Aims:
To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).
Methods:
Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.
Results:
In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).
Conclusions:
HbA1C variability is a strong predictor for HH in T1D and T2D.
Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.
Code | Description | Coding System (CPRD_product_code) | Entity type | Category |
---|---|---|---|---|
10066 | Torem 5mg tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
1021 | Innozide 20mg/12.5mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
10214 | Spironolactone 5mg/5ml oral suspension sugar free | CPRD_product_code | res50: diuretics | drug |
10251 | Eplerenone 25mg tablets | CPRD_product_code | res50: diuretics | drug |
10316 | CoAprovel 150mg/12.5mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
10323 | Losartan 100mg / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
10392 | Lasix 500mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
10422 | Lasix 50mg/5ml Injection (Hoechst UK Ltd) | CPRD_product_code | res50: diuretics | drug |
1060 | Amiloride 5mg tablets | CPRD_product_code | res50: diuretics | drug |
10627 | Co-Betaloc tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
10781 | Lasix with k Tablet (Hoechst Marion Roussel) | CPRD_product_code | res50: diuretics | drug |
10902 | Captopril 50mg with Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
11133 | Hydrochlorothiazide with captopril 25mg with 50mg Tablet | CPRD_product_code | res50: diuretics | drug |
11156 | Spirolone 25mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
1124 | Tenoretic 100mg/25mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res50: diuretics | drug |
1125 | Navidrex -k Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
11265 | Triamterene 50mg / Furosemide 40mg tablets | CPRD_product_code | res50: diuretics | drug |
11268 | Torem 2.5mg tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
11338 | Bendroflumethiazide 5mg with Nadolol 40mg tablets | CPRD_product_code | res50: diuretics | drug |
11351 | Co-zidocapt 25mg/50mg tablets | CPRD_product_code | res50: diuretics | drug |
11384 | Co-flumactone 50mg/50mg tablets | CPRD_product_code | res50: diuretics | drug |
11448 | Irbesartan 150mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
11469 | Irbesartan 300mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
11487 | Torasemide 2.5mg tablets | CPRD_product_code | res50: diuretics | drug |
11519 | Spironolactone 25mg/5ml oral suspension sugar free | CPRD_product_code | res50: diuretics | drug |
11526 | CoAprovel 300mg/12.5mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
11561 | Co-zidocapt 12.5mg/25mg tablets | CPRD_product_code | res50: diuretics | drug |
11641 | Captopril 25mg with Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
1170 | Cyclopenthiazide 500microgram tablets | CPRD_product_code | res50: diuretics | drug |
11864 | Valsartan 160mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
12054 | Propranolol 80mg / Bendroflumethiazide 2.5mg capsules | CPRD_product_code | res50: diuretics | drug |
1209 | Neo-Naclex 5mg tablets (Mercury Pharma Group Ltd) | CPRD_product_code | res50: diuretics | drug |
1211 | Bendroflumethiazide 2.5mg / Potassium chloride 630mg (potassium 8.4mmol) modified | CPRD_product_code | res50: diuretics | drug |
12110 | Hydroflumethiazide 50mg Tablet | CPRD_product_code | res50: diuretics | drug |
1213 | Neo-Naclex-K modified-release tablets (Mercury Pharma Group Ltd) | CPRD_product_code | res50: diuretics | drug |
12226 | Burinex 1mg/5ml Oral solution (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
12294 | Burinex 5mg tablets (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
12318 | Lasix 250mg/25ml Injection (Hoechst Marion Roussel) | CPRD_product_code | res50: diuretics | drug |
12354 | Etacrynic 50mg tablets | CPRD_product_code | res50: diuretics | drug |
12360 | Nephril 1mg Tablet (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
12367 | Piretanide 6mg capsule | CPRD_product_code | res50: diuretics | drug |
12440 | Hydrosaluric 25mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
1251 | Moduret 25 tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
12517 | Timolol maleate with bendroflumethiazide 20mg + 5mg Tablet | CPRD_product_code | res50: diuretics | drug |
12546 | Kalspare Tablet (Dominion Pharma) | CPRD_product_code | res50: diuretics | drug |
12547 | Triamterene 50mg / Chlortalidone 50mg tablets | CPRD_product_code | res50: diuretics | drug |
