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Insulin

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Drug
ID
PH736
Version ID
1472
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 358
Code Description Coding System (CPRD_product_code) Entity type Category
10001 Humalog Mix50 Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Li CPRD_product_code res50: insulin drug
10067 Insulin biphasic aspart human pyr 30:70; 100 units/ml Injection CPRD_product_code res50: insulin drug
10175 Insulin isophane human 100units/ml suspension for injection 1.5ml cartridges CPRD_product_code res50: insulin drug
10184 Insulin detemir 100 iu/ml Solution for injection CPRD_product_code res50: insulin drug
10207 Insulin isophane human 100units/ml suspension for injection 3ml cartridges CPRD_product_code res50: insulin drug
10208 Insulatard InnoLet 100units/ml suspension for injection 3ml pre-filled pen (Novo CPRD_product_code res50: insulin drug
10225 Lantus 100units/ml solution for injection 3ml OptiClik cartridges (Sanofi) CPRD_product_code res50: insulin drug
10229 Humulin I Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Lilly CPRD_product_code res50: insulin drug
10243 Humalog Mix25 100units/ml suspension for injection 3ml cartridges (Eli Lilly and CPRD_product_code res50: insulin drug
10244 Mixtard 40 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
10245 Mixtard 10 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
10259 Insulin glargine 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
10264 Humalog Pen 100units/ml solution for injection 3ml pre-filled pen (Eli Lilly and CPRD_product_code res50: insulin drug
10277 Humulin M3 100units/ml suspension for injection 3ml cartridges (Eli Lilly and Com CPRD_product_code res50: insulin drug
10484 Penmix 20/80 Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
10547 Humulin Lente 100units/ml suspension for injection 10ml vials (Eli Lilly and Comp CPRD_product_code res50: insulin drug
10572 Insulin soluble bovine 100unit/ml Injection CPRD_product_code res50: insulin drug
10887 Penmix 40/60 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
10910 Humaject m2 100iu/ml M2 pen (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
10915 Humaject m1 100iu/ml M1 pen (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
11055 Insulin biphasic isophane human pyr 20:80; 100 units/ml Injection CPRD_product_code res50: insulin drug
11056 Insulin biphasic isophane human pyr 30:70; 100 units/ml Injection CPRD_product_code res50: insulin drug
11080 Insulin isophane human prb 100iu/ml Injection CPRD_product_code res50: insulin drug
11107 Humulin m4 100unit/ml M4 injection (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
11337 NovoRapid Novolet 100units/ml solution for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
11521 Hypodermic U100 insulin syringe sterile single use / single patient use 1ml with CPRD_product_code res50: insulin drug
11878 Hypodermic U100 insulin syringe sterile single use / single patient use 1ml with CPRD_product_code res50: insulin drug
12035 Insulin zinc mixed bovine 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
12297 Hypurin bovine neutral 100unit/ml Injection (C P Pharmaceuticals Ltd) CPRD_product_code res50: insulin drug
12299 Semitard mc 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
12638 Insulin soluble human pyr 100unit/ml Injection CPRD_product_code res50: insulin drug
12654 Insulin soluble human prb 100unit/ml Injection CPRD_product_code res50: insulin drug
12818 Human Mixtard 50 100units/ml suspension for injection 10ml vials (Novo Nordisk Lt CPRD_product_code res50: insulin drug
13009 Hypodermic U100 insulin syringe sterile single use / single patient use 0.5ml wit CPRD_product_code res50: insulin drug
13036 Unifine hypodermic U100 insulin syringe sterile single use / single patient use 0 CPRD_product_code res50: insulin drug
13277 Mixtard 50 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
13416 Insulin biphasic 100 units/ml Injection CPRD_product_code res50: insulin drug
13516 Hypurin bovine isophane 100unit/ml Injection (C P Pharmaceuticals Ltd) CPRD_product_code res50: insulin drug
13622 Hypurin porcine neutral 100unit/ml Injection (C P Pharmaceuticals Ltd) CPRD_product_code res50: insulin drug
13729 Insulin isophane human emp 100unit/ml Injection CPRD_product_code res50: insulin drug
13819 Hypurin Porcine Isophane 100units/ml suspension for injection 1.5ml cartridges (C CPRD_product_code res50: insulin drug
