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Sulfonylureas

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Drug
ID
PH750
Version ID
1500
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 101
Code Description Coding System (CPRD_product_code) Entity type Category
10427 Tolazamide 250mg Tablet CPRD_product_code res50: sulfonylureas drug
11284 Amaryl 4mg tablets (Zentiva) CPRD_product_code res50: sulfonylureas drug
11695 Diamicron 30mg MR tablets (Servier Laboratories Ltd) CPRD_product_code res50: sulfonylureas drug
11946 Tolbutamide 50mg/ml Injection CPRD_product_code res50: sulfonylureas drug
12245 Glutril 25mg Tablet (Roche Products Ltd) CPRD_product_code res50: sulfonylureas drug
12259 Glibornuride 25mg Tablet CPRD_product_code res50: sulfonylureas drug
12455 Rastinon 500mg Tablet (Hoechst Marion Roussel) CPRD_product_code res50: sulfonylureas drug
12513 Glibenese 5mg tablets (Pfizer Ltd) CPRD_product_code res50: sulfonylureas drug
1253 Chlorpropamide 100mg tablets CPRD_product_code res50: sulfonylureas drug
1254 Glibenclamide 5mg tablets CPRD_product_code res50: sulfonylureas drug
13331 Euglucon 5mg tablets (Sanofi) CPRD_product_code res50: sulfonylureas drug
15374 Gliclazide 40mg/5ml oral suspension CPRD_product_code res50: sulfonylureas drug
16602 Calabren 2.5mg Tablet (Berk Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
17343 Gliclazide 80mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
17698 Minodiab 5mg tablets (Pfizer Ltd) CPRD_product_code res50: sulfonylureas drug
17706 Minodiab 2.5mg tablets (Pfizer Ltd) CPRD_product_code res50: sulfonylureas drug
1847 Chlorpropamide 250mg tablets CPRD_product_code res50: sulfonylureas drug
19336 Tolazamide 100mg Tablet CPRD_product_code res50: sulfonylureas drug
1964 Diamicron 80mg tablets (Servier Laboratories Ltd) CPRD_product_code res50: sulfonylureas drug
1965 Tolbutamide 500mg tablets CPRD_product_code res50: sulfonylureas drug
21424 Glibenclamide 5mg/5ml oral suspension CPRD_product_code res50: sulfonylureas drug
21489 Tolanase 250mg Tablet (Pharmacia Ltd) CPRD_product_code res50: sulfonylureas drug
21564 Gliclazide 80mg tablets (Wockhardt UK Ltd) CPRD_product_code res50: sulfonylureas drug
21832 Diabetamide 5mg tablets (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
21892 Diaglyk 80mg tablets (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
22145 Tolanase 100mg Tablet (Pharmacia Ltd) CPRD_product_code res50: sulfonylureas drug
2219 Glibenclamide 2.5mg tablets CPRD_product_code res50: sulfonylureas drug
22858 Acetohexamide 500mg tablets CPRD_product_code res50: sulfonylureas drug
24848 Glymidine sodium 500mg Tablet CPRD_product_code res50: sulfonylureas drug
25636 Libanil 2.5mg Tablet (Approved Prescription Services Ltd) CPRD_product_code res50: sulfonylureas drug
26118 Dimelor 500mg Tablet (Eli Lilly and Company Ltd) CPRD_product_code res50: sulfonylureas drug
26218 Calabren 5mg Tablet (Berk Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
27969 Glymese 250mg Tablet (DDSA Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
28708 Malix 2.5mg Tablet (Lagap) CPRD_product_code res50: sulfonylureas drug
29326 Glipizide 5mg tablets (Generics (UK) Ltd) CPRD_product_code res50: sulfonylureas drug
29939 Gliclazide 80mg tablets (Generics (UK) Ltd) CPRD_product_code res50: sulfonylureas drug
30460 Malix 5mg Tablet (Lagap) CPRD_product_code res50: sulfonylureas drug
31212 Gliclazide 80mg tablets (Actavis UK Ltd) CPRD_product_code res50: sulfonylureas drug
31474 Libanil 5mg Tablet (Approved Prescription Services Ltd) CPRD_product_code res50: sulfonylureas drug
32 Gliclazide 80mg tablets CPRD_product_code res50: sulfonylureas drug
33562 Duclazide 80mg Tablet (Dumex Ltd) CPRD_product_code res50: sulfonylureas drug
33673 Tolbutamide 500mg tablets (Actavis UK Ltd) CPRD_product_code res50: sulfonylureas drug
34399 Gliclazide 80mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: sulfonylureas drug
34507 Glibenclamide 2.5mg tablets (Wockhardt UK Ltd) CPRD_product_code res50: sulfonylureas drug
34563 Glibenclamide 5mg tablets (Wockhardt UK Ltd) CPRD_product_code res50: sulfonylureas drug
34676 Glibenclamide 2.5mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
34706 Glibenclamide 2.5mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: sulfonylureas drug
34802 Glipizide 5mg tablets (IVAX Pharmaceuticals UK Ltd) CPRD_product_code res50: sulfonylureas drug
34932 Gliclazide 80mg tablets (Genus Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
34957 Tolbutamide 500mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
36856 Gliclazide 80mg tablets (Sandoz Ltd) CPRD_product_code res50: sulfonylureas drug
37617 Rosiglitazone 2mg tablet CPRD_product_code res50: sulfonylureas drug
40365 Glimepiride 1mg tablets (Actavis UK Ltd) CPRD_product_code res50: sulfonylureas drug
