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Affective Psychotic Disorders

Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Semre Su Osam, Christian Dolman, Mathias Pierce

Type
Disease or Syndrome
ID
PH820
Version ID
1719
Data Sources
Valid event data range
01/01/2005 - 31/12/2017
Sex
Female
Agreement Date
2019-06-30
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Background:

Little information exists about the prevalence of children exposed to maternal mental illness. We aimed to estimate the prevalence of children and adolescents exposed to maternal mental illness in the UK between 2005 and 2017 using primary care data.

Methods:

In this national retrospective cohort study, we included children aged 0–16 years born between Jan 1, 1991, and Dec 31, 2015, who were linked to their mothers and registered on the primary care Clinical Practice Research Datalink (CPRD) between 2005 and 2017. We extracted data on diagnosis, symptoms, and therapy from the CRPD to define the following maternal mental illnesses: depression, anxiety, non-affective psychosis, affective psychosis, eating disorders, personality disorders, alcohol misuse disorder, and substance misuse disorder. We also extracted data on socioeconomic status from the Index of Multiple Deprivation 2010 and data on ethnicity from the Hospital Episode Statistics dataset. The main outcome was prevalence of maternal mental illness. Prevalence was calculated for each 2-year period of childhood (from age 0–<2 to 14–<16 years) using marginal predictions from a logistic regression model. We used survival analysis to estimate the incidence and cumulative risk of children experiencing maternal mental illness by age 16 years.

Findings:

We identified 783 710 children registered in the UK CPRD mother-baby link database, and included 547 747 children (381 685 mothers) in our analysis. Overall prevalence of maternal mental illness was 23·2% (95% CI 23·1–23·4), which increased during childhood (21·9%, 21·7–22·1 among the 0–<2 year age group vs 27·3%, 26·8–27·8 among the 14–<16 year age group). Depression and anxiety were the most prevalent maternal mental illnesses. The proportion of children exposed to maternal mental illness increased from 22·2% (21·9–22·4) between 2005 and 2007 to 25·1% (24·8–25·5) between 2015 and 2017. Geographically, the highest prevalence of maternal mental illness was observed in Northern Ireland (29·8%, 29·0–30·5). In England, prevalence of maternal mental illness was highest among children in the most deprived areas (28·3%, 27·8–28·8). The incidence of maternal mental illness was highest between 0–3 months (26·7 per 100 person years, 26·4–27·1). By age 16 years, the cumulative risk of maternal mental illness was 53·1% (52·8–53·3).

Interpretation:

One in four children aged 0–16 years are exposed to maternal mental illness and the prevalence of diagnosed and treated maternal mental illness is increasing. Policy makers and commissioners should consider this information and channel resources to target individuals in greatest need.

Publications

  • Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Samre Su Osam, Christian Dolman, Mathias Pierce, Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis. Lancet Public Health, 4, e291–300, 2019.

