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Type 2 Diabetes

Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis

Type
Disease or Syndrome
ID
PH753
Version ID
1506
Data Sources
Valid event data range
01/04/1997 - 31/03/2014
Sex
Female, Male
Agreement Date
2017-10-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims:

To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods:

Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.

Results:

In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).

Conclusions:

HbA1C variability is a strong predictor for HH in T1D and T2D.

Publications

  • Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017.

Clinical Code List

Rows: 117
Code Description Entity type Category Coding System (Read)
66A3.00 Diabetic on diet only res50: type 2 diabetes diagnostic Read
66A4.00 Diabetic on oral treatment res50: type 2 diabetes diagnostic Read
66AV.00 Diabetic on insulin and oral treatment res50: type 2 diabetes diagnostic Read
66Ao.00 Diabetes type 2 review res50: type 2 diabetes diagnostic Read
66At100 Type II diabetic dietary review res50: type 2 diabetes diagnostic Read
66At111 Type 2 diabetic dietary review res50: type 2 diabetes diagnostic Read
C100112 Non-insulin dependent diabetes mellitus res50: type 2 diabetes diagnostic Read
C107400 NIDDM with peripheral circulatory disorder res50: type 2 diabetes diagnostic Read
C109.00 Non-insulin dependent diabetes mellitus res50: type 2 diabetes diagnostic Read
C109.11 NIDDM - Non-insulin dependent diabetes mellitus res50: type 2 diabetes diagnostic Read
C109.12 Type 2 diabetes mellitus res50: type 2 diabetes diagnostic Read
C109.13 Type II diabetes mellitus res50: type 2 diabetes diagnostic Read
C109000 Non-insulin-dependent diabetes mellitus with renal comps res50: type 2 diabetes diagnostic Read
C109011 Type II diabetes mellitus with renal complications res50: type 2 diabetes diagnostic Read
C109012 Type 2 diabetes mellitus with renal complications res50: type 2 diabetes diagnostic Read
C109100 Non-insulin-dependent diabetes mellitus with ophthalm comps res50: type 2 diabetes diagnostic Read
C109111 Type II diabetes mellitus with ophthalmic complications res50: type 2 diabetes diagnostic Read
C109112 Type 2 diabetes mellitus with ophthalmic complications res50: type 2 diabetes diagnostic Read
C109200 Non-insulin-dependent diabetes mellitus with neuro comps res50: type 2 diabetes diagnostic Read
C109211 Type II diabetes mellitus with neurological complications res50: type 2 diabetes diagnostic Read
C109212 Type 2 diabetes mellitus with neurological complications res50: type 2 diabetes diagnostic Read
C109300 Non-insulin-dependent diabetes mellitus with multiple comps res50: type 2 diabetes diagnostic Read
C109312 Type 2 diabetes mellitus with multiple complications res50: type 2 diabetes diagnostic Read
C109400 Non-insulin dependent diabetes mellitus with ulcer res50: type 2 diabetes diagnostic Read
C109411 Type II diabetes mellitus with ulcer res50: type 2 diabetes diagnostic Read
C109412 Type 2 diabetes mellitus with ulcer res50: type 2 diabetes diagnostic Read
C109500 Non-insulin dependent diabetes mellitus with gangrene res50: type 2 diabetes diagnostic Read
C109511 Type II diabetes mellitus with gangrene res50: type 2 diabetes diagnostic Read
C109512 Type 2 diabetes mellitus with gangrene res50: type 2 diabetes diagnostic Read
C109600 Non-insulin-dependent diabetes mellitus with retinopathy res50: type 2 diabetes diagnostic Read
C109611 Type II diabetes mellitus with retinopathy res50: type 2 diabetes diagnostic Read
C109612 Type 2 diabetes mellitus with retinopathy res50: type 2 diabetes diagnostic Read
C109700 Non-insulin dependent diabetes mellitus - poor control res50: type 2 diabetes diagnostic Read
C109711 Type II diabetes mellitus - poor control res50: type 2 diabetes diagnostic Read
C109712 Type 2 diabetes mellitus - poor control res50: type 2 diabetes diagnostic Read
C109900 Non-insulin-dependent diabetes mellitus without complication res50: type 2 diabetes diagnostic Read
C109911 Type II diabetes mellitus without complication res50: type 2 diabetes diagnostic Read
