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AIDS

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH721
Version ID
1442
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 36
Code Description Entity type Category Coding System (Read)
A788.00 Acquired immune deficiency syndrome res50: AIDS diagnostic Read
A788.11 Human immunodeficiency virus infection res50: AIDS diagnostic Read
A788000 Acute human immunodeficiency virus infection res50: AIDS diagnostic Read
A788100 Asymptomatic human immunodeficiency virus infection res50: AIDS diagnostic Read
A788200 HIV infection with persistent generalised lymphadenopathy res50: AIDS diagnostic Read
A788300 Human immunodeficiency virus with constitutional disease res50: AIDS diagnostic Read
A788400 Human immunodeficiency virus with neurological disease res50: AIDS diagnostic Read
A788500 Human immunodeficiency virus with secondary infection res50: AIDS diagnostic Read
A788600 Human immunodeficiency virus with secondary cancers res50: AIDS diagnostic Read
A788W00 HIV disease resulting in unspecified malignant neoplasm res50: AIDS diagnostic Read
A788X00 HIV disease resulting/unspcf infectious+parasitic disease res50: AIDS diagnostic Read
A788y00 Human immunodeficiency virus with other clinical findings res50: AIDS diagnostic Read
A788z00 Acquired human immunodeficiency virus infection syndrome NOS res50: AIDS diagnostic Read
A789000 HIV disease resulting in mycobacterial infection res50: AIDS diagnostic Read
A789100 HIV disease resulting in cytomegaloviral disease res50: AIDS diagnostic Read
A789200 HIV disease resulting in candidiasis res50: AIDS diagnostic Read
A789300 HIV disease resulting in Pneumocystis carinii pneumonia res50: AIDS diagnostic Read
A789311 HIV disease resulting in Pneumocystis jirovecii pneumonia res50: AIDS diagnostic Read
A789400 HIV disease resulting in multiple infections res50: AIDS diagnostic Read
A789500 HIV disease resulting in Kaposi's sarcoma res50: AIDS diagnostic Read
A789511 HIV disease resulting in Kaposi sarcoma res50: AIDS diagnostic Read
A789600 HIV disease resulting in Burkitt's lymphoma res50: AIDS diagnostic Read
A789700 HIV dis resulting oth types of non-Hodgkin's lymphoma res50: AIDS diagnostic Read
A789800 HIV disease resulting in multiple malignant neoplasms res50: AIDS diagnostic Read
A789900 HIV disease resulting in lymphoid interstitial pneumonitis res50: AIDS diagnostic Read
A789A00 HIV disease resulting in wasting syndrome res50: AIDS diagnostic Read
A789X00 HIV dis reslt/oth mal neopl/lymph,h'matopoetc+reltd tissu res50: AIDS diagnostic Read
AyuC.00 [X]Human immunodeficiency virus disease res50: AIDS diagnostic Read
AyuC100 [X]HIV disease resulting in other viral infections res50: AIDS diagnostic Read
AyuC300 [X]HIV disease resulting in multiple infections res50: AIDS diagnostic Read
AyuC400 [X]HIV disease resulting/other infectious+parasitic diseases res50: AIDS diagnostic Read
AyuC600 [X]HIV disease resulting in other non-Hodgkin's lymphoma res50: AIDS diagnostic Read
AyuCC00 [X]HIV disease resulting in other specified conditions res50: AIDS diagnostic Read
AyuCD00 [X]Unspecified human immunodeficiency virus [HIV] disease res50: AIDS diagnostic Read
Eu02400 [X]Dementia in human immunodef virus [HIV] disease res50: AIDS diagnostic Read
L179.00 HIV disease complicating pregnancy childbirth puerperium res50: AIDS diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH721/version/1442/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH721/version/1442/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH721', '1442', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH721/version/1442/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH721/version/1442/export/codes/?format=json
CSV site_root/phenotypes/PH721/version/1442/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH721', '1442', api_client=client)

Version History

Version
ID
Name Owner Publish date
1442 AIDS ieuan.scanlon 2021-10-06 currently shown

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