Clinical Code List

Rows: 165
Code Description Entity type Category Coding System (Read)
146D.00 H/O: manic depressive disorder res76: Affective psychotic disorders diagnostic Read
1B16.00 Agitated res76: Affective psychotic disorders symptom Read
1B17.00 Depressed res76: Affective psychotic disorders symptom Read
1B17.11 C/O - feeling depressed res76: Affective psychotic disorders symptom Read
1B1E.00 Hallucinations res76: Affective psychotic disorders symptom Read
1B1U.00 Symptoms of depression res76: Affective psychotic disorders symptom Read
1B1U.11 Depressive symptoms res76: Affective psychotic disorders symptom Read
1BQ..00 Loss of capacity for enjoyment res76: Affective psychotic disorders symptom Read
1BT..00 Depressed mood res76: Affective psychotic disorders symptom Read
1BT..11 Low mood res76: Affective psychotic disorders symptom Read
1BU..00 Loss of hope for the future res76: Affective psychotic disorders symptom Read
1BY..00 Elevated mood res76: Affective psychotic disorders symptom Read
1JJ..00 Suspected depression res76: Affective psychotic disorders symptom Read
1S42.00 Manic mood res76: Affective psychotic disorders diagnostic Read
212T.00 Psychosis, schizophrenia + bipolar affective disord resolved res76: Affective psychotic disorders diagnostic Read
212V.00 Bipolar affective disorder resolved res76: Affective psychotic disorders diagnostic Read
2257.00 O/E - depressed res76: Affective psychotic disorders symptom Read
225C.00 O/E - elated res76: Affective psychotic disorders symptom Read
E107.00 Schizo-affective schizophrenia res76: Affective psychotic disorders diagnostic Read
E107.11 Cyclic schizophrenia res76: Affective psychotic disorders diagnostic Read
E107000 Unspecified schizo-affective schizophrenia res76: Affective psychotic disorders diagnostic Read
E107100 Subchronic schizo-affective schizophrenia res76: Affective psychotic disorders diagnostic Read
E107200 Chronic schizo-affective schizophrenia res76: Affective psychotic disorders diagnostic Read
E107300 Acute exacerbation subchronic schizo-affective schizophrenia res76: Affective psychotic disorders diagnostic Read
E107400 Acute exacerbation of chronic schizo-affective schizophrenia res76: Affective psychotic disorders diagnostic Read
E107500 Schizo-affective schizophrenia in remission res76: Affective psychotic disorders diagnostic Read
E107z00 Schizo-affective schizophrenia NOS res76: Affective psychotic disorders diagnostic Read
E11..00 Affective psychoses res76: Affective psychotic disorders diagnostic Read
E11..11 Bipolar psychoses res76: Affective psychotic disorders diagnostic Read
E11..12 Depressive psychoses res76: Affective psychotic disorders diagnostic Read
E11..13 Manic psychoses res76: Affective psychotic disorders diagnostic Read
E110.00 Manic disorder, single episode res76: Affective psychotic disorders diagnostic Read
E110.11 Hypomanic psychoses res76: Affective psychotic disorders diagnostic Read
E110000 Single manic episode, unspecified res76: Affective psychotic disorders diagnostic Read
E110100 Single manic episode, mild res76: Affective psychotic disorders diagnostic Read
E110200 Single manic episode, moderate res76: Affective psychotic disorders diagnostic Read
E110300 Single manic episode, severe without mention of psychosis res76: Affective psychotic disorders diagnostic Read
E110400 Single manic episode, severe, with psychosis res76: Affective psychotic disorders diagnostic Read
E110500 Single manic episode in partial or unspecified remission res76: Affective psychotic disorders diagnostic Read
E110600 Single manic episode in full remission res76: Affective psychotic disorders diagnostic Read
E110z00 Manic disorder, single episode NOS res76: Affective psychotic disorders diagnostic Read
E111.00 Recurrent manic episodes res76: Affective psychotic disorders diagnostic Read
E111000 Recurrent manic episodes, unspecified res76: Affective psychotic disorders diagnostic Read
E111100 Recurrent manic episodes, mild res76: Affective psychotic disorders diagnostic Read
E111200 Recurrent manic episodes, moderate res76: Affective psychotic disorders diagnostic Read
E111300 Recurrent manic episodes, severe without mention psychosis res76: Affective psychotic disorders diagnostic Read
E111400 Recurrent manic episodes, severe, with psychosis res76: Affective psychotic disorders diagnostic Read
