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Glp-1Receptoragonists

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Drug
ID
PH734
Version ID
1468
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 8
Code Description Coding System (CPRD_product_code) Entity type Category
35144 Byetta 5micrograms/0.02ml solution for injection 1.2ml pre-filled disposable devi CPRD_product_code res50: GLP-1 receptor agonists drug
35149 Exenatide 10micrograms/0.04ml solution for injection 2.4ml pre-filled disposable CPRD_product_code res50: GLP-1 receptor agonists drug
35150 Byetta 10micrograms/0.04ml solution for injection 2.4ml pre-filled disposable dev CPRD_product_code res50: GLP-1 receptor agonists drug
35251 Exenatide 5micrograms/0.02ml solution for injection 1.2ml pre-filled disposable d CPRD_product_code res50: GLP-1 receptor agonists drug
40642 Victoza 6mg/ml solution for injection 3ml pre-filled pen (Novo Nordisk Ltd) CPRD_product_code res50: GLP-1 receptor agonists drug
40693 Liraglutide 6mg/ml solution for injection 3ml pre-filled disposable devices CPRD_product_code res50: GLP-1 receptor agonists drug
46458 Exenatide 2mg powder and solvent for suspension for injection vials CPRD_product_code res50: GLP-1 receptor agonists drug
46469 Bydureon 2mg powder and solvent for suspension for injection vials (AstraZeneca U CPRD_product_code res50: GLP-1 receptor agonists drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH734/version/1468/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH734/version/1468/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH734', '1468', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH734/version/1468/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH734/version/1468/export/codes/?format=json
CSV site_root/phenotypes/PH734/version/1468/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH734', '1468', api_client=client)

Version History

Version
ID
Name Owner Publish date
1468 Glp-1Receptoragonists ieuan.scanlon 2021-10-06 currently shown

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