12651 | Timolol 10mg / Bendroflumethiazide 2.5mg tablets | CPRD_product_code | res50: diuretics | drug |
1288 | Tenoret 50mg/12.5mg tablets (AstraZeneca UK Ltd) | CPRD_product_code | res50: diuretics | drug |
12926 | Polythiazide 1mg tablets | CPRD_product_code | res50: diuretics | drug |
12946 | Spironolactone 10mg/5ml oral suspension sugar free | CPRD_product_code | res50: diuretics | drug |
1297 | Aldactide 50 tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
1301 | Frumil ls 20mg+2.5mg Tablet (Helios Healthcare Ltd) | CPRD_product_code | res50: diuretics | drug |
13246 | Chlorothiazide 150mg/5ml oral suspension | CPRD_product_code | res50: diuretics | drug |
13264 | Spironolactone 15mg/5ml oral suspension | CPRD_product_code | res50: diuretics | drug |
13352 | Midamor 5mg Tablet (MSD Thomas Morson Pharmaceuticals) | CPRD_product_code | res50: diuretics | drug |
13363 | Esidrex 50mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
13435 | Frumil Forte 10mg/80mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
13525 | Hydrenox 50mg Tablet (Knoll Ltd) | CPRD_product_code | res50: diuretics | drug |
13526 | Atenix Co 100 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
1369 | Furosemide with amiloride 40mg+5mg Tablet | CPRD_product_code | res50: diuretics | drug |
13871 | Co-prenozide 160mg/0.25mg modified-release tablets | CPRD_product_code | res50: diuretics | drug |
14109 | Spironolactone 100mg/5ml oral solution sugar free | CPRD_product_code | res50: diuretics | drug |
14126 | Acebutolol 200mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
14144 | Inspra 25mg tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
14228 | Coversyl Plus tablets (Servier Laboratories Ltd) | CPRD_product_code | res50: diuretics | drug |
14283 | Valsartan 160mg / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
14438 | Corgaretic 80mg tablets (Sanofi-Synthelabo Ltd) | CPRD_product_code | res50: diuretics | drug |
14587 | Amiloride 5mg / Bumetanide 1mg tablets | CPRD_product_code | res50: diuretics | drug |
14738 | Hydrochlorothiazide with losartan 12.5mg with 50mg Tablet | CPRD_product_code | res50: diuretics | drug |
14761 | Frusid 40mg tablets (Dr Reddy's Laboratories (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
14837 | Frusol 50mg/5ml oral solution (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
14870 | Telmisartan 40mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
15031 | Accuretic 12.5mg/10mg tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
15052 | Spiroctan 50mg Tablet (Roche Products Ltd) | CPRD_product_code | res50: diuretics | drug |
15108 | Quinapril 10mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
15127 | Hydrochlorothiazide with triamterene 25mgwith50mg Tablet | CPRD_product_code | res50: diuretics | drug |
15135 | Hydrochlorothiazide with captopril 12.5mg with 25mg Tablet | CPRD_product_code | res50: diuretics | drug |
1520 | Capozide 25mg/50mg tablets (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
15341 | Burinex 0.5mg/ml Injection (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
15457 | Baycaron 25mg Tablet (Bayer Plc) | CPRD_product_code | res50: diuretics | drug |
15488 | Metoprolol tartrate with chlortalidone Tablet | CPRD_product_code | res50: diuretics | drug |
15811 | Co-flumactone 25mg/25mg tablets | CPRD_product_code | res50: diuretics | drug |
15874 | Amiloride 2.5mg / furosemide 20mg tablets | CPRD_product_code | res50: diuretics | drug |
16060 | Valsartan 80mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
16161 | Telmisartan 80mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
16206 | Froop 40mg tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
16498 | Kalspare tablets (DHP Healthcare Ltd) | CPRD_product_code | res50: diuretics | drug |
16531 | Eplerenone 50mg tablets | CPRD_product_code | res50: diuretics | drug |
16632 | Hydrosaluric 50mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
16786 | Chlortalidone 25mg with Atenolol 100mg tablets | CPRD_product_code | res50: diuretics | drug |
17143 | Mefruside 25mg Tablet | CPRD_product_code | res50: diuretics | drug |
17149 | Monozide 10 tablets (Wyeth Pharmaceuticals) | CPRD_product_code | res50: diuretics | drug |
1721 | Dyazide 50mg/25mg tablets (AMCo) | CPRD_product_code | res50: diuretics | drug |
17252 | Esidrex 25mg Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
17462 | Bisoprolol 10mg / Hydrochlorothiazide 6.25mg tablets | CPRD_product_code | res50: diuretics | drug |
