Aims:
To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).
Methods:
Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.
Results:
In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).
Conclusions:
HbA1C variability is a strong predictor for HH in T1D and T2D.
Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.
Code | Description | Entity type | Category | Coding System (Read) |
---|---|---|---|---|
14C1.00 | H/O: peptic ulcer | res50: peptic ulcer disease | diagnostic | Read |
14C1.11 | H/O: duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
14C1.12 | H/O: gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
1956 | Peptic ulcer symptoms | res50: peptic ulcer disease | diagnostic | Read |
7612111 | Balfour excision of gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
7612500 | Resection of gastric ulcer by cautery | res50: peptic ulcer disease | diagnostic | Read |
761D500 | Endoscopic injection haemostasis of duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
761D600 | Endoscopic injection haemostasis of gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
761J.00 | Operations on gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
761J.11 | Stomach ulcer operations | res50: peptic ulcer disease | diagnostic | Read |
761J000 | Closure of perforated gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
761J100 | Closure of gastric ulcer NEC | res50: peptic ulcer disease | diagnostic | Read |
761J111 | Suture of ulcer of stomach NEC | res50: peptic ulcer disease | diagnostic | Read |
761Jy00 | Other specified operation on gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
761Jz00 | Operation on gastric ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
7627 | Operations on duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
7627000 | Closure of perforated duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
7627100 | Suture of duodenal ulcer not elsewhere classified | res50: peptic ulcer disease | diagnostic | Read |
7627200 | Oversew of blood vessel of duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
7627y00 | Other specified operation on duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
7627z00 | Operation on duodenal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J102000 | Peptic ulcer of oesophagus | res50: peptic ulcer disease | diagnostic | Read |
J11..00 | Gastric ulcer - (GU) | res50: peptic ulcer disease | diagnostic | Read |
J11..11 | Prepyloric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J11..12 | Pyloric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J110.00 | Acute gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J110000 | Acute gastric ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J110100 | Acute gastric ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J110111 | Bleeding acute gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J110200 | Acute gastric ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J110300 | Acute gastric ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J110y00 | Acute gastric ulcer unspecified | res50: peptic ulcer disease | diagnostic | Read |
J110z00 | Acute gastric ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J111.00 | Chronic gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J111000 | Chronic gastric ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J111100 | Chronic gastric ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J111111 | Bleeding chronic gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J111200 | Chronic gastric ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J111211 | Perforated chronic gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J111300 | Chronic gastric ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J111400 | Chronic gastric ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J111y00 | Chronic gastric ulcer unspecified | res50: peptic ulcer disease | diagnostic | Read |
J111z00 | Chronic gastric ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J112.00 | Anti-platelet induced gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J112z00 | Anti-platelet induced gastric ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J113.00 | Non steroidal anti inflammatory drug induced gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J11y.00 | Unspecified gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
J11y000 | Unspecified gastric ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J11y100 | Unspecified gastric ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J11y200 | Unspecified gastric ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J11y400 | Unspecified gastric ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J11yy00 | Unspec gastric ulcer; unspec haemorrhage and/or perforation | res50: peptic ulcer disease | diagnostic | Read |
J11yz00 | Unspecified gastric ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J11z.00 | Gastric ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J11z.12 | Multiple gastric ulcers | res50: peptic ulcer disease | diagnostic | Read |
J12..00 | Duodenal ulcer - (DU) | res50: peptic ulcer disease | diagnostic | Read |
J120.00 | Acute duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J120000 | Acute duodenal ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J120100 | Acute duodenal ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J120200 | Acute duodenal ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J120300 | Acute duodenal ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J120400 | Acute duodenal ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J120y00 | Acute duodenal ulcer unspecified | res50: peptic ulcer disease | diagnostic | Read |
J120z00 | Acute duodenal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J121.00 | Chronic duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J121000 | Chronic duodenal ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J121100 | Chronic duodenal ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J121111 | Bleeding chronic duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J121200 | Chronic duodenal ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J121211 | Perforated chronic duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J121300 | Chronic duodenal ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J121400 | Chronic duodenal ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J121y00 | Chronic duodenal ulcer unspecified | res50: peptic ulcer disease | diagnostic | Read |
