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Upper Gastro Intestinal Malignancy

Ellen Wright, Peter T Schofield, Paul Seed, Mariam Molokhia

Type
Disease or Syndrome
ID
PH719
Version ID
1438
Data Sources
Valid event data range
01/01/1995 - 31/12/2007
Sex
Female, Male
Agreement Date
2012-10-01
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Methodology/ Principal Findings:

Design-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non–users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1?54 (95% CI 1.27–1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83–1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56–1.09) and 0.87 (95% CI 0.55–1.36) respectively.

Publications

  • Ellen Wright, Peter T Schofield, Paul Seed, Mariam Molokhia, Bisphosphonates and Risk of Upper Gastrointestinal Cancer — A Case Control Study Using the General Practice Research Database (GPRD). PLoS ONE, 7:10, 2012.

Clinical Code List

Rows: 41
Code Description Entity type Category Coding System (Read)
B10..00 Malignant neoplasm of oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B100.00 Malignant neoplasm of cervical oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B101.00 Malignant neoplasm of thoracic oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B102.00 Malignant neoplasm of abdominal oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B103.00 Malignant neoplasm of upper third of oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B104.00 Malignant neoplasm of middle third of oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B105.00 Malignant neoplasm of lower third of oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B106.00 Malignant neoplasm; overlapping lesion of oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B107.00 Siewert type I adenocarcinoma res14: Upper gastrointestinal malignancy diagnostic Read
B10y.00 Malignant neoplasm of other specified part of oesophagus res14: Upper gastrointestinal malignancy diagnostic Read
B10z.00 Malignant neoplasm of oesophagus NOS res14: Upper gastrointestinal malignancy diagnostic Read
B10z.11 Oesophageal cancer res14: Upper gastrointestinal malignancy diagnostic Read
B11..00 Malignant neoplasm of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B11..11 Gastric neoplasm res14: Upper gastrointestinal malignancy diagnostic Read
B110.00 Malignant neoplasm of cardia of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B110100 Malignant neoplasm of cardio-oesophageal junction of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B110111 Malignant neoplasm of gastro-oesophageal junction res14: Upper gastrointestinal malignancy diagnostic Read
B110z00 Malignant neoplasm of cardia of stomach NOS res14: Upper gastrointestinal malignancy diagnostic Read
B111.00 Malignant neoplasm of pylorus of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B111000 Malignant neoplasm of prepylorus of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B111100 Malignant neoplasm of pyloric canal of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B111z00 Malignant neoplasm of pylorus of stomach NOS res14: Upper gastrointestinal malignancy diagnostic Read
B112.00 Malignant neoplasm of pyloric antrum of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B113.00 Malignant neoplasm of fundus of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B114.00 Malignant neoplasm of body of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B115.00 Malignant neoplasm of lesser curve of stomach unspecified res14: Upper gastrointestinal malignancy diagnostic Read
B116.00 Malignant neoplasm of greater curve of stomach unspecified res14: Upper gastrointestinal malignancy diagnostic Read
B117.00 Malignant neoplasm; overlapping lesion of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B118.00 Siewert type II adenocarcinoma res14: Upper gastrointestinal malignancy diagnostic Read
B119.00 Siewert type III adenocarcinoma res14: Upper gastrointestinal malignancy diagnostic Read
B11y.00 Malignant neoplasm of other specified site of stomach res14: Upper gastrointestinal malignancy diagnostic Read
B11y000 Malignant neoplasm of anterior wall of stomach NEC res14: Upper gastrointestinal malignancy diagnostic Read
B11y100 Malignant neoplasm of posterior wall of stomach NEC res14: Upper gastrointestinal malignancy diagnostic Read
B11yz00 Malignant neoplasm of other specified site of stomach NOS res14: Upper gastrointestinal malignancy diagnostic Read
B11z.00 Malignant neoplasm of stomach NOS res14: Upper gastrointestinal malignancy diagnostic Read
BB55.00 [M]Linitisplastica res14: Upper gastrointestinal malignancy diagnostic Read
BB5C.00 [M]Gastrinoma and carcinomas res14: Upper gastrointestinal malignancy diagnostic Read
BB5C000 [M]Gastrinoma NOS res14: Upper gastrointestinal malignancy diagnostic Read
BB5C011 [M]G cell tumour NOS res14: Upper gastrointestinal malignancy diagnostic Read
BB5C100 [M]Gastrinoma; malignant res14: Upper gastrointestinal malignancy diagnostic Read
BB5Cz00 [M]Gastrinoma or carcinoma NOS res14: Upper gastrointestinal malignancy diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH719/version/1438/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH719/version/1438/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH719', '1438', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH719/version/1438/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH719/version/1438/export/codes/?format=json
CSV site_root/phenotypes/PH719/version/1438/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH719', '1438', api_client=client)

Version History

Version
ID
Name Owner Publish date
1438 Upper Gastro Intestinal Malignancy ieuan.scanlon 2021-10-06 currently shown

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