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Peptic Ulcer Disease

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH743
Version ID
1486
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 130
Code Description Entity type Category Coding System (Read)
14C1.00 H/O: peptic ulcer res50: peptic ulcer disease diagnostic Read
14C1.11 H/O: duodenal ulcer res50: peptic ulcer disease diagnostic Read
14C1.12 H/O: gastric ulcer res50: peptic ulcer disease diagnostic Read
1956 Peptic ulcer symptoms res50: peptic ulcer disease diagnostic Read
7612111 Balfour excision of gastric ulcer res50: peptic ulcer disease diagnostic Read
7612500 Resection of gastric ulcer by cautery res50: peptic ulcer disease diagnostic Read
761D500 Endoscopic injection haemostasis of duodenal ulcer res50: peptic ulcer disease diagnostic Read
761D600 Endoscopic injection haemostasis of gastric ulcer res50: peptic ulcer disease diagnostic Read
761J.00 Operations on gastric ulcer res50: peptic ulcer disease diagnostic Read
761J.11 Stomach ulcer operations res50: peptic ulcer disease diagnostic Read
761J000 Closure of perforated gastric ulcer res50: peptic ulcer disease diagnostic Read
761J100 Closure of gastric ulcer NEC res50: peptic ulcer disease diagnostic Read
761J111 Suture of ulcer of stomach NEC res50: peptic ulcer disease diagnostic Read
761Jy00 Other specified operation on gastric ulcer res50: peptic ulcer disease diagnostic Read
761Jz00 Operation on gastric ulcer NOS res50: peptic ulcer disease diagnostic Read
7627 Operations on duodenal ulcer res50: peptic ulcer disease diagnostic Read
7627000 Closure of perforated duodenal ulcer res50: peptic ulcer disease diagnostic Read
7627100 Suture of duodenal ulcer not elsewhere classified res50: peptic ulcer disease diagnostic Read
7627200 Oversew of blood vessel of duodenal ulcer res50: peptic ulcer disease diagnostic Read
7627y00 Other specified operation on duodenal ulcer res50: peptic ulcer disease diagnostic Read
7627z00 Operation on duodenal ulcer NOS res50: peptic ulcer disease diagnostic Read
J102000 Peptic ulcer of oesophagus res50: peptic ulcer disease diagnostic Read
J11..00 Gastric ulcer - (GU) res50: peptic ulcer disease diagnostic Read
J11..11 Prepyloric ulcer res50: peptic ulcer disease diagnostic Read
J11..12 Pyloric ulcer res50: peptic ulcer disease diagnostic Read
J110.00 Acute gastric ulcer res50: peptic ulcer disease diagnostic Read
J110000 Acute gastric ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J110100 Acute gastric ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J110111 Bleeding acute gastric ulcer res50: peptic ulcer disease diagnostic Read
J110200 Acute gastric ulcer with perforation res50: peptic ulcer disease diagnostic Read
J110300 Acute gastric ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J110y00 Acute gastric ulcer unspecified res50: peptic ulcer disease diagnostic Read
J110z00 Acute gastric ulcer NOS res50: peptic ulcer disease diagnostic Read
J111.00 Chronic gastric ulcer res50: peptic ulcer disease diagnostic Read
J111000 Chronic gastric ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J111100 Chronic gastric ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J111111 Bleeding chronic gastric ulcer res50: peptic ulcer disease diagnostic Read
J111200 Chronic gastric ulcer with perforation res50: peptic ulcer disease diagnostic Read
J111211 Perforated chronic gastric ulcer res50: peptic ulcer disease diagnostic Read
J111300 Chronic gastric ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J111400 Chronic gastric ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J111y00 Chronic gastric ulcer unspecified res50: peptic ulcer disease diagnostic Read
J111z00 Chronic gastric ulcer NOS res50: peptic ulcer disease diagnostic Read
J112.00 Anti-platelet induced gastric ulcer res50: peptic ulcer disease diagnostic Read
J112z00 Anti-platelet induced gastric ulcer NOS res50: peptic ulcer disease diagnostic Read
J113.00 Non steroidal anti inflammatory drug induced gastric ulcer res50: peptic ulcer disease diagnostic Read
J11y.00 Unspecified gastric ulcer res50: peptic ulcer disease diagnostic Read
J11y000 Unspecified gastric ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J11y100 Unspecified gastric ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J11y200 Unspecified gastric ulcer with perforation res50: peptic ulcer disease diagnostic Read
J11y400 Unspecified gastric ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J11yy00 Unspec gastric ulcer; unspec haemorrhage and/or perforation res50: peptic ulcer disease diagnostic Read
J11yz00 Unspecified gastric ulcer NOS res50: peptic ulcer disease diagnostic Read
J11z.00 Gastric ulcer NOS res50: peptic ulcer disease diagnostic Read
J11z.12 Multiple gastric ulcers res50: peptic ulcer disease diagnostic Read
J12..00 Duodenal ulcer - (DU) res50: peptic ulcer disease diagnostic Read
J120.00 Acute duodenal ulcer res50: peptic ulcer disease diagnostic Read
J120000 Acute duodenal ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J120100 Acute duodenal ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J120200 Acute duodenal ulcer with perforation res50: peptic ulcer disease diagnostic Read
J120300 Acute duodenal ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J120400 Acute duodenal ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J120y00 Acute duodenal ulcer unspecified res50: peptic ulcer disease diagnostic Read
J120z00 Acute duodenal ulcer NOS res50: peptic ulcer disease diagnostic Read
J121.00 Chronic duodenal ulcer res50: peptic ulcer disease diagnostic Read
J121000 Chronic duodenal ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J121100 Chronic duodenal ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J121111 Bleeding chronic duodenal ulcer res50: peptic ulcer disease diagnostic Read