J121z00 | Chronic duodenal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J122.00 | Duodenal ulcer disease | res50: peptic ulcer disease | diagnostic | Read |
J123.00 | Duodenal erosion | res50: peptic ulcer disease | diagnostic | Read |
J124.00 | Recurrent duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J125.00 | Anti-platelet induced duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J126.00 | Non steroidal anti inflammatory drug induced duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J12y.00 | Unspecified duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J12y000 | Unspecified duodenal ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J12y100 | Unspecified duodenal ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J12y200 | Unspecified duodenal ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J12y300 | Unspecified duodenal ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J12y400 | Unspecified duodenal ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J12yy00 | Unspec duodenal ulcer; unspec haemorrhage and/or perforation | res50: peptic ulcer disease | diagnostic | Read |
J12yz00 | Unspecified duodenal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J12z.00 | Duodenal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J13..00 | Peptic ulcer - (PU) site unspecified | res50: peptic ulcer disease | diagnostic | Read |
J13..11 | Stress ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J130.00 | Acute peptic ulcer | res50: peptic ulcer disease | diagnostic | Read |
J130000 | Acute peptic ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J130100 | Acute peptic ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J130200 | Acute peptic ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J130300 | Acute peptic ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J130y00 | Acute peptic ulcer unspecified | res50: peptic ulcer disease | diagnostic | Read |
J130z00 | Acute peptic ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J131.00 | Chronic peptic ulcer | res50: peptic ulcer disease | diagnostic | Read |
J131000 | Chronic peptic ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J131100 | Chronic peptic ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J131200 | Chronic peptic ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J131400 | Chronic peptic ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J131y00 | Chronic peptic ulcer unspecified | res50: peptic ulcer disease | diagnostic | Read |
J131z00 | Chronic peptic ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J13y.00 | Unspecified peptic ulcer | res50: peptic ulcer disease | diagnostic | Read |
J13y000 | Unspecified peptic ulcer without mention of complication | res50: peptic ulcer disease | diagnostic | Read |
J13y100 | Unspecified peptic ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J13y200 | Unspecified peptic ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J13y300 | Unspecified peptic ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J13y400 | Unspecified peptic ulcer with obstruction | res50: peptic ulcer disease | diagnostic | Read |
J13yz00 | Unspecified peptic ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J13z.00 | Peptic ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J14..00 | Gastrojejunal ulcer (GJU) | res50: peptic ulcer disease | diagnostic | Read |
J14..12 | Gastrocolic ulcer | res50: peptic ulcer disease | diagnostic | Read |
J14..15 | Stomal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J140.00 | Acute gastrojejunal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J140100 | Acute gastrojejunal ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J140200 | Acute gastrojejunal ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J140300 | Acute gastrojejunal ulcer with haemorrhage and perforation | res50: peptic ulcer disease | diagnostic | Read |
J140z00 | Acute gastrojejunal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J141.00 | Chronic gastrojejunal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J14y.00 | Unspecified gastrojejunal ulcer | res50: peptic ulcer disease | diagnostic | Read |
J14y100 | Unspecified gastrojejunal ulcer with haemorrhage | res50: peptic ulcer disease | diagnostic | Read |
J14y200 | Unspecified gastrojejunal ulcer with perforation | res50: peptic ulcer disease | diagnostic | Read |
J14yz00 | Unspecified gastrojejunal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J14z.00 | Gastrojejunal ulcer NOS | res50: peptic ulcer disease | diagnostic | Read |
J17y800 | Healed gastric ulcer leaving a scar | res50: peptic ulcer disease | diagnostic | Read |
ZV12711 | [V]Personal history of peptic ulcer | res50: peptic ulcer disease | diagnostic | Read |
ZV12712 | [V]Personal history of duodenal ulcer | res50: peptic ulcer disease | diagnostic | Read |
ZV12C00 | [V] Personal history of gastric ulcer | res50: peptic ulcer disease | diagnostic | Read |
To Export Phenotype Details:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH743/version/1486/detail/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH743/version/1486/detail/?format=json |
R Package |
|
To Export Phenotype Code List:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH743/version/1486/export/codes/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH743/version/1486/export/codes/?format=json |
CSV | site_root/phenotypes/PH743/version/1486/export/codes/ |
R Package |
|
Version ID |
Name | Owner | Publish date | |
---|---|---|---|---|
1486 | Peptic Ulcer Disease | ieuan.scanlon | 2021-10-06 | currently shown |
Export - export all codes into a csv file/JSON/XML for the current phenotype version.
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