Aims:
To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).
Methods:
Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.
Results:
In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).
Conclusions:
HbA1C variability is a strong predictor for HH in T1D and T2D.
Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.
Code | Description | Entity type | Category | Coding System (Read) |
---|---|---|---|---|
7609 | Open operations on oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
7609300 | Local ligation of oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
7609400 | Open injection sclerotherapy to oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
7609y00 | Other specified open operation on oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
7609z00 | Open operation on oesophageal varices NOS | res50: Moderate or severe liver disease | diagnostic | Read |
760C300 | Fibreoptic endoscopic injection sclerotherapy oesoph varices | res50: Moderate or severe liver disease | diagnostic | Read |
760C500 | Fibreoptic endoscopic banding of oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
760F300 | Rigid oesophagoscopic injection sclerotherapy oesoph varices | res50: Moderate or severe liver disease | diagnostic | Read |
760F400 | Rigid oesophagoscopic banding of oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
A053.00 | Amoebic liver abscess | res50: Moderate or severe liver disease | diagnostic | Read |
A704z00 | Other specified viral hepatitis with hepatic coma NOS | res50: Moderate or severe liver disease | diagnostic | Read |
G85..11 | Oesophageal varices | res50: Moderate or severe liver disease | diagnostic | Read |
G850.00 | Oesophageal varices with bleeding | res50: Moderate or severe liver disease | diagnostic | Read |
G851.00 | Oesophageal varices without bleeding | res50: Moderate or severe liver disease | diagnostic | Read |
G852.00 | Oesophageal varices in diseases EC | res50: Moderate or severe liver disease | diagnostic | Read |
G852000 | Oesophageal varices with bleeding in diseases EC | res50: Moderate or severe liver disease | diagnostic | Read |
G852100 | Oesophageal varices without bleeding in diseases EC | res50: Moderate or severe liver disease | diagnostic | Read |
G852200 | Oesophageal varices in cirrhosis of the liver | res50: Moderate or severe liver disease | diagnostic | Read |
G852300 | Oesophageal varices in alcoholic cirrhosis of the liver | res50: Moderate or severe liver disease | diagnostic | Read |
G852z00 | Oesophageal varices in diseases EC NOS | res50: Moderate or severe liver disease | diagnostic | Read |
G858.00 | Oesophageal varices NOS | res50: Moderate or severe liver disease | diagnostic | Read |
Gyu9400 | [X]Oesophageal varices in diseases classified elsewhere | res50: Moderate or severe liver disease | diagnostic | Read |
J62..00 | Liver abscess and sequelae of chronic liver disease | res50: Moderate or severe liver disease | diagnostic | Read |
J620.00 | Liver abscess - excluding amoebic liver abscess | res50: Moderate or severe liver disease | diagnostic | Read |
J620000 | Liver abscess due to portal pyaemia | res50: Moderate or severe liver disease | diagnostic | Read |
J620100 | Liver abscess due to cholangitis | res50: Moderate or severe liver disease | diagnostic | Read |
J620200 | Liver abscess via hepatic artery | res50: Moderate or severe liver disease | diagnostic | Read |
J620300 | Liver abscess via umbilicus | res50: Moderate or severe liver disease | diagnostic | Read |
J620z00 | Liver abscess NOS | res50: Moderate or severe liver disease | diagnostic | Read |
J622.00 | Hepatic coma | res50: Moderate or severe liver disease | diagnostic | Read |
J623.00 | Portal hypertension | res50: Moderate or severe liver disease | diagnostic | Read |
J624.00 | Hepatorenal syndrome | res50: Moderate or severe liver disease | diagnostic | Read |
J62y.00 | Other sequelae of chronic liver disease | res50: Moderate or severe liver disease | diagnostic | Read |
J62z.00 | Liver abscess and chronic liver disease causing sequelae NOS | res50: Moderate or severe liver disease | diagnostic | Read |
SP14300 | Hepatorenal syndrome as a complication of care | res50: Moderate or severe liver disease | diagnostic | Read |
To Export Phenotype Details:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH740/version/1480/detail/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH740/version/1480/detail/?format=json |
R Package |
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To Export Phenotype Code List:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH740/version/1480/export/codes/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH740/version/1480/export/codes/?format=json |
CSV | site_root/phenotypes/PH740/version/1480/export/codes/ |
R Package |
|
Version ID |
Name | Owner | Publish date | |
---|---|---|---|---|
1480 | Moderate or Severe Liver disease | ieuan.scanlon | 2021-10-06 | currently shown |
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