E111500 Recurrent manic episodes, partial or unspecified remission res76: Affective psychotic disorders diagnostic Read
E111600 Recurrent manic episodes, in full remission res76: Affective psychotic disorders diagnostic Read
E111z00 Recurrent manic episode NOS res76: Affective psychotic disorders diagnostic Read
E112400 Single major depressive episode, severe, with psychosis res76: Affective psychotic disorders diagnostic Read
E113400 Recurrent major depressive episodes, severe, with psychosis res76: Affective psychotic disorders diagnostic Read
E114.00 Bipolar affective disorder, currently manic res76: Affective psychotic disorders diagnostic Read
E114.11 Manic-depressive - now manic res76: Affective psychotic disorders diagnostic Read
E114000 Bipolar affective disorder, currently manic, unspecified res76: Affective psychotic disorders diagnostic Read
E114100 Bipolar affective disorder, currently manic, mild res76: Affective psychotic disorders diagnostic Read
E114200 Bipolar affective disorder, currently manic, moderate res76: Affective psychotic disorders diagnostic Read
E114300 Bipolar affect disord, currently manic, severe, no psychosis res76: Affective psychotic disorders diagnostic Read
E114400 Bipolar affect disord, currently manic,severe with psychosis res76: Affective psychotic disorders diagnostic Read
E114500 Bipolar affect disord,currently manic, part/unspec remission res76: Affective psychotic disorders diagnostic Read
E114600 Bipolar affective disorder, currently manic, full remission res76: Affective psychotic disorders diagnostic Read
E114z00 Bipolar affective disorder, currently manic, NOS res76: Affective psychotic disorders diagnostic Read
E115.00 Bipolar affective disorder, currently depressed res76: Affective psychotic disorders diagnostic Read
E115.11 Manic-depressive - now depressed res76: Affective psychotic disorders diagnostic Read
E115000 Bipolar affective disorder, currently depressed, unspecified res76: Affective psychotic disorders diagnostic Read
E115100 Bipolar affective disorder, currently depressed, mild res76: Affective psychotic disorders diagnostic Read
E115200 Bipolar affective disorder, currently depressed, moderate res76: Affective psychotic disorders diagnostic Read
E115300 Bipolar affect disord, now depressed, severe, no psychosis res76: Affective psychotic disorders diagnostic Read
E115400 Bipolar affect disord, now depressed, severe with psychosis res76: Affective psychotic disorders diagnostic Read
E115500 Bipolar affect disord, now depressed, part/unspec remission res76: Affective psychotic disorders diagnostic Read
E115600 Bipolar affective disorder, now depressed, in full remission res76: Affective psychotic disorders diagnostic Read
E115z00 Bipolar affective disorder, currently depressed, NOS res76: Affective psychotic disorders diagnostic Read
E116.00 Mixed bipolar affective disorder res76: Affective psychotic disorders diagnostic Read
E116000 Mixed bipolar affective disorder, unspecified res76: Affective psychotic disorders diagnostic Read
E116100 Mixed bipolar affective disorder, mild res76: Affective psychotic disorders diagnostic Read
E116200 Mixed bipolar affective disorder, moderate res76: Affective psychotic disorders diagnostic Read
E116300 Mixed bipolar affective disorder, severe, without psychosis res76: Affective psychotic disorders diagnostic Read
E116400 Mixed bipolar affective disorder, severe, with psychosis res76: Affective psychotic disorders diagnostic Read
E116500 Mixed bipolar affective disorder, partial/unspec remission res76: Affective psychotic disorders diagnostic Read
E116600 Mixed bipolar affective disorder, in full remission res76: Affective psychotic disorders diagnostic Read
E116z00 Mixed bipolar affective disorder, NOS res76: Affective psychotic disorders diagnostic Read
E117.00 Unspecified bipolar affective disorder res76: Affective psychotic disorders diagnostic Read
E117000 Unspecified bipolar affective disorder, unspecified res76: Affective psychotic disorders diagnostic Read
E117100 Unspecified bipolar affective disorder, mild res76: Affective psychotic disorders diagnostic Read
E117200 Unspecified bipolar affective disorder, moderate res76: Affective psychotic disorders diagnostic Read