40425 Nazdol MR 30mg tablets (Teva UK Ltd) CPRD_product_code res50: sulfonylureas drug
41558 Glibenclamide 5mg tablets (Teva UK Ltd) CPRD_product_code res50: sulfonylureas drug
41559 Glibenclamide 5mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
41593 Glibenclamide 2.5mg tablets (Teva UK Ltd) CPRD_product_code res50: sulfonylureas drug
42790 Gliclazide 80mg Tablet (Merck Generics (UK) Ltd) CPRD_product_code res50: sulfonylureas drug
43065 Gliclazide 40mg tablets CPRD_product_code res50: sulfonylureas drug
43465 Zicron 40mg tablets (Bristol Laboratories Ltd) CPRD_product_code res50: sulfonylureas drug
44304 Glyconon 500mg Tablet (DDSA Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
44473 Edicil MR 30mg tablets (Ratiopharm UK Ltd) CPRD_product_code res50: sulfonylureas drug
44738 Niddaryl 1mg tablets (Dee Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
45215 Gliclazide 80mg Tablet (Neo Laboratories Ltd) CPRD_product_code res50: sulfonylureas drug
45831 Dacadis MR 30mg tablets (Generics (UK) Ltd) CPRD_product_code res50: sulfonylureas drug
46927 Tolbutamide 500mg tablets (Teva UK Ltd) CPRD_product_code res50: sulfonylureas drug
47074 Gliclazide 80mg/5ml oral suspension CPRD_product_code res50: sulfonylureas drug
47894 Nazdol MR 30mg tablets (Consilient Health Ltd) CPRD_product_code res50: sulfonylureas drug
48056 Gliclazide 80mg tablets (Sovereign Medical Ltd) CPRD_product_code res50: sulfonylureas drug
48120 Avandia 2mg Tablet (GlaxoSmithKline UK Ltd) CPRD_product_code res50: sulfonylureas drug
4862 Diabetamide 2.5mg tablets (Ashbourne Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
51955 Gliclazide 80mg tablets (Accord Healthcare Ltd) CPRD_product_code res50: sulfonylureas drug
5276 Glimepiride 1mg tablets CPRD_product_code res50: sulfonylureas drug
5316 Glimepiride 4mg tablets CPRD_product_code res50: sulfonylureas drug
53288 Gliclazide 30mg modified-release tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
5353 Glimepiride 2mg tablets CPRD_product_code res50: sulfonylureas drug
547 Glipizide 2.5mg tablets CPRD_product_code res50: sulfonylureas drug
54764 Gliclazide 80mg tablets (Arrow Generics Ltd) CPRD_product_code res50: sulfonylureas drug
55862 Gliclazide Oral solution CPRD_product_code res50: sulfonylureas drug
56008 Gliclazide 80mg tablets (Almus Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
5627 Gliclazide 30mg modified-release tablets CPRD_product_code res50: sulfonylureas drug
5636 Glipizide 5mg tablets CPRD_product_code res50: sulfonylureas drug
56376 Rosiglitazone 4mg with glimepiride 4mg tablet CPRD_product_code res50: sulfonylureas drug
56437 Gliclazide 60mg modified-release tablets CPRD_product_code res50: sulfonylureas drug
57601 Daonil 5mg tablets (Dowelhurst Ltd) CPRD_product_code res50: sulfonylureas drug
57830 Gliclazide 30mg modified-release tablets (Alliance Healthcare (Distribution) Ltd) CPRD_product_code res50: sulfonylureas drug
58882 Gliclazide 120mg/5ml oral suspension CPRD_product_code res50: sulfonylureas drug
60495 Gliclazide 80mg tablets (Teva UK Ltd) CPRD_product_code res50: sulfonylureas drug
61311 Glimepiride 4mg tablets (Sigma Pharmaceuticals Plc) CPRD_product_code res50: sulfonylureas drug
61957 Gliclazide 40mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: sulfonylureas drug
62014 Glimepiride 2mg tablets (Accord Healthcare Ltd) CPRD_product_code res50: sulfonylureas drug
62034 Laaglyda MR 60mg tablets (Consilient Health Ltd) CPRD_product_code res50: sulfonylureas drug
6337 Glimepiride 3mg tablets CPRD_product_code res50: sulfonylureas drug
7284 Amaryl 2mg tablets (Zentiva) CPRD_product_code res50: sulfonylureas drug
7332 Amaryl 1mg tablets (Zentiva) CPRD_product_code res50: sulfonylureas drug
7409 Amaryl 3mg tablets (Zentiva) CPRD_product_code res50: sulfonylureas drug
7744 Daonil 5mg tablets (Sanofi) CPRD_product_code res50: sulfonylureas drug
7912 Semi-Daonil 2.5mg tablets (Sanofi) CPRD_product_code res50: sulfonylureas drug
8034 Diabinese 100mg Tablet (Pfizer Ltd) CPRD_product_code res50: sulfonylureas drug
8168 Diabinese 250mg Tablet (Pfizer Ltd) CPRD_product_code res50: sulfonylureas drug
8976 Euglucon 2.5mg tablets (Aventis Pharma) CPRD_product_code res50: sulfonylureas drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH750/version/1500/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH750/version/1500/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH750', '1500', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH750/version/1500/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH750/version/1500/export/codes/?format=json
CSV site_root/phenotypes/PH750/version/1500/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH750', '1500', api_client=client)

Version History

Version
ID
Name Owner Publish date
1500 Sulfonylureas ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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