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Metastatic Tumour

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH737
Version ID
1474
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 135
Code Description Entity type Category Coding System (Read)
142..00 H/O: malignant neoplasm (*) res50: Metastatic tumour diagnostic Read
B56..00 Secondary and unspecified malignant neoplasm of lymph nodes res50: Metastatic tumour diagnostic Read
B56..11 Lymph node metastases res50: Metastatic tumour diagnostic Read
B560.00 Secondary and unspec malig neop lymph nodes head/face/neck res50: Metastatic tumour diagnostic Read
B560000 Secondary and unspec malig neop of superficial parotid LN res50: Metastatic tumour diagnostic Read
B560100 Secondary and unspec malignant neoplasm mastoid lymph nodes res50: Metastatic tumour diagnostic Read
B560200 Secondary and unspec malig neop superficial cervical LN res50: Metastatic tumour diagnostic Read
B560300 Secondary and unspec malignant neoplasm occipital lymph node res50: Metastatic tumour diagnostic Read
B560400 Secondary and unspec malig neop deep parotid lymph nodes res50: Metastatic tumour diagnostic Read
B560500 Secondary and unspec malig neop submandibular lymph nodes res50: Metastatic tumour diagnostic Read
B560600 Secondary and unspec malig neop of facial lymph nodes res50: Metastatic tumour diagnostic Read
B560700 Secondary and unspec malig neop submental lymph nodes res50: Metastatic tumour diagnostic Read
B560800 Secondary and unspec malig neop anterior cervical LN res50: Metastatic tumour diagnostic Read
B560900 Secondary and unspec malig neop deep cervical LN res50: Metastatic tumour diagnostic Read
B560z00 Secondary unspec malig neop lymph nodes head/face/neck NOS res50: Metastatic tumour diagnostic Read
B561.00 Secondary and unspec malig neop intrathoracic lymph nodes res50: Metastatic tumour diagnostic Read
B561000 Secondary and unspec malig neop internal mammary lymph nodes res50: Metastatic tumour diagnostic Read
B561100 Secondary and unspec malig neop intercostal lymph nodes res50: Metastatic tumour diagnostic Read
B561200 Secondary and unspec malig neop diaphragmatic lymph nodes res50: Metastatic tumour diagnostic Read
B561300 Secondary and unspec malig neop ant mediastinal lymph nodes res50: Metastatic tumour diagnostic Read
B561400 Secondary and unspec malig neop post mediastinal lymph nodes res50: Metastatic tumour diagnostic Read
B561500 Secondary and unspec malig neop paratracheal lymph nodes res50: Metastatic tumour diagnostic Read
B561600 Secondary and unspec malig neop superfic tracheobronchial LN res50: Metastatic tumour diagnostic Read
B561700 Secondary and unspec malig neop inferior tracheobronchial LN res50: Metastatic tumour diagnostic Read
B561800 Secondary and unspec malig neop bronchopulmonary lymph nodes res50: Metastatic tumour diagnostic Read
B561900 Secondary and unspec malig neop pulmonary lymph nodes res50: Metastatic tumour diagnostic Read
B561z00 Secondary and unspec malig neop intrathoracic LN NOS res50: Metastatic tumour diagnostic Read
B562.00 Secondary and unspec malig neop intra-abdominal lymph nodes res50: Metastatic tumour diagnostic Read
B562000 Secondary and unspec malig neop coeliac lymph nodes res50: Metastatic tumour diagnostic Read
B562100 Secondary and unspec malig neop superficial mesenteric LN res50: Metastatic tumour diagnostic Read
B562200 Secondary and unspec malig neop inferior mesenteric LN res50: Metastatic tumour diagnostic Read
B562300 Secondary and unspec malig neop common iliac lymph nodes res50: Metastatic tumour diagnostic Read
B562400 Secondary and unspec malig neop external iliac lymph nodes res50: Metastatic tumour diagnostic Read
B562z00 Secondary and unspec malig neop intra-abdominal LN NOS res50: Metastatic tumour diagnostic Read
B563.00 Secondary and unspec malig neop axilla and upper limb LN res50: Metastatic tumour diagnostic Read
B563000 Secondary and unspec malig neop axillary lymph nodes res50: Metastatic tumour diagnostic Read
B563100 Secondary and unspec malig neop supratrochlear lymph nodes res50: Metastatic tumour diagnostic Read
B563200 Secondary and unspec malig neop infraclavicular lymph nodes res50: Metastatic tumour diagnostic Read
B563300 Secondary and unspec malig neop pectoral lymph nodes res50: Metastatic tumour diagnostic Read
B563z00 Secondary and unspec malig neop axilla and upper limb LN NOS res50: Metastatic tumour diagnostic Read
B564.00 Secondary and unspec malig neop inguinal and lower limb LN res50: Metastatic tumour diagnostic Read
B564000 Secondary and unspec malig neop superficial inguinal LN res50: Metastatic tumour diagnostic Read
B564100 Secondary and unspec malig neop deep inguinal lymph nodes res50: Metastatic tumour diagnostic Read