13837 Insulin biphasic isophane human prb 10:90; 100 units/ml Injection CPRD_product_code res50: insulin drug
14270 Humalog Mix25 Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Li CPRD_product_code res50: insulin drug
14290 Insulatard Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
14299 Insulin glulisine 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
14301 Insulin detemir 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
14313 Insulin lispro 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
14330 Insulin detemir 100units/ml solution for injection 3ml pre-filled disposable devi CPRD_product_code res50: insulin drug
14339 Hypurin Bovine Neutral 100units/ml solution for injection 10ml vials (Wockhardt U CPRD_product_code res50: insulin drug
14340 Hypurin Bovine Isophane 100units/ml suspension for injection 10ml vials (Wockhard CPRD_product_code res50: insulin drug
14345 Apidra 100units/ml solution for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
14357 Humulin I 100units/ml suspension for injection 3ml cartridges (Eli Lilly and Comp CPRD_product_code res50: insulin drug
14362 Insulin lispro 100units/ml solution for injection 3ml pre-filled disposable devic CPRD_product_code res50: insulin drug
14505 Insulin protamine zinc bovine 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
14619 Insulin isophane biphasic porcine 30/70 100units/ml suspension for injection 1.5m CPRD_product_code res50: insulin drug
14644 Insulin biphasic isophane human prb 20:80; 100 units/ml Injection CPRD_product_code res50: insulin drug
14646 Hypodermic U100 insulin syringe sterile single use / single patient use 0.3ml wit CPRD_product_code res50: insulin drug
14649 Insulin biphasic isophane human pyr 10:90; 100 units/ml Injection CPRD_product_code res50: insulin drug
14918 Humulin I 100units/ml suspension for injection 10ml vials (Eli Lilly and Company CPRD_product_code res50: insulin drug
14925 Insulin isophane human vial 100unit/ml Sterile suspension injection CPRD_product_code res50: insulin drug
14928 Insulatard 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
14930 Hypurin Porcine Neutral 100units/ml solution for injection 3ml cartridges (Wockha CPRD_product_code res50: insulin drug
14933 Hypurin Porcine Isophane 100units/ml suspension for injection 3ml cartridges (Woc CPRD_product_code res50: insulin drug
14938 Insulin soluble bovine cartridge 100unit/ml Solution for injection CPRD_product_code res50: insulin drug
14944 Humulin S 100units/ml solution for injection 3ml cartridges (Eli Lilly and Compan CPRD_product_code res50: insulin drug
15199 Insuman comb 25 100iu/ml Injection (Aventis Pharma) CPRD_product_code res50: insulin drug
15484 Insulin isophane bovine 100units/ml suspension for injection 1.5ml cartridges CPRD_product_code res50: insulin drug
15710 Insulin soluble human emp 100unit/ml Injection CPRD_product_code res50: insulin drug
1587 Monotard 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1588 Actrapid 100iu/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1592 Actrapid penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1593 Insulatard penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1594 Actrapid NovoLet 100units/ml solution for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1595 Insulatard NovoLet 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
15961 Insulin isophane human crb 100iu/ml Injection CPRD_product_code res50: insulin drug
16129 Insulin soluble human 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
16142 Insulin aspart 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
16152 Insulin isophane biphasic human 30/70 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
16160 Humulin M3 Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Lilly CPRD_product_code res50: insulin drug
16389 Myjector hypodermic U100 insulin syringe sterile single use / single patient use CPRD_product_code res50: insulin drug
1649 Human actraphane 100iu/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
16682 Tempulin 100unit/ml Injection (Knoll Ltd) CPRD_product_code res50: insulin drug
16700 Insulin zinc mixed bovine vial 100unit/ml Sterile suspension injection CPRD_product_code res50: insulin drug
16866 Unifine hypodermic U100 insulin syringe sterile single use / single patient use 0 CPRD_product_code res50: insulin drug
16959 Hypodermic U100 insulin syringe sterile single use / single patient use 1ml with CPRD_product_code res50: insulin drug