17561 | Bendroflumethiazide 2.5mg / Potassium chloride 573mg (potassium 7.7mmol) modified | CPRD_product_code | res50: diuretics | drug |
17655 | Carace 10 Tablet (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
17689 | MicardisPlus 80mg/12.5mg tablets (Boehringer Ingelheim Ltd) | CPRD_product_code | res50: diuretics | drug |
17720 | Saluric 500mg Tablet (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
1776 | Burinex K modified-release tablets (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
1788 | Atenolol 100mg with Chlortalidone 25mg tablets | CPRD_product_code | res50: diuretics | drug |
17902 | Spirolone 100mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
17950 | Spirolone 50mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
17960 | Furosemide 20mg / Potassium chloride 750mg (potassium 10mmol) modified-release ta | CPRD_product_code | res50: diuretics | drug |
18096 | Torasemide 10mg tablets | CPRD_product_code | res50: diuretics | drug |
18200 | Olmesartan medoxomil 20mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
18202 | MicardisPlus 40mg/12.5mg tablets (Boehringer Ingelheim Ltd) | CPRD_product_code | res50: diuretics | drug |
18263 | Acezide 25mg/50mg tablets (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
18267 | Enduron 5mg Tablet (Abbott Laboratories Ltd) | CPRD_product_code | res50: diuretics | drug |
18287 | Co-Betaloc SA tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
18332 | Aridil 20mg+2.5mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
18361 | Amilmaxco 5mg/50mg tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
18497 | Amiloride 10mg / furosemide 80mg tablets | CPRD_product_code | res50: diuretics | drug |
18606 | Diltiazem and hydrochlorothiazide 150mg+12.5mg modified-release capsules | CPRD_product_code | res50: diuretics | drug |
18650 | Edecrin 50mg Tablet (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
18716 | Dryptal 10mg/ml Injection (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
18726 | Triamaxco 50mg/25mg tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
18733 | Co-amilozide 5mg with 50mg/ml oral solution | CPRD_product_code | res50: diuretics | drug |
18743 | Tenben 25mg/1.25mg capsules (Galen Ltd) | CPRD_product_code | res50: diuretics | drug |
18903 | Olmesartan medoxomil 20mg / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
18973 | Centyl 2.5mg Tablet (Edwin Burgess Ltd) | CPRD_product_code | res50: diuretics | drug |
18983 | Brinaldix k Effervescent tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
19055 | Chlortalidone 12.5mg with Atenolol 50mg tablets | CPRD_product_code | res50: diuretics | drug |
19056 | Furosemide 50mg/5ml sugar free Oral solution (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
19142 | Bendroflumethiazide 2.5mg with Timolol maleate 10mg tablets | CPRD_product_code | res50: diuretics | drug |
19192 | Furosemide 40mg Tablet (M & A Pharmachem Ltd) | CPRD_product_code | res50: diuretics | drug |
19194 | Furosemide 20mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
19195 | Spironolactone 50mg Tablet (Wyeth Pharmaceuticals) | CPRD_product_code | res50: diuretics | drug |
19258 | Furosemide 50mg/5ml solution for injection ampoules | CPRD_product_code | res50: diuretics | drug |
193 | Co-amilofruse 2.5mg/20mg tablets | CPRD_product_code | res50: diuretics | drug |
19300 | Bumetanide 2mg/4ml solution for injection ampoules | CPRD_product_code | res50: diuretics | drug |
19352 | Xuret 0.5mg Tablet (Galen Ltd) | CPRD_product_code | res50: diuretics | drug |
19890 | Hydrochlorothiazide with amiloride 25mgwith2.5mg Tablet | CPRD_product_code | res50: diuretics | drug |
2 | Bendroflumethiazide 2.5mg tablets | CPRD_product_code | res50: diuretics | drug |
2001 | Aldactide 25 tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
2002 | Amiloride 5mg / hydrochlorothiazide 50mg tablets | CPRD_product_code | res50: diuretics | drug |
20057 | Methyclothiazide 5mg Tablet | CPRD_product_code | res50: diuretics | drug |
20066 | Amil-Co 5mg/50mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
20093 | Metoprolol 200mg modified-release / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
20426 | Centyl k 2.5mg+7.7mmol Tablet (Edwin Burgess Ltd) | CPRD_product_code | res50: diuretics | drug |
20431 | Centyl K modified-release tablets (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
2046 | Navidrex 500microgram tablets (AMCo) | CPRD_product_code | res50: diuretics | drug |
