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Myocardial Infarction

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH741
Version ID
1482
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 93
Code Description Entity type Category Coding System (Read)
14A3.00 H/O: myocardial infarct <60 res50: myocardial infarction diagnostic Read
14A4.00 H/O: myocardial infarct >60 res50: myocardial infarction diagnostic Read
14AH.00 H/O: Myocardial infarction in last year res50: myocardial infarction diagnostic Read
14AT.00 History of myocardial infarction res50: myocardial infarction diagnostic Read
14AW.00 H/O acute coronary syndrome res50: myocardial infarction diagnostic Read
322..00 ECG: myocardial ischaemia res50: myocardial infarction diagnostic Read
3222 ECG:shows myocardial ischaemia res50: myocardial infarction diagnostic Read
322Z.00 ECG: myocardial ischaemia NOS res50: myocardial infarction diagnostic Read
323..00 ECG: myocardial infarction res50: myocardial infarction diagnostic Read
3232 ECG: old myocardial infarction res50: myocardial infarction diagnostic Read
3236 ECG: lateral infarction res50: myocardial infarction diagnostic Read
323Z.00 ECG: myocardial infarct NOS res50: myocardial infarction diagnostic Read
G30..00 Acute myocardial infarction res50: myocardial infarction diagnostic Read
G30..11 Attack - heart res50: myocardial infarction diagnostic Read
G30..12 Coronary thrombosis res50: myocardial infarction diagnostic Read
G30..13 Cardiac rupture following myocardial infarction (MI) res50: myocardial infarction diagnostic Read
G30..14 Heart attack res50: myocardial infarction diagnostic Read
G30..15 MI - acute myocardial infarction res50: myocardial infarction diagnostic Read
G30..16 Thrombosis - coronary res50: myocardial infarction diagnostic Read
G30..17 Silent myocardial infarction res50: myocardial infarction diagnostic Read
G300.00 Acute anterolateral infarction res50: myocardial infarction diagnostic Read
G301.00 Other specified anterior myocardial infarction res50: myocardial infarction diagnostic Read
G301000 Acute anteroapical infarction res50: myocardial infarction diagnostic Read
G301100 Acute anteroseptal infarction res50: myocardial infarction diagnostic Read
G301z00 Anterior myocardial infarction NOS res50: myocardial infarction diagnostic Read
G302.00 Acute inferolateral infarction res50: myocardial infarction diagnostic Read
G303.00 Acute inferoposterior infarction res50: myocardial infarction diagnostic Read
G304.00 Posterior myocardial infarction NOS res50: myocardial infarction diagnostic Read
G305.00 Lateral myocardial infarction NOS res50: myocardial infarction diagnostic Read
G306.00 True posterior myocardial infarction res50: myocardial infarction diagnostic Read
G307.00 Acute subendocardial infarction res50: myocardial infarction diagnostic Read
G307000 Acute non-Q wave infarction res50: myocardial infarction diagnostic Read
G307100 Acute non-ST segment elevation myocardial infarction res50: myocardial infarction diagnostic Read
G308.00 Inferior myocardial infarction NOS res50: myocardial infarction diagnostic Read
G309.00 Acute Q-wave infarct res50: myocardial infarction diagnostic Read
G30A.00 Mural thrombosis res50: myocardial infarction diagnostic Read
G30B.00 Acute posterolateral myocardial infarction res50: myocardial infarction diagnostic Read
G30X.00 Acute transmural myocardial infarction of unspecif site res50: myocardial infarction diagnostic Read
G30X000 Acute ST segment elevation myocardial infarction res50: myocardial infarction diagnostic Read
G30y.00 Other acute myocardial infarction res50: myocardial infarction diagnostic Read
G30y000 Acute atrial infarction res50: myocardial infarction diagnostic Read
G30y100 Acute papillary muscle infarction res50: myocardial infarction diagnostic Read
G30y200 Acute septal infarction res50: myocardial infarction diagnostic Read
G30yz00 Other acute myocardial infarction NOS res50: myocardial infarction diagnostic Read
G30z.00 Acute myocardial infarction NOS res50: myocardial infarction diagnostic Read
G310.00 Postmyocardial infarction syndrome res50: myocardial infarction diagnostic Read
G311.00 Preinfarction syndrome res50: myocardial infarction diagnostic Read
G311.12 Impending infarction res50: myocardial infarction diagnostic Read
G311000 Myocardial infarction aborted res50: myocardial infarction diagnostic Read
G311011 MI - myocardial infarction aborted res50: myocardial infarction diagnostic Read
G311500 Acute coronary syndrome res50: myocardial infarction diagnostic Read
G311z00 Preinfarction syndrome NOS res50: myocardial infarction diagnostic Read