17076 Omnican 100 hypodermic U100 insulin syringe sterile single use / single patient u CPRD_product_code res50: insulin drug
17336 Novopen 100unit/ml Injection device (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
17712 Hypurin Bovine Lente 100units/ml suspension for injection 10ml vials (Wockhardt U CPRD_product_code res50: insulin drug
17731 Penmix 50/50 100iu/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
17809 Humaject m4 100iu/ml M4 pen (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
1805 Mixtard 30/70 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1806 Penmix 30/70 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
18224 Humalog 100units/ml solution for injection 10ml vials (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
1840 Humulin s 100unit/ml Injection (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
1842 Pork velosulin 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
1843 Pork Insulatard 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd CPRD_product_code res50: insulin drug
1844 Ultratard 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
18446 Unifine hypodermic U100 insulin syringe sterile single use / single patient use 1 CPRD_product_code res50: insulin drug
18461 Insulin zinc mixed human 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
18590 Insulin isophane bovine 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
18592 Insulin soluble bovine 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
18593 Humalog Mix50 100units/ml suspension for injection 3ml cartridges (Eli Lilly and CPRD_product_code res50: insulin drug
1886 Insulatard 100iu/ml GE injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
18931 Insulin zinc crystalline human 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
19491 Apidra 100units/ml solution for injection 10ml vials (Sanofi) CPRD_product_code res50: insulin drug
19513 Humulin M3 100units/ml suspension for injection 10ml vials (Eli Lilly and Company CPRD_product_code res50: insulin drug
19877 Insulin aspart 100units/ml solution for injection 3ml pre-filled disposable devic CPRD_product_code res50: insulin drug
19878 Insulin isophane biphasic human 30/70 100units/ml suspension for injection 3ml pr CPRD_product_code res50: insulin drug
19977 Omnican 50 hypodermic U100 insulin syringe sterile single use / single patient us CPRD_product_code res50: insulin drug
20422 Insuman comb 15 100iu/ml Injection (Aventis Pharma) CPRD_product_code res50: insulin drug
20995 Hypurin Porcine 30/70 Mix 100units/ml suspension for injection 3ml cartridges (Wo CPRD_product_code res50: insulin drug
21110 Insulin biphasic isophane human prb 50:50; 100 units/ml Injection CPRD_product_code res50: insulin drug
21232 Insulin isophane biphasic human 30/70 100units/ml suspension for injection 10ml v CPRD_product_code res50: insulin drug
21235 Humulin S 100units/ml solution for injection 10ml vials (Eli Lilly and Company Lt CPRD_product_code res50: insulin drug
21347 Penmix 40/60 100iu/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
21374 Insulin biphasic isophane human prb 40:60; 100 units/ml Injection CPRD_product_code res50: insulin drug
21395 Insulin biphasic isophane human pyr 40:60; 100 units/ml Injection CPRD_product_code res50: insulin drug
21422 Insulin isophane biphasic human 40/60 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
21554 Insuman comb 50 100iu/ml Injection (Aventis Pharma) CPRD_product_code res50: insulin drug
21583 Apidra 100units/ml solution for injection 3ml pre-filled OptiSet pen (Sanofi) CPRD_product_code res50: insulin drug
21590 Insulin glulisine 100units/ml solution for injection 3ml pre-filled disposable de CPRD_product_code res50: insulin drug
22058 Pur-in mix 15/85 Injection (C P Pharmaceuticals Ltd) CPRD_product_code res50: insulin drug
22155 Humaject m5 100iu/ml M5 pen (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
2220 Penmix 20/80 Pen (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
2221 Mixtard 30 NovoLet 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
22697 Insulin isophane biphasic human 50/50 100units/ml suspension for injection 1.5ml CPRD_product_code res50: insulin drug
22945 Insuman rapid 100iu/ml Injection (Aventis Pharma) CPRD_product_code res50: insulin drug
22946 Omnican 100 hypodermic U100 insulin syringe sterile single use / single patient u CPRD_product_code res50: insulin drug
22983 Insuman Rapid 100units/ml solution for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
