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Type 1 Diabetes

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH752
Version ID
1504
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 124
Code Description Entity type Category Coding System (Read)
66An.00 Diabetes type 1 review res50: type 1 diabetes diagnostic Read
66At000 Type I diabetic dietary review res50: type 1 diabetes diagnostic Read
66At011 Type 1 diabetic dietary review res50: type 1 diabetes diagnostic Read
C100000 Diabetes mellitus, juvenile type, no mention of complication res50: type 1 diabetes diagnostic Read
C100011 Insulin dependent diabetes mellitus res50: type 1 diabetes diagnostic Read
C101000 Diabetes mellitus, juvenile type, with ketoacidosis res50: type 1 diabetes diagnostic Read
C102000 Diabetes mellitus, juvenile type, with hyperosmolar coma res50: type 1 diabetes diagnostic Read
C103000 Diabetes mellitus, juvenile type, with ketoacidotic coma res50: type 1 diabetes diagnostic Read
C104000 Diabetes mellitus, juvenile type, with renal manifestation res50: type 1 diabetes diagnostic Read
C105000 Diabetes mellitus, juvenile type, + ophthalmic manifestation res50: type 1 diabetes diagnostic Read
C106000 Diabetes mellitus, juvenile, + neurological manifestation res50: type 1 diabetes diagnostic Read
C107000 Diabetes mellitus, juvenile +peripheral circulatory disorder res50: type 1 diabetes diagnostic Read
C107300 IDDM with peripheral circulatory disorder res50: type 1 diabetes diagnostic Read
C108.00 Insulin dependent diabetes mellitus res50: type 1 diabetes diagnostic Read
C108.11 IDDM-Insulin dependent diabetes mellitus res50: type 1 diabetes diagnostic Read
C108.12 Type 1 diabetes mellitus res50: type 1 diabetes diagnostic Read
C108.13 Type I diabetes mellitus res50: type 1 diabetes diagnostic Read
C108000 Insulin-dependent diabetes mellitus with renal complications res50: type 1 diabetes diagnostic Read
C108011 Type I diabetes mellitus with renal complications res50: type 1 diabetes diagnostic Read
C108012 Type 1 diabetes mellitus with renal complications res50: type 1 diabetes diagnostic Read
C108100 Insulin-dependent diabetes mellitus with ophthalmic comps res50: type 1 diabetes diagnostic Read
C108112 Type 1 diabetes mellitus with ophthalmic complications res50: type 1 diabetes diagnostic Read
C108200 Insulin-dependent diabetes mellitus with neurological comps res50: type 1 diabetes diagnostic Read
C108211 Type I diabetes mellitus with neurological complications res50: type 1 diabetes diagnostic Read
C108212 Type 1 diabetes mellitus with neurological complications res50: type 1 diabetes diagnostic Read
C108300 Insulin dependent diabetes mellitus with multiple complicatn res50: type 1 diabetes diagnostic Read
C108311 Type I diabetes mellitus with multiple complications res50: type 1 diabetes diagnostic Read
C108400 Unstable insulin dependent diabetes mellitus res50: type 1 diabetes diagnostic Read
C108411 Unstable type I diabetes mellitus res50: type 1 diabetes diagnostic Read
C108412 Unstable type 1 diabetes mellitus res50: type 1 diabetes diagnostic Read
C108500 Insulin dependent diabetes mellitus with ulcer res50: type 1 diabetes diagnostic Read
C108511 Type I diabetes mellitus with ulcer res50: type 1 diabetes diagnostic Read
C108512 Type 1 diabetes mellitus with ulcer res50: type 1 diabetes diagnostic Read
C108600 Insulin dependent diabetes mellitus with gangrene res50: type 1 diabetes diagnostic Read
C108700 Insulin dependent diabetes mellitus with retinopathy res50: type 1 diabetes diagnostic Read
C108711 Type I diabetes mellitus with retinopathy res50: type 1 diabetes diagnostic Read
C108712 Type 1 diabetes mellitus with retinopathy res50: type 1 diabetes diagnostic Read
C108800 Insulin dependent diabetes mellitus - poor control res50: type 1 diabetes diagnostic Read
C108811 Type I diabetes mellitus - poor control res50: type 1 diabetes diagnostic Read
C108812 Type 1 diabetes mellitus - poor control res50: type 1 diabetes diagnostic Read
C108900 Insulin dependent diabetes maturity onset res50: type 1 diabetes diagnostic Read
C108911 Type I diabetes mellitus maturity onset res50: type 1 diabetes diagnostic Read