C109912 Type 2 diabetes mellitus without complication res50: type 2 diabetes diagnostic Read
C109A00 Non-insulin dependent diabetes mellitus with mononeuropathy res50: type 2 diabetes diagnostic Read
C109A11 Type II diabetes mellitus with mononeuropathy res50: type 2 diabetes diagnostic Read
C109B00 Non-insulin dependent diabetes mellitus with polyneuropathy res50: type 2 diabetes diagnostic Read
C109B11 Type II diabetes mellitus with polyneuropathy res50: type 2 diabetes diagnostic Read
C109C00 Non-insulin dependent diabetes mellitus with nephropathy res50: type 2 diabetes diagnostic Read
C109C11 Type II diabetes mellitus with nephropathy res50: type 2 diabetes diagnostic Read
C109C12 Type 2 diabetes mellitus with nephropathy res50: type 2 diabetes diagnostic Read
C109D00 Non-insulin dependent diabetes mellitus with hypoglyca coma res50: type 2 diabetes diagnostic Read
C109D11 Type II diabetes mellitus with hypoglycaemic coma res50: type 2 diabetes diagnostic Read
C109D12 Type 2 diabetes mellitus with hypoglycaemic coma res50: type 2 diabetes diagnostic Read
C109E00 Non-insulin depend diabetes mellitus with diabetic cataract res50: type 2 diabetes diagnostic Read
C109E11 Type II diabetes mellitus with diabetic cataract res50: type 2 diabetes diagnostic Read
C109E12 Type 2 diabetes mellitus with diabetic cataract res50: type 2 diabetes diagnostic Read
C109F00 Non-insulin-dependent d m with peripheral angiopath res50: type 2 diabetes diagnostic Read
C109F11 Type II diabetes mellitus with peripheral angiopathy res50: type 2 diabetes diagnostic Read
C109F12 Type 2 diabetes mellitus with peripheral angiopathy res50: type 2 diabetes diagnostic Read
C109G00 Non-insulin dependent diabetes mellitus with arthropathy res50: type 2 diabetes diagnostic Read
C109G11 Type II diabetes mellitus with arthropathy res50: type 2 diabetes diagnostic Read
C109G12 Type 2 diabetes mellitus with arthropathy res50: type 2 diabetes diagnostic Read
C109H00 Non-insulin dependent d m with neuropathic arthropathy res50: type 2 diabetes diagnostic Read
C109H11 Type II diabetes mellitus with neuropathic arthropathy res50: type 2 diabetes diagnostic Read
C109H12 Type 2 diabetes mellitus with neuropathic arthropathy res50: type 2 diabetes diagnostic Read
C109J00 Insulin treated Type 2 diabetes mellitus res50: type 2 diabetes diagnostic Read
C109J11 Insulin treated non-insulin dependent diabetes mellitus res50: type 2 diabetes diagnostic Read
C109J12 Insulin treated Type II diabetes mellitus res50: type 2 diabetes diagnostic Read
C109K00 Hyperosmolar non-ketotic state in type 2 diabetes mellitus res50: type 2 diabetes diagnostic Read
C10F.00 Type 2 diabetes mellitus res50: type 2 diabetes diagnostic Read
C10F.11 Type II diabetes mellitus res50: type 2 diabetes diagnostic Read
C10F000 Type 2 diabetes mellitus with renal complications res50: type 2 diabetes diagnostic Read
C10F011 Type II diabetes mellitus with renal complications res50: type 2 diabetes diagnostic Read
C10F100 Type 2 diabetes mellitus with ophthalmic complications res50: type 2 diabetes diagnostic Read
C10F111 Type II diabetes mellitus with ophthalmic complications res50: type 2 diabetes diagnostic Read
C10F200 Type 2 diabetes mellitus with neurological complications res50: type 2 diabetes diagnostic Read
C10F211 Type II diabetes mellitus with neurological complications res50: type 2 diabetes diagnostic Read
C10F300 Type 2 diabetes mellitus with multiple complications res50: type 2 diabetes diagnostic Read
C10F311 Type II diabetes mellitus with multiple complications res50: type 2 diabetes diagnostic Read
C10F400 Type 2 diabetes mellitus with ulcer res50: type 2 diabetes diagnostic Read
C10F411 Type II diabetes mellitus with ulcer res50: type 2 diabetes diagnostic Read
C10F500 Type 2 diabetes mellitus with gangrene res50: type 2 diabetes diagnostic Read
C10F511 Type II diabetes mellitus with gangrene res50: type 2 diabetes diagnostic Read
C10F600 Type 2 diabetes mellitus with retinopathy res50: type 2 diabetes diagnostic Read
C10F611 Type II diabetes mellitus with retinopathy res50: type 2 diabetes diagnostic Read
