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Dementia

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH728
Version ID
1456
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 115
Code Description Entity type Category Coding System (Read)
1461 H/O: dementia res50: dementia diagnostic Read
A411.00 Jakob-Creutzfeldt disease res50: dementia diagnostic Read
BBC9.11 [M]Pick's tubular adenoma res50: dementia diagnostic Read
E00..00 Senile and presenile organic psychotic conditions res50: dementia diagnostic Read
E00..11 Senile dementia res50: dementia diagnostic Read
E00..12 Senile/presenile dementia res50: dementia diagnostic Read
E000.00 Uncomplicated senile dementia res50: dementia diagnostic Read
E001.00 Presenile dementia res50: dementia diagnostic Read
E001000 Uncomplicated presenile dementia res50: dementia diagnostic Read
E001100 Presenile dementia with delirium res50: dementia diagnostic Read
E001200 Presenile dementia with paranoia res50: dementia diagnostic Read
E001300 Presenile dementia with depression res50: dementia diagnostic Read
E001z00 Presenile dementia NOS res50: dementia diagnostic Read
E002.00 Senile dementia with depressive or paranoid features res50: dementia diagnostic Read
E002000 Senile dementia with paranoia res50: dementia diagnostic Read
E002100 Senile dementia with depression res50: dementia diagnostic Read
E002z00 Senile dementia with depressive or paranoid features NOS res50: dementia diagnostic Read
E003.00 Senile dementia with delirium res50: dementia diagnostic Read
E004.00 Arteriosclerotic dementia res50: dementia diagnostic Read
E004.11 Multi infarct dementia res50: dementia diagnostic Read
E004000 Uncomplicated arteriosclerotic dementia res50: dementia diagnostic Read
E004100 Arteriosclerotic dementia with delirium res50: dementia diagnostic Read
E004200 Arteriosclerotic dementia with paranoia res50: dementia diagnostic Read
E004300 Arteriosclerotic dementia with depression res50: dementia diagnostic Read
E004z00 Arteriosclerotic dementia NOS res50: dementia diagnostic Read
E00y.00 Other senile and presenile organic psychoses res50: dementia diagnostic Read
E00y.11 Presbyophrenic psychosis res50: dementia diagnostic Read
E00z.00 Senile or presenile psychoses NOS res50: dementia diagnostic Read
E012.00 Other alcoholic dementia res50: dementia diagnostic Read
E012.11 Alcoholic dementia NOS res50: dementia diagnostic Read
E012000 Chronic alcoholic brain syndrome res50: dementia diagnostic Read
E02y100 Drug-induced dementia res50: dementia diagnostic Read
E040.11 Korsakoff's non-alcoholic psychosis res50: dementia diagnostic Read
E041.00 Dementia in conditions EC res50: dementia diagnostic Read
Eu00.00 [X]Dementia in Alzheimer's disease res50: dementia diagnostic Read
Eu00000 [X]Dementia in Alzheimer's disease with early onset res50: dementia diagnostic Read
Eu00011 [X]Presenile dementia,Alzheimer's type res50: dementia diagnostic Read
Eu00012 [X]Primary degen dementia, Alzheimer's type, presenile onset res50: dementia diagnostic Read
Eu00013 [X]Alzheimer's disease type 2 res50: dementia diagnostic Read
Eu00100 [X]Dementia in Alzheimer's disease with late onset res50: dementia diagnostic Read
Eu00111 [X]Alzheimer's disease type 1 res50: dementia diagnostic Read
Eu00112 [X]Senile dementia,Alzheimer's type res50: dementia diagnostic Read
Eu00113 [X]Primary degen dementia of Alzheimer's type, senile onset res50: dementia diagnostic Read
Eu00200 [X]Dementia in Alzheimer's dis, atypical or mixed type res50: dementia diagnostic Read
Eu00z00 [X]Dementia in Alzheimer's disease, unspecified res50: dementia diagnostic Read
Eu00z11 [X]Alzheimer's dementia unspec res50: dementia diagnostic Read
Eu01.00 [X]Vascular dementia res50: dementia diagnostic Read
Eu01.11 [X]Arteriosclerotic dementia res50: dementia diagnostic Read
Eu01000 [X]Vascular dementia of acute onset res50: dementia diagnostic Read
Eu01100 [X]Multi-infarct dementia res50: dementia diagnostic Read
Eu01111 [X]Predominantly cortical dementia res50: dementia diagnostic Read
Eu01200 [X]Subcortical vascular dementia res50: dementia diagnostic Read
Eu01300 [X]Mixed cortical and subcortical vascular dementia res50: dementia diagnostic Read
Eu01y00 [X]Other vascular dementia res50: dementia diagnostic Read
Eu01z00 [X]Vascular dementia, unspecified res50: dementia diagnostic Read
Eu02.00 [X]Dementia in other diseases classified elsewhere res50: dementia diagnostic Read
Eu02000 [X]Dementia in Pick's disease res50: dementia diagnostic Read
Eu02100 [X]Dementia in Creutzfeldt-Jakob disease res50: dementia diagnostic Read
Eu02200 [X]Dementia in Huntington's disease res50: dementia diagnostic Read
Eu02300 [X]Dementia in Parkinson's disease res50: dementia diagnostic Read
