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Alpha-Blockers

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Drug
ID
PH722
Version ID
1444
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 168
Code Description Coding System (CPRD_product_code) Entity type Category
10088 Doxadura 4mg tablets (Discovery Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
10134 Flomaxtra XL 400microgram tablets (Astellas Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
11394 Baratol 25mg Tablet (Shire Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
119 Doxazosin 1mg tablets CPRD_product_code res50: alpha-blockers drug
12545 Phentolamine 10mg/1ml solution for injection ampoules CPRD_product_code res50: alpha-blockers drug
1292 Hypovase 1mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
1294 Doxazosin 4mg tablets CPRD_product_code res50: alpha-blockers drug
13610 Alphavase 2 tablets (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
1455 Prazosin 500microgram tablets CPRD_product_code res50: alpha-blockers drug
14932 Tabphyn MR 400microgram capsules (ProStrakan Ltd) CPRD_product_code res50: alpha-blockers drug
16198 Baratol 50mg Tablet (Shire Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
16201 Hytrin bph 2mg Tablet (Amdipharm Plc) CPRD_product_code res50: alpha-blockers drug
19193 Doxazosin 2mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
19216 Doxazosin 4mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: alpha-blockers drug
19823 Alphavase 5 tablets (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
20369 Doxazosin 1mg/5ml oral suspension CPRD_product_code res50: alpha-blockers drug
2088 Alfuzosin 2.5mg tablets CPRD_product_code res50: alpha-blockers drug
2117 Doralese Tiltab 20mg tablets (Chemidex Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
2120 Alfuzosin 5mg modified-release tablets CPRD_product_code res50: alpha-blockers drug
23010 Rogitine 10mg/1ml solution for injection ampoules (Alliance Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
2345 Hytrin BPH tablets starter pack (AMCo) CPRD_product_code res50: alpha-blockers drug
23459 Hypovase benign prostatic hyperplasia 2mg Tablet (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
2346 Hytrin 5mg Tablet (Abbott Laboratories Ltd) CPRD_product_code res50: alpha-blockers drug
2347 Hytrin 10mg Tablet (Abbott Laboratories Ltd) CPRD_product_code res50: alpha-blockers drug
2348 Hytrin bph 10mg Tablet (Amdipharm Plc) CPRD_product_code res50: alpha-blockers drug
24369 Petyme 400microgram MR capsules (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
25047 Hypovase benign prostatic hyperplasia 500microgram Tablet (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
25487 Cascor 2mg tablets (Ranbaxy (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
25551 Cascor 4mg tablets (Ranbaxy (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
26237 Alphavase 500microgram Tablet (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
26238 Alphavase 1 tablets (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
26693 Hypovase benign prostatic hyperplasia bd BD Starter pack (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
27403 Omnic MR 400microgram capsules (Astellas Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
2816 Indoramin 20mg tablets CPRD_product_code res50: alpha-blockers drug
28441 Pamsvax XL 400microgram capsules (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
31109 Prosurin XL 400microgram capsules (Generics (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
33094 Doxazosin 2mg tablets (Generics (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
34080 Stronazon 400microgram MR capsules (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
34342 Doxazosin 1mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
34553 Doxazosin 4mg tablets (Generics (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
34601 Doxazosin 1mg tablets (Generics (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
34625 Doxazosin 2mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