23099 Insulin aspart biphasic 30/70 100units/ml suspension for injection 3ml pre-filled CPRD_product_code res50: insulin drug
23231 Hypurin Bovine Neutral 100units/ml solution for injection 3ml cartridges (Wockhar CPRD_product_code res50: insulin drug
23992 Insuman Basal 100units/ml suspension for injection 3ml pre-filled OptiSet pen (Sa CPRD_product_code res50: insulin drug
23993 Insuman Rapid 100units/ml solution for injection 3ml pre-filled OptiSet pen (Sano CPRD_product_code res50: insulin drug
24002 Insuman Comb 25 100units/ml suspension for injection 5ml vials (Sanofi) CPRD_product_code res50: insulin drug
2454 Mixtard 30 penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
2455 Mixtard 20 NovoLet 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
2456 Mixtard 10 NovoLet 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
2459 Pork Mixtard 30 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd CPRD_product_code res50: insulin drug
24593 Neutral insulin bovine 100unit/ml Injection CPRD_product_code res50: insulin drug
24795 Insulin aspart biphasic 30/70 100units/ml suspension for injection 3ml cartridges CPRD_product_code res50: insulin drug
24800 Hypurin Porcine 30/70 Mix 100units/ml suspension for injection 10ml vials (Wockha CPRD_product_code res50: insulin drug
24846 Pur-in neutral 100unit/ml Injection (C P Pharmaceuticals Ltd) CPRD_product_code res50: insulin drug
24993 Insuman Comb 25 100units/ml suspension for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
25133 Insuman Comb 25 100units/ml suspension for injection 3ml pre-filled OptiSet pen ( CPRD_product_code res50: insulin drug
25479 Insulin soluble porcine 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
25735 Insulin isophane biphasic human 20/80 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
25736 Insulin isophane biphasic human 10/90 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
25812 Insulin isophane human 100units/ml suspension for injection 3ml pre-filled dispos CPRD_product_code res50: insulin drug
26060 Insulin lispro 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
26098 Hypurin Porcine Neutral 100units/ml solution for injection 10ml vials (Wockhardt CPRD_product_code res50: insulin drug
26338 Injex starter set 60500 (Ocon Chemicals Ltd) CPRD_product_code res50: insulin drug
26403 Pur-in mix 25/75 Injection (C P Pharmaceuticals Ltd) CPRD_product_code res50: insulin drug
26498 Insulin zinc suspension mixed bovine and porcine 100unit/ml Injection CPRD_product_code res50: insulin drug
26621 Insulin soluble human crb 100iu/ml Injection CPRD_product_code res50: insulin drug
27177 Insulin biphasic lispro human prb 50:50; 100 units/ml Injection CPRD_product_code res50: insulin drug
27280 Insulin isophane biphasic porcine 30/70 100units/ml suspension for injection 10ml CPRD_product_code res50: insulin drug
27396 Insulin soluble porcine 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
27402 Insulin soluble human 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
27461 Insuman Basal 100units/ml suspension for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
27614 Penmix 30/70 100iu/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
28096 Insulin isophane biphasic human 50/50 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
28101 Insulin glulisine 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
2812 Mixtard 40 NovoLet 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
28183 Hypurin Porcine Isophane 100units/ml suspension for injection 10ml vials (Wockhar CPRD_product_code res50: insulin drug
28185 Insulin lispro biphasic 25/75 100units/ml suspension for injection 3ml cartridges CPRD_product_code res50: insulin drug
28442 Insulin glulisine 100unit/ml Solution for injection CPRD_product_code res50: insulin drug
28588 Hypurin Bovine Isophane 100units/ml suspension for injection 3ml cartridges (Wock CPRD_product_code res50: insulin drug
28666 Omnican 50 hypodermic U100 insulin syringe sterile single use / single patient us CPRD_product_code res50: insulin drug
2929 Mixtard 30 100iu/ml GE injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
29567 Insulin aspart 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
29837 Insulin biphasic isophane human prb 25:75; 100 units/ml Injection CPRD_product_code res50: insulin drug
29953 Apidra 100units/ml solution for injection 3ml OptiClik cartridges (Sanofi) CPRD_product_code res50: insulin drug
30209 Actrapid mc 100unit/ml Injection (Arun Products Ltd) CPRD_product_code res50: insulin drug
