiolitics Multilex drug
64733020 Zolpidem 5mg tablets (A A H Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
64738020 Zolpidem 10mg tablets (A A H Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
65546020 Zopiclone 3.75mg tablets (Kent Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
65832020 Zolpidem 5mg tablets (IVAX Pharmaceuticals UK Ltd) res38: Anxiolitics Multilex drug
65835020 Zolpidem 10mg tablets (IVAX Pharmaceuticals UK Ltd) res38: Anxiolitics Multilex drug
66946020 Zolpidem 10mg tablets (Generics (UK) Ltd) res38: Anxiolitics Multilex drug
72408020 Zimovane 7.5mg tablets (Sanofi) res38: Anxiolitics Multilex drug
72416020 Zopiclone 7.5mg tablets res38: Anxiolitics Multilex drug
72417020 Zopiclone 3.75mg tablets res38: Anxiolitics Multilex drug
75692020 Zolpidem 5mg tablets res38: Anxiolitics Multilex drug
75693020 Zolpidem 10mg tablets res38: Anxiolitics Multilex drug
75696020 Stilnoct 5mg tablets (Sanofi) res38: Anxiolitics Multilex drug
75697020 Stilnoct 10mg tablets (Sanofi) res38: Anxiolitics Multilex drug
83069020 Zimovane LS 3.75mg tablets (Sanofi) res38: Anxiolitics Multilex drug
85821020 Zileze 3.75 tablets (Opus Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
85822020 Zileze 7.5 tablets (Opus Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
86240020 Zaleplon 5mg capsules res38: Anxiolitics Multilex drug
86241020 Zaleplon 10mg capsules res38: Anxiolitics Multilex drug
86243020 Sonata 5mg capsules (Meda Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
86244020 Sonata 10mg capsules (Meda Pharmaceuticals Ltd) res38: Anxiolitics Multilex drug
91009020 Zopiclone 3.75mg/5ml oral suspension res38: Anxiolitics Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH695/version/1390/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH695/version/1390/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH695', '1390', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH695/version/1390/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH695/version/1390/export/codes/?format=json
CSV site_root/phenotypes/PH695/version/1390/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH695', '1390', api_client=client)

Version History

Version
ID
Name Owner Publish date
1390 Anxiolitics ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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