3470 Terazosin 1mg tablets CPRD_product_code res50: alpha-blockers drug
34715 Doxazosin 1mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
35058 Diffundox XL 400microgram capsules (Zentiva) CPRD_product_code res50: alpha-blockers drug
35272 Doxadura XL 4mg tablets (Discovery Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
35312 Bazetham MR 400microgram capsules (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
35466 Alphacard MR 400microgram capsules (Ratiopharm UK Ltd) CPRD_product_code res50: alpha-blockers drug
35603 Doxazosin 4mg/5ml oral suspension CPRD_product_code res50: alpha-blockers drug
35639 Besavar XL 10mg tablets (Zentiva) CPRD_product_code res50: alpha-blockers drug
35925 Contiflo XL 400microgram capsules (Ranbaxy (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
36023 Cardozin xl 4mg Tablet (Hillcross Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
36282 Morvesin XL 400microgram capsules (Sandoz Ltd) CPRD_product_code res50: alpha-blockers drug
36439 Zufal XL 10mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
36649 Hytrin 2mg tablets (AMCo) CPRD_product_code res50: alpha-blockers drug
36740 Slocinx XL 4mg tablets (Zentiva) CPRD_product_code res50: alpha-blockers drug
36780 Hytrin 5mg tablets (AMCo) CPRD_product_code res50: alpha-blockers drug
3715 Prazosin 5mg tablets CPRD_product_code res50: alpha-blockers drug
37243 Cardozin xl 4mg Tablet (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
37428 Hytrin 10mg tablets (AMCo) CPRD_product_code res50: alpha-blockers drug
38461 Cardozin XL 4mg tablets (Arrow Generics Ltd) CPRD_product_code res50: alpha-blockers drug
3923 Terazosin BPH starter pack 7x1mg with 14x2mg with 7x5mg CPRD_product_code res50: alpha-blockers drug
3924 Terazosin 5mg tablets CPRD_product_code res50: alpha-blockers drug
39373 Fuzatal XL 10mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
40256 Baratol 25mg tablets (Amdipharm Plc) CPRD_product_code res50: alpha-blockers drug
40678 Doxazosin 4mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
40810 Phenoxybenzamine 10mg/5ml oral suspension CPRD_product_code res50: alpha-blockers drug
40891 Doxazosin 2mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: alpha-blockers drug
4111 Hypovase 500microgram tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
41543 Doxazosin 1mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: alpha-blockers drug
41651 Prazosin 500microgram Tablet (Approved Prescription Services Ltd) CPRD_product_code res50: alpha-blockers drug
41652 Prazosin 500microgram tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
41721 Prazosin 1mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
42462 Kirtacap mr 400microgram Capsule (Consilient Health Ltd) CPRD_product_code res50: alpha-blockers drug
42820 Alfuzosin xl 10mg Tablet (Hillcross Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
42936 Flomax Relief MR 400microgram capsules (Boehringer Ingelheim Self-Medication Divi CPRD_product_code res50: alpha-blockers drug
43458 Tamsulosin 400microgram / Dutasteride 500microgram capsules CPRD_product_code res50: alpha-blockers drug
43547 Prazosin 500microgram tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: alpha-blockers drug
43567 Combodart 0.5mg/0.4mg capsules (GlaxoSmithKline UK Ltd) CPRD_product_code res50: alpha-blockers drug
43695 Colixil XL 4mg tablets (Sandoz Ltd) CPRD_product_code res50: alpha-blockers drug
44268 Vasran XL 10mg tablets (Ranbaxy (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
4449 Cardura 1mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
44553 Pinexel PR 400microgram capsules (Wockhardt UK Ltd) CPRD_product_code res50: alpha-blockers drug
45040 Larbex XL 4mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
45265 Doxazosin sr 4mg Tablet (Generics (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
45328 Doxazosin 1mg tablets (Sandoz Ltd) CPRD_product_code res50: alpha-blockers drug
45342 Doxazosin 4mg tablets (Sandoz Ltd) CPRD_product_code res50: alpha-blockers drug