B564z00 Secondary and unspec malig neop of inguinal and leg LN NOS res50: Metastatic tumour diagnostic Read
B565.00 Secondary and unspec malig neop intrapelvic lymph nodes res50: Metastatic tumour diagnostic Read
B565000 Secondary and unspec malig neop internal iliac lymph nodes res50: Metastatic tumour diagnostic Read
B565200 Secondary and unspec malig neop circumflex iliac LN res50: Metastatic tumour diagnostic Read
B565300 Secondary and unspec malig neop sacral lymph nodes res50: Metastatic tumour diagnostic Read
B565z00 Secondary and unspec malig neop intrapelvic LN NOS res50: Metastatic tumour diagnostic Read
B56y.00 Secondary and unspec malig neop lymph nodes multiple sites res50: Metastatic tumour diagnostic Read
B56z.00 Secondary and unspec malig neop lymph nodes NOS res50: Metastatic tumour diagnostic Read
B57..00 Secondary malig neop of respiratory and digestive systems res50: Metastatic tumour diagnostic Read
B57..11 Metastases of respiratory and/or digestive systems res50: Metastatic tumour diagnostic Read
B57..12 Secondary carcinoma of respiratory and/or digestive systems res50: Metastatic tumour diagnostic Read
B570.00 Secondary malignant neoplasm of lung res50: Metastatic tumour diagnostic Read
B571.00 Secondary malignant neoplasm of mediastinum res50: Metastatic tumour diagnostic Read
B572.00 Secondary malignant neoplasm of pleura res50: Metastatic tumour diagnostic Read
B573.00 Secondary malignant neoplasm of other respiratory organs res50: Metastatic tumour diagnostic Read
B574.00 Secondary malignant neoplasm of small intestine and duodenum res50: Metastatic tumour diagnostic Read
B574000 Secondary malignant neoplasm of duodenum res50: Metastatic tumour diagnostic Read
B574200 Secondary malignant neoplasm of ileum res50: Metastatic tumour diagnostic Read
B574z00 Secondary malig neop of small intestine or duodenum NOS res50: Metastatic tumour diagnostic Read
B575.00 Secondary malignant neoplasm of large intestine and rectum res50: Metastatic tumour diagnostic Read
B575000 Secondary malignant neoplasm of colon res50: Metastatic tumour diagnostic Read
B575100 Secondary malignant neoplasm of rectum res50: Metastatic tumour diagnostic Read
B575z00 Secondary malig neop of large intestine or rectum NOS res50: Metastatic tumour diagnostic Read
B576.00 Secondary malig neop of retroperitoneum and peritoneum res50: Metastatic tumour diagnostic Read
B576000 Secondary malignant neoplasm of retroperitoneum res50: Metastatic tumour diagnostic Read
B576100 Secondary malignant neoplasm of peritoneum res50: Metastatic tumour diagnostic Read
B576200 Malignant ascites res50: Metastatic tumour diagnostic Read
B576z00 Secondary malig neop of retroperitoneum or peritoneum NOS res50: Metastatic tumour diagnostic Read
B577.00 Secondary malignant neoplasm of liver res50: Metastatic tumour diagnostic Read
B577.11 Liver metastases res50: Metastatic tumour diagnostic Read
B57y.00 Secondary malignant neoplasm of other digestive organ res50: Metastatic tumour diagnostic Read
B57z.00 Secondary malig neop of respiratory or digestive system NOS res50: Metastatic tumour diagnostic Read
B58..00 Secondary malignant neoplasm of other specified sites res50: Metastatic tumour diagnostic Read
B58..11 Secondary carcinoma of other specified sites res50: Metastatic tumour diagnostic Read
B580.00 Secondary malignant neoplasm of kidney res50: Metastatic tumour diagnostic Read
B581.00 Secondary malignant neoplasm of other urinary organs res50: Metastatic tumour diagnostic Read
B581000 Secondary malignant neoplasm of ureter res50: Metastatic tumour diagnostic Read
B581100 Secondary malignant neoplasm of bladder res50: Metastatic tumour diagnostic Read
B581200 Secondary malignant neoplasm of urethra res50: Metastatic tumour diagnostic Read
B581z00 Secondary malignant neoplasm of other urinary organ NOS res50: Metastatic tumour diagnostic Read
B582.00 Secondary malignant neoplasm of skin res50: Metastatic tumour diagnostic Read
B582000 Secondary malignant neoplasm of skin of head res50: Metastatic tumour diagnostic Read
B582100 Secondary malignant neoplasm of skin of face res50: Metastatic tumour diagnostic Read
B582200 Secondary malignant neoplasm of skin of neck res50: Metastatic tumour diagnostic Read
B582300 Secondary malignant neoplasm of skin of trunk res50: Metastatic tumour diagnostic Read
B582400 Secondary malignant neoplasm of skin of shoulder and arm res50: Metastatic tumour diagnostic Read
B582500 Secondary malignant neoplasm of skin of hip and leg res50: Metastatic tumour diagnostic Read
B582600 Secondary malignant neoplasm of skin of breast res50: Metastatic tumour diagnostic Read
B582z00 Secondary malignant neoplasm of skin NOS res50: Metastatic tumour diagnostic Read