30236 Isophane insulin 100iu/ml Injection CPRD_product_code res50: insulin drug
30305 Hypodermic U100 insulin syringe sterile single use / single patient use 0.5ml wit CPRD_product_code res50: insulin drug
30686 Insulin isophane porcine 100units/ml suspension for injection 3ml cartridges CPRD_product_code res50: insulin drug
30819 Insuman Comb 15 100units/ml suspension for injection 3ml pre-filled OptiSet pen ( CPRD_product_code res50: insulin drug
31205 Insuman Comb 50 100units/ml suspension for injection 3ml pre-filled OptiSet pen ( CPRD_product_code res50: insulin drug
31258 Insulin lispro biphasic 25/75 100units/ml suspension for injection 3ml pre-filled CPRD_product_code res50: insulin drug
31465 Exubera 1mg inhalation powder blisters (Pfizer Ltd) CPRD_product_code res50: insulin drug
31467 Exubera 3mg inhalation powder blisters (Pfizer Ltd) CPRD_product_code res50: insulin drug
322 Humalog 100units/ml solution for injection 1.5ml cartridges (Eli Lilly and Compan CPRD_product_code res50: insulin drug
33167 Insulin biphasic isophane human crb 25:75; 100 units/ml Injection CPRD_product_code res50: insulin drug
33232 Insulin isophane biphasic human 50/50 100units/ml suspension for injection 5ml vi CPRD_product_code res50: insulin drug
3396 Penmix 10/90 Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
33966 Insulatard 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
34031 Monotard mc 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
34097 Human initard 50/50 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
3439 Penmix 10/90 Pen (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
35253 Insuman Comb 50 100units/ml suspension for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
35260 Levemir InnoLet 100units/ml solution for injection 3ml pre-filled pen (Novo Nordi CPRD_product_code res50: insulin drug
35468 Insuman Basal 100units/ml suspension for injection 5ml vials (Sanofi) CPRD_product_code res50: insulin drug
3550 Mixtard 40 penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
3551 Mixtard 20 penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
35701 Insulin lispro biphasic 50/50 100units/ml suspension for injection 3ml pre-filled CPRD_product_code res50: insulin drug
36031 Insulin isophane biphasic porcine 30/70 100units/ml suspension for injection 3ml CPRD_product_code res50: insulin drug
36066 Insulin isophane bovine 100units/ml suspension for injection 3ml cartridges CPRD_product_code res50: insulin drug
36146 Insulin lispro biphasic 50/50 100units/ml suspension for injection 3ml cartridges CPRD_product_code res50: insulin drug
36194 Insulin isophane biphasic human 25/75 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
36355 Insulin human 1mg inhalation powder blisters CPRD_product_code res50: insulin drug
36356 Insulin human 3mg inhalation powder blisters CPRD_product_code res50: insulin drug
36430 Insulin soluble human 100units/ml solution for injection 3ml pre-filled disposabl CPRD_product_code res50: insulin drug
36513 Velosulin cartridge 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
36853 Lantus 100units/ml solution for injection 3ml pre-filled SoloStar pen (Sanofi) CPRD_product_code res50: insulin drug
36920 Apidra 100units/ml solution for injection 3ml pre-filled SoloStar pen (Sanofi) CPRD_product_code res50: insulin drug
37055 Comfort Point hypodermic U100 insulin syringe sterile single use / single patient CPRD_product_code res50: insulin drug
38236 Comfort Point hypodermic U100 insulin syringe sterile single use / single patient CPRD_product_code res50: insulin drug
38422 Isophane 100iu/ml Injection (Celltech Pharma Europe Ltd) CPRD_product_code res50: insulin drug
38986 Humalog KwikPen 100units/ml solution for injection 3ml pre-filled pen (Eli Lilly CPRD_product_code res50: insulin drug
39006 Humalog Mix25 KwikPen 100units/ml suspension for injection 3ml pre-filled pen (El CPRD_product_code res50: insulin drug
39086 Humalog Mix50 KwikPen 100units/ml suspension for injection 3ml pre-filled pen (El CPRD_product_code res50: insulin drug
39150 Hypodermic U100 insulin syringe sterile single use / single patient use 1ml with CPRD_product_code res50: insulin drug
4093 Humulin M2 100units/ml suspension for injection 3ml cartridges (Eli Lilly and Com CPRD_product_code res50: insulin drug
41120 Insulin isophane biphasic human 50/50 100units/ml suspension for injection 3ml pr CPRD_product_code res50: insulin drug
4129 Insulin soluble porcine 100units/ml solution for injection 1.5ml cartridges CPRD_product_code res50: insulin drug