45583 Doxazosin 2mg tablets (Dexcel-Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
45584 Phenoxybenzamine 100mg/2ml solution for infusion ampoules CPRD_product_code res50: alpha-blockers drug
460 Flomax MR 400microgram capsules (Astellas Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
46066 Cardozin XL 4mg tablets (Almus Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
46206 Pamsvax XL 400microgram capsules (Almus Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
4637 Terazosin 2mg tablets CPRD_product_code res50: alpha-blockers drug
46526 Raporsin XL 4mg tablets (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
46922 Prazosin 1mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: alpha-blockers drug
4694 Terazosin 2mg tablets and Terazosin 1mg tablets CPRD_product_code res50: alpha-blockers drug
47563 Besavar XL 10mg tablets (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
47807 Doxazosin xl 4mg Tablet (Hillcross Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
4802 Cardura 2mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
48150 Doxazosin 1mg tablets (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
4875 Terazosin 10mg tablets CPRD_product_code res50: alpha-blockers drug
493 Doxazosin 2mg tablets CPRD_product_code res50: alpha-blockers drug
50467 Doxazosin 2mg tablets (Alliance Healthcare (Distribution) Ltd) CPRD_product_code res50: alpha-blockers drug
51665 Tamurex 400microgram modified-release capsules (Somex Pharma) CPRD_product_code res50: alpha-blockers drug
51685 Doxazosin 4mg tablets (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
5179 Xatral XL 10mg tablets (Sanofi) CPRD_product_code res50: alpha-blockers drug
5183 Hypovase 2mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
52055 Tamsulosin 400microgram oral powder sachets CPRD_product_code res50: alpha-blockers drug
52159 Tamsulosin 400microgram modified-release capsules (Focus Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
53033 Doxzogen XL 4mg tablets (Generics (UK) Ltd) CPRD_product_code res50: alpha-blockers drug
53084 Cositam XL 400microgram tablets (Consilient Health Ltd) CPRD_product_code res50: alpha-blockers drug
53322 Doxazosin 4mg tablets (Bristol Laboratories Ltd) CPRD_product_code res50: alpha-blockers drug
5337 Hytrin bph 5mg Tablet (Amdipharm Plc) CPRD_product_code res50: alpha-blockers drug
53964 Tamsulosin 400microgram modified-release capsules (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
54497 Galebon 400microgram modified-release capsules (Consilient Health Ltd) CPRD_product_code res50: alpha-blockers drug
54785 Doxazosin 4mg tablets (Medreich Plc) CPRD_product_code res50: alpha-blockers drug
5485 Alfuzosin 10mg modified-release tablets CPRD_product_code res50: alpha-blockers drug
54918 Phenoxybenzamine oral liquid CPRD_product_code res50: alpha-blockers drug
5496 Doxazosin 8mg modified-release tablets CPRD_product_code res50: alpha-blockers drug
55005 Kelanu XL 10mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
55826 Prazosin 5mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
55906 Doxazosin 1mg tablets (Dexcel-Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
55916 Doxazosin 1mg tablets (Alliance Healthcare (Distribution) Ltd) CPRD_product_code res50: alpha-blockers drug
56145 Doxazosin 2mg tablets (Actavis UK Ltd) CPRD_product_code res50: alpha-blockers drug
5618 Cardura XL 8mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
5624 Xatral 2.5mg tablets (Sanofi) CPRD_product_code res50: alpha-blockers drug
56793 Alfuzosin 2.5mg tablets (Teva UK Ltd) CPRD_product_code res50: alpha-blockers drug
57074 Doxazosin 2mg tablets (Sigma Pharmaceuticals Plc) CPRD_product_code res50: alpha-blockers drug
57145 Terazosin 2mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
57448 Doxazosin 4mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
57549 Xatral 2.5mg tablets (Necessity Supplies Ltd) CPRD_product_code res50: alpha-blockers drug
57784 Doxazosin 2mg/5ml oral suspension CPRD_product_code res50: alpha-blockers drug