C108912 Type 1 diabetes mellitus maturity onset res50: type 1 diabetes diagnostic Read
C108A00 Insulin-dependent diabetes without complication res50: type 1 diabetes diagnostic Read
C108A11 Type I diabetes mellitus without complication res50: type 1 diabetes diagnostic Read
C108B00 Insulin dependent diabetes mellitus with mononeuropathy res50: type 1 diabetes diagnostic Read
C108B11 Type I diabetes mellitus with mononeuropathy res50: type 1 diabetes diagnostic Read
C108C00 Insulin dependent diabetes mellitus with polyneuropathy res50: type 1 diabetes diagnostic Read
C108D00 Insulin dependent diabetes mellitus with nephropathy res50: type 1 diabetes diagnostic Read
C108D11 Type I diabetes mellitus with nephropathy res50: type 1 diabetes diagnostic Read
C108E00 Insulin dependent diabetes mellitus with hypoglycaemic coma res50: type 1 diabetes diagnostic Read
C108E11 Type I diabetes mellitus with hypoglycaemic coma res50: type 1 diabetes diagnostic Read
C108E12 Type 1 diabetes mellitus with hypoglycaemic coma res50: type 1 diabetes diagnostic Read
C108F00 Insulin dependent diabetes mellitus with diabetic cataract res50: type 1 diabetes diagnostic Read
C108F11 Type I diabetes mellitus with diabetic cataract res50: type 1 diabetes diagnostic Read
C108G00 Insulin dependent diab mell with peripheral angiopathy res50: type 1 diabetes diagnostic Read
C108H00 Insulin dependent diabetes mellitus with arthropathy res50: type 1 diabetes diagnostic Read
C108H11 Type I diabetes mellitus with arthropathy res50: type 1 diabetes diagnostic Read
C108J00 Insulin dependent diab mell with neuropathic arthropathy res50: type 1 diabetes diagnostic Read
C108J11 Type I diabetes mellitus with neuropathic arthropathy res50: type 1 diabetes diagnostic Read
C108J12 Type 1 diabetes mellitus with neuropathic arthropathy res50: type 1 diabetes diagnostic Read
C10E.00 Type 1 diabetes mellitus res50: type 1 diabetes diagnostic Read
C10E.11 Type I diabetes mellitus res50: type 1 diabetes diagnostic Read
C10E.12 Insulin dependent diabetes mellitus res50: type 1 diabetes diagnostic Read
C10E000 Type 1 diabetes mellitus with renal complications res50: type 1 diabetes diagnostic Read
C10E012 Insulin-dependent diabetes mellitus with renal complications res50: type 1 diabetes diagnostic Read
C10E100 Type 1 diabetes mellitus with ophthalmic complications res50: type 1 diabetes diagnostic Read
C10E111 Type I diabetes mellitus with ophthalmic complications res50: type 1 diabetes diagnostic Read
C10E112 Insulin-dependent diabetes mellitus with ophthalmic comps res50: type 1 diabetes diagnostic Read
C10E200 Type 1 diabetes mellitus with neurological complications res50: type 1 diabetes diagnostic Read
C10E212 Insulin-dependent diabetes mellitus with neurological comps res50: type 1 diabetes diagnostic Read
C10E300 Type 1 diabetes mellitus with multiple complications res50: type 1 diabetes diagnostic Read
C10E311 Type I diabetes mellitus with multiple complications res50: type 1 diabetes diagnostic Read
C10E312 Insulin dependent diabetes mellitus with multiple complicat res50: type 1 diabetes diagnostic Read
C10E400 Unstable type 1 diabetes mellitus res50: type 1 diabetes diagnostic Read
C10E411 Unstable type I diabetes mellitus res50: type 1 diabetes diagnostic Read
C10E412 Unstable insulin dependent diabetes mellitus res50: type 1 diabetes diagnostic Read
C10E500 Type 1 diabetes mellitus with ulcer res50: type 1 diabetes diagnostic Read
C10E511 Type I diabetes mellitus with ulcer res50: type 1 diabetes diagnostic Read
C10E512 Insulin dependent diabetes mellitus with ulcer res50: type 1 diabetes diagnostic Read
C10E600 Type 1 diabetes mellitus with gangrene res50: type 1 diabetes diagnostic Read
C10E611 Type I diabetes mellitus with gangrene res50: type 1 diabetes diagnostic Read
C10E612 Insulin dependent diabetes mellitus with gangrene res50: type 1 diabetes diagnostic Read
C10E700 Type 1 diabetes mellitus with retinopathy res50: type 1 diabetes diagnostic Read
C10E711 Type I diabetes mellitus with retinopathy res50: type 1 diabetes diagnostic Read
C10E712 Insulin dependent diabetes mellitus with retinopathy res50: type 1 diabetes diagnostic Read
C10E800 Type 1 diabetes mellitus - poor control res50: type 1 diabetes diagnostic Read