4163 Rapitard MC 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
41834 Insulin zinc suspension lente 100iu/ml Injection (Celltech Pharma Europe Ltd) CPRD_product_code res50: insulin drug
41959 Penject 100unit/ml Injection device (Hypoguard Ltd) CPRD_product_code res50: insulin drug
4198 Humulin m3 100unit/ml M3 injection (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
4199 Humulin m1 100unit/ml M1 injection (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
42305 Injex 10ml vial adaptor pack 60502 (Ocon Chemicals Ltd) CPRD_product_code res50: insulin drug
42395 Humalog Mix25 100units/ml suspension for injection 10ml vials (Eli Lilly and Comp CPRD_product_code res50: insulin drug
4247 Insulin isophane porcine 100units/ml suspension for injection 1.5ml cartridges CPRD_product_code res50: insulin drug
42797 Injex ampoule pack 60501 (Ocon Chemicals Ltd) CPRD_product_code res50: insulin drug
42954 Insulin isophane biphasic human 25/75 100units/ml suspension for injection 5ml vi CPRD_product_code res50: insulin drug
43950 Humulin I KwikPen 100units/ml suspension for injection 3ml pre-filled pen (Eli Li CPRD_product_code res50: insulin drug
43953 Insulin lispro biphasic 25/75 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
43991 Humulin M3 KwikPen 100units/ml suspension for injection 3ml pre-filled pen (Eli L CPRD_product_code res50: insulin drug
44251 Insulin zinc suspension mixed porcine 100unit/ml Injection CPRD_product_code res50: insulin drug
44378 Insulin isophane biphasic human 25/75 100units/ml suspension for injection 3ml pr CPRD_product_code res50: insulin drug
44480 Insuman Comb 25 100units/ml suspension for injection 3ml pre-filled SoloStar pen CPRD_product_code res50: insulin drug
44601 Injex 4 monthly refill pack 60504 (Ocon Chemicals Ltd) CPRD_product_code res50: insulin drug
45158 Insuman Comb 15 100units/ml suspension for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
46001 Insuman Basal 100units/ml suspension for injection 3ml pre-filled SoloStar pen (S CPRD_product_code res50: insulin drug
46666 NovoRapid FlexTouch 100units/ml solution for injection 3ml pre-filled pen (Novo N CPRD_product_code res50: insulin drug
4706 Velosulin 100units/ml solution for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
4715 Humalog mix 25 25/75 100units/ml Injection (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
47360 Neutral insulin 100unit/ml Injection (Celltech Pharma Europe Ltd) CPRD_product_code res50: insulin drug
4760 Humulin i 100unit/ml Injection (Eli Lilly and Company Ltd) CPRD_product_code res50: insulin drug
47751 TS-A Safety hypodermic U100 insulin syringe sterile single use / single patient u CPRD_product_code res50: insulin drug
4784 Lentard mc 100unit/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
47856 Neuphane 100unit/ml Injection (Wellcome Medical Division) CPRD_product_code res50: insulin drug
4790 Mixtard 50 penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
4896 Monoject hypodermic U100 insulin syringe sterile single use / single patient use CPRD_product_code res50: insulin drug
49108 NovoRapid Penfill 100units/ml solution for injection 3ml cartridges (Necessity Su CPRD_product_code res50: insulin drug
49507 InsuJet nozzle pack 012070GB15 (Spirit Healthcare Ltd) CPRD_product_code res50: insulin drug
49508 InsuJet 10ml vial adaptor pack 01207GB1510 (Spirit Healthcare Ltd) CPRD_product_code res50: insulin drug
49509 InsuJet starter set 012005GBSP Blue (Spirit Healthcare Ltd) CPRD_product_code res50: insulin drug
49831 Lantus 100units/ml solution for injection 3ml pre-filled SoloStar pen (Necessity CPRD_product_code res50: insulin drug
5021 NovoRapid Penfill 100units/ml solution for injection 3ml cartridges (Novo Nordisk CPRD_product_code res50: insulin drug
50633 Lantus 100units/ml solution for injection 3ml cartridges (Necessity Supplies Ltd) CPRD_product_code res50: insulin drug
50691 Human Mixtard 20 Penfill 100units/ml suspension for injection 1.5ml cartridges (N CPRD_product_code res50: insulin drug
51182 InsuJet starter set 012003GBSP Lime (Spirit Healthcare Ltd) CPRD_product_code res50: insulin drug
51743 NovoRapid Penfill 100units/ml solution for injection 3ml cartridges (Sigma Pharma CPRD_product_code res50: insulin drug
51836 InsuJet 3ml cartridge adaptor pack 012071GB1503 (Spirit Healthcare Ltd) CPRD_product_code res50: insulin drug
5214 Insulin lispro 100units/ml solution for injection 1.5ml cartridges CPRD_product_code res50: insulin drug