C10F700 Type 2 diabetes mellitus - poor control res50: type 2 diabetes diagnostic Read
C10F711 Type II diabetes mellitus - poor control res50: type 2 diabetes diagnostic Read
C10F900 Type 2 diabetes mellitus without complication res50: type 2 diabetes diagnostic Read
C10F911 Type II diabetes mellitus without complication res50: type 2 diabetes diagnostic Read
C10FA00 Type 2 diabetes mellitus with mononeuropathy res50: type 2 diabetes diagnostic Read
C10FA11 Type II diabetes mellitus with mononeuropathy res50: type 2 diabetes diagnostic Read
C10FB00 Type 2 diabetes mellitus with polyneuropathy res50: type 2 diabetes diagnostic Read
C10FB11 Type II diabetes mellitus with polyneuropathy res50: type 2 diabetes diagnostic Read
C10FC00 Type 2 diabetes mellitus with nephropathy res50: type 2 diabetes diagnostic Read
C10FC11 Type II diabetes mellitus with nephropathy res50: type 2 diabetes diagnostic Read
C10FD00 Type 2 diabetes mellitus with hypoglycaemic coma res50: type 2 diabetes diagnostic Read
C10FD11 Type II diabetes mellitus with hypoglycaemic coma res50: type 2 diabetes diagnostic Read
C10FE00 Type 2 diabetes mellitus with diabetic cataract res50: type 2 diabetes diagnostic Read
C10FE11 Type II diabetes mellitus with diabetic cataract res50: type 2 diabetes diagnostic Read
C10FF00 Type 2 diabetes mellitus with peripheral angiopathy res50: type 2 diabetes diagnostic Read
C10FF11 Type II diabetes mellitus with peripheral angiopathy res50: type 2 diabetes diagnostic Read
C10FG00 Type 2 diabetes mellitus with arthropathy res50: type 2 diabetes diagnostic Read
C10FG11 Type II diabetes mellitus with arthropathy res50: type 2 diabetes diagnostic Read
C10FH00 Type 2 diabetes mellitus with neuropathic arthropathy res50: type 2 diabetes diagnostic Read
C10FH11 Type II diabetes mellitus with neuropathic arthropathy res50: type 2 diabetes diagnostic Read
C10FJ00 Insulin treated Type 2 diabetes mellitus res50: type 2 diabetes diagnostic Read
C10FJ11 Insulin treated Type II diabetes mellitus res50: type 2 diabetes diagnostic Read
C10FK00 Hyperosmolar non-ketotic state in type 2 diabetes mellitus res50: type 2 diabetes diagnostic Read
C10FK11 Hyperosmolar non-ketotic state in type II diabetes mellitus res50: type 2 diabetes diagnostic Read
C10FL00 Type 2 diabetes mellitus with persistent proteinuria res50: type 2 diabetes diagnostic Read
C10FL11 Type II diabetes mellitus with persistent proteinuria res50: type 2 diabetes diagnostic Read
C10FM00 Type 2 diabetes mellitus with persistent microalbuminuria res50: type 2 diabetes diagnostic Read
C10FM11 Type II diabetes mellitus with persistent microalbuminuria res50: type 2 diabetes diagnostic Read
C10FN00 Type 2 diabetes mellitus with ketoacidosis res50: type 2 diabetes diagnostic Read
C10FN11 Type II diabetes mellitus with ketoacidosis res50: type 2 diabetes diagnostic Read
C10FP00 Type 2 diabetes mellitus with ketoacidotic coma res50: type 2 diabetes diagnostic Read
C10FP11 Type II diabetes mellitus with ketoacidotic coma res50: type 2 diabetes diagnostic Read
C10FQ00 Type 2 diabetes mellitus with exudative maculopathy res50: type 2 diabetes diagnostic Read
C10FR00 Type 2 diabetes mellitus with gastroparesis res50: type 2 diabetes diagnostic Read
C10P100 Type II diabetes mellitus in remission res50: type 2 diabetes diagnostic Read
L180600 Pre-existing diabetes mellitus, non-insulin-dependent res50: type 2 diabetes diagnostic Read
ZC2CA00 Dietary advice for type II diabetes res50: type 2 diabetes diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH753/version/1506/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH753/version/1506/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH753', '1506', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH753/version/1506/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH753/version/1506/export/codes/?format=json
CSV site_root/phenotypes/PH753/version/1506/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH753', '1506', api_client=client)

Version History

Version
ID
Name Owner Publish date
1506 Type 2 Diabetes ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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