C10E811 Type I diabetes mellitus - poor control res50: type 1 diabetes diagnostic Read
C10E812 Insulin dependent diabetes mellitus - poor control res50: type 1 diabetes diagnostic Read
C10E900 Type 1 diabetes mellitus maturity onset res50: type 1 diabetes diagnostic Read
C10E911 Type I diabetes mellitus maturity onset res50: type 1 diabetes diagnostic Read
C10E912 Insulin dependent diabetes maturity onset res50: type 1 diabetes diagnostic Read
C10EA00 Type 1 diabetes mellitus without complication res50: type 1 diabetes diagnostic Read
C10EA11 Type I diabetes mellitus without complication res50: type 1 diabetes diagnostic Read
C10EA12 Insulin-dependent diabetes without complication res50: type 1 diabetes diagnostic Read
C10EB00 Type 1 diabetes mellitus with mononeuropathy res50: type 1 diabetes diagnostic Read
C10EC00 Type 1 diabetes mellitus with polyneuropathy res50: type 1 diabetes diagnostic Read
C10EC11 Type I diabetes mellitus with polyneuropathy res50: type 1 diabetes diagnostic Read
C10EC12 Insulin dependent diabetes mellitus with polyneuropathy res50: type 1 diabetes diagnostic Read
C10ED00 Type 1 diabetes mellitus with nephropathy res50: type 1 diabetes diagnostic Read
C10ED12 Insulin dependent diabetes mellitus with nephropathy res50: type 1 diabetes diagnostic Read
C10EE00 Type 1 diabetes mellitus with hypoglycaemic coma res50: type 1 diabetes diagnostic Read
C10EE12 Insulin dependent diabetes mellitus with hypoglycaemic coma res50: type 1 diabetes diagnostic Read
C10EF00 Type 1 diabetes mellitus with diabetic cataract res50: type 1 diabetes diagnostic Read
C10EF12 Insulin dependent diabetes mellitus with diabetic cataract res50: type 1 diabetes diagnostic Read
C10EG00 Type 1 diabetes mellitus with peripheral angiopathy res50: type 1 diabetes diagnostic Read
C10EH00 Type 1 diabetes mellitus with arthropathy res50: type 1 diabetes diagnostic Read
C10EJ00 Type 1 diabetes mellitus with neuropathic arthropathy res50: type 1 diabetes diagnostic Read
C10EK00 Type 1 diabetes mellitus with persistent proteinuria res50: type 1 diabetes diagnostic Read
C10EL00 Type 1 diabetes mellitus with persistent microalbuminuria res50: type 1 diabetes diagnostic Read
C10EL11 Type I diabetes mellitus with persistent microalbuminuria res50: type 1 diabetes diagnostic Read
C10EM00 Type 1 diabetes mellitus with ketoacidosis res50: type 1 diabetes diagnostic Read
C10EM11 Type I diabetes mellitus with ketoacidosis res50: type 1 diabetes diagnostic Read
C10EN00 Type 1 diabetes mellitus with ketoacidotic coma res50: type 1 diabetes diagnostic Read
C10EN11 Type I diabetes mellitus with ketoacidotic coma res50: type 1 diabetes diagnostic Read
C10EP00 Type 1 diabetes mellitus with exudative maculopathy res50: type 1 diabetes diagnostic Read
C10EP11 Type I diabetes mellitus with exudative maculopathy res50: type 1 diabetes diagnostic Read
C10EQ00 Type 1 diabetes mellitus with gastroparesis res50: type 1 diabetes diagnostic Read
C10EQ11 Type I diabetes mellitus with gastroparesis res50: type 1 diabetes diagnostic Read
C10P000 Type I diabetes mellitus in remission res50: type 1 diabetes diagnostic Read
C10z000 Diabetes mellitus, juvenile type, + unspecified complication res50: type 1 diabetes diagnostic Read
L180500 Pre-existing diabetes mellitus, insulin-dependent res50: type 1 diabetes diagnostic Read
ZC2C900 Dietary advice for type I diabetes res50: type 1 diabetes diagnostic Read
ZRbH.00 Perceived control of insulin-dependent diabetes res50: type 1 diabetes diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH752/version/1504/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH752/version/1504/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH752', '1504', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH752/version/1504/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH752/version/1504/export/codes/?format=json
CSV site_root/phenotypes/PH752/version/1504/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH752', '1504', api_client=client)

Version History

Version
ID
Name Owner Publish date
1504 Type 1 Diabetes ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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