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Diseases causing hypoglycemia

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

ID
PH730
Version ID
1460
Type
Disease or Syndrome
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
♀  Female ♂  Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Collections
ClinicalCodes Repository Phenotype Library
Tags
No tags

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 46
Code Description Entity type Category Coding System (Read)
14CH.00 History of chronic pancreatitis res50: diseases causing hypoglycemia diagnostic Read
677C100 Cystic fibrosis gene carrier res50: diseases causing hypoglycemia diagnostic Read
A176.00 Tuberculosis of adrenal glands - Addison's disease res50: diseases causing hypoglycemia diagnostic Read
B7H2.11 Pituitary adenoma res50: diseases causing hypoglycemia diagnostic Read
BB5B.00 [M]Pancreatic adenomas and carcinomas res50: diseases causing hypoglycemia diagnostic Read
BB5B200 [M]Insulinoma NOS res50: diseases causing hypoglycemia diagnostic Read
BB5B300 [M]Insulinoma, malignant res50: diseases causing hypoglycemia diagnostic Read
BB5Bz00 [M]Pancreatic adenoma or carcinoma NOS res50: diseases causing hypoglycemia diagnostic Read
BB5V.00 [M]Pituitary adenomas and carcinomas res50: diseases causing hypoglycemia diagnostic Read
BB5Vz00 [M]Pituitary adenoma or carcinoma NOS res50: diseases causing hypoglycemia diagnostic Read
C10N100 Cystic fibrosis related diabetes mellitus res50: diseases causing hypoglycemia diagnostic Read
C132.00 Panhypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C132.11 Hypopituitarism NOS res50: diseases causing hypoglycemia diagnostic Read
C132000 Idiopathic panhypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C132100 Post-birth injury panhypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C132200 Postinfarction panhypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C132300 Postinfective panhypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C132y00 Other specified panhypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C132z00 Panhypopituitarism NOS res50: diseases causing hypoglycemia diagnostic Read
C137.11 Iatrogenic hypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C137000 Hormone-induced hypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C137100 Post-hypophysectomy hypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C137111 Surgically-induced hypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C137200 Post-radiotherapy hypopituitarism res50: diseases causing hypoglycemia diagnostic Read
C154.00 Corticoadrenal insufficiency res50: diseases causing hypoglycemia diagnostic Read
C154000 Acute adrenal insufficiency res50: diseases causing hypoglycemia diagnostic Read
C154100 Addison's disease res50: diseases causing hypoglycemia diagnostic Read
C154z00 Corticoadrenal insufficiency NOS res50: diseases causing hypoglycemia diagnostic Read
C154z12 Adrenal insufficiency NEC res50: diseases causing hypoglycemia diagnostic Read
C370.00 Cystic fibrosis res50: diseases causing hypoglycemia diagnostic Read
C370000 Cystic fibrosis with no meconium ileus res50: diseases causing hypoglycemia diagnostic Read
C370100 Cystic fibrosis with meconium ileus res50: diseases causing hypoglycemia diagnostic Read
C370111 Meconium ileus in cystic fibrosis res50: diseases causing hypoglycemia diagnostic Read
C370200 Cystic fibrosis with pulmonary manifestations res50: diseases causing hypoglycemia diagnostic Read
C370300 Cystic fibrosis with intestinal manifestations res50: diseases causing hypoglycemia diagnostic Read
C370400 Arthropathy in cystic fibrosis res50: diseases causing hypoglycemia diagnostic Read
C370500 Cystic fibrosis with distal intestinal obstruction syndrome res50: diseases causing hypoglycemia diagnostic Read
C370800 Cystic fibrosis related cirrhosis res50: diseases causing hypoglycemia diagnostic Read
C370900 Exacerbation of cystic fibrosis res50: diseases causing hypoglycemia diagnostic Read
C370y00 Cystic fibrosis with other manifestations res50: diseases causing hypoglycemia diagnostic Read
C370z00 Cystic fibrosis NOS res50: diseases causing hypoglycemia diagnostic Read
F395000 Myopathy due to Addison's disease res50: diseases causing hypoglycemia diagnostic Read
J671.00 Chronic pancreatitis res50: diseases causing hypoglycemia diagnostic Read
J671000 Alcohol-induced chronic pancreatitis res50: diseases causing hypoglycemia diagnostic Read
J671100 Gallstone chronic pancreatitis res50: diseases causing hypoglycemia diagnostic Read
Jyu8400 [X]Other chronic pancreatitis res50: diseases causing hypoglycemia diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH730/version/1460/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH730/version/1460/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH730', '1460', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH730/version/1460/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH730/version/1460/export/codes/?format=json
CSV site_root/phenotypes/PH730/version/1460/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH730', '1460', api_client=client)

Version History

Version
ID
Name Owner Publish date
1460 Diseases causing hypoglycemia ieuan.scanlon 2021-10-06 currently shown

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