Methodology/ Principal Findings:
Design-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non–users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1?54 (95% CI 1.27–1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83–1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56–1.09) and 0.87 (95% CI 0.55–1.36) respectively.
Ellen Wright, Peter T Schofield, Paul Seed, Mariam Molokhia, Bisphosphonates and Risk of Upper Gastrointestinal Cancer — A Case Control Study Using the General Practice Research Database (GPRD). PLoS ONE, 7:10, 2012.
Code | Description | Entity type | Category | Coding System (Read) |
---|---|---|---|---|
B10..00 | Malignant neoplasm of oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B100.00 | Malignant neoplasm of cervical oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B101.00 | Malignant neoplasm of thoracic oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B102.00 | Malignant neoplasm of abdominal oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B103.00 | Malignant neoplasm of upper third of oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B104.00 | Malignant neoplasm of middle third of oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B105.00 | Malignant neoplasm of lower third of oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B106.00 | Malignant neoplasm; overlapping lesion of oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B107.00 | Siewert type I adenocarcinoma | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B10y.00 | Malignant neoplasm of other specified part of oesophagus | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B10z.00 | Malignant neoplasm of oesophagus NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B10z.11 | Oesophageal cancer | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11..00 | Malignant neoplasm of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11..11 | Gastric neoplasm | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B110.00 | Malignant neoplasm of cardia of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B110100 | Malignant neoplasm of cardio-oesophageal junction of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B110111 | Malignant neoplasm of gastro-oesophageal junction | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B110z00 | Malignant neoplasm of cardia of stomach NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B111.00 | Malignant neoplasm of pylorus of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B111000 | Malignant neoplasm of prepylorus of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B111100 | Malignant neoplasm of pyloric canal of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B111z00 | Malignant neoplasm of pylorus of stomach NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B112.00 | Malignant neoplasm of pyloric antrum of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B113.00 | Malignant neoplasm of fundus of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B114.00 | Malignant neoplasm of body of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B115.00 | Malignant neoplasm of lesser curve of stomach unspecified | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B116.00 | Malignant neoplasm of greater curve of stomach unspecified | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B117.00 | Malignant neoplasm; overlapping lesion of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B118.00 | Siewert type II adenocarcinoma | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B119.00 | Siewert type III adenocarcinoma | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11y.00 | Malignant neoplasm of other specified site of stomach | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11y000 | Malignant neoplasm of anterior wall of stomach NEC | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11y100 | Malignant neoplasm of posterior wall of stomach NEC | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11yz00 | Malignant neoplasm of other specified site of stomach NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
B11z.00 | Malignant neoplasm of stomach NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
BB55.00 | [M]Linitisplastica | res14: Upper gastrointestinal malignancy | diagnostic | Read |
BB5C.00 | [M]Gastrinoma and carcinomas | res14: Upper gastrointestinal malignancy | diagnostic | Read |
BB5C000 | [M]Gastrinoma NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
BB5C011 | [M]G cell tumour NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
BB5C100 | [M]Gastrinoma; malignant | res14: Upper gastrointestinal malignancy | diagnostic | Read |
BB5Cz00 | [M]Gastrinoma or carcinoma NOS | res14: Upper gastrointestinal malignancy | diagnostic | Read |
To Export Phenotype Details:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH719/version/1438/detail/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH719/version/1438/detail/?format=json |
R Package |
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To Export Phenotype Code List:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH719/version/1438/export/codes/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH719/version/1438/export/codes/?format=json |
CSV | site_root/phenotypes/PH719/version/1438/export/codes/ |
R Package |
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Version ID |
Name | Owner | Publish date | |
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1438 | Upper Gastro Intestinal Malignancy | ieuan.scanlon | 2021-10-06 | currently shown |
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