20538 | Frumax 40mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
20652 | Mannitol 10% Infusion | CPRD_product_code | res50: diuretics | drug |
21025 | Prestim forte Tablet (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
211 | Frumil 40mg+5mg Tablet (Helios Healthcare Ltd) | CPRD_product_code | res50: diuretics | drug |
21182 | Hydrochlorothiazide with timolol and amiloride 25mg with 10mg with 2.5mg Tablet | CPRD_product_code | res50: diuretics | drug |
21231 | Caralpha 20mg/12.5mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
2142 | Spironolactone 100mg tablets | CPRD_product_code | res50: diuretics | drug |
21423 | Cozaar-Comp 100mg/25mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
2179 | Triamterene 50mg capsules | CPRD_product_code | res50: diuretics | drug |
21803 | Berkozide 2.5mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
21849 | Dryptal 40mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
21867 | Berkozide 5mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
21873 | Atenix Co 50 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
21911 | Spirospare 25mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
21938 | Froop Co 5mg/40mg tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
2255 | Navispare 2.5mg/250microgram tablets (AMCo) | CPRD_product_code | res50: diuretics | drug |
22658 | Torem 10mg tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
22839 | Clopamide with Potassium effervescent tablets | CPRD_product_code | res50: diuretics | drug |
22912 | Bendroflumethiazide 2.5mg with Propanolol 80mg capsules | CPRD_product_code | res50: diuretics | drug |
22923 | Hydrochlorothiazide with amiloride 50mg with 5mg Tablet | CPRD_product_code | res50: diuretics | drug |
23091 | Spirospare 100 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
23131 | Bendroflumethiazide 5mg with Propanolol 160mg modified-release capsules | CPRD_product_code | res50: diuretics | drug |
23134 | Nadolol 40mg / Bendroflumethiazide 5mg tablets | CPRD_product_code | res50: diuretics | drug |
23427 | Bendroflumethiazide 5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
23456 | Hydrochlorothiazide with valsartan 25mg with 160mg Tablet | CPRD_product_code | res50: diuretics | drug |
23505 | Adizem xl plus 150mg+12.5mg Modified-release capsule (Napp Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
2389 | Aldactone 25mg tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
24008 | Vasetic Tablet (Shire Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
24189 | Neo-bendromax 2.5mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
24190 | Neo-bendromax 5mg Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
24268 | Hydrochlorothiazide with valsartan 12.5mg with 80mg Tablet | CPRD_product_code | res50: diuretics | drug |
24280 | Totaretic 100mg+25mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
24484 | Hydrochlorothiazide with valsartan 12.5mg with 160mg Tablet | CPRD_product_code | res50: diuretics | drug |
24632 | Hydrochlorothiazide with losartan 25mg with 100mg Tablet | CPRD_product_code | res50: diuretics | drug |
24832 | Lasipressin Tablet (Hoechst UK Ltd) | CPRD_product_code | res50: diuretics | drug |
24835 | Min-i-jet furosemide 10mg/ml Injection (Celltech Pharma Europe Ltd) | CPRD_product_code | res50: diuretics | drug |
24893 | Amilospare Tablet (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
2493 | Burinex A 5mg/1mg tablets (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
2495 | Bumetanide with Amiloride tablets | CPRD_product_code | res50: diuretics | drug |
25334 | Furosemide 500mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
25363 | Prestim tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
25382 | Co-Diovan 160mg/25mg tablets (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
25494 | Diatensec 50mg Tablet (Pharmacia Ltd) | CPRD_product_code | res50: diuretics | drug |
25500 | Hypertane 50 Tablet (Schwarz Pharma Ltd) | CPRD_product_code | res50: diuretics | drug |
25505 | Spiro-co 50mg+50mg Tablet (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
25717 | Furosemide 40mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
25730 | Timolol maleate with amiloride and hydrochlorothiazide Tablet | CPRD_product_code | res50: diuretics | drug |
25965 | Co-amilofruse 2.5mg/20mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
2612 | Indapamide 2.5mg tablets | CPRD_product_code | res50: diuretics | drug |
26217 | Berkamil 5mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
