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Mild Liver Disease

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH739
Version ID
1478
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 73
Code Description Entity type Category Coding System (Read)
A785200 Cytomegaloviral hepatitis res50: mild liver disease diagnostic Read
A916100 Secondary syphilitic hepatitis res50: mild liver disease diagnostic Read
A98yy11 Gonococcal hepatitis res50: mild liver disease diagnostic Read
A98yy13 Gonococcal perihepatitis res50: mild liver disease diagnostic Read
AD05.00 Toxoplasma hepatitis res50: mild liver disease diagnostic Read
AE23.00 Sequelae of viral hepatitis res50: mild liver disease diagnostic Read
AyuB.00 [X]Viral hepatitis res50: mild liver disease diagnostic Read
AyuB000 [X]Other specified acute viral hepatitis res50: mild liver disease diagnostic Read
AyuB100 [X]Other chronic viral hepatitis res50: mild liver disease diagnostic Read
AyuB200 [X]Chronic viral hepatitis, unspecified res50: mild liver disease diagnostic Read
AyuJ900 [X]Sequelae of viral hepatitis res50: mild liver disease diagnostic Read
C310400 Glycogenosis with hepatic cirrhosis res50: mild liver disease diagnostic Read
C350012 Pigmentary cirrhosis of liver res50: mild liver disease diagnostic Read
C370800 Cystic fibrosis related cirrhosis res50: mild liver disease diagnostic Read
C376100 Alpha-1-antitrypsin hepatitis res50: mild liver disease diagnostic Read
G852200 Oesophageal varices in cirrhosis of the liver res50: mild liver disease diagnostic Read
G852300 Oesophageal varices in alcoholic cirrhosis of the liver res50: mild liver disease diagnostic Read
J61..00 Cirrhosis and chronic liver disease res50: mild liver disease diagnostic Read
J611.00 Acute alcoholic hepatitis res50: mild liver disease diagnostic Read
J612.00 Alcoholic cirrhosis of liver res50: mild liver disease diagnostic Read
J612.11 Florid cirrhosis res50: mild liver disease diagnostic Read
J612.12 Laennec's cirrhosis res50: mild liver disease diagnostic Read
J614.00 Chronic hepatitis res50: mild liver disease diagnostic Read
J614000 Chronic persistent hepatitis res50: mild liver disease diagnostic Read
J614100 Chronic active hepatitis res50: mild liver disease diagnostic Read
J614111 Autoimmune chronic active hepatitis res50: mild liver disease diagnostic Read
J614200 Chronic aggressive hepatitis res50: mild liver disease diagnostic Read
J614300 Recurrent hepatitis res50: mild liver disease diagnostic Read
J614400 Chronic lobular hepatitis res50: mild liver disease diagnostic Read
J614y00 Chronic hepatitis unspecified res50: mild liver disease diagnostic Read
J614z00 Chronic hepatitis NOS res50: mild liver disease diagnostic Read
J615.00 Cirrhosis - non alcoholic res50: mild liver disease diagnostic Read
J615.11 Portal cirrhosis res50: mild liver disease diagnostic Read
J615100 Multilobular portal cirrhosis res50: mild liver disease diagnostic Read
J615300 Diffuse nodular cirrhosis res50: mild liver disease diagnostic Read
J615400 Fatty portal cirrhosis res50: mild liver disease diagnostic Read
J615500 Hypertrophic portal cirrhosis res50: mild liver disease diagnostic Read
J615600 Capsular portal cirrhosis res50: mild liver disease diagnostic Read
J615700 Cardiac portal cirrhosis res50: mild liver disease diagnostic Read
J615711 Congestive cirrhosis res50: mild liver disease diagnostic Read
J615800 Juvenile portal cirrhosis res50: mild liver disease diagnostic Read
J615812 Indian childhood cirrhosis res50: mild liver disease diagnostic Read
J615C00 Xanthomatous portal cirrhosis res50: mild liver disease diagnostic Read
J615D00 Bacterial portal cirrhosis res50: mild liver disease diagnostic Read
J615H00 Infectious cirrhosis NOS res50: mild liver disease diagnostic Read
J615y00 Portal cirrhosis unspecified res50: mild liver disease diagnostic Read
J615z00 Non-alcoholic cirrhosis NOS res50: mild liver disease diagnostic Read
J615z11 Macronodular cirrhosis of liver res50: mild liver disease diagnostic Read
J615z12 Cryptogenic cirrhosis of liver res50: mild liver disease diagnostic Read
J615z13 Cirrhosis of liver NOS res50: mild liver disease diagnostic Read
J616.00 Biliary cirrhosis res50: mild liver disease diagnostic Read
J616000 Primary biliary cirrhosis res50: mild liver disease diagnostic Read
J616100 Secondary biliary cirrhosis res50: mild liver disease diagnostic Read
J616200 Biliary cirrhosis of children res50: mild liver disease diagnostic Read
J616z00 Biliary cirrhosis NOS res50: mild liver disease diagnostic Read
J617.00 Alcoholic hepatitis res50: mild liver disease diagnostic Read
J617000 Chronic alcoholic hepatitis res50: mild liver disease diagnostic Read
J61y.00 Other non-alcoholic chronic liver disease res50: mild liver disease diagnostic Read
J61y300 Portal fibrosis without cirrhosis res50: mild liver disease diagnostic Read
J61y800 Nonalcoholic steatohepatitis res50: mild liver disease diagnostic Read
J61yz00 Other non-alcoholic chronic liver disease NOS res50: mild liver disease diagnostic Read
J61z.00 Chronic liver disease NOS res50: mild liver disease diagnostic Read
J633000 Toxic hepatitis res50: mild liver disease diagnostic Read
J635300 Toxic liver disease with chronic persistent hepatitis res50: mild liver disease diagnostic Read
J635400 Toxic liver disease with chronic lobular hepatitis res50: mild liver disease diagnostic Read
J635500 Toxic liver disease with chronic active hepatitis res50: mild liver disease diagnostic Read
J635600 Toxic liver disease with fibrosis and cirrhosis of liver res50: mild liver disease diagnostic Read
J63B.00 Autoimmune hepatitis res50: mild liver disease diagnostic Read
J63X.00 Granulomatous hepatitis, not elsewhere classified res50: mild liver disease diagnostic Read
J63y100 Nonspecific reactive hepatitis res50: mild liver disease diagnostic Read
Jyu7100 [X]Other and unspecified cirrhosis of liver res50: mild liver disease diagnostic Read
Jyu7700 [X]Granulomatous hepatitis, not elsewhere classified res50: mild liver disease diagnostic Read
L176500 Viral hepatitis comp pregnancy, childbirth & the puerperium res50: mild liver disease diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH739/version/1478/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH739/version/1478/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH739', '1478', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH739/version/1478/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH739/version/1478/export/codes/?format=json
CSV site_root/phenotypes/PH739/version/1478/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH739', '1478', api_client=client)

Version History

Version
ID
Name Owner Publish date
1478 Mild Liver Disease ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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