G312.00 Coronary thrombosis not resulting in myocardial infarction res50: myocardial infarction diagnostic Read
G31y100 Microinfarction of heart res50: myocardial infarction diagnostic Read
G31y300 Transient myocardial ischaemia res50: myocardial infarction diagnostic Read
G32..00 Old myocardial infarction res50: myocardial infarction diagnostic Read
G32..11 Healed myocardial infarction res50: myocardial infarction diagnostic Read
G32..12 Personal history of myocardial infarction res50: myocardial infarction diagnostic Read
G33z000 Status anginosus res50: myocardial infarction diagnostic Read
G33z400 Ischaemic chest pain res50: myocardial infarction diagnostic Read
G33z500 Post infarct angina res50: myocardial infarction diagnostic Read
G344.00 Silent myocardial ischaemia res50: myocardial infarction diagnostic Read
G34y100 Chronic myocardial ischaemia res50: myocardial infarction diagnostic Read
G35..00 Subsequent myocardial infarction res50: myocardial infarction diagnostic Read
G350.00 Subsequent myocardial infarction of anterior wall res50: myocardial infarction diagnostic Read
G351.00 Subsequent myocardial infarction of inferior wall res50: myocardial infarction diagnostic Read
G353.00 Subsequent myocardial infarction of other sites res50: myocardial infarction diagnostic Read
G35X.00 Subsequent myocardial infarction of unspecified site res50: myocardial infarction diagnostic Read
G36..00 Certain current complication follow acute myocardial infarct res50: myocardial infarction diagnostic Read
G360.00 Haemopericardium/current comp folow acut myocard infarct res50: myocardial infarction diagnostic Read
G361.00 Atrial septal defect/curr comp folow acut myocardal infarct res50: myocardial infarction diagnostic Read
G362.00 Ventric septal defect/curr comp fol acut myocardal infarctn res50: myocardial infarction diagnostic Read
G363.00 Ruptur cardiac wall w'out haemopericard/cur comp fol ac MI res50: myocardial infarction diagnostic Read
G364.00 Ruptur chordae tendinae/curr comp fol acute myocard infarct res50: myocardial infarction diagnostic Read
G365.00 Rupture papillary muscle/curr comp fol acute myocard infarct res50: myocardial infarction diagnostic Read
G366.00 Thrombosis atrium,auric append&vent/curr comp foll acute MI res50: myocardial infarction diagnostic Read
G37..00 Cardiac syndrome X res50: myocardial infarction diagnostic Read
G38..00 Postoperative myocardial infarction res50: myocardial infarction diagnostic Read
G380.00 Postoperative transmural myocardial infarction anterior wall res50: myocardial infarction diagnostic Read
G381.00 Postoperative transmural myocardial infarction inferior wall res50: myocardial infarction diagnostic Read
G383.00 Postoperative transmural myocardial infarction unspec site res50: myocardial infarction diagnostic Read
G384.00 Postoperative subendocardial myocardial infarction res50: myocardial infarction diagnostic Read
G38z.00 Postoperative myocardial infarction, unspecified res50: myocardial infarction diagnostic Read
G501.00 Post infarction pericarditis res50: myocardial infarction diagnostic Read
G550.00 Endomyocardial fibrosis res50: myocardial infarction diagnostic Read
G574011 Cardiac arrest-ventricular fibrillation res50: myocardial infarction diagnostic Read
G575.00 Cardiac arrest res50: myocardial infarction diagnostic Read
G575000 Cardiac arrest with successful resuscitation res50: myocardial infarction diagnostic Read
G575100 Sudden cardiac death, so described res50: myocardial infarction diagnostic Read
G575z00 Cardiac arrest, unspecified res50: myocardial infarction diagnostic Read
Gyu3400 [X]Acute transmural myocardial infarction of unspecif site res50: myocardial infarction diagnostic Read
Gyu3500 [X]Subsequent myocardial infarction of other sites res50: myocardial infarction diagnostic Read
Gyu3600 [X]Subsequent myocardial infarction of unspecified site res50: myocardial infarction diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH741/version/1482/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH741/version/1482/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH741', '1482', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH741/version/1482/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH741/version/1482/export/codes/?format=json
CSV site_root/phenotypes/PH741/version/1482/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH741', '1482', api_client=client)

Version History

Version
ID
Name Owner Publish date
1482 Myocardial Infarction ieuan.scanlon 2021-10-06 currently shown

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