26219 | Zida-co 5mg+50mg Tablet (Opus Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
26220 | Delvas Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
26248 | Tenchlor 100mg/25mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
26256 | Opumide 2.5mg Tablet (Opus Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
26275 | Nindaxa 2.5 tablets (Ashbourne Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
26292 | Diuresal 40mg Tablet (Lagap) | CPRD_product_code | res50: diuretics | drug |
26529 | Furosemide with penbutolol Tablet | CPRD_product_code | res50: diuretics | drug |
26741 | Totaretic 50mg+12.5mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
27256 | Bendroflumethiazide 2.5mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
27447 | Furosemide 40mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
27520 | Olmetec Plus 20mg/25mg tablets (Daiichi Sankyo UK Ltd) | CPRD_product_code | res50: diuretics | drug |
27689 | Bendroflumethiazide 2.5mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
27690 | Furosemide 40mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
27696 | Furosemide 40mg tablets (Kent Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
2772 | Lasoride 5mg/40mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
2788 | Burinex 1mg tablets (LEO Pharma) | CPRD_product_code | res50: diuretics | drug |
27926 | Furosemide 20mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
27946 | Nadolol 80mg / Bendroflumethiazide 5mg tablets | CPRD_product_code | res50: diuretics | drug |
27957 | Natramid 2.5mg Tablet (Trinity Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
28129 | Co-amilofruse 5mg/40mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
28157 | Kalspare ls Tablet (Dominion Pharma) | CPRD_product_code | res50: diuretics | drug |
28177 | Hydrochlorothiazide with atenolol and amiloride Capsule | CPRD_product_code | res50: diuretics | drug |
2833 | CYCLOPENTHIAZIDE -K tablets | CPRD_product_code | res50: diuretics | drug |
29397 | Spiretic 100mg Tablet (DDSA Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
29427 | Hydrochlorothiazide with metoprolol tartrate 12.5mg with 100mg tablet | CPRD_product_code | res50: diuretics | drug |
29529 | Hydroflumethiazide with spironolactone 25mg+25mg Tablet | CPRD_product_code | res50: diuretics | drug |
2961 | Frusene 50mg/40mg tablets (Orion Pharma (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
29634 | Olmetec Plus 20mg/12.5mg tablets (Daiichi Sankyo UK Ltd) | CPRD_product_code | res50: diuretics | drug |
29694 | Inspra 50mg tablets (Pfizer Ltd) | CPRD_product_code | res50: diuretics | drug |
29696 | Methoserpidine with benzthiazide Tablet | CPRD_product_code | res50: diuretics | drug |
29780 | Furosemide 20mg Tablet (C P Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
2979 | Centyl k Tablet (Edwin Burgess Ltd) | CPRD_product_code | res50: diuretics | drug |
2982 | Zestoretic 20- 20mg+12.5mg Tablet (AstraZeneca UK Ltd) | CPRD_product_code | res50: diuretics | drug |
29991 | Centyl 5mg Tablet (Edwin Burgess Ltd) | CPRD_product_code | res50: diuretics | drug |
30272 | Benthiazide with Triamterene capsules | CPRD_product_code | res50: diuretics | drug |
3050 | Furosemide with triamterene 40mgwith50mg Tablet | CPRD_product_code | res50: diuretics | drug |
30519 | Amiloride with timolol with hydrochlorothiazide tablets | CPRD_product_code | res50: diuretics | drug |
3054 | Hygroton 100mg Tablet (Alliance Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
3056 | Natrilix SR 1.5mg tablets (Servier Laboratories Ltd) | CPRD_product_code | res50: diuretics | drug |
30625 | Furosemide 20mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
30773 | Co-amilofruse 5mg+40mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
30875 | Furosemide 250mg/25ml solution for injection ampoules | CPRD_product_code | res50: diuretics | drug |
30913 | Betinex 1mg Tablet (Berk Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
30965 | Mannitol 20% Infusion | CPRD_product_code | res50: diuretics | drug |
31013 | Mersalyl 50mg/ml Injection | CPRD_product_code | res50: diuretics | drug |
31131 | Spiro-co 25mg+25mg Tablet (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31150 | Co-amilozide 5mg/50mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31219 | Spironolactone 100mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
31375 | Amilamont 5mg/5ml oral solution sugar free (Rosemont Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