5815 Indoramin 25mg tablets CPRD_product_code res50: alpha-blockers drug
582 Doxazosin 4mg modified-release tablets CPRD_product_code res50: alpha-blockers drug
58276 Doxazosin 2mg tablets (Medreich Plc) CPRD_product_code res50: alpha-blockers drug
58325 Doxazosin 4mg tablets (Phoenix Healthcare Distribution Ltd) CPRD_product_code res50: alpha-blockers drug
58517 Faramsil 400microgram modified-release tablets (Sandoz Ltd) CPRD_product_code res50: alpha-blockers drug
58985 Xatral SR 5mg tablets (Sanofi-Synthelabo Ltd) CPRD_product_code res50: alpha-blockers drug
591 Prazosin 1mg tablets CPRD_product_code res50: alpha-blockers drug
59209 Doxazosin 1mg tablets (Kent Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
59462 Vesomni 6mg/0.4mg modified-release tablets (Astellas Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
59676 Solifenacin 6mg / Tamsulosin 400microgram modified-release tablets CPRD_product_code res50: alpha-blockers drug
59862 Doxazosin 4mg tablets (Dexcel-Pharma Ltd) CPRD_product_code res50: alpha-blockers drug
6008 Omnic 400microgram Modified-release capsule (Paines & Byrne Ltd) CPRD_product_code res50: alpha-blockers drug
60200 Doxazosin 4mg tablets (DE Pharmaceuticals) CPRD_product_code res50: alpha-blockers drug
60316 Prazosin 1mg Tablet (Approved Prescription Services Ltd) CPRD_product_code res50: alpha-blockers drug
60319 Doxazosin 1mg tablets (Bristol Laboratories Ltd) CPRD_product_code res50: alpha-blockers drug
61066 Doxazosin 2mg tablets (Bristol Laboratories Ltd) CPRD_product_code res50: alpha-blockers drug
61123 Doxazosin 4mg/5ml oral solution CPRD_product_code res50: alpha-blockers drug
61283 Doxazosin 4mg tablets (Alliance Healthcare (Distribution) Ltd) CPRD_product_code res50: alpha-blockers drug
61844 Invicorp 2 solution for injection (Senetek Plc) CPRD_product_code res50: alpha-blockers drug
62019 Doxazosin 1mg tablets (Almus Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
62158 Doxazosin 4mg tablets (Almus Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
634 Tamsulosin 400microgram modified-release capsules CPRD_product_code res50: alpha-blockers drug
7056 Tamsulosin 400microgram modified-release tablets CPRD_product_code res50: alpha-blockers drug
726 Prazosin 2mg tablets CPRD_product_code res50: alpha-blockers drug
7547 Doxadura 2mg tablets (Discovery Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
7549 Doxadura 1mg tablets (Discovery Pharmaceuticals Ltd) CPRD_product_code res50: alpha-blockers drug
755 Cardura XL 4mg tablets (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
7759 Phenoxybenzamine 10mg capsules CPRD_product_code res50: alpha-blockers drug
8076 Hytrin tablets starter pack (AMCo) CPRD_product_code res50: alpha-blockers drug
8077 Hytrin 2mg Tablet (Abbott Laboratories Ltd) CPRD_product_code res50: alpha-blockers drug
8086 Cardura 4mg Tablet (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
8198 Hypovase 5mg Tablet (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
8863 Hypovase benign prostatic hyperplasia 1mg Tablet (Pfizer Ltd) CPRD_product_code res50: alpha-blockers drug
8942 Dibenyline 10mg capsules (Mercury Pharma Group Ltd) CPRD_product_code res50: alpha-blockers drug
9019 Indoramin 50mg Tablet CPRD_product_code res50: alpha-blockers drug
9422 Xatral sr 5mg Tablet (Sanofi-Synthelabo Ltd) CPRD_product_code res50: alpha-blockers drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH722/version/1444/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH722/version/1444/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH722', '1444', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH722/version/1444/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH722/version/1444/export/codes/?format=json
CSV site_root/phenotypes/PH722/version/1444/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH722', '1444', api_client=client)

Version History

Version
ID
Name Owner Publish date
1444 Alpha-Blockers ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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