B583.00 Secondary malignant neoplasm of brain and spinal cord res50: Metastatic tumour diagnostic Read
B583000 Secondary malignant neoplasm of brain res50: Metastatic tumour diagnostic Read
B583100 Secondary malignant neoplasm of spinal cord res50: Metastatic tumour diagnostic Read
B583200 Cerebral metastasis res50: Metastatic tumour diagnostic Read
B583z00 Secondary malignant neoplasm of brain or spinal cord NOS res50: Metastatic tumour diagnostic Read
B584.00 Secondary malignant neoplasm of other part of nervous system res50: Metastatic tumour diagnostic Read
B585.00 Secondary malignant neoplasm of bone and bone marrow res50: Metastatic tumour diagnostic Read
B585000 Pathological fracture due to metastatic bone disease res50: Metastatic tumour diagnostic Read
B586.00 Secondary malignant neoplasm of ovary res50: Metastatic tumour diagnostic Read
B587.00 Secondary malignant neoplasm of adrenal gland res50: Metastatic tumour diagnostic Read
B58y.00 Secondary malignant neoplasm of other specified sites res50: Metastatic tumour diagnostic Read
B58y000 Secondary malignant neoplasm of breast res50: Metastatic tumour diagnostic Read
B58y100 Secondary malignant neoplasm of uterus res50: Metastatic tumour diagnostic Read
B58y200 Secondary malignant neoplasm of cervix uteri res50: Metastatic tumour diagnostic Read
B58y211 Secondary cancer of the cervix res50: Metastatic tumour diagnostic Read
B58y300 Secondary malignant neoplasm of vagina res50: Metastatic tumour diagnostic Read
B58y400 Secondary malignant neoplasm of vulva res50: Metastatic tumour diagnostic Read
B58y411 Secondary cancer of the vulva res50: Metastatic tumour diagnostic Read
B58y500 Secondary malignant neoplasm of prostate res50: Metastatic tumour diagnostic Read
B58y600 Secondary malignant neoplasm of testis res50: Metastatic tumour diagnostic Read
B58y700 Secondary malignant neoplasm of penis res50: Metastatic tumour diagnostic Read
B58y800 Secondary malignant neoplasm of epididymis and vas deferens res50: Metastatic tumour diagnostic Read
B58y900 Secondary malignant neoplasm of tongue res50: Metastatic tumour diagnostic Read
B58yz00 Secondary malignant neoplasm of other specified site NOS res50: Metastatic tumour diagnostic Read
B58z.00 Secondary malignant neoplasm of other specified site NOS res50: Metastatic tumour diagnostic Read
B59..00 Malignant neoplasm of unspecified site res50: Metastatic tumour diagnostic Read
B591.00 Other malignant neoplasm NOS res50: Metastatic tumour diagnostic Read
B592.00 Malignant neoplasms of independent (primary) multiple sites res50: Metastatic tumour diagnostic Read
B593.00 Primary malignant neoplasm of unknown site res50: Metastatic tumour diagnostic Read
B594.00 Secondary malignant neoplasm of unknown site res50: Metastatic tumour diagnostic Read
B59z.00 Malignant neoplasm of unspecified site NOS res50: Metastatic tumour diagnostic Read
B5y..00 Malignant neoplasm of other and unspecified site OS res50: Metastatic tumour diagnostic Read
B5z..00 Malignant neoplasm of other and unspecified site NOS res50: Metastatic tumour diagnostic Read
ByuC.00 [X]Malignant neoplasm of ill-defined, secondary and unspeci res50: Metastatic tumour diagnostic Read
ByuC000 [X]Malignant neoplasm of other specified sites res50: Metastatic tumour diagnostic Read
ByuC100 [X]Malignant neoplasm/overlap lesion/other+ill-defined sites res50: Metastatic tumour diagnostic Read
ByuC200 [X]2ndry+unspcf malignant neoplasm lymph nodes/multi regions res50: Metastatic tumour diagnostic Read
ByuC300 [X]Secondary malignant neoplasm/oth+unspc respiratory organs res50: Metastatic tumour diagnostic Read
ByuC400 [X]Secondary malignant neoplasm/oth+unspcfd digestive organs res50: Metastatic tumour diagnostic Read
ByuC500 [X]2ndry malignant neoplasm/bladder+oth+unsp urinary organs res50: Metastatic tumour diagnostic Read
ByuC600 [X]2ndry malignant neoplasm/oth+unspec parts/nervous system res50: Metastatic tumour diagnostic Read
ByuC700 [X]Secondary malignant neoplasm of other specified sites res50: Metastatic tumour diagnostic Read
ByuC800 [X]Malignant neoplasm without specification of site res50: Metastatic tumour diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH737/version/1474/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH737/version/1474/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH737', '1474', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH737/version/1474/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH737/version/1474/export/codes/?format=json
CSV site_root/phenotypes/PH737/version/1474/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH737', '1474', api_client=client)

Version History

Version
ID
Name Owner Publish date
1474 Metastatic Tumour ieuan.scanlon 2021-10-06 currently shown

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