J121200 Chronic duodenal ulcer with perforation res50: peptic ulcer disease diagnostic Read
J121211 Perforated chronic duodenal ulcer res50: peptic ulcer disease diagnostic Read
J121300 Chronic duodenal ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J121400 Chronic duodenal ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J121y00 Chronic duodenal ulcer unspecified res50: peptic ulcer disease diagnostic Read
J121z00 Chronic duodenal ulcer NOS res50: peptic ulcer disease diagnostic Read
J122.00 Duodenal ulcer disease res50: peptic ulcer disease diagnostic Read
J123.00 Duodenal erosion res50: peptic ulcer disease diagnostic Read
J124.00 Recurrent duodenal ulcer res50: peptic ulcer disease diagnostic Read
J125.00 Anti-platelet induced duodenal ulcer res50: peptic ulcer disease diagnostic Read
J126.00 Non steroidal anti inflammatory drug induced duodenal ulcer res50: peptic ulcer disease diagnostic Read
J12y.00 Unspecified duodenal ulcer res50: peptic ulcer disease diagnostic Read
J12y000 Unspecified duodenal ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J12y100 Unspecified duodenal ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J12y200 Unspecified duodenal ulcer with perforation res50: peptic ulcer disease diagnostic Read
J12y300 Unspecified duodenal ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J12y400 Unspecified duodenal ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J12yy00 Unspec duodenal ulcer; unspec haemorrhage and/or perforation res50: peptic ulcer disease diagnostic Read
J12yz00 Unspecified duodenal ulcer NOS res50: peptic ulcer disease diagnostic Read
J12z.00 Duodenal ulcer NOS res50: peptic ulcer disease diagnostic Read
J13..00 Peptic ulcer - (PU) site unspecified res50: peptic ulcer disease diagnostic Read
J13..11 Stress ulcer NOS res50: peptic ulcer disease diagnostic Read
J130.00 Acute peptic ulcer res50: peptic ulcer disease diagnostic Read
J130000 Acute peptic ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J130100 Acute peptic ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J130200 Acute peptic ulcer with perforation res50: peptic ulcer disease diagnostic Read
J130300 Acute peptic ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J130y00 Acute peptic ulcer unspecified res50: peptic ulcer disease diagnostic Read
J130z00 Acute peptic ulcer NOS res50: peptic ulcer disease diagnostic Read
J131.00 Chronic peptic ulcer res50: peptic ulcer disease diagnostic Read
J131000 Chronic peptic ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J131100 Chronic peptic ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J131200 Chronic peptic ulcer with perforation res50: peptic ulcer disease diagnostic Read
J131400 Chronic peptic ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J131y00 Chronic peptic ulcer unspecified res50: peptic ulcer disease diagnostic Read
J131z00 Chronic peptic ulcer NOS res50: peptic ulcer disease diagnostic Read
J13y.00 Unspecified peptic ulcer res50: peptic ulcer disease diagnostic Read
J13y000 Unspecified peptic ulcer without mention of complication res50: peptic ulcer disease diagnostic Read
J13y100 Unspecified peptic ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J13y200 Unspecified peptic ulcer with perforation res50: peptic ulcer disease diagnostic Read
J13y300 Unspecified peptic ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J13y400 Unspecified peptic ulcer with obstruction res50: peptic ulcer disease diagnostic Read
J13yz00 Unspecified peptic ulcer NOS res50: peptic ulcer disease diagnostic Read
J13z.00 Peptic ulcer NOS res50: peptic ulcer disease diagnostic Read
J14..00 Gastrojejunal ulcer (GJU) res50: peptic ulcer disease diagnostic Read
J14..12 Gastrocolic ulcer res50: peptic ulcer disease diagnostic Read
J14..15 Stomal ulcer res50: peptic ulcer disease diagnostic Read
J140.00 Acute gastrojejunal ulcer res50: peptic ulcer disease diagnostic Read
J140100 Acute gastrojejunal ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J140200 Acute gastrojejunal ulcer with perforation res50: peptic ulcer disease diagnostic Read
J140300 Acute gastrojejunal ulcer with haemorrhage and perforation res50: peptic ulcer disease diagnostic Read
J140z00 Acute gastrojejunal ulcer NOS res50: peptic ulcer disease diagnostic Read
J141.00 Chronic gastrojejunal ulcer res50: peptic ulcer disease diagnostic Read
J14y.00 Unspecified gastrojejunal ulcer res50: peptic ulcer disease diagnostic Read
J14y100 Unspecified gastrojejunal ulcer with haemorrhage res50: peptic ulcer disease diagnostic Read
J14y200 Unspecified gastrojejunal ulcer with perforation res50: peptic ulcer disease diagnostic Read
J14yz00 Unspecified gastrojejunal ulcer NOS res50: peptic ulcer disease diagnostic Read
J14z.00 Gastrojejunal ulcer NOS res50: peptic ulcer disease diagnostic Read
J17y800 Healed gastric ulcer leaving a scar res50: peptic ulcer disease diagnostic Read
ZV12711 [V]Personal history of peptic ulcer res50: peptic ulcer disease diagnostic Read
ZV12712 [V]Personal history of duodenal ulcer res50: peptic ulcer disease diagnostic Read
ZV12C00 [V] Personal history of gastric ulcer res50: peptic ulcer disease diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH743/version/1486/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH743/version/1486/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH743', '1486', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH743/version/1486/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH743/version/1486/export/codes/?format=json
CSV site_root/phenotypes/PH743/version/1486/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH743', '1486', api_client=client)

Version History

Version
ID
Name Owner Publish date
1486 Peptic Ulcer Disease ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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