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Hemiplegia and paraplegia

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH735
Version ID
1470
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 18
Code Description Entity type Category Coding System (Read)
2833 O/E - hemiplegia res50: hemiplegia and paraplegia diagnostic Read
2835 O/E - paraplegia res50: hemiplegia and paraplegia diagnostic Read
F038.00 Tropical spastic paraplegia res50: hemiplegia and paraplegia diagnostic Read
F141.00 Hereditary spastic paraplegia res50: hemiplegia and paraplegia diagnostic Read
F22..00 Hemiplegia res50: hemiplegia and paraplegia diagnostic Read
F220.00 Flaccid hemiplegia res50: hemiplegia and paraplegia diagnostic Read
F221.00 Spastic hemiplegia res50: hemiplegia and paraplegia diagnostic Read
F222.00 Left hemiplegia res50: hemiplegia and paraplegia diagnostic Read
F223.00 Right hemiplegia res50: hemiplegia and paraplegia diagnostic Read
F22z.00 Hemiplegia NOS res50: hemiplegia and paraplegia diagnostic Read
F230.11 Paraplegia - congenital res50: hemiplegia and paraplegia diagnostic Read
F230000 Congenital paraplegia res50: hemiplegia and paraplegia diagnostic Read
F231.00 Congenital hemiplegia res50: hemiplegia and paraplegia diagnostic Read
F234.00 Infantile hemiplegia NOS res50: hemiplegia and paraplegia diagnostic Read
F241.00 Paraplegia res50: hemiplegia and paraplegia diagnostic Read
F241000 Flaccid paraplegia res50: hemiplegia and paraplegia diagnostic Read
F241100 Spastic paraplegia res50: hemiplegia and paraplegia diagnostic Read
N231011 Massive muscular calcification associated with paraplegia res50: hemiplegia and paraplegia diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH735/version/1470/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH735/version/1470/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH735', '1470', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH735/version/1470/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH735/version/1470/export/codes/?format=json
CSV site_root/phenotypes/PH735/version/1470/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH735', '1470', api_client=client)

Version History

Version
ID
Name Owner Publish date
1470 Hemiplegia and paraplegia ieuan.scanlon 2021-10-06 currently shown

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