E117300 Unspecified bipolar affective disorder, severe, no psychosis res76: Affective psychotic disorders diagnostic Read
E117400 Unspecified bipolar affective disorder,severe with psychosis res76: Affective psychotic disorders diagnostic Read
E117500 Unspecified bipolar affect disord, partial/unspec remission res76: Affective psychotic disorders diagnostic Read
E117600 Unspecified bipolar affective disorder, in full remission res76: Affective psychotic disorders diagnostic Read
E117z00 Unspecified bipolar affective disorder, NOS res76: Affective psychotic disorders diagnostic Read
E11y.00 Other and unspecified manic-depressive psychoses res76: Affective psychotic disorders diagnostic Read
E11y000 Unspecified manic-depressive psychoses res76: Affective psychotic disorders diagnostic Read
E11y100 Atypical manic disorder res76: Affective psychotic disorders diagnostic Read
E11y300 Other mixed manic-depressive psychoses res76: Affective psychotic disorders diagnostic Read
E11yz00 Other and unspecified manic-depressive psychoses NOS res76: Affective psychotic disorders diagnostic Read
E11z.00 Other and unspecified affective psychoses res76: Affective psychotic disorders diagnostic Read
E11z000 Unspecified affective psychoses NOS res76: Affective psychotic disorders diagnostic Read
E11zz00 Other affective psychosis NOS res76: Affective psychotic disorders diagnostic Read
E130.00 Reactive depressive psychosis res76: Affective psychotic disorders diagnostic Read
Eu0z.12 [X]Symptomatic psychosis NOS res76: Affective psychotic disorders symptom Read
Eu20400 [X]Post-schizophrenic depression res76: Affective psychotic disorders diagnostic Read
Eu25.00 [X]Schizoaffective disorders res76: Affective psychotic disorders diagnostic Read
Eu25000 [X]Schizoaffective disorder, manic type res76: Affective psychotic disorders diagnostic Read
Eu25011 [X]Schizoaffective psychosis, manic type res76: Affective psychotic disorders diagnostic Read
Eu25100 [X]Schizoaffective disorder, depressive type res76: Affective psychotic disorders diagnostic Read
Eu25111 [X]Schizoaffective psychosis, depressive type res76: Affective psychotic disorders diagnostic Read
Eu25200 [X]Schizoaffective disorder, mixed type res76: Affective psychotic disorders diagnostic Read
Eu25211 [X]Cyclic schizophrenia res76: Affective psychotic disorders diagnostic Read
Eu25212 [X]Mixed schizophrenic and affective psychosis res76: Affective psychotic disorders diagnostic Read
Eu25y00 [X]Other schizoaffective disorders res76: Affective psychotic disorders diagnostic Read
Eu25z00 [X]Schizoaffective disorder, unspecified res76: Affective psychotic disorders diagnostic Read
Eu25z11 [X]Schizoaffective psychosis NOS res76: Affective psychotic disorders diagnostic Read
Eu30.00 [X]Manic episode res76: Affective psychotic disorders diagnostic Read
Eu30.11 [X]Bipolar disorder, single manic episode res76: Affective psychotic disorders diagnostic Read
Eu30000 [X]Hypomania res76: Affective psychotic disorders diagnostic Read
Eu30100 [X]Mania without psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu30200 [X]Mania with psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu30211 [X]Mania with mood-congruent psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu30212 [X]Mania with mood-incongruent psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu30y00 [X]Other manic episodes res76: Affective psychotic disorders diagnostic Read
Eu30z00 [X]Manic episode, unspecified res76: Affective psychotic disorders diagnostic Read
Eu30z11 [X]Mania NOS res76: Affective psychotic disorders diagnostic Read
Eu31.00 [X]Bipolar affective disorder res76: Affective psychotic disorders diagnostic Read
Eu31.11 [X]Manic-depressive illness res76: Affective psychotic disorders diagnostic Read
Eu31.12 [X]Manic-depressive psychosis res76: Affective psychotic disorders diagnostic Read
Eu31.13 [X]Manic-depressive reaction res76: Affective psychotic disorders diagnostic Read
Eu31000 [X]Bipolar affective disorder, current episode hypomanic res76: Affective psychotic disorders diagnostic Read
Eu31100 [X]Bipolar affect disorder cur epi manic wout psychotic symp res76: Affective psychotic disorders diagnostic Read
Eu31200 [X]Bipolar affect disorder cur epi manic with psychotic symp res76: Affective psychotic disorders diagnostic Read
Eu31300 [X]Bipolar affect disorder cur epi mild or moderate depressn res76: Affective psychotic disorders diagnostic Read
