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Thiazolidinediones

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Drug
ID
PH751
Version ID
1502
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
GPRD product codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 27
Code Description Coding System (CPRD_product_code) Entity type Category
10051 Pioglitazone 45mg tablets CPRD_product_code res50: thiazolidinediones drug
11601 Rosiglitazone 2mg / Metformin 500mg tablets CPRD_product_code res50: thiazolidinediones drug
11604 Rosiglitazone 1mg / Metformin 500mg tablets CPRD_product_code res50: thiazolidinediones drug
11717 Rosiglitazone 2mg / Metformin 1g tablets CPRD_product_code res50: thiazolidinediones drug
13628 Romozin 400mg Tablet (Glaxo Wellcome UK Ltd) CPRD_product_code res50: thiazolidinediones drug
14164 Avandamet 2mg/1000mg tablets (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
15232 Avandia 8mg tablets (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
17580 Avandamet 1mg/500mg tablets (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
18220 Pioglitazone 15mg / Metformin 850mg tablets CPRD_product_code res50: thiazolidinediones drug
19472 Actos 45mg tablets (Takeda UK Ltd) CPRD_product_code res50: thiazolidinediones drug
20287 Actos 15mg tablets (Takeda UK Ltd) CPRD_product_code res50: thiazolidinediones drug
20889 Actos 30mg tablets (Takeda UK Ltd) CPRD_product_code res50: thiazolidinediones drug
31077 Competact 15mg/850mg tablets (Takeda UK Ltd) CPRD_product_code res50: thiazolidinediones drug
37617 Rosiglitazone 2mg tablet CPRD_product_code res50: thiazolidinediones drug
469 Rosiglitazone 4mg tablets CPRD_product_code res50: thiazolidinediones drug
48120 Avandia 2mg Tablet (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
48139 Pioglitazone 30mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: thiazolidinediones drug
5227 Rosiglitazone 8mg tablets CPRD_product_code res50: thiazolidinediones drug
548 Pioglitazone 15mg tablets CPRD_product_code res50: thiazolidinediones drug
56208 Pioglitazone 15mg tablets (A A H Pharmaceuticals Ltd) CPRD_product_code res50: thiazolidinediones drug
56376 Rosiglitazone 4mg with glimepiride 4mg tablet CPRD_product_code res50: thiazolidinediones drug
57659 Pioglitazone 30mg tablets (Actavis UK Ltd) CPRD_product_code res50: thiazolidinediones drug
6855 Avandamet 2mg/500mg tablets (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
7325 Avandamet 4mg/1000mg tablets (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
7375 Rosiglitazone 4mg / Metformin 1g tablets CPRD_product_code res50: thiazolidinediones drug
9662 Avandia 4mg tablets (GlaxoSmithKline UK Ltd) CPRD_product_code res50: thiazolidinediones drug
9699 Pioglitazone 30mg tablets CPRD_product_code res50: thiazolidinediones drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH751/version/1502/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH751/version/1502/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH751', '1502', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH751/version/1502/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH751/version/1502/export/codes/?format=json
CSV site_root/phenotypes/PH751/version/1502/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH751', '1502', api_client=client)

Version History

Version
ID
Name Owner Publish date
1502 Thiazolidinediones ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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