5250 Insulin biphasic lispro human prb 25:75; 100 units/ml Injection CPRD_product_code res50: insulin drug
52522 Humalog Mix50 KwikPen 100units/ml suspension for injection 3ml pre-filled pen (DE CPRD_product_code res50: insulin drug
5255 Mixtard 10 penfill 100 100iu/ml Penfill (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
5267 BD Micro-Fine + hypodermic U100 insulin syringe sterile single use / single patie CPRD_product_code res50: insulin drug
52722 Human Mixtard 30 Penfill 100units/ml suspension for injection 1.5ml cartridges (N CPRD_product_code res50: insulin drug
52748 Insulatard Penfill 100units/ml suspension for injection 3ml cartridges (Waymade H CPRD_product_code res50: insulin drug
53118 NovoRapid FlexPen 100units/ml solution for injection 3ml pre-filled pen (Mawdsley CPRD_product_code res50: insulin drug
53251 NovoRapid Penfill 100units/ml solution for injection 3ml cartridges (DE Pharmaceu CPRD_product_code res50: insulin drug
5345 Monoject hypodermic U100 insulin syringe sterile single use / single patient use CPRD_product_code res50: insulin drug
53710 Insulin human 500units/ml solution for injection 20ml vials CPRD_product_code res50: insulin drug
54462 Insulin biphasic isophane human emp 25:75; 100 units/ml Injection CPRD_product_code res50: insulin drug
5501 Insuman basal 100iu/ml Injection (Aventis Pharma) CPRD_product_code res50: insulin drug
55234 Tresiba FlexTouch 200units/ml solution for injection 3ml pre-filled pen (Novo Nor CPRD_product_code res50: insulin drug
55462 Tresiba FlexTouch 100units/ml solution for injection 3ml pre-filled pen (Novo Nor CPRD_product_code res50: insulin drug
55517 Insulin isophane human 100units/ml suspension for injection 10ml vials CPRD_product_code res50: insulin drug
55603 Humalog KwikPen 100units/ml solution for injection 3ml pre-filled pen (DE Pharmac CPRD_product_code res50: insulin drug
55618 Levemir FlexPen 100units/ml solution for injection 3ml pre-filled pen (Waymade He CPRD_product_code res50: insulin drug
55687 Insulin degludec 100units/ml solution for injection 3ml pre-filled disposable dev CPRD_product_code res50: insulin drug
55907 Insulin degludec 100units/ml solution for injection 3ml cartridges CPRD_product_code res50: insulin drug
55910 Tresiba Penfill 100units/ml solution for injection 3ml cartridges (Novo Nordisk L CPRD_product_code res50: insulin drug
56115 Human Actrapid Penfill 100units/ml solution for injection 1.5ml cartridges (Novo CPRD_product_code res50: insulin drug
5634 Hypodermic U100 insulin syringe sterile single use / single patient use 1ml with CPRD_product_code res50: insulin drug
56489 NovoMix 30 Penfill 100units/ml suspension for injection 3ml cartridges (Waymade H CPRD_product_code res50: insulin drug
56495 Lantus 100units/ml solution for injection 3ml pre-filled OptiSet pen (Waymade Hea CPRD_product_code res50: insulin drug
56502 Actrapid Penfill 100units/ml solution for injection 3ml cartridges (Novo Nordisk CPRD_product_code res50: insulin drug
56624 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
56656 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
56691 Insulin degludec 200units/ml solution for injection 3ml pre-filled disposable dev CPRD_product_code res50: insulin drug
56857 Insulin isophane biphasic human 15/85 100units/ml suspension for injection 3ml ca CPRD_product_code res50: insulin drug
57153 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
57387 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
57388 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
57529 Humalog 100units/ml solution for injection 10ml vials (Dowelhurst Ltd) CPRD_product_code res50: insulin drug
57564 Humalog KwikPen 100units/ml solution for injection 3ml pre-filled pen (Waymade He CPRD_product_code res50: insulin drug
57620 Humulin M3 100units/ml suspension for injection 10ml vials (Mawdsley-Brooks & Com CPRD_product_code res50: insulin drug
57622 Humalog Mix50 KwikPen 100units/ml suspension for injection 3ml pre-filled pen (Wa CPRD_product_code res50: insulin drug
5769 Hypodermic U100 insulin syringe sterile single use / single patient use 0.5ml wit CPRD_product_code res50: insulin drug
5789 Hypodermic U100 insulin syringe sterile single use / single patient use 0.5ml wit CPRD_product_code res50: insulin drug
5845 Mixtard 30 InnoLet 100units/ml suspension for injection 3ml pre-filled pen (Novo CPRD_product_code res50: insulin drug
58578 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
58754 BD SafetyGlide hypodermic U100 insulin syringe sterile single use / single patien CPRD_product_code res50: insulin drug