31470 | Tenchlor 50mg/12.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31529 | Spironolactone 25mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31548 | Furosemide 20mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31670 | Bendroflumethiazide 2.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31708 | Co-tenidone 50mg/12.5mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31773 | Co-amilofruse 5mg/40mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31820 | Bendroflumethiazide 5mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
31932 | Bumetanide 1mg tablets (C P Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
32002 | Etacrynic 50mg/vial injection | CPRD_product_code | res50: diuretics | drug |
3203 | Capozide LS Tablet (E R Squibb and Sons Ltd) | CPRD_product_code | res50: diuretics | drug |
32091 | Bumetanide 1mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
32094 | Co-tenidone 50mg/12.5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
32166 | Capto-co 25mg+50mg Tablet (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
32277 | Furosemide 80mg/8ml solution for injection pre-filled syringes | CPRD_product_code | res50: diuretics | drug |
3248 | Furosemide 500mg tablets | CPRD_product_code | res50: diuretics | drug |
32837 | Spironolactone 50mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
3287 | Furosemide 1mg/ml Oral solution | CPRD_product_code | res50: diuretics | drug |
32896 | Furosemide 40mg tablets (Ranbaxy (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
32918 | Furosemide 20mg tablets (Sandoz Ltd) | CPRD_product_code | res50: diuretics | drug |
3293 | Moduretic Oral solution (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
33083 | Indapamide 2.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
33353 | Lisinopril 20mg / Hydrochlorothiazide 12.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
33415 | Bendroflumethiazide 2.5mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
33527 | Co-amilofruse 5mg/40mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
33651 | Bendroflumethiazide 2.5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
33658 | Co-amilofruse 5mg/40mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
33659 | Hydrochlorothiazide with metoprolol tartrate 25mg with 200mg Modified-release tab | CPRD_product_code | res50: diuretics | drug |
33724 | Diuril 250mg/5ml oral suspension (Imported (United States)) | CPRD_product_code | res50: diuretics | drug |
33837 | Amiloride 5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
34006 | Furosemide 40mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34012 | Co-tenidone 100mg/25mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34034 | Co-tenidone 50mg/12.5mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34059 | Bendroflumethiazide 2.5mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34124 | Bendroflumethiazide 5mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34280 | Co-amilofruse 2.5mg/20mg tablets (Sandoz Ltd) | CPRD_product_code | res50: diuretics | drug |
34296 | Spironolactone 25mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
34324 | Amiloride 5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34347 | Spironolactone 25mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34367 | Co-amilozide 2.5mg/25mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34374 | Furosemide 40mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34449 | Co-tenidone 50mg/12.5mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
34551 | Indapamide 2.5mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
34557 | Furosemide 40mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34602 | Bendroflumethiazide 2.5mg tablets (Sovereign Medical Ltd) | CPRD_product_code | res50: diuretics | drug |
34613 | Bumetanide 5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34622 | Co-amilofruse 10mg/80mg tablets (Wockhardt UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34750 | Amiloride 5mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
348 | Moduretic Tablet (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
34803 | Bendroflumethiazide 2.5mg Tablet (Regent Laboratories Ltd) | CPRD_product_code | res50: diuretics | drug |
34825 | Co-tenidone 50mg/12.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34899 | Co-tenidone 100mg/25mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
34908 | Spironolactone 25mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
34934 | Bumetanide 1mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