Eu02400 [X]Dementia in human immunodef virus [HIV] disease res50: dementia diagnostic Read
Eu02500 [X]Lewy body dementia res50: dementia diagnostic Read
Eu02y00 [X]Dementia in other specified diseases classif elsewhere res50: dementia diagnostic Read
Eu02z00 [X] Unspecified dementia res50: dementia diagnostic Read
Eu02z11 [X] Presenile dementia NOS res50: dementia diagnostic Read
Eu02z12 [X] Presenile psychosis NOS res50: dementia diagnostic Read
Eu02z13 [X] Primary degenerative dementia NOS res50: dementia diagnostic Read
Eu02z14 [X] Senile dementia NOS res50: dementia diagnostic Read
Eu02z15 [X] Senile psychosis NOS res50: dementia diagnostic Read
Eu02z16 [X] Senile dementia, depressed or paranoid type res50: dementia diagnostic Read
Eu04000 [X]Delirium not superimposed on dementia, so described res50: dementia diagnostic Read
Eu04100 [X]Delirium superimposed on dementia res50: dementia diagnostic Read
Eu05700 [X]Mild cognitive disorder res50: dementia diagnostic Read
Eu10711 [X]Alcoholic dementia NOS res50: dementia diagnostic Read
Eu10712 [X]Chronic alcoholic brain syndrome res50: dementia diagnostic Read
Eu84311 [X]Dementia infantalis res50: dementia diagnostic Read
F10..00 Cerebral degenerations usually manifest in childhood res50: dementia diagnostic Read
F102100 Cerebral degeneration in Niemann-Pick disease res50: dementia diagnostic Read
F103.00 Cerebral degeneration in diseases EC res50: dementia diagnostic Read
F103000 Cerebral degeneration in Hunter's disease res50: dementia diagnostic Read
F103100 Cerebral degeneration in mucopolysaccharidoses res50: dementia diagnostic Read
F103z00 Cerebral degeneration in disease NOS res50: dementia diagnostic Read
F10z.00 Childhood cerebral degenerations NOS res50: dementia diagnostic Read
F11..00 Other cerebral degenerations res50: dementia diagnostic Read
F110.00 Alzheimer's disease res50: dementia diagnostic Read
F110000 Alzheimer's disease with early onset res50: dementia diagnostic Read
F110100 Alzheimer's disease with late onset res50: dementia diagnostic Read
F111.00 Pick's disease res50: dementia diagnostic Read
F112.00 Senile degeneration of brain res50: dementia diagnostic Read
F113000 Normal pressure hydrocephalus res50: dementia diagnostic Read
F116.00 Lewy body disease res50: dementia diagnostic Read
F11x.00 Cerebral degeneration in other disease EC res50: dementia diagnostic Read
F11x000 Cerebral degeneration due to alcoholism res50: dementia diagnostic Read
F11x200 Cerebral degeneration due to cerebrovascular disease res50: dementia diagnostic Read
F11x400 Cerebral degeneration due to neoplastic disease res50: dementia diagnostic Read
F11x500 Cerebral degeneration due to myxoedema res50: dementia diagnostic Read
F11x600 Cerebral degeneration due to vitamin B12 deficiency res50: dementia diagnostic Read
F11x700 Cerebral degeneration due to Jakob - Creutzfeldt disease res50: dementia diagnostic Read
F11x800 Cerebral degeneration due to multifocal leucoencephalopathy res50: dementia diagnostic Read
F11x900 Cerebral degeneration in Parkinson's disease res50: dementia diagnostic Read
F11xz00 Cerebral degeneration other disease NOS res50: dementia diagnostic Read
F11y.00 Other cerebral degeneration res50: dementia diagnostic Read
F11y000 Reye's syndrome res50: dementia diagnostic Read
F11y100 Cerebral ataxia res50: dementia diagnostic Read
F11yz00 Other cerebral degeneration NOS res50: dementia diagnostic Read
F11z.00 Cerebral degeneration NOS res50: dementia diagnostic Read
F11z.11 Cerebral atrophy res50: dementia diagnostic Read
F12..00 Parkinson's disease res50: dementia diagnostic Read
F12z.00 Parkinson's disease NOS res50: dementia diagnostic Read
F13..11 Extrapyramidal disease excluding Parkinson's disease res50: dementia diagnostic Read
F134.00 Huntington's chorea res50: dementia diagnostic Read
Fyu3000 [X]Other Alzheimer's disease res50: dementia diagnostic Read
G532100 Pick's disease of heart res50: dementia diagnostic Read
ZR1T.00 Arizona battery for communication disorders of dementia res50: dementia diagnostic Read
ZS7C500 Language disorder of dementia res50: dementia diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH728/version/1456/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH728/version/1456/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH728', '1456', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH728/version/1456/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH728/version/1456/export/codes/?format=json
CSV site_root/phenotypes/PH728/version/1456/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH728', '1456', api_client=client)

Version History

Version
ID
Name Owner Publish date
1456 Dementia ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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