Eu31400 [X]Bipol aff disord, curr epis sev depress, no psychot symp res76: Affective psychotic disorders diagnostic Read
Eu31500 [X]Bipolar affect dis cur epi severe depres with psyc symp res76: Affective psychotic disorders diagnostic Read
Eu31600 [X]Bipolar affective disorder, current episode mixed res76: Affective psychotic disorders diagnostic Read
Eu31700 [X]Bipolar affective disorder, currently in remission res76: Affective psychotic disorders diagnostic Read
Eu31800 [X]Bipolar affective disorder type I res76: Affective psychotic disorders diagnostic Read
Eu31900 [X]Bipolar affective disorder type II res76: Affective psychotic disorders diagnostic Read
Eu31911 [X]Bipolar II disorder res76: Affective psychotic disorders diagnostic Read
Eu31y00 [X]Other bipolar affective disorders res76: Affective psychotic disorders diagnostic Read
Eu31y11 [X]Bipolar II disorder res76: Affective psychotic disorders diagnostic Read
Eu31y12 [X]Recurrent manic episodes res76: Affective psychotic disorders diagnostic Read
Eu31z00 [X]Bipolar affective disorder, unspecified res76: Affective psychotic disorders diagnostic Read
Eu32300 [X]Severe depressive episode with psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu32311 [X]Single episode of major depression and psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu32312 [X]Single episode of psychogenic depressive psychosis res76: Affective psychotic disorders diagnostic Read
Eu32313 [X]Single episode of psychotic depression res76: Affective psychotic disorders diagnostic Read
Eu32314 [X]Single episode of reactive depressive psychosis res76: Affective psychotic disorders diagnostic Read
Eu32800 [X]Major depression, severe with psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu32900 [X]Single major depr ep, severe with psych, psych in remiss res76: Affective psychotic disorders diagnostic Read
Eu32A00 [X]Recurr major depr ep, severe with psych, psych in remiss res76: Affective psychotic disorders diagnostic Read
Eu33213 [X]Manic-depress psychosis,depressd,no psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu33300 [X]Recurrent depress disorder cur epi severe with psyc symp res76: Affective psychotic disorders diagnostic Read
Eu33311 [X]Endogenous depression with psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu33312 [X]Manic-depress psychosis,depressed type+psychotic symptoms res76: Affective psychotic disorders diagnostic Read
Eu33313 [X]Recurr severe episodes/major depression+psychotic symptom res76: Affective psychotic disorders diagnostic Read
Eu33314 [X]Recurr severe episodes/psychogenic depressive psychosis res76: Affective psychotic disorders diagnostic Read
Eu33315 [X]Recurrent severe episodes of psychotic depression res76: Affective psychotic disorders diagnostic Read
Eu33316 [X]Recurrent severe episodes/reactive depressive psychosis res76: Affective psychotic disorders diagnostic Read
Eu3z.11 [X]Affective psychosis NOS res76: Affective psychotic disorders diagnostic Read
F481K00 Visual hallucinations res76: Affective psychotic disorders symptom Read
R001.00 [D]Hallucinations res76: Affective psychotic disorders symptom Read
R001000 [D]Hallucinations, auditory res76: Affective psychotic disorders symptom Read
R001400 [D]Visual hallucinations res76: Affective psychotic disorders symptom Read
R001z00 [D]Hallucinations NOS res76: Affective psychotic disorders symptom Read
ZV11111 [V]Personal history of manic-depressive psychosis res76: Affective psychotic disorders diagnostic Read
ZV11112 [V]Personal history of manic-depressive psychosis res76: Affective psychotic disorders diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH820/version/1719/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH820/version/1719/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH820', '1719', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH820/version/1719/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH820/version/1719/export/codes/?format=json
CSV site_root/phenotypes/PH820/version/1719/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH820', '1719', api_client=client)

Version History

Version
ID
Name Owner Publish date
1719 Affective Psychotic Disorders ieuan.scanlon 2022-04-04 currently shown

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