35162 | Furosemide 20mg/2ml solution for injection ampoules | CPRD_product_code | res50: diuretics | drug |
3517 | Hydrochlorothiazide 50mg tablets | CPRD_product_code | res50: diuretics | drug |
35196 | CoAprovel 300mg/25mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
3526 | Amiloride with atenolol with hydrochlorothiazide capsules | CPRD_product_code | res50: diuretics | drug |
35380 | Hydrochlorothiazide with olmesartan medoxomil 12.5mg with 20mg tablet | CPRD_product_code | res50: diuretics | drug |
3548 | Chlortalidone 100mg tablets | CPRD_product_code | res50: diuretics | drug |
35481 | Irbesartan 300mg / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
35789 | Spironolactone 25mg Tablet (Celltech Pharma Europe Ltd) | CPRD_product_code | res50: diuretics | drug |
36190 | Furosemide 5mg/5ml oral solution sugar free | CPRD_product_code | res50: diuretics | drug |
36519 | Esidrex -k Tablet (Novartis Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
36767 | Bumetanide 1mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
3701 | Amiloride 2.5mg / hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
37294 | Triamterene with chlortalidone 50mg + 25mg Tablet | CPRD_product_code | res50: diuretics | drug |
37650 | Losartan 100mg / Hydrochlorothiazide 12.5mg tablets | CPRD_product_code | res50: diuretics | drug |
37710 | Lisinopril 10mg / Hydrochlorothiazide 12.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
37725 | Co-tenidone 100mg/25mg tablets (Generics (UK) Ltd) | CPRD_product_code | res50: diuretics | drug |
37747 | Cozaar-Comp 100mg/12.5mg tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
37908 | Coversyl Arginine Plus 5mg/1.25mg tablets (Servier Laboratories Ltd) | CPRD_product_code | res50: diuretics | drug |
3793 | Co-amilofruse 10mg/80mg tablets | CPRD_product_code | res50: diuretics | drug |
37978 | Perindopril arginine 5mg / Indapamide 1.25mg tablets | CPRD_product_code | res50: diuretics | drug |
38367 | Hydrochlorothiazide with losartan 12.5mg with 100mg Tablet | CPRD_product_code | res50: diuretics | drug |
38459 | Telmisartan 80mg / Hydrochlorothiazide 25mg tablets | CPRD_product_code | res50: diuretics | drug |
38889 | MicardisPlus 80mg/25mg tablets (Boehringer Ingelheim Ltd) | CPRD_product_code | res50: diuretics | drug |
38901 | Frumil LS 20mg/2.5mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
38995 | Zestoretic 20 tablets (AstraZeneca UK Ltd) | CPRD_product_code | res50: diuretics | drug |
39021 | Hydrochlorothiazide with olmesartan medoxomil 25mg with 20mg tablet | CPRD_product_code | res50: diuretics | drug |
39137 | Zestoretic 10 tablets (AstraZeneca UK Ltd) | CPRD_product_code | res50: diuretics | drug |
39147 | Carace 20 Plus tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
39227 | Capozide LS 12.5mg/25mg tablets (Bristol-Myers Squibb Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
39242 | Carace 10 Plus tablets (Merck Sharp & Dohme Ltd) | CPRD_product_code | res50: diuretics | drug |
39447 | Varbim XL 1.5mg tablets (Teva UK Ltd) | CPRD_product_code | res50: diuretics | drug |
39602 | Bumetanide 1mg tablets (Actavis UK Ltd) | CPRD_product_code | res50: diuretics | drug |
39807 | Frumil 40mg/5mg tablets (Sanofi) | CPRD_product_code | res50: diuretics | drug |
3997 | Hygroton 50mg tablets (Alliance Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
40149 | Bendroflumethiazide 5mg tablets (IVAX Pharmaceuticals UK Ltd) | CPRD_product_code | res50: diuretics | drug |
40190 | Torasemide iv 20mg/4ml Intravenous injection | CPRD_product_code | res50: diuretics | drug |
40247 | Furosemide 10mg/ml Injection (Martindale Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
4034 | Amiloride 5mg / hydrochlorothiazide 50mg/5ml solution | CPRD_product_code | res50: diuretics | drug |
4044 | Diurexan 20mg tablets (Meda Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
4068 | Dytac 50mg capsules (AMCo) | CPRD_product_code | res50: diuretics | drug |
40738 | Torem iv 10mg/2ml Intravenous injection (Boehringer Mannheim UK Ltd) | CPRD_product_code | res50: diuretics | drug |
40886 | Bendroflumethiazide 2.5mg tablets (Almus Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
40898 | Torasemide 5mg tablets (A A H Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
40907 | Indapamide 2.5mg tablets (Genus Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |
41074 | Spironolactone 25mg tablets (Almus Pharmaceuticals Ltd) | CPRD_product_code | res50: diuretics | drug |