5891 Insulatard FlexPen 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
5892 NovoRapid FlexPen 100units/ml solution for injection 3ml pre-filled pen (Novo Nor CPRD_product_code res50: insulin drug
58995 BD SafetyGlide hypodermic U100 insulin syringe sterile single use / single patien CPRD_product_code res50: insulin drug
59133 BD SafetyGlide hypodermic U100 insulin syringe sterile single use / single patien CPRD_product_code res50: insulin drug
59243 BD SafetyGlide hypodermic U100 insulin syringe sterile single use / single patien CPRD_product_code res50: insulin drug
59311 Kendall Magellan hypodermic U100 insulin syringe sterile single use / single pati CPRD_product_code res50: insulin drug
5933 Mixtard 50 NovoLet 100units/ml suspension for injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
59500 Insulin isophane human 100units/ml suspension for injection 5ml vials CPRD_product_code res50: insulin drug
5953 Insulin glargine 100iu/ml Injection CPRD_product_code res50: insulin drug
59533 NovoRapid FlexPen 100units/ml solution for injection 3ml pre-filled pen (Sigma Ph CPRD_product_code res50: insulin drug
5967 Hypodermic U100 insulin syringe sterile single use / single patient use 0.5ml wit CPRD_product_code res50: insulin drug
6009 Myjector hypodermic U100 insulin syringe sterile single use / single patient use CPRD_product_code res50: insulin drug
6057 Lantus 100iu/ml Injection (Aventis Pharma) CPRD_product_code res50: insulin drug
6061 Novomix 30 30/70 100units/ml Injection (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
60626 InsuJet starter set 012007GBSP Grey (Spirit Healthcare Ltd) CPRD_product_code res50: insulin drug
60933 Humulin M3 100units/ml suspension for injection 10ml vials (Sigma Pharmaceuticals CPRD_product_code res50: insulin drug
60938 Mixtard 30 100units/ml suspension for injection 10ml vials (Waymade Healthcare Pl CPRD_product_code res50: insulin drug
60951 Insulin human 100units/ml solution for injection 10ml vials CPRD_product_code res50: insulin drug
61845 NovoRapid PumpCart 100units/ml solution for injection 1.6ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
6209 NovoRapid 100units/ml solution for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
62180 Insulin aspart 100units/ml solution for injection 1.6ml cartridges CPRD_product_code res50: insulin drug
62276 Humulin R 500units/ml solution for injection 20ml vials (Imported (United States) CPRD_product_code res50: insulin drug
6228 BD Micro-Fine + hypodermic U100 insulin syringe sterile single use / single patie CPRD_product_code res50: insulin drug
6378 Hypodermic U100 insulin syringe sterile single use / single patient use 0.3ml wit CPRD_product_code res50: insulin drug
6447 Insulin aspart human pyr 100 iu/ml Injection CPRD_product_code res50: insulin drug
6730 Hypodermic U100 insulin syringe sterile single use / single patient use 1ml with CPRD_product_code res50: insulin drug
6958 Levemir FlexPen 100units/ml solution for injection 3ml pre-filled pen (Novo Nordi CPRD_product_code res50: insulin drug
6965 Levemir Penfill 100units/ml solution for injection 3ml cartridges (Novo Nordisk L CPRD_product_code res50: insulin drug
6991 BD Micro-Fine + hypodermic U100 insulin syringe sterile single use / single patie CPRD_product_code res50: insulin drug
7062 Myjector hypodermic U100 insulin syringe sterile single use / single patient use CPRD_product_code res50: insulin drug
7127 BD Micro-Fine + hypodermic U100 insulin syringe sterile single use / single patie CPRD_product_code res50: insulin drug
7228 NovoMix 30 FlexPen 100units/ml suspension for injection 3ml pre-filled pen (Novo CPRD_product_code res50: insulin drug
7231 Mixtard 30 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
7237 Lantus 100units/ml solution for injection 3ml pre-filled OptiSet pen (Sanofi) CPRD_product_code res50: insulin drug
7266 Lantus 100units/ml solution for injection 3ml cartridges (Sanofi) CPRD_product_code res50: insulin drug
7267 NovoMix 30 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
7300 Mixtard 30 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin drug
7318 Humalog 100units/ml solution for injection 3ml cartridges (Eli Lilly and Company CPRD_product_code res50: insulin drug
7319 Mixtard 20 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nord CPRD_product_code res50: insulin drug
7349 Actrapid 100units/ml solution for injection 10ml vials (Novo Nordisk Ltd) CPRD_product_code res50: insulin