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Moderate or Severe Liver disease

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH740
Version ID
1480
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 35
Code Description Entity type Category Coding System (Read)
7609 Open operations on oesophageal varices res50: Moderate or severe liver disease diagnostic Read
7609300 Local ligation of oesophageal varices res50: Moderate or severe liver disease diagnostic Read
7609400 Open injection sclerotherapy to oesophageal varices res50: Moderate or severe liver disease diagnostic Read
7609y00 Other specified open operation on oesophageal varices res50: Moderate or severe liver disease diagnostic Read
7609z00 Open operation on oesophageal varices NOS res50: Moderate or severe liver disease diagnostic Read
760C300 Fibreoptic endoscopic injection sclerotherapy oesoph varices res50: Moderate or severe liver disease diagnostic Read
760C500 Fibreoptic endoscopic banding of oesophageal varices res50: Moderate or severe liver disease diagnostic Read
760F300 Rigid oesophagoscopic injection sclerotherapy oesoph varices res50: Moderate or severe liver disease diagnostic Read
760F400 Rigid oesophagoscopic banding of oesophageal varices res50: Moderate or severe liver disease diagnostic Read
A053.00 Amoebic liver abscess res50: Moderate or severe liver disease diagnostic Read
A704z00 Other specified viral hepatitis with hepatic coma NOS res50: Moderate or severe liver disease diagnostic Read
G85..11 Oesophageal varices res50: Moderate or severe liver disease diagnostic Read
G850.00 Oesophageal varices with bleeding res50: Moderate or severe liver disease diagnostic Read
G851.00 Oesophageal varices without bleeding res50: Moderate or severe liver disease diagnostic Read
G852.00 Oesophageal varices in diseases EC res50: Moderate or severe liver disease diagnostic Read
G852000 Oesophageal varices with bleeding in diseases EC res50: Moderate or severe liver disease diagnostic Read
G852100 Oesophageal varices without bleeding in diseases EC res50: Moderate or severe liver disease diagnostic Read
G852200 Oesophageal varices in cirrhosis of the liver res50: Moderate or severe liver disease diagnostic Read
G852300 Oesophageal varices in alcoholic cirrhosis of the liver res50: Moderate or severe liver disease diagnostic Read
G852z00 Oesophageal varices in diseases EC NOS res50: Moderate or severe liver disease diagnostic Read
G858.00 Oesophageal varices NOS res50: Moderate or severe liver disease diagnostic Read
Gyu9400 [X]Oesophageal varices in diseases classified elsewhere res50: Moderate or severe liver disease diagnostic Read
J62..00 Liver abscess and sequelae of chronic liver disease res50: Moderate or severe liver disease diagnostic Read
J620.00 Liver abscess - excluding amoebic liver abscess res50: Moderate or severe liver disease diagnostic Read
J620000 Liver abscess due to portal pyaemia res50: Moderate or severe liver disease diagnostic Read
J620100 Liver abscess due to cholangitis res50: Moderate or severe liver disease diagnostic Read
J620200 Liver abscess via hepatic artery res50: Moderate or severe liver disease diagnostic Read
J620300 Liver abscess via umbilicus res50: Moderate or severe liver disease diagnostic Read
J620z00 Liver abscess NOS res50: Moderate or severe liver disease diagnostic Read
J622.00 Hepatic coma res50: Moderate or severe liver disease diagnostic Read
J623.00 Portal hypertension res50: Moderate or severe liver disease diagnostic Read
J624.00 Hepatorenal syndrome res50: Moderate or severe liver disease diagnostic Read
J62y.00 Other sequelae of chronic liver disease res50: Moderate or severe liver disease diagnostic Read
J62z.00 Liver abscess and chronic liver disease causing sequelae NOS res50: Moderate or severe liver disease diagnostic Read
SP14300 Hepatorenal syndrome as a complication of care res50: Moderate or severe liver disease diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH740/version/1480/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH740/version/1480/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH740', '1480', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH740/version/1480/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH740/version/1480/export/codes/?format=json
CSV site_root/phenotypes/PH740/version/1480/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH740', '1480', api_client=client)

Version History

Version
ID
Name Owner Publish date
1480 Moderate or Severe Liver disease ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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